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Tania Khaerunnisa
"[ABSTRAK
Penyakit kardiovaskular seperti gagal jantung kongestif memiliki prevalensi yang tinggi yang dapat disebabkan oleh perubahan pola hidup pada masyarakat urban. Kenaikan prevalensi penyakit kardiovaskular berhubungan dengan proses urbanisasi yang progresif dan globalisasi dari pola hidup tidak sehat yang ada pada masyarakat urban atau perkotaan. Tanda klinis yang muncul serta proses hospitalisasi dapat menjadi salah satu faktor munculnya masalah psikososial pada pasien gagal jantung kongestif. Masalah psikososial yang sering ditemukan adalah ansietas. Penulisan karya ilmiah ini bertujuan memberikan analisis mengenai asuhan keperawatan ansietas pada pasien gagal jantung kongestif. Intervensi yang dianalisis meliputi relaksasi napas dalam, hipnosis lima jari, distraksi sosialisasi dan pemberian informasi. Evaluasi tindakan menunjukan bahwa lebih banyak tanda gejala yang menghilang saat memberikan kombinasi tarik napas dalam dan hipnosis lima jari selama lima hari perawatan. ABSTRACT Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined.;Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined.;Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined.;Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined.;Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined., Cardiovascular disease such as congestive heart failure have high prevalence due to the transition of lifestyle in urban society. The increase of prevalence relates to the progressive and global urbanization which has unhealthy sedentary lifestyle in urban society. The presence of sign and symptom or hospitalization may cause the psychosocial problem in patient with CHF such as anxiety. The objective was to analyze the psychosocial nursing care plan specifically anxiety in CHF patient. Nursing intervention which has given are deep breathing relaxation, five finger hypnosis, distraction and health education. It shows that sign and symptom of anxiety decreased significantly when deep breathing and hypnosis is combined.]"
Depok: Fakultas Farmasi Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Euntong Army
"Penelitian ini membahas mengenai pemantauan terapi obat pada pasien hipertensi dengan komorbid diruang rawat inap RSUD Cengkareng. Metode yang digunakan dalam penelitian ini adalah metode non-eksperimental yang dilakukan secara observasional yang bersifat kualitatif dengan cara pengamatan dan wawancara. Hasil penelitian ini menyarankan untuk melakukan pemantauan lebih cepat pada saat pasien pertama kali dirawat agar dapat dilakukan pemantauan secara berkala dan dapat diidentifikasi masalah terkait obat serta dapat diberikan intervensi. Berdasarkan pengamatan yang telah dilakukan dapat disimpulkan bahwa terapi yang diberikan pada pasien sudah sesuai walaupun terdapat masalah interaksi dan polifarmasi yang telah ditangani dengan pengaturan dosis dan waktu pemberian.

This study discusses the monitoring of drug therapy in hypertensive patients with comorbidities in the inpatient room of Cengkareng Hospital. The method used in this study is a non-experimental method conducted in an observational manner that is qualitative in nature by means of observations and interviews. The results of this study suggest monitoring more quickly when the patient is first admitted so that regular monitoring can be carried out and drug-related problems can be identified and interventions can be given. Based on the observations that have been made, it can be concluded that the therapy given to patients is appropriate even though there are problems of interaction and polypharmacy that have been handled by adjusting the dose and time of administration.
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Depok: Fakultas Farmasi Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Rina Yuliaty
"[ABSTRAK
Sesak nafas merupakan keluhan yang umum terjadi pada penderita gagal jantung
kongestif akibat penumpukan cairan. Pemberian semifowler derajat menjadi salah
satu intervensi untuk mengurangi rasa sesak dan mencegah komplikasi akibat sesak.
