Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Pengobatan pada pasien lansia sangat kompleks karena biasanya bersifat multipatologi sehingga menyebabkan peningkatan jumlah obat yang digunakan (polifarmasi) untuk kondisi klinis yang berbeda-beda. Terdapatnya hipertensi, diabetes dan/atau dislipidemia menyebabkan pengobatan yang berpotensi menimbulkan Reaksi Obat yang Tidak Dikehendaki (ROTD), karena umumnya pengobatan pada pasien dengan hipertensi, diabetes dan/atau dislipidemia bersifat jangka panjang dengan menggunakan beberapa jenis obat. Penelitian ini bertujuan untuk menilai pengaruh umur lansia terhadap kejadian reaksi obat yang tidak dikehendaki pada pasien dengan hipertensi, diabetes dan/atau dislipidemia di Puskesmas Pancoran Mas, Puskesmas Tanah Baru, dan Puskesmas Beji kota Depok. Penelitian menggunakan rancangan kohort prospektif. Sampel penelitian terdiri dari 62 pasien lansia sebagai kelompok kohort dan 62 pasien non lansia sebagai kelompok kontrol. Pengambilan sampel dilakukan selama Januari-Juni 2014. Sampel dimonitoring keadaannya setiap minggu selama satu bulan. Manifestasi klinik ROTD merupakan hasil evaluasi terhadap keluhan-keluhan yang dialami pasien yang dievaluasi menggunakan skala Naranjo. Manifestasi klinik ROTD yang didapat pada kedua kelompok dianalisis menggunakan uji kaikuadrat dan uji regresi logistik. Pasien dengan hipertensi, diabetes dan/atau dislipidemia yang mengalami kejadian ROTD 30,6% dengan frekuensi kejadian 39 kali, presentase terbesar adalah batuk kering karena kaptopril (56,3%), dan tingkat keparahan manifestasi klinik ROTD yang terjadi pada mayoritas (53,8%) pasien tersebut adalah level 2 (mild/sedang). Risiko umur lansia 3,577 kali lebih besar untuk terjadinya ROTD. ...... Treatment in elderly patients is very complex, because it is usually multiphatology thus causing an increase in number of drugs used (polypharmacy) for every clinical conditions. The presence of hypertension, diabetes and/or dyslipidemia will increase the risk of cause Adverse Drug Reaction (ADR) because of polypharmacy and long term of treatment. This study aimed to assess the effect of elderly age on the incidence of ADR in patients with hypertension, diabetes and/or dyslipidemia at Puskesmas Pancoran Mas, Beji, and Tanah Baru Depok. The design of the study is cohort study. The Sampling was conducted at January- June 2014. 62 elderly patients was collected as a risk factor group and 62 non- elderly patients as a control group. Sample was monitored every weeks in a month. Clinical Manifestation of ADR event was an evaluation result of the recording complaints experienced by the sampel using Naranjo scale. Clinical manifestation of ADR events obtained in the both group were analyzed using Chi- Square and Logistic Regression test. Patient with hypertension, diabetes and/or dyslipidemia experienced ADR event 30,6% with a frequency of accurrence was 39 times. Dry cough because of captopril (56,3%) was the most common clinical manifestation found, while severity level clinical manifestation ADR which occured in most of patient (53,8%) was at level 2 (mild). The risk of elderly age was 3,577 times greater for ADR event.

