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"ABSTRACTAloe Vera is one of plant that can be used as food and traditionaltreatment. In traditional treatment, this plant has effect on healingacceleration of oral mucous ulceration. In dentistry, this plant can be used as oral mucous ulceration treatment. The aim of this research is to examine the effective dose of Aloe Vera inner leaf extract on healing acceleration of oral mucous ulceration. Twelve Sprague Dawley rats were used in this research, and divided into 2 groups, 3 rats to control group and 9 rats to treatment group. Each rat received application of hydrogen peroxide 10% to create ulceration. Control group received application of NaCl 0.9% for 3,5,7 days. Treatment group received application 6.25%, 12.5%, and 25% Aloe Vera Inner Leaf Extract for 3,5,7 days. Wound healing was observed by in histological method with light microscope, and then was scored using stages of inflammation score of Schlossberg & Ferigino and Eda. S & Fukuyama methods. Statistical analysis with Mann Whitney and Kruskal Wallis methods showed that Aloe Vera inner leaf extract 25% is the most effective concentration on healing acceleration of oral mucousulceration (p< 0,05). "

"Latar belakang: Aloe vera adalah tanaman yang telah banyak digunakan sebagai obat tradisional, salah satunya dalam penyembuhan ulserasi. Namun, belum ada penelitian yang menguji pengaruh bagian kulit Aloe vera dalam penyembuhan ulserasi mukosa mulut.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit Aloe vera dalam mempercepat penyembuhan ulserasi mukosa mulut.Metode: Penelitian ini menggunakan 12 ekor tikus Sprague Dawley, yang dibagi dalam 4 kelompok secara acak, yaitu kelompok kontrol (3 ekor), kelompok perlakuan ekstrak kulit Aloe vera 6.25% (3 ekor), kelompok perlakuan ekstrak kulit Aloe vera 12.5% (3 ekor), dan kelompok perlakuan ekstrak kulit Aloe vera 25% (3 ekor). Daerah aplikasi adalah mukosa labial rahang bawah. Pada hari pertama kelompok kontrol dan perlakuan diaplikasikan H2O2 10% 3 X 5 menit dengan interval 5 menit, setiap hari selama 3 hari berturut-turut untuk menimbulkan ulserasi. Pada hari ke-4, 5 dan 6, kelompok kontrol diaplikasikan NaCl 0.9%, kelompok perlakuan diaplikasikan ekstrak kulit Aloe vera sebanyak 3 X 5 menit, dengan interval 90 menit. Pada hari ke-7 dan ke-9, satu ekor tikus dari tiap-tiap kelompok dimatikan dan dibuat sediaan mikroskopiknya, sementara sisanya tetap diberi perlakuan. Pada hari ke-11 seluruh sisa tikus dimatikan dan dibuat sediaan mikroskopiknya. Penilaian dilakukan secara mikroskopik dengan menggunakan metode skoring modifikasi Schlossberg A dan Ferigino PD serta Eda dan Fukuyama.Hasil: Ekstrak kulit Aloe vera konsentrasi 6.25%, 12.5%, dan 25% dapat menurunkan tingkat peradangan ulserasi mukosa mulut, sehingga mempercepat proses penyembuhannya. Secara statistik, uji Mann-Whitney pada tiap kelompok menunjukkan perbedaan yang bermakna (p<0.05).Kesimpulan: Berdasarkan penelitian, dapat disimpulkan bahwa ekstrak kulit Aloe vera konsentrasi 6.25% adalah konsentrasi terkecil yang efektif dalam mempercepat penyembuhan ulserasi mukosa mulut.

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Background: Aloe vera has been known as traditional treatment for many health problems, one of them is for ulceration healing. However, there has not been a research about the effect of outer leaf of Aloe vera on oral mucous ulceration healing.Objectives: This research?s intention is to find out the effect of Aloe vera outer leaf extract on Healing acceleration of oral mucous ulceration.Methods: Twelve Sprague Dawley rats were used in this research, and divided into 4 groups: control group with NaCl 0.9% (3 rats), concentration 6.25% group (3 rats), concentration 12.5% group (3 rats), and concentration 25% group (3 rats). The application area is mandible labial oral mucous. On the first day, each rat received application of hydrogen peroxide 10% 3 x 5 minutes, with 5 minutes interval, for 3 days to create the ulceration. On day 4th, 5th and 6th, each group received their own application 3 x 5 minutes, with 90 minutes interval. On day 7th and 9th one of the rat in each group were taken and the microscopic preparatory were made, while the rest of the rats were receiving the same application. On the day 11th, All the rats remain were taken and the microscopic preparatory were made. Microscopic examination was done by scoring using modification of Schlossberg & Ferigino and Eda. S & Fukuyama methods.Result: Aloe vera outer leaf extract 6.25%, 12.5%, and 25%, reduce the inflammation, thus accelerate the healing process of oral mucous ulceration. Statistically with Mann-Whitney test showed that there are significant differences among each group (p<0.05).Conclusion: Based on this research, it can be concluded that Aloe vera outer leaf extract 6.25% is the lowest concentration that is effective for accelerating oral mucous inflammation."