Karya ilmiah akhir ners ini bertujuan menganalisis keefektifan pemberian posisi
tidur 45 derajat dalam mengurangi sesak nafas pada penderita gagal jantung
kongestif dengan pemberian posisi tidur 45 derajat. Implementasi ini dilakukan
selama pasien mengeluh sesak nafas. Hasil perawatan selama lima hari
menunjukkan bahwa pasien melaporkan terjadinya penurunan sesak nafas selama
pemberian posisi tidur 45 derajat. Hal tersebut ditunjukkan dengan adanya
penurunan laju pernafasan 4-6 kali permenit. Karya Ilmiah akhir ners ini
merekomendasikan perlu dilakukan penelitian terkait efektivitas intervensi yang
dilakukan dengan melihat perbedaan antara sebelum dan sesudah pemberian posisi
45o,90o, dan orthopnea.ABSTRACT Breathlessness is a common symptom in patient with congestive hearth failure
that caused by fluid retention. The semifowler position is one of the intervention
to reduce the breathlessness and prevent the complications due to breathlessness.
The aim of this study was to analyzing the effectiveness of 45 degrees position in
reducing breathlessness in patient with congestive hearth failure. Implementation
was performed while the patient had breathlessness. Results showed that patients
reported a decrease in breathlessness during 45 degrees positions. Which was
indicated by a decrease in respiratory rate 4-6 times per minute. This result
suggest to perform research that identify the difference between before and after
administration of 45o,90o, and orthopnea.;Breathlessness is a common symptom in patient with congestive hearth failure
that caused by fluid retention. The semifowler position is one of the intervention
to reduce the breathlessness and prevent the complications due to breathlessness.
The aim of this study was to analyzing the effectiveness of 45 degrees position in
reducing breathlessness in patient with congestive hearth failure. Implementation
was performed while the patient had breathlessness. Results showed that patients
reported a decrease in breathlessness during 45 degrees positions. Which was
indicated by a decrease in respiratory rate 4-6 times per minute. This result
suggest to perform research that identify the difference between before and after
administration of 45o,90o, and orthopnea.;Breathlessness is a common symptom in patient with congestive hearth failure
that caused by fluid retention. The semifowler position is one of the intervention
to reduce the breathlessness and prevent the complications due to breathlessness.
The aim of this study was to analyzing the effectiveness of 45 degrees position in
reducing breathlessness in patient with congestive hearth failure. Implementation
was performed while the patient had breathlessness. Results showed that patients
reported a decrease in breathlessness during 45 degrees positions. Which was
indicated by a decrease in respiratory rate 4-6 times per minute. This result
suggest to perform research that identify the difference between before and after
administration of 45o,90o, and orthopnea.;Breathlessness is a common symptom in patient with congestive hearth failure
that caused by fluid retention. The semifowler position is one of the intervention
to reduce the breathlessness and prevent the complications due to breathlessness.
The aim of this study was to analyzing the effectiveness of 45 degrees position in
reducing breathlessness in patient with congestive hearth failure. Implementation
was performed while the patient had breathlessness. Results showed that patients
reported a decrease in breathlessness during 45 degrees positions. Which was
indicated by a decrease in respiratory rate 4-6 times per minute. This result
suggest to perform research that identify the difference between before and after
administration of 45o,90o, and orthopnea., Breathlessness is a common symptom in patient with congestive hearth failure
that caused by fluid retention. The semifowler position is one of the intervention
to reduce the breathlessness and prevent the complications due to breathlessness.
The aim of this study was to analyzing the effectiveness of 45 degrees position in
reducing breathlessness in patient with congestive hearth failure. Implementation
was performed while the patient had breathlessness. Results showed that patients
reported a decrease in breathlessness during 45 degrees positions. Which was
indicated by a decrease in respiratory rate 4-6 times per minute. This result
suggest to perform research that identify the difference between before and after
administration of 45o,90o, and orthopnea.]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Vika Rachma Sari
"CHF merupakan salah satu penyakit penyebab kematian tertinggi di masyarakat perkotaan. CHF dapat menimbulkan terjadinya masalah pernapasan seperti dyspnea, napas cepat, kelemahan otot napas, serta masalah pernapasan lainnya. Salah satu intervensi yang dapat dilakukan untuk mengatasi masalah tersebut adalah teknik bernapas siklus aktif. Intervensi teknik bernapas siklus aktif yang dilakukan terhadap pasien kelolaan terbukti dapat menurunkan keparahan dyspnea meskipun tidak signifikan serta dapat meningkatkan kualitas hidup pasien. Hasil yang didapatkan dari intervensi ini masih perlu dilakukan penelitian lanjutan untuk mengetahui keefektifan intervensi dalam mengatasi masalah pernapasan pada pasien dengan CHF.