Abstrak :
Kontrasepsi oral menempati peringkat kedua metode kontrasepsi yang paling banyak digunakan di Indonesia, namun tingkat putus obat akibat reaksi obat yang tidak dikehendaki (ROTD) cukup tinggi (13,2%). Hanya sebagian kecil akseptor (23,9%) yang diberikan informasi tentang hal yang dapat dilakukan jika mengalami ROTD seperti pilihan kontrasepsi oral dengan progestin generasi terbaru yang memiliki efek samping lebih rendah. Tujuan penelitian ini adalah membandingkan ROTD dari pil kontrasepsi kombinasi yang berisi levonorgestrel (generasi kedua) dengan desogestrel (generasi ketiga). Metode penelitian ini adalah potong lintang komparatif dengan sampel yang diperoleh secara acak dari enam kelurahan di kecamatan Sukmajaya Depok pada rentang waktu Agustus ? November 2015. Pengambilan data dilakukan menggunakan metode wawancara. Sampel penelitian adalah 60 akseptor kelompok levonorgestrel dan 40 akseptor kelompok desogestrel. Keluhan ROTD meliputi perdarahan di luar menstruasi (16,7%;5%), sakit kepala (16,7% ; 5%), mual/muntah (25% ; 0), nyeri payudara (13,3% ; 0), gangguan terkait hubungan seksual (23,3% ; 7,5%), penambahan berat badan (35% ; 22,5%), jerawat (3,3% ; 7,5%) dan chloasma (28,3% ; 5%). Proporsi kejadian tersebut secara signifikan lebih tinggi pada kelompok levonorgestrel pada gangguan hubungan seksual (OR 3,75, 95% CI : 1,003 ? 14,050, p = 0,039) dan chloasma (OR 7,51, 95% CI : 1,629 ? 34,647, p = 0,004). ...... Oral contraceptive was second contraception method most widely used in Indonesia, but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions (ADR). Only small portion users (23,9%) who had been provided information about other oral contraceptive with the newer progestin generation as alternative option to minimize ADR. This study was conducted to compare prevalence of ADR between combined oral contraceptives contain levonorgestrel (second generation) and desogestrel (third generation) which expected to have less side effects. Study was done as cross sectional comparative design with random sampling from users in six villages in Sukmajaya district, Depok City. Data were collected by interview. Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%), nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and chloasma (28.3%; 5%). The proportion of these events was significantly higher in the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI: 1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p = 0.004).

Abstrak :
Rumah sakit dengan pelayanan farmasi klinik mengimplementasikan Pemantauan Terapi Obat (PTO) sebagai suatu proses yang mencakup kegiatan untuk memastikan terapi obat yang aman, efektif, dan rasional bagi pasien, dengan tujuan meningkatkan efektivitas terapi dan meminimalkan risiko Reaksi Obat yang Tidak Dikehendaki (ROTD). Pelaksanaan tugas khusus ini bertujuan untuk melakukan pemantauan terapi obat pada salah satu pasien dispepsia di Rumah Sakit Umum Pusat Persahabatan Jakarta. Metode menggunakan desain observasional dengan pengambilan data dilakukan secara prospektif pada tanggal 12 sampai 16 Juni 2023. Populasi yang digunakan adalah seluruh pasien yang dirawat inap di Gedung Cempaka, RSUP Persahabatan dan teknik sampel yang digunakan yaitu sesuai dengan kriteria inklusi dan eksklusi. Hasil dari pelaksanaan tugas khusus yang dilakukan selama 5 ( lima ) hari ini adalah ditemukannya pemilihan obat yang tidak tepat terjadi karena pasien menggunakan jaminan BPJS yang mengharuskan penggunaan rujukan Formularium Nasional untuk panduan pengobatan, pemberian obat kepada pasien sudah melebihi aturan yang ditetapkan oleh Formularium Nasional, (DRP) terkait interaksi obat dan indikasi tanpa obat, penyesuaian terapi berdasarkan konsultasi antara Apoteker dan DPJP, serta implementasi sistem informasi untuk pemantauan pasien secara terintegrasi. Hal ini didapatkan berdasarkan pemantauan terapi obat pasien rawat inap Ny. F di gedung Cempaka RSUP Persahabatan.  ...... Hospitals with clinical pharmacy services implement Drug Therapy Monitoring (PTO) as a process that includes activities to ensure safe, effective, and rational drug therapy for patients, with the aim of increasing the effectiveness of therapy and minimizing the risk of unintended drug reactions (ROTD). The implementation of this special assignment aims to monitor drug therapy in one of the dyspepsia patients at the Friendship Central General Hospital Jakarta. The method uses an observational design, with data collection carried out prospectively on June 12–16, 2023. The population used was all patients hospitalized in the Cempaka Building, Friendship General Hospital, and the sample technique used was purposeful sampling in accordance with the inclusion and exclusion criteria. The results of the implementation of this special assignment, which was carried out for five (five) days, were the discovery of inappropriate drug selection that occurred because the patient used BPJS insurance, which required the use of the National Formulary reference for treatment guidance; the administration of drugs to patients had exceeded the rules set by the National Formulary; drug- related problems (DRP) related to drug interactions and indications without drugs; therapy adjustments based on consultation between pharmacists and DPJP as well as the implementation of an information system for integrated patient monitoring. This was obtained based on monitoring the drug therapy of inpatient Mrs. F in the Cempaka building of Friendship Hospital.

