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"Hipertensi sebagai salah satu jenis Penyakit Tidak Menular (PTM) menjadi penyumbang terbanyak penyebab kematian di dunia. Komplikasi dari hipertensi menyumbang sebagian besar kematian secara global. Perilaku kesehatan yang tidak terkontrol pada penderita hipertensi erat kaitannya dengan peningkatan angka kesakitan yang diakibatkan komplikasi dari hipertensi setiap tahunnya. Patuh minum obat dan pengendalian perilaku merokok merupakan upaya untuk membentuk perilaku kesehatan yang positif untuk mencegah komplikasi dari hipertensi. Penelitian ini bertujuan untuk mengidentifikasi hubungan perilaku kesehatan dengan kepatuhan minum obat dan perilaku merokok pada klien hipertensi di Kecamatan Cipayung Jakarta Timur. Desain penelitian ini menggunakan pendekatan cross sectional dengan 109 partisipan, yang dipilih dengan pengambilan sampel purposive sampling yaitu klien hipertensi primer usia dewasa menengah. Hasil uji chi square menunujukan ada hubungan antara perilaku kesehatan dengan kepatuhan minum obat (p value : 0,024) CI 90%. Uji chi square antara perilaku kesehatan dengan perilaku merokok pada CI 90% menujukan nilai p value 0,217 yang menujukan tidak terdapat hubungan. Berdasarkan hasil penelitian dapat disimpulkan bahwa semakin positif perilaku kesehatan maka semakin tinggi kepatuhan minum obat pada klien hipertensi. Perawat komunitas memiliki peran pening dalam memodifikasi perilaku penderita hipertensi dengan berbagai pendekatan baik sebagai individu, keluarga, mapupun masyarakat dapat mempertahankan kesejahteraan kesehatannya.

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Hypertension as Non-Communicable Diseases (PTM) is the largest contributor to the causes of death in the world. Complications of hypertension account for the majority of deaths globally. Uncontrolled health behavior in patients with hypertension is closely related to an increase in morbidity rates due to complications from hypertension each year. Medication adherence and controlling smoking behavior is an effort to form positive health behaviors to prevent complications from hypertension. This study aims to identify the relationship between health behavior with medication adherence and smoking behavior in hypertensive clients in Cipayung District, East Jakarta. using cross sectional design, approach with 109 participants, who were selected by purposive sampling, are choosen primary hypertensive clients of middle adulthood. The results of the chi square test showed that there was a relationship between health behavior and medication adherence (p value: 0.024) 90% CI. Chi square test between health behavior and smoking behavior in CI 90% addressed p value 0.217 which showed no relationship. Based on the results of the study it can be concluded that the more positive the health behavior, the higher the adherence to taking medication in hypertensive clients. Community nurses have an important role in modifying the behavior of hypertensive patients with a variety of approaches both as individuals, families, and the public can maintain their health well-being."

"Meningkatnya prevalensi hipertensi di Indonesia mempengaruhi jumlah penggunaan obat antihipertensi, serta masih banyak penderita hipertensi yang belum mendapatkan pengobatan yang efektif dan rasional membuat evaluasi penggunaan obat antihipertensi pada pasien hipertensi penting untuk dilakukan. Penggunaan obat antihipertensi harus mengikuti acuan yang berlaku di Indonesia yaitu Formularium Nasional. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat antihipertensi. Desain penelitian adalah cross-sectional dan bersifat deskriptif. Data yang digunakan adalah data sekunder dari resep dan rekam medis dengan metode retrospektif. Pengambilan sampel dilakukan secara total sampling. Jumlah sampel penelitian ini adalah sebanyak 2814 resep. Berdasarkan hasil penelitian, hipertensi lebih banyak terjadi pada perempuan 65,79, kelompok usia 45-64 51,78, dan pasien Non BPJS 68,68. Jumlah total penggunaan obat antihipertensi sebesar 38972,03 DDD dengan peringkat tiga besar obat antihipertensi dengan penggunaan terbanyak diantaranya adalah amlodipin 24812,97 DDD, 1,4096 DDD/1000 pasien/hari, dan 0,7698 DDD/1000 penduduk/hari , valsartan 5397,22 DDD, 0,3066 DDD/1000 pasien/hari, dan 0,1674 DDD/1000 penduduk/hari, dan kaptopril 4979,64 DDD, 0,2829 DDD/1000 pasien/hari, dan 0,1545 DDD/1000 penduduk/hari. Kesesuaian penggunaan obat antihipertensi di RSUD Jagakarsa pada tahun 2017 dengan Formularium Nasional adalah 100. Penggunaan obat antihipertensi telah sesuai dengan Formularium Nasional, sehingga penggunaan obat antihipertensi yang efektif diharapkan dapat tercapai.