CHF is one of the leading cause of death in urban society. CHF may cause respiratory problems such as dyspnea, rapid breathing, weakness of the breathing muscles, and other respiratory problems. One of the interventions that can be done to overcome the problem is Active Cycle Breathing Technique ACBT. ACBT conducted on the underlying patient has been proved to decrease the severity of dyspnea although not very significant. In addition, ACBT can also improve the quality of life of patients. The results obtained from this intervention still need further research to determine the effectiveness of ACBT in overcoming respiratory problems in patients with CHF."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2017
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UI - Tugas Akhir  Universitas Indonesia Library
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I Putu Eka Krisnha Wijaya
"ABSTRAK
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that more commonly affects women of childbearing age. It is a multi-organ disease and can involve virtually any organ in the body. Pleural effusion can occurred in 30% of patients with SLE, which may be a result of SLE itself, pulmonary emboli, or end-organ damage such as heart or renal failure. The management of pleural effusions in SLE patient can be challenging because the numerous of potential underlying cause and sometimes effusion recur despite appropriate treatment of primary process. Case Report: We reported 33 years old woman patient admitted to our ED with chief complaint of shortness of breath for last 1 week. Chest X-ray result showed bilateral pleural effusion. Serial pleural fluid analysis consistent with conclusion of transudate fluid. Echochardiograpy showed dilatation of left atrium and ventricle and reduced LVEF 34%. These data suggest congestive heart failure as the cause of pleura effusion. A few days after initial thoracocentesis, the patient become dyspnea again because of reccurent pleural effusion. To relieve the symptom, we did insertion of pigtail catheter connected with mini WSD (Water seal drainage). Conclusion: Pleural effusion is a relatively common clinical presentation of a patient with SLE. Pleural effusions may be a result of SLE itself, pulmonary emboli, or end-organ damage such as heart or renal failure. The management of pleural effusions are mainly to relieve the symptoms and treatment of underlying cause."
Bandung : Interna Publishing (Pusat Penerbitan Ilmu Penyakit Dalam), 2019
CHEST 6:1 (2019)
Artikel Jurnal  Universitas Indonesia Library
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Bambang Julianto
"

Congestive Heart Failure (CHF) merupakan masalah kesehatan yang progresif dengan tingkat mortalitas dan morbiditas tinggi di Indonesia. Pemberian asuhan keperawatan yang tepat melalui intervensi keperawatan non farmakologi memiliki peran dalam mengatasi masalah keperawatan intoleransi aktivitas yang banyak ditemui pada pasien CHF. Latihan fisik active range of motion adalah salah satu dari banyak intervensi keperawatan yang dapat diterapkan. Tujuan dari pelaksanaan latihan aktif ROM ini adalah untuk mengatasi ketidakseimbangan antara suplai dan kebutuhan oksigen tubuh. Dengan memperhatikan kondisi klien sebelum dilakukannya intervensi dan waktu pelaksanaan setelah pemberian terapi farmakologi antihipertensi, maka dapat dianalisis melalui evaluasi setelah dilakukan selama empat hari dalam waktu 20 menit setiap kali intervensi dilakukan. Hasil evaluasi tersebut secara subjektif klien tidak melaporkan adanya keluhan dan klien menunjukkan parameter tanda-tanda vital dan hemodinamik dalam batas normal sebagai bagian dari aspek penilaian dari capaian tujuan masalah keperawatan penurunan curah jantung.


