Hasil Pencarian  ::  Simpan CSV :: Kembali

"Background: Systemic Lupus Erythematosus (SLE), an autoimmune disease, can cause damage and impairment in the nervous system. Patients who had any manifestation of neurology can be classified as patients with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). One of the most frequent NPSLE manifestation is anxiety disorder. The presence of anxiety disorder is believed to be correlated with their ability to carry out daily activities. This study aims to see the correlation between anxiety disorder and quality of life (QOL) in patients with SLE. Method: an analitic cross-sectional study was done. The data were collected by distributing validated questionnaires to patients diagnosed with SLE in the outpatient clinic of dr. Hasan Sadikin General Hospital. Quality of life and anxiety disorder was measured using Short From-36 (SF-36) and Zung Self-Rating Anxiety Scale (Zung-SAS), respectively. Normality test was done before correlating the variables using Pearson method. Result: Forty-six SLE patients fitted with the inclusion criteria were participated in the study. The assessment using Zung-SAS showed that 9 (19.56%) correspondents had mild–moderate anxiety, and 1 (2.17%) had severe anxiety. The analysis of SF-36 showed the means of Physical Component Summary (PCS) and Mental Component Summary (MCS) which were 45.18 ± 8.23 and 47.11± 9.78, in order. The correlation test of Zung-SAS with PCS and MCS showed the result of r= -0.651 (p < 0,01) and -0.654 (p < 0,01), respectively. Conclusion: There is a significant negative correlation between anxiety disorder and QOL in patients with SLE. The result of this study showed that the high degree of ones anxiety was in a parallel line with their low level of QOL, so it is important to do an early detection and prevention of anxiety disorder in SLE patients."

"ABSTRAKSystemic Lupus Erythematosus SLE adalah penyakit autoimun, dimana sistem kekebalan tubuh menyerang organ tubuh sendiri. Orang dengan Lupus Odapus mengalami berbagai perubahan secara fisik, ekonomi, sosial, dan psikologis yang menyebabkan mereka memiliki penghayatan akan penyakit yang dimiliki, atau disebut juga illness cognition. Penghayatan ini mempengaruhi kognisi Odapus dalam memandang penyakit dan mempengaruhi perilaku kesehatan serta coping akan permasalahan yang disebabkan oleh SLE. Penelitian bertujuan untuk mengubah illness cognition Odapus terkait penyakit SLE yang dimiliki. Penelitian merupakan penelitian kuasi-eksperimental dengan one group pretest-posttest design. Kelompok terdiri dari lima orang yang diperoleh lewat accidental sampling. Partisipan mengikuti lima kali sesi individual serta satu kali pra-sesi dan satu kali sesi follow-up. Analisis dilakukan dengan cara membandingkan data kuantitatif menggunakan adaptasi alat ukur Illness Cognition Questionnaire ICQ serta data kualitatif tentang perubahan kognitif, perilaku, dan strategi pemecahan masalah sebelum dan sesudah mengikuti intervensi. Hasil penelitian menunjukkan bahwa intervensi kognitif-perilaku dapat meningkatkan illness cognition pada Odapus. Partisipan dapat menerima penyakit SLE sebagai bagian dari hidupnya, menghayati adanya berbagai hal positif dari penyakit SLE, dan memiliki harapan serta dapat melakukan kontrol terhadap berbagai keterbatasan yang diakibatkan oleh penyakit SLE. Pada akhirnya, partisipan dapat meningkatkan kemampuan untuk menyelesaikan masalah yang diakibatkan oleh penyakit SLE secara lebih efektif.

---

ABSTRACTSystemic Lupus Erythematosus SLE is autoimmune disease which the immune system damage their own body. Patient with SLE experience change in physical, economic, social, and psychology that caused a perception to their own disease, called illness cognition. This perception influence patient rsquo s cognition about their disease and predispose their health behavior and coping problem related to their disease. This study aimed to identify effectiveness of cognitive behavior therapy to change illness cognition patient about SLE. This was quasi experimental study conducted with one group pre test post test design. Group consisted of five participant recruited through accidental sampling. Participants participated in five individual sessions, preceded by a pre session and followed by a follow up session. Analysis was conducted by comparing quantitative data obtained by Indonesian adaptation of Illness Cognition Questionnaire ICQ and qualitative data showing changes in participants rsquo cognition, behavior, and problem solving before and after the intervention took place. This study showed that cognitive behavior therapy can successfully enhance illness cognition in patient with SLE. Participants may receive SLE disease as a part of their life, appreciate many positive things of SLE, have hope also can control various limitations caused by SLE. Participants can improve their ability to coping with problem related to SLE more effectively."