"Pendahuluan: Aloe vera adalah tanaman yang telah banyak digunakan sebagai obat tradisional, salah satunya adalah untuk pengobatan ulserasi. Aloe vera mengandung bahan-bahan anti inflamasi yang berperan dalam proses penyembuhan.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak campuran kulit dan daging Aloe vera dalam mempercepat proses penyembuhan ulserasi mukosa mulut.Metode: Dalam penelitian ini digunakan 12 ekor tikus Sprague Dawley, yang dibagi dalam 4 kelompok secara acak, yaitu kelompok kontrol yang diaplikasi larutan NaCl 0,9% (3 ekor), kelompok perlakuan yang diaplikasi ekstrak campuran kulit dan daging Aloe vera 6.25% (3 ekor), 12.5% (3 ekor), dan 25% (3 ekor). Pada hari pertama kelompok kontrol dan perlakuan diaplikasi larutan H2O2 10% sebanyak 3 X 5 menit dengan interval 5 menit, selama 3 hari berturut-turut pada daerah vestibulum mukosa labial inferior. Pada hari ke-4, 5 dan 6, kelompok kontrol diaplikasi NaCl 0.9% dan kelompok perlakuan diaplikasi ekstrak kulit dan daging Aloe vera sebanyak 3 X 5 menit, dengan interval 90 menit. Pada hari ke-7 dan 9 satu ekor tikus dari tiap-tiap kelompok dimatikan dan dibuat sediaan mikroskopik, sementara sisanya tetap diberi perlakuan. Pada hari ke-11 seluruh sisa tikus dimatikan dan dibuat sediaan mikroskopik. Penilaian dilakukan secara histologik dengan menggunakan kombinasi skor radang menurut Schlossberg A. dan Eda S.Hasil: Ekstrak campuran kulit dan daging Aloe vera 6.25%, 12.5% dan 25% dapat menurunkan tingkat radang pada ulserasi mukosa mulut. Secara statistik, uji Mann Whitney pada tiap kelompok menunjukkan perbedaan bermakna (p< 0.05).Kesimpulan: Berdasarkan hasil penelitian diperoleh bahwa aplikasi ekstrak campuran kulit dan daging Aloe vera 6.25% selama 3 hari adalah konsentrasi terendah dan waktu tercepat dalam penyembuhan ulserasi mukosa mulut.

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Introduction: Aloe vera has been known as a herbal plant that is used to treat many health problems like mucous ulceration. The whole leaf Aloe vera consists of some anti inflammatory agents that contribute on healing process.Objective: The aim of this study is to examine the effect of the whole leaf Aloe vera extract on accelerate healing of oral mucous ulceration.Methods: Twelve Sprague Dawley rats were used in this research, and divided into 4 groups: control group applied with Natrium Chloride solution 0.9% (3 rats), treatment group applied with the whole leaf Aloe vera extract 6.25% (3 rats), 12.5% (3 rats), and 25% group (3 rats). On the first day, Hydrogen Peroxide solution 10% is applied in each rat for 3 x 5 minutes on the vestibulum of labial inferior mucous. This method is continued for 3 days. On day 4th, 5th and 6th, each group received its own application 3 x 5 minutes, with 90 minutes interval. On day 7th and 9th, one rat in each groups were sacrificed and the microscopic slide were made, while other remain treated. On the day 11th, all the rats were sacrificed and the microscopic slides were made. Histological examination was done using combined score of Schlossberg A. and Eda S?s methods.Result: The whole leaf Aloe vera extract 6.25%, 12.5% and 25% could reduce inflammation on oral mucous ulceration. Statistically with Mann Whitney test showed that there is significant differences among each group (p<0.05).Conclusion: Application of the whole leaf Aloe vera extract 6.25% for 3 days is the lowest concentration and the shortest time in healing process of oral mucous ulceration."