Abstrak :
[ABSTRAK
Penggunaan obat golongan statin (penghambat hidroksimetil glutaril-CoA reduktase) sebagai terapi lini pertama pada hiperkolesterolemia dapat menyebabkan terjadinya beberapa reaksi obat yang tidak dikehendaki (ROTD). Tujuan penelitian ini adalah menilai risiko penggunaan obat golongan statin terhadap kejadian ROTD pada pasien hiperkolesterolemia di Instalasi Rawat Jalan RSUD Pasar Rebo, Jakarta. Penelitian dilakukan dengan metode kohort prospektif pada pasien yang menggunakan atorvastatin dan simvastatin. Data primer diperoleh melalui wawancara dengan menggunakan kuesioner, data sekunder diperoleh melalui rekam medis dan resep yang diterima oleh pasien. Data yang diperoleh dianalisis menggunakan chi-square dan regresi logistik. Dari penelitian diketahui bahwa ROTD terjadi pada 38.20% pasien yang menggunakan obat golongan statin, kejadian ROTD terbesar adalah gangguan sistem pencernaan (35.45%) dan gangguan sistem saraf (23.64%). Sedangkan ROTD pada otot dan hati masing-masing sebesar 2.73%. Pasien yang menggunakan simvastatin memiliki risiko relatif mengalami ROTD lebih besar jika dibandingkan dengan pasien yang menggunakan atorvastatin (RR: 6.439; CI: 2.963-13.992). Variabel perancu yang secara signifikan mempengaruhi kejadian ROTD adalah aktivitas fisik. Pasien yang mengalami ROTD memiliki risiko relatif lebih besar mengalami putus obat daripada pasien yang tidak mengalami ROTD (RR: 2.554; CI: 1.724- 3.754).

---

ABSTRACT
The use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754).;The use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754)., The use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754).]

Abstrak :
Penelitian ini bertujuan untuk mengembangkan model sistem notifikasi interaksi obat otomatis bagi petugas kefarmasian, sehingga dapat segera mengedukasi pasien atau keluarganya. Pelayanan kesehatan di rumah sakit sangat penting dalam menjamin keselamatan pasien, dan salah satu unit pelayanan yang penting adalah pelayanan kefarmasian, khususnya pelayanan informasi obat (PIO). PIO berfungsi untuk mengidentifikasi obat-obatan dengan kewaspadaan tinggi serta obat-obatan berisiko tinggi sebagai penyebab terjadinya reaksi obat yang merugikan (ROTD) terutama pada usia lanjut, interaksi obat merupakan masalah utama yang perlu mendapat perhatian. Saat ini pendataan dalam penelitian ini diprioritaskan untuk lansia, terdapat 55 orang geriatri yang dirawat, 7 orang terdeteksi bahwa interaksi obat dengan obat lain dalam resep dilakukan melalui review resep secara manual. Memang klinik farmasi tidak selalu salah, tetapi dalam banyak kasus dapat menyebabkan hasil yang negatif atau efektivitas pengobatan yang buruk. Oleh karena itu, pemantauan dan tinjauan diperlukan untuk memvalidasi apakah semua obat masih diperlukan, dan bagaimana reaksi obat dan interaksi obat terjadi. Pemantauan dalam sistem terintegrasi untuk interaksi obat sangat diperlukan dan juga mendidik pasien agar efek obat tidak terganggu. Pengumpulan informasi dan data untuk studi awal dilakukan melalui Focus Group Discussion (FGD). Wawancara mendalam dengan apoteker, asisten apoteker, tenaga promosi kesehatan rumah sakit, dan programmer rumah sakit merupakan kajian mendalam dari hasil FGD. Analisis sistem berdasarkan wawancara menjadi dasar perancangan sistem dengan pendekatan pengembangan sistem, yaitu menggunakan metode prototyping hingga tahap pemodelan. Sedangkan uji kelayakan Sistema menggunakan uji Usability Test dan Technology Acceptance Model (TAM). Metode pengolahan data kuesioner dari studi kelayakan Aplikasi menggunakan program SPSS. Berdasarkan hasil pengujian prototipe sistem notifikasi interaksi obat-ke-obat, sebanyak 53 responden lansia dengan 125 jenis data obat menunjukkan bahwa database prototipe sistem notifikasi interaksi