Congestive Heart Failure (CHF) are progressive health problems with high mortality and morbidity in Indonesia. The provision of appropriate nursing care through non-pharmacological nursing interventions has a role in overcoming the nursing problem of activity intolerance as the major problem of CHF. Active range of motion is one of many nursing interventions that can be applied. The purpose of performing active ROM exercises is to overcome the imbalance between the bodys oxygen supply and demand. By paying attention to the clients condition before the intervention and the time of implementation after the administration of antihypertensive pharmacological therapy, evaluation of the evaluation can be carried out for four days within 20 minutes of each intervention. The results of the subjective evaluation that the client did not report complaints and the client showed vital signs and hemodynamic parameters within normal limits as part of the report on nursing goals that determine the reduction in cardiac output.

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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2020
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UI - Tugas Akhir  Universitas Indonesia Library
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Gregorino Al Josan
"Cardiovascular diseases (CVD) merupakan salah satu penyebab utama kematian di dunia. WHO memperkirakan angka 17,9 juta kematian pada tahun 2021 disebabkan oleh CVD. Di Indonesia sendiri, prevalensi penyakit jantung mencapai angka 1,5% atau sekitar 2,7 juta orang pada tahun 2018. CVD mencakup berbagai macam jenis penyakit jantung. Salah satu tipe penyakit jantung tersebut adalah congestive heart failure. Congestive heart failure (CHF) adalah kondisi dimana jantung tidak dapat memompa darah yang cukup ke seluruh bagian tubuh. CHF dapat terjadi dikarenakan melemahnya kemampuan otot jantung untuk memompa darah sehingga mempengaruhi heart rate atau detak jantung manusia. Heart rate dapat direpresentasikan menggunakan sinyal yang dapat diukur menggunakan alat rekaman electrocardiogram (ECG/EKG). EKG adalah rekaman aktivitas elektrik jantung yang ditangkap melalui bagian permukaan tubuh. Heart rate variability (HRV) diketahui berkorelasi dengan berbagai penyakit jantung dan salah satunya adalah CHF. Dengan berkembangnya teknologi, terdapat beberapa penelitian mengenai implementasi artificial intelligence (AI) untuk mendeteksi keberadaan CHF menggunakan model machine learning dan HRV sebagai fitur bagi model. Pada penelitian ini, akan dibangun dan dievaluasi kinerja model XGBoost untuk mendeteksi eksistensi penyakit CHF pada short-term HRV dari rekaman EKG 5 menit. Dataset yang digunakan berasal dari empat database yang berbeda yang diambil dari situs PhysioNet, yaitu NSRDB dan NSR2DB sebagai kelas sehat dan CHFDB dan CHF2DB sebagai kelas CHF. Masing-masing database memiliki rekaman long-term EKG. Seluruh rekaman tersebut dilakukan segmentasi selama 5 menit pada 2 jam pertama rekaman. Dari hasil segmentasi rekaman 5 menit tersebut akan dihitung nilai HRV yang akan menjadi fitur bagi model XGBoost. XGBoost dilatih menggunakan kombinasi teknik Grid Search dan K-Fold Cross Validation dengan nilai 𝐾 = 10. Terdapat 4 metrik yang dijadikan objektif optimisasi Grid Search, yaitu akurasi, sensitivitas, spesifisitas, dan skor AUC. XGBoost yang dilatih dengan mengoptimasi akurasi berhasil mencapai nilai akurasi sebesar 0,954, sensitivitas sebesar 0,935, spesifisitas sebesar 0,96, dan skor AUC sebesar 0,947. XGBoost yang dilatih dengan mengoptimasi sensitivitas berhasil mencapai nilai akurasi sebesar 0,966, sensitivitas sebesar 0,977, spesifisitas sebesar 0,963, dan skor AUC sebesar 0,97. XGBoost yang dilatih dengan mengoptimasi spesifisitas berhasil mencapai nilai akurasi sebesar 0,962, sensitivitas sebesar 0,931, spesifisitas sebesar 0,971, dan skor AUC sebesar 0,951. Kemudian XGBoost yang dilatih dengan mengoptimasi skor AUC berhasil mencapai nilai akurasi sebesar 0,955, sensitivitas sebesar 0,935, spesifisitas sebesar 0,962, dan skor AUC sebesar 0,948.

Cardiovascular diseases (CVD) is one of the major causes of death in the world. WHO estimated that 17.9 million of deaths during 2021 are caused by CVD. In Indonesia alone, the prevalence of heart diseases reached 1.5% or around 2,7 million people in 2018. CVD consists of various types of heart disease. Congestive heart failure is one of them. Congestive heart failure (CHF) is a condition where the heart cannot pump enough blood for the entire body. CHF can occur due to a weakening of the heart muscle's ability to pump blood, thereby affecting the human heart rate. Heart rate can be represented using signal that can be measured using electrocardiogram (ECG/EKG) recording. EKG is a recording of the heart's electrical activity captured through the surface of the body. Heart rate variability (HRV) have been known to be correlated with various heart diseases with CHF is one of it. With the advance of technology, there have been various research regarding the implementation of artificial intelligence (AI) to detect the presence of CHF using machine learning model and HRV as features for the model. In this research, we built and evaluated the performance of XGBoost model to detect the existence of CHF on short-term HRV from 5 minutes EKG recording. The dataset came from four different databases that can be accessed from PhysioNet website. Those are NSRDB and NSR2DB datasets to represent healthy class and CHFDB and CHF2DB to represent CHF class. Each database contains long-term EKG. All records are segmented by 5 minutes on the first 2 hours of the recording. HRV metrics are calculated from those 5 minutes segments to become features for the XGBoost model. XGBoost was trained using a combination of Grid Search and K-Fold Cross Validation techniques with 𝐾 = 10. There are 4 metrics that become the objective scoring function for the Grid Search. Those are accuracy, sensitivity, specificity, and AUC score. XGBoost trained to optimize accuracy managed to achieve 0.954 accuracy, 0.935 sensitivity, 0.96 specificity, and 0.947 AUC score. XGBoost trained to optimize sensitivity managed to achieve 0.966 accuracy, 0.977 sensitivity, 0.963 specificity, and 0.97 AUC score. XGBoost trained to optimize specificity managed to achieve 0.962 accuracy, 0.931 sensitivity, 0.971 specificity, and 0.951 AUC score. Lastly, XGBoost trained to optimize AUC score managed to achieve 0.955 accuracy, 0.935 sensitivity, 0.962 specificity, and 0.948 AUC score."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2024
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UI - Skripsi Membership  Universitas Indonesia Library
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Nadya Tsurayya
"Pemantauan terapi obat merupakan salah satu pelayanan farmasi klinis yang harus dilakukan oleh apoteker klinis di RSUD Cengkareng. Pada laporan tugas khusus ini dilakukan kegiatan pemantauan terapi obat pada pasien dengan diagnosis Congestive Heart Failure (CHF) yang disertai komorbid CKD dan CAD di Ruang Rawat Inap RSUD Cengkareng. Berdasarkan hasil pengamatan dan pemantaun yang dilakukan selama kegiatan PTO pada pasien CHF dengan komorbid CKD dan CAD dapat disimpulkan bahwa pemberian terapi obat pada pasien sudah cukup baik dan sesuai dengan literatur dan ketentuan pada peraturan yang berlaku. Rekomendasi yang diberikan yaitu pemberian obat untuk indikasi yang belum ada terapi, penggantian obat yang lebih efektif, dan pemberian alternatif obat yang lebih aman untuk pasien jantung, Tindak lanjut yang dapat dilakukan yaitu mengkomunikasikan kepada dokter penanggung jawab pasien (DPJP) terkait hasil identifikasi masalah terkait obat. Selain itu juga perlu dilakukan pemantauan pemantauan hasil laboratorium seperti kadar elektrolit dan fungsi ginjal, pemantauan efek samping dan interaksi obat lainnya.