"Latar Belakang. Pentingnya peranan protektif keratinized mucosa (KM) yang adekuat (>2mm) di sekitar implan sebagai soft tissue seal dalam menjaga barrier terhadap penetrasi bakteri yang dapat menyebabkan penyakit peri-implant masih menjadi perdebatan karena adanya inkonsistensi hasil. Tujuan. Untuk mengetahui hubungan lebar mukosa berkeratin di sekitar implan dengan brushing discomfort (BD) dan kesehatan jaringan peri-implan secara klinis dan radiografis. Metode. Penelitian cross-sectional ini mengevaluasi 17 pasien dengan 31 implan di klinik spesialis periodonsia RSKGM FKG UI. Sampel di bagi menjadi kelompok KM adekuat dan inadekuat. Pasien di periksa secara klinis dengan skor mPI, DI dan GI pada bagian bukal permukaan implan, radiografis periapkcal untuk mendapatkan data marginal bone level (MBL). BD di nilai menggunakan visual analogue scale (VAS). Hasil. Perbandingan antar dua kelompok dengan skala numerik di uji dengan independent t-test. Terdapat perbedaan skor mPI (0,01), DI (0,03) dan GI (0,05) di antara dua kelompok. Sedangkan untuk brushing discomfort (0,88) dan MBL (0,46) tidak terdapat perbedaan yang signifikan. Kesimpulan. Inadekuat KMberkaitan dengan peningkatan akumulasi plak, debris dan inflamasi mukosa di sekitar implan.

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Background. The importance of the protective role of adequate keratinized mucosa (KM) around an implant as a soft tissue seal in maintaining a barrier against bacterial penetration that can cause peri-implant disease is still being debated due to inconsistentresults. Aim. To determine the relationship between the width of the keratinized mucosa around the implant with brushing discomfort and peri-implant tissue clinically and radiographically. Method. This cross-sectional study evaluates 17 patients (31implants) at the periodontic specialist clinic, RSKGM FKG UI. The sample group was divided into adequate and inadequate KM groups. Patients were clinically examined using score mPI, DI and GI on the buccal site of the implant, and periapical radiographs were taken to evaluate marginal bone level (MBL). Brushing discomfort was assessed using a visual analogue scale (VAS). Results. The comparison between the two groups with a numerical scale was tested using an independent t-test. There were significant differences in (0.01), DI (0.03), and GI (0.05) between the two groups. However, there was no significant difference for brushing discomfort (0.88) and MBL (0.46). Conclusion. Inadequate KM is associated with increased accumulation of plaque,debris, and mucosal inflammation around the implant."

"Leukemia Limfoblas Akut merupakan salah satu jenis kanker yang banyak ditemukan pada anak-anak di Indonesia. Kemoterapi adalah salah satu pengobatan efektif untuk mengobati leukemia limfoblastik akut. Selain memberikan efek penyembuhan, kemoterapi juga memiliki efek toksik. Mucositis adalah efek samping kemoterapi yang umumnya ditemukan pada anak-anak yang menjalani kemoterapi. Pencegahan dan penatalaksanaan komplikasi rongga mulut diperlukan untuk meningkatkan kualitas hidup anak. Salah satu pencegahan dan pengobatannya adalah perawatan mulut. Perawatan mulut melibatkan empat komponen utama yaitu, sikat gigi, pembilasan, flossing, dan perawatan bibir. Penelitian ini bertujuan untuk mengetahui hubungan antara perawatan mulut dengan kejadian mucositis. Desain penelitian menggunakan desain cross sectional dengan jumlah sampel 34 anak yang dipilih dengan metode snowball sampling. Alat ukur yang digunakan adalah Oral Assessment Guide (OAG) dan kuesioner perawatan mulut yang dikembangkan oleh peneliti. Analisis data menggunakan Chi-square. Hasil penelitian menunjukkan bahwa sebagian besar anak mengalami mukositis setelah menjalani siklus kemoterapi terakhir (51,5%). Hasil uji statistik menunjukkan adanya hubungan yang bermakna antara perawatan mulut dengan kejadian mucositis (p = 0,039). Hasil penelitian ini merekomendasikan kesadaran anak dan orang tua untuk melakukan perawatan mulut secara rutin yang berguna dalam mencegah dan mengobati mucositis.

