Tujuan: Penelitian ini bertujuan membandingkan kadar 25 (OH) D serum ibu dan tali pusat pada kelahiran preterm dan cukup bulan. Selain itu juga dicarikorelasi antara kadar 25 (OH) D serum ibu dengan tali pusat.
Metode: Pada penelitian ini digunakan desain potong-lintang. Penelitian dilakukan di RSUPN Cipto Mangunkusumo dan RS Budi Kemuliaan Jakarta, mulai dari Januari 2017 sampai dengan Februari 2018. Kadar 25 (OH) D ibu dan tali pusat dibandingkan antara kelompok cukup bulan dan preterm.Hasil: Didapatkan 81 subjek yang dapat dilakukan analisis, yaitu 36 subjek (44,4%) melahirkan cukup bulan dan 45 (55,6%) preterm. Median 25 (OH) D maternal pada kelompok preterm dan cukup bulan berturut-turut 15 ng/mL dan 13,95ng/mL, sedangkan tali pusat 13 ng/ml dan 11,85 ng/ml.Tidak terdapat perbedaan kadar 25 (OH) D serum maternal (p=0,96) dan tali pusat (p=0,80) antara kedua kelompok. Terdapat korelasi positif antara kadar 25(OH) ibu dengan tali pusat (r=0,59, p<0,001 untuk kelompok cukup bulan dan r=0,44, p<0,002 untuk kelompok preterm).Kesimpulan: Kadar 25 (OH) D serum ibu dan tali pusat tidak berbeda bermakna antara kelompok kelahiran preterm dancukup bulan. Terdapat korelasi antara kadar 25 (OH) D ibu dengan tali pusat.Methods: This is a retrospective cross-sectional research that uses secondary data with the aim to determine the relationship of factors that affecting ovarian response at Yasmin Clinic, Dr. Hospital. Cipto Mangunkusumo Jakarta in 5 years (2013 to 2017). Two definitions of poor response were used (after a COS procedure) in this study; based on the number of oocytes (Bologna criteria) and Poseidon criteria. Results: From 2013-2017 there were 749 patients who met the inclusion criteria. Based on the number of oocytes produced there were 188 patients (25%) poor responder and 561 patients (75%) normo responder. Age, endometriosis, and history of ovarian surgery were significantly associated with a poor response group (p <0.001), although in the multivariate analysis only age that significantly predicted poor response (p = 0.004). Based on Poseidon criteria, there were 262 subjects (35%) included in the non Poseidon group (normo responder). There were 7 people (0.9%) according to the Poseidon 1a group, 64 people (8.5%) included in the Poseidon 1b group, 30 people (4%) in the Poseidon 2a group, 113 people (15.1%) according with the Poseidon 2b group, 73 people (9.7%) according to the Poseidon 3 group, and the remaining 200 people (26.7%) in accordance with the Poseidon group 4. Each factor has its own influence on the Poseidon group. Endometriosis is a significant determinant for the Poseidon group 1 and 4. The surgical history is a significant determinant for the Poseidon group 2 and 3, while an increase in BMI actually decreases the risk of a woman entering the Poseidon group 3. Endometriosis and surgical history cannot be said to have a direct relationship with the group Poseidon 1 and 2 because of individual variations underlying the division of the Poseidon group.
Conclusions: on the findings above, these factors become important in predicting a woman's ovarian response after SOT on IVF, due to their significance effect. This becomes important as a consideration for counseling and deciding better management."