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Increasing prevalence of hypertension in Indonesia affecting the amount of antihypertensive use, and there were still many hypertensive patients who did not receive effective and rational treatment made it necessary to evaluate the use of antihypertensive. The uses of drugs in health facilities must comply with national reference, namely the National Formulary. This study was conducted to evaluate the use of antihypertensive in hypertensive patients. The research design was cross sectional and descriptive. Data used were secondary data from prescriptions and medical records by retrospective method. Sampling was done in total sampling, with total samples of 2814 prescriptions. The results showed that 65,79 of hypertension outpatients were females, 51,78 were 44 to 64 years old, and 68,68 did not follow the BPJS Program. The total use of antihypertensive was 38972,03 DDD and the three most widely used antihypertensives were amlodipine 24812,97 DDD, 1,4096 DDD 1000 patients day, and 0,7698 DDD 1000 inhabitants day, valsartan 5397,22 DDD, 0,3066 DDD 1000 patients day, and 0,1674 DDD 1000 inhabitants day, and captopril 4979,64 DDD, 0,2829 DDD 1000 patients day, and 0,1545 DDD 1000 inhabitants day. The use of antihypertensive was 100 appropriate according to National Formulary. The use of antihypertensive was appropriate according to National Formulary, therefore effective use of antihypertensive is expected to be achieved."

"Hipertensi adalah suatu keadaan pasien memiliki tekanan darah ≥140/90 mmHg ketika dilakukan pengukuran darah minimal dua kali dengan jarak satu minggu dan berdasarkan diagnosis dokter. Riset Kesehatan Dasar (Riskesdas) tahun 2018 menunjukkan peningkatan prevalensi hipertensi di Indonesia dengan jumlah penduduk sekitar 260 juta adalah 34,1% dibandingkan 27,8% pada Riskesdas tahun 2013.5 Berdasarkan Profil Kesehatan Puskesmas Kecamatan Matraman Tahun 2021, Penyakit Tidak Menular (PTM) yang memiliki pasien terbanyak adalah hipertensi yaitu sejumlah 5.026 orang. Menurut laporan WHO pada tahun 2003, kepatuhan rata-rata pasien pada terapi jangka panjang terhadap penyakit kronis di negara berkembang bahkan lebih rendah dari 50%. Kepatuhan minum obat merupakan faktor penentu yang penting dalam keberhasilan terapi terutama pada terapi penyakit tidak menular seperti hipertensi. Profil kepatuhan minum obat antihipertensi pada pasien hipertensi di Puskesmas Matraman menunjukkan bahwa sampel dengan kepatuhan sedang memiliki jumlah terbanyak yaitu 24 orang, kemudian sampel dengan kepatuhan tinggi berjumlah 8 orang dan sampel kepatuhan rendah berjumlah 11 orang. Karakteristik sampel yang memiliki hubungan dengan kepatuhan minum obat berdasarkan hasil uji Chi-square adalah umur (nilai p = 0,040) dan pendidikan terakhir (nilai p = 0,004). Hasil pengamatan menunjukkan bahwa semakin tinggi umur maka kepatuhan semakin rendah dan semakin tinggi pendidikan terakhir maka tingkat kepatuhan semakin tinggi.

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Hypertension is a condition in which a patient has blood pressure ≥140/90 mmHg when blood measurements are taken at least twice one week apart and based on a doctor's diagnosis. The 2018 Basic Health Research (Riskesdas) showed an increase in the prevalence of hypertension in Indonesia with a population of around 260 million, which was 34.1% compared to 27.8% in the 2013 Riskesdas. 5 Based on the health profile of the Matraman District Health Center in 2021, noncommunicable diseases The most patients with hypertension are 5,026 people. According to a WHO report in 2003, the average patient adherence to long-term therapy for chronic diseases in developing countries is even lower than 50%. Compliance with taking medication is an important determining factor in the success of therapy, especially in the treatment of non-communicable diseases such as hypertension. The profile of adherence to taking antihypertensive medication in hypertensive patients at the Matraman Health Center shows that the sample with moderate adherence has the highest number, namely 24 people, then the sample with high adherence is 8 people and the sample with low adherence is 11 people. Based on the results of the Chi-square test, the characteristics of the sample that had a relationship with medication adherence were age (p-value = 0.040) and recent education (p-value = 0.004). Observations showed that the higher the age, the lower the compliance, and the higher the last education, the higher the level of compliance. "

