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"Latar belakang: Kanker mulut merupakan salah satu dari enam keganasan yang paling sering terjadi di Asia dengan frekuensi kejadian hampir 274.300 kasus baru setiap tahunnya. Dibandingkan dengan benua lain di dunia, Asia memiliki insidensi, mortalitas, dan prevalensi yang paling tinggi dengan persentase sebanyak 65,8%, 74%, dan 60,9% secara berurutan. Tingginya angka kejadian kanker mulut di Asia ini dihubungkan dengan beberapa faktor seperti smokeless tobacco, rokok, dan alkohol yang digunakan secara luas di berbagai wilayah di Asia. Tujuan: Untuk mengetahui apakah smokeless tobacco, rokok, dan alkohol merupakan faktor risiko dari kanker mulut. Metode: Pencarian studi dilakukan melalui tiga database elektronik, kemudian dilakukan seleksi menggunakan pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Setelah itu, dilakukan penentuan studi-studi yang diinklusi untuk dianalisis secara kualitatif dan kuantitatif. Analisis kuantitatif dihitung menggunakan OR pooled analysis yang diolah melalui perangkat lunak Review Manager 5.4. Hasil: Didapatkan 15 studi yang diinklusi untuk analisis kualitatif dan 14 studi untuk analisis kuantitatif. Berdasarkan systematic review, seluruh studi yang membahas mengenai hubungan antara smokeless tobacco dan rokok dengan kanker mulut menyatakan bahwa kedua faktor tersebut merupakan faktor risiko kanker mulut. Sedangkan, sebagian besar studi yang membahas mengenai hubungan alkohol dengan kanker mulut menyatakan bahwa alkohol merupakan fakor risiko kanker mulut. Berdasarkan hasil meta-analisis secara keseluruhan, didapatkan bahwa smokeless tobacco dan rokok merupakan faktor risiko dari kanker mulut, namun tidak demikian dengan alkohol. Namun, berdasarkan meta-analisis subgrup, alkohol tetap merupakan faktor risiko kanker mulut. Kesimpulan: Penggunaan tembakau dalam bentuk smokeless tobacco dan rokok merupakan faktor risiko kanker mulut. Alkohol juga merupakan faktor risiko kanker mulut berdasarkan meta-analisis subgrup dan didukung dengan sebagian besar studi pada systematic review.

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Background: Oral cancer is one of the six most common malignancies in Asia with an incidence of nearly 274,300 new cases each year. Compared to other continents in the world, Asia has the highest incidence, mortality, and prevalence with percentages of 65.8%, 74%, and 60.9% respectively. The high incidence of oral cancer in Asia is associated with several factors such as smokeless tobacco, smoking, and alcohol which are widely used in various regions in Asia. Objectives: To determine whether smokeless tobacco, cigarettes, and alcohol are risk factors for oral cancer. Methods: Study searches were carried out through three electronic databases, then the study selection was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After that, the included studies were determined to be analyzed qualitatively and quantitatively. Quantitative analysis was calculated using OR pooled analysis which was processed through the Review Manager 5.4 software. Results: Fifteen studies were included for qualitative analysis and fourteen studies for quantitative analysis. Based on the systematic review, all of the studies discussing the relationship between smokeless tobacco and smoking with oral cancer state that these two factors are risk factors for oral cancer. Meanwhile, most of the studies discussing the relationship between alcohol and oral cancer state that alcohol is a risk factor for oral cancer. Based on the results of the meta-analysis, it was found that smokeless tobacco and smoking were risk factors for oral cancer, except for alcohol. However, according to subgroup meta-analysis, alcohol is still considered as risk factor for oral cancer. Conclusion: Smokeless tobacco and smoking are risk factors for oral cancer. Alcohol is a risk factor for oral cancer based on subgroup meta-analysis and supported by the majority of studies in the systematic review."

"ABSTRAKLatar Belakang: Beta Defensin-1 saliva merupakan salah satu peptida anti mikroba yang mempunyai peranan penting dalam pertahanan imun bawaan terhadap serangan mikroba oral. Aktifitas merokok dapat menyebabkan perubahan profil saliva dan profil kesehatan rongga mulut yang dapat mempengaruhi kadar Beta Defensin-1 saliva. Penelitian sebelumnya mengenai kadar Beta Defensin-1 saliva pada perokok dengan periodontitis kronis dan belum ada penelitian mengenai penilaian kadar Beta Defensin-1 pada perokok dikaitkan dengan profil merokok dan profil kesehatan rongga mulut.Tujuan: Mengetahui profil saliva dan profil kesehatan rongga mulut serta pengaruhnya terhadap perubahan kadar Beta Defensin-1 saliva pada perokok dan bukan perokok, dikaitkan dengan profil merokok partisipan, yang terdiri dari jenis rokok, durasi merokok, dan frekuensi merokok serta kondisi kesehatan rongga mulut.Metode: Sebanyak 68 partisipan, yang dibagi menjadi 2 kelompok: 44 (64,7%) perokok dan 24(35,5%) bukan perokok. Data dikumpulkan dari anamnesis, status klinis (gigi, mukosa rongga mulut, dan saliva), dan pemeriksaan laboratorium. Sampel saliva non-stimulasi dengan metode pengumpulan spitting dan disimpan pada -80°C. Analisis kadar Beta defensin-1 dengan menggunakan kit Beta Defensin-1 (Elabscience®, USA), dengan uji ELISA.Hasil Penelitian: Kadar Beta Defensin-1 saliva perokok dibandingkan dengan pada bukan perokok secara statistik terdapat perbedaan signifikan (p< 0,05). Profil merokok (jenis, durasi dan frekuensi) tidak mempengaruhi kadar Beta Defensin-1, namun kadar Beta Defensin-1 saliva pada perokok jenis kretek cenderung lebih tinggi dibanding perokok non-kretek. Keberadaan lesi rongga mulut tidak berpengaruh terhadap kadar Beta Defensin-1 saliva. Profil saliva pada perokok khususnya pH lebih rendah dan berbeda secara statistik dibandingkan dengan bukan perokok (p< 0,05). Laju Alir Saliva pada perokok lebih tinggi dibandingkan bukan perokok. Nilai OHIS dan DMF-T pada kelompok bukan perokok cenderung lebih baik dibandingkan dengan perokok.Kesimpulan: Aktifitas merokok berpengaruh terhadap peningkatan kadar Beta Defensin-1 saliva. Terdapat perbedaan bermakna pada kadar Beta Defensin-1 antara perokok dan bukan perokok. Peningkatan kadar Beta Defensin-1 cenderung terjadi pada rongga mulut yang terdapat lesi. Perokok lebih rentan mengalami karies dan penurunan pH saliva dibandingkan dengan bukan perokok. Profil kesehatan bukan perokok lebih baik jika dibandingkan dengan perokok.

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ABSTRACTBackground: Salivary Human Beta Defensin-1 (SHBD-1) is one of the anti-microbial peptides that has an important role in innate immune defense against oral microbial attacks. Smoking activity can cause changes in saliva profile and health profile of the oral cavity that can affect levels of SHBD-1. The previous studies were focused on SHBD-1 levels in smokers with chronic periodontitis, but there are no studies to assess the SHBD-1 levels in smokers and associated with smoking profiles and oral health profile.Objective: To compare the salivary profile and health profile of the oral cavity and its effect on changes in SHBD-1 levels in smokers and nonsmokers. The alteration of SHBD-1 levels was associated with smoking profiles of the participants, which consist of the type of cigarette, duration of smoking, and frequency of smoking and oral health conditions.Methods: A total of 68 participants were divided into 2 groups: 44 (64.7%) smokers and 24 (35.5%) non-smokers. Data were collected from interviews, clinical examination (teeth, oral mucosa, and saliva), and laboratory examination. The unstimulated salivary flow rate was collected by spitting method and stored at -80 ° C. SHBD-1 level was analyzed by ELISA test using Human Beta Defensin-1 kit (Elabscience®, USA).Results: The smoker's SHBD-1 levels was compared with non-smokers, and there were statistically significant (p <0.05). The smoking profile (type, duration and frequency) did not affect the SHBD-1 levels, but the SHBD-1 levels in kretek smokers tended to be higher than non-clove cigarette smokers. The presence of oral lesions did not affect the SHBD-1 levels. The saliva profile in smokers typically in lower pH was statistically different with nonsmokers (p <0.05). Salivary Flow Rate (SFR) for smokers is higher than for nonsmokers. OHIS and DMF-T indexes in nonsmokers tend to be better than smokers.Conclusion: Smoking effected the increasing levels of SHBD-1. There were significant differences in SHBD-1 levels between smokers and nonsmokers. Increasing SHBD-1 levels tend to occur in the oral cavity with lesions. Smokers are prone to have caries and the decrease of salivary pH compared to nonsmokers. The health profile of non-smokers is better than smokers."

"ABSTRAKPenelitian bertujuan menganalisis pengaruh pembatasan rokok terhadap penerimaan cukai industri hasil tembakau, faktor-faktor yang mempengaruhi penerimaan cukai industri hasil tembakau, dan kendala yang dihadapi dalan pencapaian target penerimaan cukai industri hasil tembakau tersebut. Penelitian ini menggunakan regresi linear berganda dan data hasil wawancara. Hasil analisis menunjukkan pembatasan rokok berpengaruh signifikan terhadap kinerja penerimaan cukai Industri Hasil Tembakau IHT Direktorat Jenderal Bea dan Cukai DJBC . Faktor-faktor yang mempengaruhi penerimaan cukai IHT selain tarif cukai dan produksi rokok adalah pendapatan per kapita dan dummy1 yaitu faktor pembatasan rokok dalam PP 19 tahun 2003. Sedangkan kendala dalam pencapaian target adanya pelanggaran di bidang cukai seperti rokok tanpa pita cukai dan pita cukai palsu.

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ABSTRACTThe aim of this study is to analyze the effect of tobacco banned on the Performance in Tobacco Excise Revenue, the factors influencing tobacco excise revenue and the obstacles encountered in achieving the revenue targets of the tobacco industry excise. This study uses analysis method of multiple linear regression and interview results. Smoking restriction analysis showed a significant effect on the performance of tax revenues Tobacco Industry Directorate General of Customs and Excise DGCE . Factors affecting tax revenues in addition IHT tax rates and cigarette production is a factor of per capita income and dummy1 that is smoking restrictions in Government Regulation no 19 of 2003. While constraints in achieving the targets of violations in the field of customs such as cigarettes without excise bands and ribbons counterfeit stamps. "

"Parameter spinopelvic alignment (sagittal balance) merupakan salah satu etiologi yang dicuriga dalam menyebabkan spondilolisthesis degeneratif. Namun, hasil dari studi-studi sebelumnya menunjukkan hasil yang berlawanan; dimana beberapa studi menemukan hubungan yang signifikan dari beberapa parameter tersebut sedangkan yang lain tidak. Sebelumnya, belum terdapat meta-analisis mengenai hubungan spinopelvic alignment dengan terjadinya spondilolistesis degeneratif. Meta-analisis ini bertujuan untuk mengetahui hubungan parameter spinopelvic alignment dengan terjadinya spondilolisthesis degeneratif. Systematic review dan meta-analisis yang dikerjakan berdasarkan metode Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Pencarian literatur dilakukan melalui PubMed, EMBASE, ScienceDirect, Cochrane, dan Google Scholar. Kualitas metodologis berdasarkan ceklis Agency for Healthcare Research and Quality (AHRQ) cross-sectional study quality methodology checklis dan Newcastle-Ottawa Scale (NOS) untuk studi kohort. Analisis statistik dilakukan menggunakan Rev-Man 5.3. Kekuatan asosiasi diperkirakan menggunakan MD, RR, atau OR dan 95% IK nya. Data disajikan dalam bentuk tabel dan forest plot. Nilai P dibawah 0,05 dianggap sebagai bermakna secara statistik. Efek fixed-effect digunakan ketika tidak terdapat heterogenitas statistik signifikan (I2 < 50%, P > 0.10). Jika tidak, efek random-effects (metode Dersimonian dan Laird) digunakan. Grup disajikan antara lain usia, jenis kelamin, PI, PT, SS, LL, dan TK. Studi subgrup dilakukan berdasarkan area dan desain studi untuk memastikan hubungan area dan heterogenitas. Didapatkan total 3,236 artikel. Sejumlah 281 artikel penelitian didapatkan dari PubMed, 959 artikel dari ScienceDirect, 24 artikel dari Cochrane, 1820 artikel pada Google Scholar. Selain itu, dilakukan juga pencarian artikel secara hand searching dari daftar pustaka masing-masing artikel. Didapatkan sebanyak 10 artikel yang dianggap berhubungan dengan kata kunci penelitian. Ditemukan bahwa pelvic incidence (mean difference [MD] = 11,94 [1,81-22,08], P = 0,02), pelvic tilt (MD = 4,47 [0,81-8,14]), P = 0,02), dan usia (MD = 11,94 [1,81-22,08], P = 0,02) berhubungan terjadinya spondilolistesis degeneratif. Ditemukan pula perempuan memiliki risiko 2,86 kali lipat mengalami spondilolistesis degeneratif dibandingkan dengan laki-laki (OR = 2,86, IK95%=1,49-5,48; p = 0,002). Meta-analisis ini menunjukkan bahwa pelvic incidence, pelvic tilt, usia, dan jenis kelamin perempuan berhubungan terjadinya spondilolistesis degeneratif

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Spinopelvic parameter may result in the development of degenerative spondylolisthesis. However, results from previous studies show conflicting results; some studies found significant relationship of some of these parameters with degenerative spondylolisthesis, while others did not. Previously, there was no meta-analysis regarding the association between spinopelvic alignment and degenerative spondylolisthesis. This meta-analysis aims to determine the association between spinopelvic alignment and degenerative spondylolisthesis. Systematic reviews and meta-analyzes are carried out based on the Selected Item Reporting method for Systematic Review and Meta Analysis (PRISMA). Literature search was performed using PubMed, EMBASE, ScienceDirect, Cochrane, and Google Scholar. Methodological quality based on the cross-sectional checklist of the Agency for Healthcare Research and Quality (AHRQ) quality check methodology and the Newcastle-Ottawa Scale (NOS) for cohort studies. Statistical analysis was performed using Rev-Man 5.3. The strength of the association is estimated using MD, RR, or OR and 95% of its IK. Data is presented in table and forest plot form. P values below 0.05 are considered as statistically significant. Fixed-effect effects are used when there is no statistically significant heterogeneity (I2 <50%, P> 0.10). Otherwise, random-effects (the Dersimonian and Laird methods) are used. Groups presented include age, gender, PI, PT, SS, LL, and TK. Subgroup studies are conducted based on ethnic and study design to ascertain racial relations and heterogeneity.A total of 3,236 articles were obtained. Get 281 research articles from PubMed, 959 articles from ScienceDirect, 24 articles from Cochrane, 1820 articles on Google Scholar. In addition, a hand searching article was also conducted from the bibliography of each article. 10 articles related to research keywords were obtained. It was found that pelvic incidence (mean difference [MD] = 11.94 [1.81-22.08], P = 0.02), pelvic tilt (MD = 4.47 [0.81-8.14]), P = 0.02), and age (MD = 11.94 [1.81-22.08], P = 0.02) associated with degenerative spondylolisthesis. Compared with men (OR = 2.86, IK95% = 1.49-5.48; p = 0.002). This meta-analysis proves that pelvic incidence, pelvic tilt, age, and female sex are associated with degenerative spondylolisthesis."

"Pendahuluan: Wasting, underweight, dan stunting meningkatkan angka mortalitas dan morbiditas serta merupakan permasalahan yang masih ditemukan di Indonesia. Paparan asap rokok terhadap anak meningkatkan resiko wasting, underweight, dan stunting pada anak. Penelitian ini bertujuan untuk mengetahui asosiasi antara paparan asap rokok terhadap status gizi anak 0-59 bulan yang berdomisili di DKI Jakarta.Metode: Studi dengan pendekatan potong lintang dilakukan terhadap 121 orangtua dengan anak yang berusia 0-59 bulan pada Jakarta Pusat. Data mengenai paparan asap rokok diambil melalui kuesioner yang dibagikan kepada responded. Analisis data dilakukan dengan program SPSS. Status gizi anak dianlisa berdasarkan WHO Weight-for-Height, Weight-for-Age, and Height-for-Age Z-score.Hasil: Dalam riset ini, prevalensi wasting, underweight, and stunting masing-masing adalah 6.6%, 9.1% and 31.4%. Analisis statistik bivariat dilakukan menggunakan chi-square dan fisher’s exact test yang menunjukan tidak adanya asosiasi antara paparan asap rokok dari ayah dan ibu yang merokok dengan wasting, underweight, dan stunting pada anak. Ditemukan adanya asosiasi anatara paparan asap rokok terhadap ibu saat kehamilan terhadap stunting pada anak (p= 0.024; OR= 0.409; CI(95%)= 0.186-0.898). Melalui analisa logistic regression, ditemukan assosiasi anatara umur ibu (p=0.042; OR= 3.223) dan pendidikan ayah (p=0.011; OR= 4.082) terhadap terjadinya stunting pada anak. Terdapat pula asosiasi antara umur ibu dan underweight pada anak (p= 0.047; OR= 4.229).Kesimpulan: Tidak ditemukan asosiasi anatara paparan asap rokok terhadap anak dan wasting, underweight, dan stunting. Terdapat asosiasi anatara paparan asap rokok terhadap ibu saat hamil terhadap stunting pada anak.

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Introduction:Wasting, underweight, and stunting is associated with an increase morbidity and mortality in children and is still a problem in Indonesia. Environmental tobacco smoke exposure towards children has been associated with an increase risk of wasting, underweight, and stunting in children. In this research, we aim to investigate the association between tobacco smoke exposure in DKI Jakarta household and nutritional status of children <5 years old.Methods : Cross-sectional study with random sampling technique in 121 parents with children age 0-59 months in Central Jakarta. Tobacco smoke exposure is measured through questionnaire. The results are analyzed using SPPS statistic program. Nutritional status of children is analyzed through WHO Weight-for-Height, Weight-for-Age, and Height-for-Age Z-score.Results: In this research, the prevalence of wasting, underweight, and stunting are 6.6%, 9.1% and 31.4%, respectively. Bivariate statistical analysis using chi-square and Fisher’s Exact Test showed no association between tobacco smoke exposure with wasting, underweight, and stunting, while an association was found between tobacco smoke exposure during pregnancy with stunting in children aged 0-59 months (p= 0.024; OR= 0.409; CI(95%)= 0.186-0.898). Logistic regression analysis showed that Mother's age (p and paternal education (p=0.011; OR= 4.082) increases risk of stunting in children. Age of mother is associated with Underweight in children (p= 0.047; OR= 4.229).Conclusion: No association between paternal and maternal smoking with underweight, wasting, and stunting is found, while an association was found between tobacco smoke exposure during pregnancy with stunting in children."