obat-ke-obat lebih banyak ditemukan interaksi obat. dibandingkan proses manual oleh petugas apoteker, sehingga dapat memberikan notifikasi kepada apoteker lebih cepat. Rancangan logis dari sistem notifikasi interaksi obat ini berfungsi sebagai notifikasi kepada petugas apotek saat penginputan resep obat dengan sistem yang terintegrasi, sehingga pasien akan diberikan edukasi yang lebih tepat. Sistem ini dapat mempermudah akses informasi dan efisiensi waktu. Secara teoritis, desain tersebut dapat memberikan solusi yang efisien dan efektif dalam mengidentifikasi obat-obatan yang diberikan secara hati-hati kepada pasien lansia dengan diintegrasikan ke dalam sistem notifikasi interaksi obat di rumah sakit, pasien lanjut usia dapat dengan aman mengonsumsi obat yang diberikan setelah mendapatkan edukasi yang tepat tentang cara penggunaan obat-obatan. ......This research aimed to develop an automatic drug interaction notification system model for pharmaceutical officers, so that they can immediately educate patients or families. Medical services in hospitals are especially important in ensuring patient safety, and one of the important service units is the pharmaceutical service, especially the drug information service (DIC). DIC serves to identify high-alert medication as well as high-risk drugs as a cause of adverse drug reactions (ADR) especially in the erderly, drug interaction is a major problem thet needs attention. Currently the data collection in this research prioriting for the elderly, there were 55 geriatric who were being treated, 7 people were detected that drug interactions with other drug in the prescription were given through manual review of prescriptions. Indeed pharmacy clinics are not always wrong, but in many cases it can lead to negative results or poor effectiveness of treatment. Therefore, monitoring and review is needed to validate whether all drugs are still needed, and how drug reactions and drug interactions are present. Monitoring in integrated system for drug interactions is indispensable and also educates patients so that drug effects are not disrupted. The information and data collection for the initial study were conducted through Focus Group Discussion (FGD). In-depth interviews with pharmacists, pharmacist assistants, hospital health promotion staff, and hospital programmers were the in-depth studies of the results of the FGD. The system analysis based on the interviews was the basis for the system design with a systems development approach, that is, using the prototyping method to the modeling stage. While the Sistema feasibility test used the Usability Test and the Technology Acceptance Model (TAM) test. The questioner data processing method from the Application feasibility study used the SPSS program. Based on the results of testing the prototype of drug-to-drug interaction notification system, as many as 53 elderly respondents with 125 types of drug data indicated that the database of the prototype of drug-to-drug interaction notification system discovered more drug interactions than the manual process by pharmacist officers, so as to provide notification to pharmacists more quickly. The logical design of this drug interaction notification system functions as a notification to pharmacy officers when inputting drug prescriptions with the integrated system, so that patients will be given more precise education. This system can simplify the access to information and time efficiency. Theoretically, the design can provide an efficient and effective solution in identifying cautious drugs that are administered to erderly patients by being integrated into the drug interaction notification system of the hospital, elderly patients can safely consume the drugs given after receiving proper education about how to use the drugs.

Abstrak :
[ABSTRAK
Terapi Paliatif bertujuan untuk meningkatkan kualitas hidup dan mengurangi gejala, namun menambah kompleksitas terapi pasien. Penelitian ini bertujuan untuk menganalisis profil pengobatan dan prevalensi DRPs yang terjadi pada pasien yang menjalani terapi paliatif di RSK ?Dharmais?. Penelitian ini adalah penelitian cross sectional. Data pada penelitian diambil secara prospektif dari data medis pasien bulan maret sampai juni 2011. Karakteristik pasien, 33 orang (68,8%) perempuan, 15 orang (31,3%) laki-laki, dan kasus kanker padat terbesar adalah kasus kanker payudara sebanyak 15 orang (33,3%). Berdasarkan profil pengobatan, 64,6% hanya menjalani satu kali terapi paliatif. Reaksi obat yang tidak diinginkan (ROTD) manifestasi dialami olah 70,1% subyek uji dan 66,2% mengalami ROTD potensial. Lima koma tujuh persen (5,7%) mengalami interaksi dengan signifikansi moderate dan 15,0% terjadi karena pemakaian morphine, dan amitriptyline. Peningkatan risiko kejadian ROTD dipengaruhi oleh (1) usia, bertambahnya usia tidak selalu menyebabkan peningkatan ROTD manifestasi; (2) jenis kelamin, laki-laki akan lebih berisiko mengalami peningkatan ROTD manifestasi; (3) riwayat rejimen kemoterapi kuratif, meningkatkan risiko ROTD manifestasi; (4) penyakit penyerta, meningkatkan risiko ROTD manifestasi dan potensial; (5) jumlah obat; penggunaan > 5 jenis obat dapat meningkatkan risiko ROTD manifestasi dan ROTD potensial. Risiko kejadian interaksi obat dipengaruhi oleh faktor adanya penyakit penyerta dan penggunaan > 5 jenis obat.

---

ABSTRACT
The goal of palliative care is to increase the quality of life and to reduce the symptomps, but its often increace the complexity of patient?s therapy. The aim of these research is to analyst the patient?s therapy profile and the prevalence of DRPs of patient undergoing the palliative care at ?Dharmais? Hospital National Cancer Center. This reasearch is a cross sectional study. The data of the research is prospectively taken from the patients? medical records start from march to june 2011. The patient characteristic who followed the reasearch are 33 patients (68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had once palliative care. Manifest adverse reaction happen in 70.1% patient of subject and 66.2% subjects get potential adverse reaction. Five point seven percent (5.7%) of drug interaction had moderate signification, 15.0% caused by the morphine, and amitriptyline use. The risk of incident adverse reactions influenced by (1) age, increasing the age not always increase the risk of having the manifest adverse reaction, (2) sex, men will have higher risk of manifest adverse reaction, (3) history of curative chemotherapy regimen, increase the risk of manifest adverse reaction, (4) comorbidities will increase the risk of manifest and potential adverse reaction, (5) the number of drug use, using more than 5 drugs ( > 5 drugs) will increase the risk of manifest and potential adverse reaction. The risk of drug interaction will increase because of the comorbidities and the number of drugs using ( > 5 drugs).;The goal of palliative care is to increase the quality of life and to reduce the symptomps, but its often increace the complexity of patient’s therapy. The aim of these research is to analyst the patient’s therapy profile and the prevalence of DRPs of patient undergoing the palliative care at “Dharmais” Hospital National Cancer Center. This reasearch is a cross sectional study. The data of the research is prospectively taken from the patients’ medical records start from march to june 2011. The patient characteristic who followed the reasearch are 33 patients (68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had once palliative care. Manifest adverse reaction happen in 70.1% patient of subject and 66.2% subjects get potential adverse reaction. Five point seven percent (5.7%) of drug interaction had moderate signification, 15.0% caused by the morphine, and amitriptyline use. The risk of incident adverse reactions influenced by (1) age, increasing the age not always increase the risk of having the manifest adverse reaction, (2) sex, men will have higher risk of manifest adverse reaction, (3) history of curative chemotherapy regimen, increase the risk of manifest adverse reaction, (4) comorbidities will increase the risk of manifest and potential adverse reaction, (5) the number of drug use, using more than 5 drugs ( > 5 drugs) will increase the risk of manifest and potential adverse reaction. The risk of drug interaction will increase because of the comorbidities and the number of drugs using ( > 5 drugs)., The goal of palliative care is to increase the quality of life and to reduce the symptomps, but its often increace the complexity of patient’s therapy. The aim of these research is to analyst the patient’s therapy profile and the prevalence of DRPs of patient undergoing the palliative care at “Dharmais” Hospital National Cancer Center. This reasearch is a cross sectional study. The data of the research is prospectively taken from the patients’ medical records start from march to june 2011. The patient characteristic who followed the reasearch are 33 patients (68.8%) women, 15 patient (31.3%) men, and the most solid cancer case are breast cancer, 15 patients (31.3%). Based on therapy profile, 64.6% only had once palliative care. Manifest adverse reaction happen in 70.1% patient of subject and 66.2% subjects get potential adverse reaction. Five point seven percent (5.7%) of drug interaction had moderate signification, 15.0% caused by the morphine, and amitriptyline use. The risk of incident adverse reactions influenced by (1) age, increasing the age not always increase the risk of having the manifest adverse reaction, (2) sex, men will have higher risk of manifest adverse reaction, (3) history of curative chemotherapy regimen, increase the risk of manifest adverse reaction, (4) comorbidities will increase the risk of manifest and potential adverse reaction, (5) the number of drug use, using more than 5 drugs ( > 5 drugs) will increase the risk of manifest and potential adverse reaction. The risk of drug interaction will increase because of the comorbidities and the number of drugs using ( > 5 drugs).]