"Hipertensi merupakan salah satu penyakit kronis yang membutuhkan pengelolaan dan terapi jangka panjang. Penyakit hipertensi tidak dapat disembuhkan tetapi harus selalu dikontrol. Kontrol tekanan darah sangat diperlukan untuk mencegah adanya komplikasi yang dapat terjadi akibat hipertensi yang tidak terkontrol. Ada beberapa faktor yang dapat mempengaruhi pasien patuh minum obat, termasuk di dalamnya yaitu pengetahuan. Puskesmas berperan sebagai fasilitas kesehatan tingkat pertama dalam penanganan awal dan kontrol pengobatan hipertensi. Puskesmas adalah fasilitas pelayanan kesehatan yang menyelenggarakan upaya kesehatan masyarakat dan upaya kesehatan perseorangan tingkat pertama, dengan lebih mengutamakan upaya promotif dan preventif di wilayah kerjanya. Maka dari itu perlu dilakukan promosi kesehatan terkait pentingnya kepatuhan minum obat antihipertensi dalam upaya meningkatkan kepatuhan minum obat bagi penderita hipertensi. Upaya tersebut dapat dilakukan dengan melakukan Pelayanan Informasi Obat (PIO) melalui media leaflet. Leaflet penyampaian mengenai Pentingnya Kepatuhan Minum Obat Antihipertensi pada Pasien Hipertensi di Puskesmas Jatinegara terdiri dari beberapa point yang meliputi pengertian penyakit hipertensi, pengertian patuh minum obat, pentingnya minum antihipertensi secara teratur, faktor – faktor penyebab ketidakpatuhan minum obat, serta dampak yang diakibatkan oleh ketidakpatuhan minum obat antihipertensi. Isi leaflet juga menyertakan solusi yaitu beberapa cara untuk meningkatkan kepatuhan minum obat.

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Hypertension is one of the chronic diseases that requires long-term management and therapy. It cannot be cured but must always be controlled. Blood pressure control is crucial to prevent complications that can arise from uncontrolled hypertension. Several factors can affect patient adherence to medication, including knowledge. Community health centers (Puskesmas) play a role as primary healthcare facilities in the initial management and treatment control of hypertension. Puskesmas provides health services aimed at both community and individual health promotion and prevention efforts primarily in its operational area. Therefore, health promotion related to the importance of adherence to antihypertensive medication is essential to improve compliance among hypertensive patients. This effort can be achieved through Drug Information Services (DIS), using leaflets as a medium. The leaflet on the Importance of Adherence to Antihypertensive Medication among Hypertensive Patients at Jatinegara Community Health Center consists of several points, including understanding hypertension, the concept of medication adherence, the importance of regular intake of antihypertensive medication, factors contributing to non-adherence, and the impacts of non-adherence to antihypertensive medication. The leaflet also includes solutions such as strategies to enhance medication adherence."

"Hipertensi adalah salah satu penyakit tidak menular dengan prevalensi tertinggi di Indonesia yaitu 34,1% kasus. Sebagai faktor risiko penyakit lain, pasien hipertensi biasanya mengalami komplikasi dan membutuhkan terapi tambahan yang dapat menyebabkan polifarmasi. Tujuan dari penelitian ini adalah untuk menganalisis masalah terkait obat pada pasien rawat inap dengan hipertensi di Rumah Sakit Distrik Koja dari Februari-April 2019 berdasarkan PCNE V6.2. Penelitian ini adalah studi cross-sectional berdasarkan resep lengkap, rekam medis, dan kartu indeks yang dapat dibaca dari pasien yang menggunakan obat antihipertensi dan dirawat di rumah sakit di Rumah Sakit Distrik Koja dari Februari - April 2019. Analisis ini dilakukan untuk 90 pasien yang memenuhi kriteria. Dari penelitian ini, ada 148 masalah terkait obat yang diidentifikasi, terdiri dari masalah dengan efektivitas pengobatan (66,21%) dan reaksi obat yang merugikan (33,78%) dengan reaksi obat yang tidak alergi sebagai subdomain dengan prevalensi tertinggi (31), 75%) dan penyebab masalah terkait narkoba yang sebagian besar terjadi adalah kombinasi obat yang tidak tepat, atau obat-obatan dan makanan (48,51%). Dari penelitian ini, diketahui bahwa masalah dengan efektivitas pengobatan adalah masalah terkait obat yang paling banyak terjadi.