"Latar belakang: Destruksi yang parah pada individu dalam bencana membuat identifikasi dan pemeriksaan sulit. Estimasi usia dental adalah salah satu cara untuk identifikasi individual. Estimasi usia pada orang dewasa cukup sulit karena proses penuaan yang terkait usia dipengaruhi oleh berbagai faktor. Metode Kvaal dan Cameriere adalah metode radiografi pemeriksaan pulpa untuk estimasi usia dewasa. Tujuan: Mengetahui penelitian terbaru terkait metode Kvaal dan Cameriere serta penilaian akurasi untuk kedua metode. Metode: Pencarian dilakukan melalui database seperti Scielo, PubMed, EBSCO, Scopus, Science direct, dan Wiley Online Library. Pencarian menggunakan panduan Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil: Pencarian menghasilkan 1190 studi dimana 39 studi memenuhi kriteria untuk diinklusikan. Studi dari 12 populasi dengan 7510 sampel individu ditemukan. Underestimasi ditemukan dengan metode Kvaal (-2.95 tahun, 95% CI) dan overestimasi ditemukan dengan metode Cameriere (0.89 tahun, 95% CI) pada metaanalisis ini. Metode Cameriere menghasilkan beda rerata dan kesalahan standar estimasi yang lebih rendah dibandingkan metode Kvaal. Kesimpulan: Metode Kvaal dan Cameriere dapat digunakan sebagai metode pendukung untuk estimasi usia dewasa melalui formula spesifik populasi. Metode Cameriere menunjukkan hasil yang lebih baik dibandingkan metode Kvaal.

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Background: Significant destruction of human remains in disasters lead to a challenging examination and identification. Dental age estimation is one of the ways to identify individuals. Age estimation in adults has been a challenge as the changes related to the aging process are affected by numerous factors. Kvaal and Cameriere method are the pulp assessment radiological method to estimate adult age. Aim: To summarize the recent research using Kvaal and Cameriere method as pulp assessment methods and to assess the accuracy of the Kvaal and Cameriere method. Method: Searches were conducted through databases including Scielo, PubMed, EBSCO, Scopus, Science direct, and Wiley Online Library. The searches were performed using the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Results: The search resulted in 1190 studies in which 39 studies were eligible to be included in the studies. Research from 12 populations were found with a total of 7510 individual samples. Underestimation was found using the Kvaal method (-2.95 years, 95% CI) and overestimation was found using Cameriere method (0.89 years, 95% CI) in this meta-analysis. The Cameriere method

presented lower mean difference and Standard Error of Estimation (S.E.E) compared to the

Kvaal method. Conclusion: The Cameriere method and Kvaal method as pulp assessment

radiological methods can be used as an adjunctive method to estimate adult age through population specific equation. Cameriere method showed better result in this study"

"Latar Belakang: Menurut Global Youth Tobacco Survey GYTS Indonesia 2014, 57,3 siswa terpajan asap rokok. Pajanan asap rokok menyebabkan inflamasi saluran nafas dan paru, serta penurunan fungsi paru. Kotinin sebagai metabolisme nikotin dapat digunakan sebagai biomarker pajanan asap rokok.Tujuan: Mengetahui efek pajanan asap rokok lingkungan terhadap kadar kotinin urin dan uji fungsi paru pada anak.Metode: Penelitian teknik potong lintang dengan subyek siswa berusia 11-16 tahun di Jakarta. Data didapat dari kuesioner, spirometri, dan penghitungan kadar kotinin urin dengan metode ELISA.Hasil: Terdapat 92 subyek, terdiri dari 46 kelompok kasus dan 46 kelompok kontrol. Kadar kotinin urin >10 ng/ml ditemukan pada 37,0 kelompok kasus dan 4,3 kelompok kontrol; p=0,000; OR=8,50 95 IK 2,08-34,71 . Terdapat perbedaan bermakna kadar kotinin urin terhadap jumlah perokok p=0,027 dan jumlah batang rokok per hari p=0,037 . Tidak ditemukan hubungan pajanan asap rokok dengan uji fungsi paru. Terdapat perbedaan bermakna absensi anak pada kelompok kasus dibandingkan kelompok kontrol; p=0,004; OR=6,00 95 IK 1,42-25,33 .Kesimpulan: Anak yang terpajan asap rokok memiliki kadar kotinin urin lebih tinggi dibandingkan yang tidak terpajan, yang dapat dipengaruhi oleh jumlah perokok dan jumlah batang rokok per hari.