"ABSTRAKSLE atau lupus yang mengalami peningkatan dari tahun ke tahun merupakan salah satu penyakit tidak menular yang menjadi masalah di perkotaan. Perjalanan penyakit SLE/lupus yang bersifat episodik berulang yang diselingi periode sembuh membuat klien merasakan kecemasan dan ketidakberdayaan yang diakbatkan dari kondisi penyakitnya. Karya ilmiah akhir ners ini akan menganalisis mengenai asuhan keperawatan masalah ketidakberdayaan dan ansietas pada klien dengan penyakit SLE/lupus selama 4 hari. Tindakan keperawatan bertujuan untuk mengontrol perasaan tidak berdaya dengan membuat klien mampu mengambil keputusan yang efektif untuk mengendalikan situasi kehidupannya serta untuk mengeatasi kecemasan. Hasil evaluasi yang dilakukan terlihat dalam keseharian klien selama klien mendapatkan perawatan, klien menunjukkan perkembangan dan berkurangnya tanda gejala masalah tersebut.Dibutuhkan upaya seperti menjaga keefektifan koping, mengurangi/menjauhi stres, dan sistem dukungan support system yang baik dari lingkungan di sekitar klien untuk membantu klien untuk mengurangi masalah terutama masalah psikososial yang dirasakan klien. Kata Kunci :Ansietas, asuhan keperawatan, ketidakberdayaan, sistemik lupus eritematosus SLE /lupus

---

ABSTRACTSLE /lupus is not contagious diseases which prevalence increases each year and causing a problem especially in urban areas. The course of episodic SLE / lupus disease recurrent interspersed with periods of recovery makes the client feel the anxiety and powerlessness implied by the condition of the illness. This final paper will analyze the nursing care of powerlessness and anxiety in clients with SLE / lupus disease for 4 days. Nursing actions aim to control feelings of powerlessness by allowing clients to make effective decisions to control their life situations and to overcome anxiety. The results of evaluations made visible in the client 39;s daily life as long as the client gets treatment, the client shows the development and decrease of symptoms of the problem. It takes efforts such as maintaining the effectiveness of coping, reducing / avoiding stress, and a good support system from the environment around the client to help clients reducing the problem, especially the psychosocial problems felt by the client. Keywords: Anxiety, nursing care, powerlessness, systemic lupus erythematosus SLE /lupus."

"Tujuan: Tujuan penelitian ini adalah mengetahui korelasi antara asupan vitamin D dengan kadar 25(OH)D serum pada pasien lupus eritematosus sistemik perempuan usia dewasa. Metode: Peneltian ini merupakan penelitian potong lintang pada 36 pasien SLE perempuan dewasa dari Poliklinik Reumatologi di RS Dr. Cipto Mangunkusumo. Pengambilan data subyek meliputi usia, klasifikasi penyakit SLE, obat-obatan yang digunakan, tipe kulit, penggunaan tabir surya, bagian tubuh yang tertutup pakaian, lama terpajan sinar matahari, indeks massa tubuh (IMT), asupan vitamin D, dan kadar 25(OH)D serum. Hasil: Sebagian besar (41,7%) subyek berusia antara 36–45 tahun, tergolong klasifikasi SLE ringan (52,8%), selalu menggunakan tabir surya (63,9%), tipe kulit IV (69,4%), dan memakai pakaian yang menutupi seluruh/sebagian besar tubuh (69,4%), serta tidak terpajan dan terpajan sinar matahari <30 menit (77,8%). Semua subyek menggunakan kortikosteroid. Separuh subyek memiliki berat badan normal berdasarkan IMT, sebagian besar (55,6%) subyek mempunyai asupan vitamin D cukup berdasarkan AKG 2012, dan 28 subyek (77,8%) menderita defisiensi vitamin D ( kadar 25(OH)D serum <50 nmol/L). Didapatkan korelasi positif yang sedang antara asupan vitamin D dengan kadar 25(OH)D serum pada subyek penelitian (r = 0,52; P <0,01). Kesimpulan: Terdapat korelasi positif yang sedang antara asupan vitamin D dengan kadar 25(OH)D serum pada pasien SLE perempuan dewasa (r = 0,52; P <0,01).

---

Objective: the aim of the study is to investigate the correlation between vitamin D intake and serum 25(OH)D concentration of adult woman SLE patients.

Methods: A cross-sectional study was conducted in 36 adult woman patients with SLE from Rheumatology Clinic of the Departemen of Internal Medicine Dr. Cipto Mangunkusumo hospital. Data collection included age, SLE classification, drugs, skin type, use of sunscreen, part of the body covered by clothes, length of sun exposure, body mass index (BMI), vitamin D intake, and serum 25(OH)D concentration.

Results: Most of the subjects (41.7%) aged 36–45 years old, classified as mild SLE (52.8%), always used sunscreen (63.9%), skin type IV (69.4%), wearing clothes that covered all or almost of the body (69.4%), and not exposed or had sun exposure less than 30 minute (77.8%). All subjects used corticosteroid. Based on BMI half of the subjects had normal body weight, Based on AKG 2012 most (55.6%) had adequate vitamin D intakes, and 28 subjects (77.8%) were in vitamin D-deficient (serum 25(OH)D concentration <50 nmol/L). There were moderate positive correlation between vitamin D intake and serum 25(OH)D concentration in subjects (r = 0.52; P <0.01).

Conclusion: There were moderate positive correlation between vitamin D intake and serum 25(OH)D concentration of adult woman SLE patients (r = 0.52, P <0.01)."

"LES merupakan penyakit inflamasi autoimun kronis dan banyak terjadi pada  anak remaja dengan rata-rata onset usia 11-12 tahun. Sekitar 10% dari remaja dengan penyakit kronis seperti LES mengalami masalah psikososial, termasuk masalah emosi seperti depresi dan kecemasan. Penelitian ini bertujuan untuk mengetahui apakah pelatihan kecakapan hidup pada anak dengan LES dapat memperbaiki masalah emosi. Penelitian dilakukan dengan 30 subjek remaja perempuan dengan LES yang sudah mendapatkan pengobatan, dan nilai SLEDAI 0-5. Subjek dibagi menjadi 2 kelompok secara acak tanpa penyamaran, perlakuan dan kontrol.  Pelatihan kecakapan hidup diberikan pada kelompok perlakuan sebanyak 1 kali dalam kelas. Perbaikan masalah emosi dinilai dengan membandingkan nilai SDQ sebelum pelatihan dan 4 minggu setelah pelatihan. Penelitian melibatkan 30 remaja perempuan dengan LES dengan usia rerata 14 tahun. Sebanyak 20/30 subjek memiliki nilai SDQ normal, 4/30 dengan SDQ borderline dan 6/30 dengan SDQ abnormal. Terdapat perbedaan bermakna selisih masalah emosi pada kedua kelompok (p: 0,025; effect size: 0,87). Pada kelompok yang mendapatkan pelatihan terdapat perbaikan nilai SDQ total (p: 0,001), nilai masalah emosi (p: 0,002), nilai masalah perilaku (p: 0,027) dan nilai masalah perilaku hiperaktif (p: 0,040) dibandingkan dengan awal studi. Sedangkan pada kelompok kontrol hanya terdapat perubahan nilai masalah dengan teman sebaya (p: 0,011). Selain itu ditemukan pula perbaikan masalah emosi pada kelompok pelatihan yakni keluhan sakit fisik (p: 0,021), rasa khawatir (p: 0,020) dan perasaan gugup (p: 0,020). Studi ini menyimpulkan bahwa pelatihan kecakapan hidup-modul pengelolaan emosi efektif dalam memperbaiki masalah emosi pada remaja perempuan dengan LES secara signifikan, terutama gugup atau sulit berpisah dengan orangtua/pengasuhnya pada situasi baru, mudah kehilangan rasa percaya diri dan banyak kekhawatiran atau sering tampak khawatir.

---

SLE is a chronic autoimmune inflammatory disease and many occur in adolescents with an average age of onset of 11-12 years. About 10% of adolescents with chronic diseases such as SLE experience psycho-mental problems, including emotional problems such as depression and anxiety. The aim of this study is to determine whether life skills training in children with SLE can improve emotional problems. The study was conducted with 30 female adolescent with SLE who had received treatment and SLEDAI score 0-5. Subjects were divided into 2 groups randomly, not-blinding, experiment and control. Life skills training is given to the experiment group one time in group. Emotional problem improvement was assessed by comparing SDQ scores before training and 4 weeks after training. The study involves a total of 30 female adolescent with SLE with an average age of 14 years. A total of 20/30 subjects had normal SDQ values, 4/30 with borderline SDQ and 6/30 with abnormal SDQ. There were significant differences in the difference between emotional problems in the two groups (p: 0.025; effect size: 0.87). In the group that received training there was an improvement in the total SDQ value (p: 0.001), the value of emotional problems (p: 0.002), the value of conductive problems (p: 0.027) and the value of hyperactive behavior problems (p: 0.040) compared to the beginning of the study. Whereas in the control group there were only changes in the value of problems with peers (p: 0.011). In addition it also found improvements in emotional problems in the experiment group, they are complaints of physical pain (p: 0.021), anxiety (p: 0.020) and nervous feelings (p: 0.020). This study concludes that life skills training-emotion management module is significantly effective in improving emotional problems in female adolescent with LES, especially nervous or having difficulty separating from parents/caregivers in new situations, easily losing self-confidence and many worries or often seems worried."

"Background. Antibody to complement C1q (Anti-C1q Antibody) can be found in Systemic Lupus Erythematosus (SLE) patients. Complement C1q plays a role in the clearance of apoptotic cells and immune complexes. Anti-C1q causes complement C1q become inactive so that the clearance decreases, which induces self antigen and inflammatory response. Many tissue inflammation are associated with disease activity and lupus manifestations. The aim of this study is to find out the correlation of anti-C1q level with disease activity, so that anti-C1q can be used as an objective indicator of inflammation along with SELENA-SLEDAI. Method. This is an analytic descriptive study with cross sectional design. Anti-C1q antibody levels were measured in 52 SLE patients who are hospitalized or treated routinely in outpatient clinic of Rheumatology Dr.Hasan Sadikin Hospital Bandung Indonesia from October to December 2015. Result. Most of the study subjects were women (94%), with a median age of 33 years. There were 13 new patients (25%), and the rest 42 patients were treated routinely. The median SELENA-SLEDAI was 6 (0-32). Subject were divided into no activity (11.5%), low disease activity (34.6%), medium disease activity (25%) high disease activity (15.4%) and very high disease activity (13.5%). Median anti-C1q level was 3.92 U/mL (range 0.6-100.2 U/mL). Anti-C1q antibody levels were positively correlated with SLE disease activity based on SELENA-SLEDAI scores (r=+0.304; p=0.014) Conclusion. Anti-C1q antibody levels has mild correlated with lupus disease activity based on SELENA-SLEDAI score"

"Background. Systemic Lupus Erythematosus (SLE) is an Autoimmune inflammatory disease that is systemic and chronic inflammation with heterogeneous of history, clinical manifestations, and prognosis. The disease activity of SLE has been proven as a predictor of organ damage and death by evidenced of inflammatory markers involved in this disease. Neutrophil to Lymphocyte Ratio (NLR) is useful for estimating the activity of autoimmune disease and inflammation that easily obtained from blood test and low cost and measurable as new biomarker to assess inflammatory response or activity of SLE. This study aimed to determine the relationship between NRL and Disease Activity based on Mex-SLEDAI in patients SLE. Methods. This study is an analytic study with cross sectional design. It started from November 2016 until March 2017. Mex-SLEDAI and blood sampling used in this study. Result. Total sample in this study is 54 patients with median age was 28.5 years, with mostly female (85,2%). Result analysis with positive correlation between NLR with disease activity on SLE (r=0.399 p=0.003 n=54), thus the Scatter plot shows there is a correlation between NRL with Mex-SLEDAI. Conclusion. Positive correlation between NLR and disease activity of the SLE, the higher of the disease activity/Mex-SLEDAI will be followed by the increase of NLR."

"Background Patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), have to cope with lifelong disease manifestation and impaired physical function. Limited physical activities along the disease will affect their quality of life (QoL). The QoL is recognized as an important factor of treatment strategy. This study aims to compare the quality of life of patient with SLE and SSc. Method This study was a cross-sectional study and conducted in rheumatology outpatient clinic of Hasan Sadikin Hospital Bandung, Indonesia from January 2015 until March 2017. The respondents were patients diagnosed as SLE and SSc who regularly visit rheumatology outpatient clinic. Respondents were asked to complete the Short Form-36 (SF-36). Baseline characteristics, including age, gender, and duration of disease, were collected during the visit. The Mann-Whitney U test was used to analyze the comparison. Result There were 242 patients who completed the SF-36 questionnaires, consisted of 193 SLE patients and 49 SSc patients. SLE patients were slightly younger and had a longer duration of disease compared to SSc. The SF-36 Physical Component Summary (PCS) score was significantly higher on SLE patients (40.6 vs 40.4, p = 0.0001), but the mean of Mental Component Summary (MCS) score was similar among both diseases. Conclusion Physical functioning aspect on quality of life is better in SLE patients compared to SSc patients. However, mental aspect for both diseases are relatively similar."

"ABSTRAKLatar Belakang:Perkembangan dalam tatalaksana Lupus eritematosus sistemik (LES) telah meningkatkankesintasan pasien dengan LES. Kualitas hidup merupakan komponen evaluasi terapi LES danvalue based medicine. Salah satu kuesioner khusus untuk menilai kualitas hidup adalahLupus QoL. Saat ini di Indonesia belum ada kuesioner khusus penilaian kualitas hidup padapasien dengan LES. Penelitian ini bertujuan membuktikan Lupus QoL sahih dan andal dalammenilai kualitas hidup pasien dengan LES di Indonesia.Metode:Penelitian ini merupakan studi potong lintang. Penelitian diawali dengan menerjemahkanLupus QoL ke dalam bahasa Indonesia kemudian diujicobakan pada 10 responden. Penelitiankemudian dilanjutkan pada jumlah sampel yang lebih besar. Keandalan dievaluasi denganIntraclass Correlation Coefficient (ICC) pada tes dan tes ulang dan cronbach α padakonsistensi internal. Kesahihan konstruksi dinilai dengan multi trait scaling analysis.Kesahihan eksternal dinilai dengan menilai korelasi antara Short form 36 (SF36) denganLupus QoL dan aktivitas penyakit.Hasil:Pengambilan data terhadap 65 pasien LES yang berobat di unit rawat jalan Ilmu PenyakitDalam RSCM selama bulan Oktober ? November 2015. Kesahihan eksternal Lupus QoL baikdengan korelasi terhadap SF36 dengan r :0.38 ? 0.66 (p<0.05). Multi trait analysis scalingmenunjukkan korelasi yang baik antara nilai tiap domain dengan nilai total (r:0.46 ? 0.85)dan antara skor tiap butir pertanyaan dan skor total domain (r:0.44 ? 0.93). Nilai ICC(interval 7 hari) baik (ICC>0.7). Nilai cronbach α> 0.7 pada setiap domain. Korelasi LupusQoL terhadap aktivitas penyakit memiliki korelasi yang lemah dan tidak bermakna yangsesuai dengan penelitian ? penelitian sebelumnya.Simpulan:Kuesioner Lupus QoL Indonesia sahih dan andal dalam menilai kualitas hidup pada pasiendengan LES di Indonesia

---

ABSTRACTBackground:The development in Systemic Lupus Erythematosus treatment has led into the increasment of survival.Quality of life has become a component to evaluate therapy ini SLE and value based medicine. Onespesific questionnaire to asses quality of life is Lupus Quality of Life (Lupus QoL). Currently inIndonesia there has not been spesific questionnaire to asses quality of life in SLE patients. This studyaims to prove that Lupus QoL is valid and reliable to asses the quality of life in SLE patients inIndonesia.Methods:This study is cross sectional study. This study began with the translation the Lupus QoL intoindonesian language then tested in 10 respondents. After that,this study continued with a largersample size. The intraclass coefficient correlation was used to evaluate test and re test reliability, thecronbach alpha was used to evaluate internal consistency. Construct validity evaluated using multitrait scaling analysis and the extrenal validity evaluated using the correlation between domains inshort form 36 (SF 36) with Lupus QoL and with disease activity. Results:Data collection were doneon 65 SLE patients in Oktober ? November 2015 in RSCM. The external validity with SF 36 was goodwith r:0.38-0.66(p<0.05). The construct validity is good with r > 0.4 (0.44 ? 0.93). The ICC value inone week >0.7 and Cronbach α was >0.7 in each domain. The correlation with disease activity wasweak and consistent with another studies.Conclusion:Lupus QoL questionnaire is valid and reliable to asses quality of life in SLE patients in Indonesia."

"The book is an up-to-date introduction to the disease and includes high quality colour photographs and evidence-based guidelines for diagnosing, treating and managing Lupus in primary care."