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Hypertension is one of the non-communicable diseases with the highest prevalence in Indonesia, which is 34.1% of cases. As a risk factor for other diseases, hypertensive patients usually experience complications and require additional therapy that can cause polypharmacy. The purpose of this study was to analyze drug-related problems in hospitalized patients with hypertension at the Koja District Hospital from February to April 2019 based on PCNE V6.2. This study is a cross-sectional study based on complete prescriptions, medical records, and index cards that can be read from patients who use antihypertensive drugs and are hospitalized in the Koja District Hospital from February to April 2019. This analysis was carried out for 90 patients who met criteria. From this study, there were 148 drug-related problems identified, consisting of problems with treatment effectiveness (66.21%) and adverse drug reactions (33.78%) with non-allergic drug reactions as subdomains with the highest prevalence (31), 75%) and the most common cause of drug related problems is an improper combination of drugs, or drugs and food (48.51%). From this research, it is known that the problem with the effectiveness of treatment is the most drug-related problems."

"Penelitian ini bertujuan untuk menganalisis keamanan, efektivitas, dan efisiensi biaya dari suplemen berbahan dasar bawang putih untuk pasien hipertensi di Apotek Kimia Farma 583 Pasadena, Cikarang. Analisis difokuskan pada dua produk suplemen, yaitu Nutrimax Ultra Garlic dan Sea-Quill Garlicol 800. Penelitian ini menggunakan kombinasi pengumpulan data primer melalui observasi langsung dan data sekunder dari laporan inventarisasi obat hipertensi. Studi literatur dilakukan untuk mengevaluasi keamanan dan efektivitas suplemen tersebut, sementara analisis efisiensi biaya membandingkan keuntungan per unit dari suplemen tersebut dengan obat generik dan paten yang umum digunakan untuk hipertensi. Hasil penelitian menunjukkan bahwa Nutrimax Ultra Garlic dan Sea-Quill Garlicol 800 memiliki efektivitas seperti yang diklaim, yaitu membantu menurunkan tekanan darah pada pasien hipertensi. Kandungan bawang putih (Allium sativum) dalam suplemen ini terbukti secara signifikan menurunkan tekanan darah sistolik dan diastolik. Dari segi keamanan, kedua suplemen ini aman digunakan bersamaan dengan obat antihipertensi lainnya, meskipun penelitian jangka panjang masih terbatas. Analisis biaya mengungkapkan bahwa Nutrimax Ultra Garlic menghasilkan keuntungan sebesar Rp962/unit, sedangkan Sea-Quill Garlicol 800 menghasilkan keuntungan sebesar Rp1.126/unit. Oleh karena itu, penggunaan suplemen berbahan dasar alami seperti bawang putih tidak hanya memberikan keuntungan ekonomi bagi apotek, tetapi juga menawarkan pilihan pengobatan alternatif yang lebih aman dan terjangkau bagi pasien hipertensi.

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This study aims to analyze the safety, efficacy, and cost-effectiveness of garlic-based supplements for hypertensive patients at Kimia Farma Pharmacy 583 Pasadena, Cikarang. The analysis focused on two supplement products: Nutrimax Ultra Garlic and Sea-Quill Garlicol 800. The study employed a combination of primary data collection through direct observation and secondary data from hypertension medication inventory reports. Literature studies were conducted to evaluate the safety and efficacy of the supplements, while cost-effectiveness analysis compared the profit per unit of the supplements with commonly used generic and patented medications for hypertension. The results indicate that Nutrimax Ultra Garlic and Sea-Quill Garlicol 800 are efficacious as claimed, helping to reduce blood pressure in hypertensive patients. The garlic content (Allium sativum) in these supplements has been proven to significantly lower both systolic and diastolic blood pressure. In terms of safety, both supplements are safe for use alongside other antihypertensive medications, although long-term studies are limited. The cost analysis revealed that Nutrimax Ultra Garlic generates a profit of Rp962/unit, while Sea-Quill Garlicol 800 generates Rp1,126/unit. Therefore, the utilization of natural ingredient-based supplements, such as garlic, not only provides economic benefits for pharmacies but also offers a safer and more affordable alternative treatment option for hypertensive patients. "