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Acute Lymphoblast Leukemia is a type of cancer that is mostly found in children in Indonesia. Chemotherapy is one of the effective treatments for treating acute lymphoblastic leukemia. Apart from providing a healing effect, chemotherapy also has toxic effects. Mucositis is a side effect of chemotherapy that is commonly found in children undergoing chemotherapy. Prevention and management of oral complications is needed to improve the quality of life of children. One of the prevention and treatment is oral care. Oral care involves four main components namely, toothbrush, rinsing, flossing, and lip care. This study aims to determine the relationship between oral care and the incidence of mucositis. The research design used a cross sectional design with a sample size of 34 children who were selected by the snowball sampling method. The measuring instruments used were the Oral Assessment Guide (OAG) and the oral care questionnaire developed by the researcher. Data analysis using Chi-square. The results showed that most children had mucositis after undergoing the last chemotherapy cycle (51.5%). The results of statistical tests showed a significant relationship between oral care and the incidence of mucositis (p = 0.039). The results of this study recommend the awareness of children and parents to carry out routine oral care which is useful in preventing and treating mucositis."

"Mucous membrane pemphigoid (MMP) also known as cicatricial pemphigoid is a chronic autoimmune subepithelial blistering disease primarily affecting people over 50 years old. MMP may affect any mucosal surface which is particularly oral mucosal, conjungtiva, esophagus, or larinx is involved. MMP rarely occurs in children and adolescents, but several cases of MMP affecting 2 to 18 years old patients have been reported in previous studies. In this paper we reported a case of MMP in an eighteen year old male patient who had been diagnosed with oral mucous membrane pemphigoid by anamnesis, clinical feature, histopathology. The patient was treated with systemic corticosteroid, topical corticosteroid, oral rinse and multivitamins. Until recently corticosteroid remains as the most effective and the drug of choice to treat pemphigoid lesions. Clinicians need to pay attention in using this drug because of its potential side effect."

"Kelainan rongga mulut sebagai manifestasi leukemia dapat disebabkan antara lain karena adanya penekanan sumsum tulang, efek dari kemoterapi dan infiltrasi sel-sel leukemia. Selain dari faktor tersebut kelainan rongga mulut dapat diperberat oleh faktor Iokal (dental plak don kalkulus). Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh kondisi status kebersihan mulut dan status hematologi terhadap timbulnya kelainan rongga mulut.Dari hasil penelitian terhadap 62 penderita leukemia baik akut maupun kronis ditemukan kelainan rongga mulut sebenyak 77,41 Z. Kelainan yang terbanyak ditemukan adalah perdarahan gusi dengan petekie don ekimosis diikuti pembesaran gusi, ulkus, gingivitis dan kelainan lain berupa pigmentasi. Hasil penelitian ini menunjukkan status hemetologi (gambaran darah tepi) sangat berpengaruh terhadap timbulnya kelainan rongga mulut don Oral Hygiene memperbera t kelainan tersebut dan Pekerjaan merupakan faktor-faktor yang memungkinkan terjadinya piutang. Karakteristik Piutang Dan Pasien Rawest Inap Bayar Sendiri adalah Pelunasan dan Angsuran Piutang Tanpa Tanggal Pembayaran dan Piutang Ragu-Ragu.Saran-saran yang bisa disampaikan adalah mengoptimalkan fungsi-fungsi yang terkait dengan manajemen piutang terutama Penataan Rekening dan Penagihan. Monitoring ketat atas pemilihan kelas, pelaksanaan prosedur tetap pasien masuk dan lepas rawat serta meningkatkan kemampuan dan motivasi kerja petugas melalui pendidikan, latihan dan Reward yang memadai.vii + 99 halaman : 9 tabel, 2 gambar, 12 lampiran."

"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 7-11Mucous membrane pemphigoid (MMP) is an autoimmune mucocutaneous blistering disease characterized by autoantibodies to components within the basement membrane zone. The lesions may produce risk of scarring of the canthus (symblepharon), inversion of the eyelashes (entropion) and trauma to the cornea (trichiasis). We reported a case of MMP in a 56-year old female with diabetes mellitus and hypertension whose ocular involvement has lead to blindness of the right eye. The diagnosis MMP was base on the history and clinical findings in oral medicine department. Management of this patient inclueded the administration of antifungal, corticosteroid ; diaminodiphenylsulfone, nutritional supplementation. oral hygiene promotion and consultation to internal medicine specialist and opthalmologis. The improvement of oral lesions progressed well within five months. we conclude that optimal improvement can be reached by comprehesieve management with controlling systemic factors and good cooperation between medical team and patient. and patien"