Abstrak :
Pelayanan farmasi klinik merupakan pelayanan langsung yang diberikan oleh apoteker kepada pasien dalam rangka meningkatkan outcome terapi dan meminimalisir risiko terjadinya efek samping obat. Salah satu pelayanan farmasi klinik ialah pemantaun terapi obat (PTO). Pemantauan terapi obat merupakan rangkaian proses yang mencakup kegiatan untuk memastikan terapi obat aman, efektif, dan rasional bagi pasien dengan tujuan meningkatkan efektivitas terapi dan meminimalisir risiko reaksi obat yang tidak dikehendaki (ROTD). Tujuan dilaksanakannya PKPA ini adalah mengetahui peran apoteker dalam melakukan pemantauan terapi obat dan mengidentifikasi masalah terkait obat yang terjadi pada pasien dengan diagnosa superimposed preeclampsia with severe features pada G1 hamil 22 minggu dan obesitas grade II di VK Kebidanan Gedung Bougenville RSUP Fatmawati menggunakan klasifikasi PCNE V9.0. Peran apoteker dalam pemantauan terapi obat adalah melakukan identifikasi dan analisis mengenai masalah terkait obat yang timbul serta memberikan rekomendasi penyelesain terhadap masalah tersebut dalam rangka meminimalisasi risiko masalah terkait obat dan memaksimalkan keselamatan dan kualitas hidup pasien. Hasil pemantauan terapi obat terhadap pasien Ny. IK menunjukkan bahwa secara keseluruhan pengobatan yang diterima Ny. IK sudah sesuai dengan tatalaksana terapi dan terdapat beberapa permasalahan terkait obat (DRP) yang terjadi, namun tidak terdapat adanya interaksi obat yang timbul pada pasien. Ny. IK. ......Clinical pharmacy services are direct services provided by pharmacists to patients in order to improve therapeutic outcomes and minimize the risk of drug side effects. One of the clinical pharmacy services is Therapeutic Drug Monitoring (TDM). Therapeutic Drug Monitoring is a series of processes that include activities to ensure safe, effective and rational drug therapy for patients with the aim of increasing the effectiveness of therapy and minimizing the risk of Adverse Drug Reactions (ADR). The purpose of implementing this report is to determine the role of pharmacists in monitoring drug therapy and identifying drug-related problems that occur in patients with a diagnosis of superimposed preeclampsia with severe features at G1 22 weeks pregnant and grade II obesity at the Midwifery VK Bougenville Building Fatmawati Hospital using the PCNE V9.0 classification. The pharmacist's role in monitoring drug therapy is to identify and analyze drug-related problems that arise and provide recommendations for solutions to these problems in order to minimize the risk of drug-related problems and maximize patient safety and quality of life. The results of drug therapy monitoring of Mrs. IK shows that the overall treatment received by Mrs. IK was in accordance with the management of therapy and there were several drug-related problems (DRP) that occurred, but there were no drug interactions that occurred in patient Mrs. IK.