"ABSTRAK Latar Belakang : Hipertensi merupakan faktor resiko utama penyakit kardiovaskular, terutama sindrom koroner akut dan stroke. Peningkatan konsumsi garam berhubungandengan kenaikan tekanan darah. Beberapa studi randomized-controlled trial (RCT)menyatakan bahwa konsumsi rendah garam dapat menurunkan tekanan darah padapopulasi dewasa dengan atau tanpa hipertensi. Variabilitas tekanan darah selama 24 jambersifat dinamis. Peningkatan darah nokturnal memiliki makna klinis yang cukup besar,merupakan salah satu prediktor dari penyebab kerusakan target organ, terutama kejadiankardiovaskular dan stroke. Asupan garam dapat mempengaruhi variasi tekanan darah 24jam, yang dalam hal ini dapat juga berpengaruh pada hipertensi nokturnal. Obat penyekatEKA merupakan obat hipertensi lini pertama yang sering digunakan, terutama pada usiamuda dan hipertensi yang disertai sindrom metabolik, mengingat peranan Sistem ReninAngiotensin memiliki peranan yang sangat penting dalam patofisiologi hipertensi. Asupangaram juga memiliki peranan pada patofisiologi terjadinya hipertensi dalam sistem ReninAngiotensin. Sedikit studi yang meneliti perpaduan obat penyekat EKA dengan asupanrendah garam dalam menrunkan kejadian hipertensi. Oleh karena itu, Menarik untuk ditelitipengaruh asupan garam dengan tekanan darah nokturnal pada pasien yang mengkonsumsiobat penyekat EKA.Tujuan : Menilai pengaruh asupan garam dengan tekanan darah nokturnal pada pasienhipertensi yang mendapatkan terapi penyekat EKA. Metode : Pasien poliklinik berusia 30 ? 50 tahun yang terdiagnosis hipertensi dan belumpernah mendapatkan anti-hipertensi sebelumnya, dibagi menjadi 2 kelompok (asupanrendah garam (Na <15 g/hari) dan asupan tinggi garam ≥15 g/hari). Kedua kelompok akandiberikan lisinopril dan dilakukan pemeriksaan natrium urin 24 jam dan home bloodpressure monitoring..Hasil Penelitian : Sebanyak 80 pasien hipertensi pasien hipertensi yang belummendapatkan terapi diikutsetakan dalam penelitian ini, yang terdiri dari 37 pasienkelompok rendah garam dan 43 pasien kelompok tinggi garam. Kelompok pasien denganasupan rendah garam memliki delta penurunan darah nokturnal sistolik (p<0,001),diastolic (p<0,001), dan rerata arteri (p<0,001) yang lebih besar dibandingkan padakelompok asupan tinggi garam. Rerata asupan garam pada penelitian ini sebesar 16,77gram/hari. Pada analisa multivariat didapatkan delta penurunan tekanan darah tidakdipengaruhi oleh usia, jenis kelamin, dislipidemia, IMT, dan durasi tidur.Kesimpulan : Penelitian ini membuktikan asupan rendah garam dapat mempengaruhi efektivitas terapi penyekat EKA dalam menurunkan tekanan darah nokturnal. ABSTRACT Background : Hypertension is one of important risk factor of cardiovascular disease, especially acute coronary syndrome and stroke. High salt intake correlatesto high blood pressure. Some Randomized-Controlled-Trials stated that low saltintake may decrease blood pressure in adult population with or withouthypertension. Blood pressure variation in 24 hours is not static but dynamicallychanges. Increasing nocturnal blood pressure has significantly impacts, and becomeone of predictor of target organ damage, especially cardiovascular events andstroke. Salt intake may interferes both 24 hours blood pressure variation and nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first drug of choice anti-hypertensive therapy, especially in young age and associatedwith metabolic syndrome, due to important role of Renin Angiotensin AldosteroneSystem in pathophysiology of hypertension, whereas salt intake also has role in thatsystem. Only few of studies that had proved combination of ACE Inhibitors andlow salt intake in decreasing blood pressure in hypertension population. Therefore,it is so important to know the impact of low salt intake to nocturnal blood pressurein hypertension patient treated with ACE Inhibitors.Objectives : To know impact of low salt intake to nocturnal blood pressure inhypertension patient treated with ACE Inhibitors.Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreatedhypertension, divided into two groups (low salt intake (Na <15 grams/day) and highsalt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg andunderwent 24-hours sodium urine collection and home blood pressure monitoringperiodically.Results : There are 80 ambulatory patients diagnosed as untreated hypertension,consist of 37 patients in low salt intake group and 43 patients in high salt intakegroup. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic(p<0.001), and mean arterial (p<0.001) blood pressure compared with high saltintake group. Mean salt intake in this study was 16.77 grams/day. Multivariateanalyzes showed that the difference of decreasing nocturnal blood pressure was notinterfered by age, sex, dyslipidemia, BMI, and sleep duration.Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure.;Background : Hypertension is one of important risk factor of cardiovascular disease, especially acute coronary syndrome and stroke. High salt intake correlatesto high blood pressure. Some Randomized-Controlled-Trials stated that low saltintake may decrease blood pressure in adult population with or withouthypertension. Blood pressure variation in 24 hours is not static but dynamicallychanges. Increasing nocturnal blood pressure has significantly impacts, and becomeone of predictor of target organ damage, especially cardiovascular events andstroke. Salt intake may interferes both 24 hours blood pressure variation and nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first drug of choice anti-hypertensive therapy, especially in young age and associatedwith metabolic syndrome, due to important role of Renin Angiotensin AldosteroneSystem in pathophysiology of hypertension, whereas salt intake also has role in thatsystem. Only few of studies that had proved combination of ACE Inhibitors andlow salt intake in decreasing blood pressure in hypertension population. Therefore,it is so important to know the impact of low salt intake to nocturnal blood pressurein hypertension patient treated with ACE Inhibitors.Objectives : To know impact of low salt intake to nocturnal blood pressure inhypertension patient treated with ACE Inhibitors.Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreatedhypertension, divided into two groups (low salt intake (Na <15 grams/day) and highsalt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg andunderwent 24-hours sodium urine collection and home blood pressure monitoringperiodically.Results : There are 80 ambulatory patients diagnosed as untreated hypertension,consist of 37 patients in low salt intake group and 43 patients in high salt intakegroup. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic(p<0.001), and mean arterial (p<0.001) blood pressure compared with high saltintake group. Mean salt intake in this study was 16.77 grams/day. Multivariateanalyzes showed that the difference of decreasing nocturnal blood pressure was notinterfered by age, sex, dyslipidemia, BMI, and sleep duration.Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure.;Background : Hypertension is one of important risk factor of cardiovascular disease, especially acute coronary syndrome and stroke. High salt intake correlatesto high blood pressure. Some Randomized-Controlled-Trials stated that low saltintake may decrease blood pressure in adult population with or withouthypertension. Blood pressure variation in 24 hours is not static but dynamicallychanges. Increasing nocturnal blood pressure has significantly impacts, and becomeone of predictor of target organ damage, especially cardiovascular events andstroke. Salt intake may interferes both 24 hours blood pressure variation and nocturnal blood pressure. Angiotensin Converting Enzyme(ACE) Inhibitors is first drug of choice anti-hypertensive therapy, especially in young age and associatedwith metabolic syndrome, due to important role of Renin Angiotensin AldosteroneSystem in pathophysiology of hypertension, whereas salt intake also has role in thatsystem. Only few of studies that had proved combination of ACE Inhibitors andlow salt intake in decreasing blood pressure in hypertension population. Therefore,it is so important to know the impact of low salt intake to nocturnal blood pressurein hypertension patient treated with ACE Inhibitors.Objectives : To know impact of low salt intake to nocturnal blood pressure inhypertension patient treated with ACE Inhibitors.Methods : There are 30 ? 50 years old ambulatory patients diagnosed as untreatedhypertension, divided into two groups (low salt intake (Na <15 grams/day) and highsalt intake (≥15 grams/day). Both of groups were administered Lisinopril 10mg andunderwent 24-hours sodium urine collection and home blood pressure monitoringperiodically.Results : There are 80 ambulatory patients diagnosed as untreated hypertension,consist of 37 patients in low salt intake group and 43 patients in high salt intakegroup. Low salt intake group has lower nocturnal systolic (p<0.001), diastolic(p<0.001), and mean arterial (p<0.001) blood pressure compared with high saltintake group. Mean salt intake in this study was 16.77 grams/day. Multivariateanalyzes showed that the difference of decreasing nocturnal blood pressure was notinterfered by age, sex, dyslipidemia, BMI, and sleep duration.Conclusion : This study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure."