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"Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics"

"This book features: current, thorough coverage of important immunology and rheumatology topics, including the immune system in health and disease, disorders of immune-mediated injury, and disorders of the joints and adjacent tissues; delivers insights designed to reduce pain, lesson joint and organ damage, and improve overall patient outcomes and integrates pathophysiology with clinical management."

"Background: Systemic Lupus Erythematosus (SLE), an autoimmune disease, can cause damage and impairment in the nervous system. Patients who had any manifestation of neurology can be classified as patients with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). One of the most frequent NPSLE manifestation is anxiety disorder. The presence of anxiety disorder is believed to be correlated with their ability to carry out daily activities. This study aims to see the correlation between anxiety disorder and quality of life (QOL) in patients with SLE. Method: an analitic cross-sectional study was done. The data were collected by distributing validated questionnaires to patients diagnosed with SLE in the outpatient clinic of dr. Hasan Sadikin General Hospital. Quality of life and anxiety disorder was measured using Short From-36 (SF-36) and Zung Self-Rating Anxiety Scale (Zung-SAS), respectively. Normality test was done before correlating the variables using Pearson method. Result: Forty-six SLE patients fitted with the inclusion criteria were participated in the study. The assessment using Zung-SAS showed that 9 (19.56%) correspondents had mild–moderate anxiety, and 1 (2.17%) had severe anxiety. The analysis of SF-36 showed the means of Physical Component Summary (PCS) and Mental Component Summary (MCS) which were 45.18 ± 8.23 and 47.11± 9.78, in order. The correlation test of Zung-SAS with PCS and MCS showed the result of r= -0.651 (p < 0,01) and -0.654 (p < 0,01), respectively. Conclusion: There is a significant negative correlation between anxiety disorder and QOL in patients with SLE. The result of this study showed that the high degree of ones anxiety was in a parallel line with their low level of QOL, so it is important to do an early detection and prevention of anxiety disorder in SLE patients."

"Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. One of the etiologies of gastrointestinal manifestations in SLE is acute appendicitis. Patients with acute appendicitis usually have abdominal pain as its chief complaint. The pathophysiology of acute appendicitis can occur primarily from SLE and secondary from other causes eg: infection, inflammation, etc. When a SLE patient has acute appendicitis as its initial assessment, determining its etiology is pivotal to give comprehensive management and preventing life-threatening complications.

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Lupus eritematosus sistemik (LES) adalah suatu penyakit autoimun kronis eksaserbatif dengan manifestasi klinis yang sangat beragam. Manifestasi gastrointestinal merupakan manifestasi yang sering dijumpai namun dapat terjadi efek masking oleh karena penggunaan obat-obatan untuk mengontrol penyakitnya seperti obat anti-inflamasi non-steroid (OAINS) dan kortikosteroid. Appendisitis akut merupakan salah satu penyebab nyeri abdomen pada penderita LES. Patofisiologi appendisitis akut dapat terjadi primer oleh aktivitas penyakitnya maupun sekunder oleh sebab lain. Membedakan etiologi appendisitis akut perlu dilakukan untuk memberikan tatalaksana yang komprehensif pada penderita dengan LES."

"Background: systemic lupus erythematosus (SLE) is still a challenging autoimmune disease, especially in pregnancy setting. An early risk factors awareness of poor pregnancy outcome is important to optimize the outcome of pregnancy in SLE patients. This study was conducted to describe pregnancy outcome and determine the risk factors associated with poor pregnancy outcome in SLE patients.Methods: a retrospective case-control study of SLE patients with poor and normal pregnancy outcome was performed. Pregnancy histories were reviewed from Dr. Hasan Sadikin General Hospital lupus registry study. The case group was pregnancy with poor outcome, defined as abortion, premature birth, stillbirth, intrauterine growth restriction (IUGR) and neonatal death. The control group was pregnancy with good outcome, defined as live birth and full term.Results: a total of 84 SLE patients were enrolled in this study with 109 pregnancies after SLE diagnosis. The median age of subjects at the time of pregnancy was 28 (25-32) years old. Poor pregnancy outcome comprising 22.9% abortion, 14.7% premature birth, 5.5% stillbirth, 1.8% IUGR and 4.6% neonatal death. There was a significant difference in the number of planned pregnancy (P=0.011) between groups with poor and good outcome. Clinical variables significantly associated with poor pregnancy outcome were lupus nephritis (OR = 4.813, 95% CI 1.709 - 13.557, P = 0.003) and neuropsychiatric SLE (OR = 5.045, 95% CI 1.278 - 19.920, P = 0.021).Conclusion: the pregnancy in SLE patient should be planned to have better outcome. Lupus nephritis and neuropsychiatric (NP) SLE were risk factors for poor pregnancy outcome in SLE patient.

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Latar belakang: lupus eritematosus sistemik (LES) merupakan penyakit autoimun kompleks yang membutuhkan penanganan khusus, terutama saat kehamilan. Kesadaran akan faktor-faktor yang menyebabkan luaran kehamilan yang buruk penting untuk optimalisasi luaran kehamilan pada pasien LES. Penelitian ini bertujuan memberikan gambaran mengenai luaran kehamilan dan faktor risiko yang berhubungan dengan buruknya luaran kehamilan pada pasien LES.

Metode: penelitian kasus-kontrol retrospektif dilakukan pada pasien LES dengan berbagai luaran kehamilan. Riwayat dan komplikasi kehamilan diketahui dari data registri lupus di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung. Kelompok kasus berupa kehamilan dengan luaran yang buruk; yaitu aborsi, kelahiran prematur, lahir mati, pertumbuhan janin terhambat (PJT), dan kematian neonatal. Kelompok kontrol berupa kehamilan dengan luaran yang baik yakni lahir hidup dan cukup bulan.

Hasil: Total 84 pasien LES terlibat di dalam penelitian ini dengan 109 data kehamilan setelah diagnosis LES. Median usia subjek pada saat kehamilan adalah 28 (25-32) tahun. Luaran kehamilan yang buruk terdiri dari 22,9% abortus, 14,7% kelahiran prematur, 5,5% lahir mati, 1,8% PJT, dan 4,6% kematian neonatal. Kelompok kasus dan kontrol memiliki perbedaan yang bermakna dalam hal jumlah kehamilan terencana (P=0,011). Luaran kehamilan yang buruk dalam penelitian ini berhubungan dengan lupus nefritis (OR = 4,813, 95% CI 1,709 – 13,557, P = 0,003) dan SLE neuropsikiatri (OR = 5,045, 95% CI 1,278 – 19,920, P = 0,021). Kesimpulan: perencanaan kehamilan diperlukan untuk mendapatkan luaran kehamilan yang lebih baik. Nefritis dan neuropsikiatri lupus merupakan faktor risiko bagi terjadinya luaran kehamilan yang buruk"