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Background Global Youth Tobacco Survey GYTS 2014 in Indonesia showed that 57,3 of students are exposed to enviromental tobacco smoke, which causes inflammation of respiratory tracts and decrease of lung function. Urinary cotinine can be used as biomarker for cigarette smoke exposure.Objectives To examine effects of enviromental tobacco smoke exposure on urinary cotinine level and lung function test in children.Methods Subjects were students aged 11 16 years old in Jakarta. Data were obtained from questionnaire, spirometry, and urinary cotinine test using ELISA method.Results There were 92 subjects, consisted of 46 case group and 46 control group. Urinary cotinine level 10 ng ml was found in 37,0 of case group and 4,3 of control group p 0,000 OR 8,50 CI 95 2,08 34,71 . There were significant differences between urinary cotinine level with number of smokers p 0,027 and number of cigarettes per day p 0,037 . No association was found between cigarette smoke exposure and lung function test. There was a significant difference in school abscence between case group and control group p 0,004 OR 6,00 CI 95 1,42 25,33 .Conclusions Children exposed to enviromental tobacco smoke have higher urinary cotinine level than non exposed children. Factor such as number of smokers and number of cigarettes per day may affect urinary cotinine level. "

"Kualitas tidur yang buruk merupakan salah satu masalah utama pasien kanker dan dampaknya akan mempengaruhi kualitas hidup. Tujuan dari telaah literatur ini ialah untuk mengidentifikasi hubungan antara kualitas tidur dan kualitas hidup pada pasien kanker. Telaah review  dilakukan dengan menggunakan studi yang dicari di  7 database (Proquest, Ebscohost, SpringerLink, Sciencedirect, Wiley, Google Scholar, dan Pubmed). PRISMA checklist digunakan dalam penyeleksian literatur. Sintesis data disajikan dalam tabel dan narasi. Sebanyak 14 artikel yang terpilih memenuhi kriteria inklusi. Studi terpilih memiliki sampel mulai dari  35-515. Kualitas tidur memiliki hubungan yang negatif signifikan pada kualitas hidup di setiap domainnya dan memiliki hubungan positif dengan gejala . Hal ini menunjukkan, masalah tidur pada pasien kanker memiliki pengaruh negatif terhadap kualitas hidup. Masalah in perlu mendapatkan perhatian dengan tujuan meminimalkan pengaruh terhadap penurunan kualitas hidup.

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Poor sleep quality is one of the main symptoms in cancer patients and it may cause reducing the quality of life. The aim of this literature review is to identify the correlation between sleep quality and quality of life in cancer patients. This literature review using the articles in journals by searched from 7 journal databases (Proquest, Ebscohost, SpringerLink, Sciencedirect, Wiley, google scholar, and  Pubmed.  The PRISMA checklist used for assessing the eligibility of the studies. The result of the study showed in tabular and narrative. There are 14 that met the inclusion and used on this study. The samples are about 35 to 515 respondents. The result of this study shows that sleep quality has a negative significant correlation with quality of life in cancer patients. It signifies that sleep problem has negative influences to quality of life. It is needed to be more concern to assess sleep problem to minimize the impact of decreasing quality of life."