Monitoring drug therapy is one of the clinical pharmacy services that must be carried out by clinical pharmacists at Cengkareng Regional Hospital. In this special assignment report, drug therapy monitoring activities were carried out in patients with a diagnosis of Congestive Heart Failure (CHF) accompanied by comorbid CKD and CAD in the Inpatient Room at Cengkareng Regional Hospital. Based on the results of observations and monitoring carried out during Monitoring drug therapy activities in CHF patients with comorbid CKD and CAD, it can be concluded that the administration of drug therapy to patients is quite good and in accordance with the literature and provisions in applicable regulations. The recommendations given are administering drugs for indications for which there is no therapy, replacing more effective drugs, and providing alternative drugs that are safer for heart patients. Follow-up that can be done is communicating to the doctor in charge of the patient regarding the results of identifying related problems. drug. Apart from that, it is also necessary to monitor laboratory results such as electrolyte levels and kidney function, monitor side effects and other drug interactions."
Depok: Fakultas Farmasi Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Thadeus, Maria Selvester
"Ruang Lingkup dan Cara Penelitian: DaIam kehidupan sehari-hari penggunaan minyak jelantah berasal dari restoran makanan cepat saji dan hotel, umum digunakan oleh pedagang gorengan. Pemanasan minyak goreng berulang kali menyebabkan oksidasi dan polimerisasi asam lemak yang dikandungnya. Oksidasi Iemak ini akan menghasilkan senyawa peroksida yang merupakan radikal bebas yang akan menyebabkan kerusakan membran sel. Vitamin C dan vitamin E telah diketahui merupakan antioksidan yang berperan dalam melindungi sel terhadap daya destruktif radikal bebas. Penelitian ini dilakukan untuk melihat efek pemberian vitamin C dan vitamin E pada kerusakan. hati, jantung dan aorta yang ditimbulkan akibat pemberian minyak jelantah dengan angka peroksida 125-130 meq/kg, dengan dosis 10 ul/g BB selama 12 minggu pada mencit jantan (Mus musculus L) galur Swiss derived Lima kelompok masing-masing terdiri dari 8 ekor mencit dengan diet standar, yaitu kelompok kontrol (K), kelompok perlakuan dengan minyak jelantah (MJ), kelompok perlakuan dengan minyak jelantah dan suplemen vitamin C 2.5 mg/hr (MJC); kelompok perlakuan dengan suplemen vitamin E 0.1 mg/hr (MJE); kelompok perlakuan dengan suplemen kombinasi vitamin C dan vitamin E (MJCE). Pada minggu ke-13 dilakukan eutanasia dan dilakukan pembedahan untuk melihat perubahan histopatologik hati, jantung dan aorta dengan pulasan HE dan pulasan elastika Verhaeff?s.
Hasil dan kesimpulan: Ditemukan perubahan gambaran histopatologik berupa bendungan hati, peningkatan apoptosis, perlemakan, penipisan miokardium dan `hilangnya gelombang tunika elastika aorta. Bendungan hati ditemukan pada semua kelompok, terrnasuk kelompok konrol walaupun derajatnya lebih ringan (Kruskal Wallis, p=0.048). Pelebaran vena sentralis ditemukan pada kelompok perlakuan, walaupun tidak berbeda bermakna. Perlemakan ditemukan pada seluruh kelompok perlakuan dengan derajat yang lebih berat terutama pada kelompok MJE dan MJCE. (Kruskal Wallis, p=0.001), menunjukkan vitamin E tidak memberikan daya proteksi pada hati. Peningkatan derajat apoptosis sel hati terutama di zona 1 menunjukkan berbeda bermakna (Kruskal Wallis, p=0.006). Ditemukan penipisan miokardium yang berbeda bermakna pada seluruh kelompok perlakuan dengan atau tanpa suplemen (Anova,P=0.000) Ditemukan pula korelasi terbalik antara penipisan miokardium dengan pelebaran diameter ventrikel yang berbeda bermakna (Pearson, r = - 0.437). Kelainan dinding aorta berupa ketidak-teraturan putusnya gelombang tunika elastika ditemukan berbeda makna (Kruskal Wallis, p=0..000) antara kelompok kontrol dan kelompok perlakuan baik yang mendapat suplemen maupun tidak, dengan derajat yang lebih berat terutama pada kelompok MJC dan MJCE, menunjukkan vitamin C tidak memberikan proteksi pada aorta.
Dari penelitian ini dapat disimpulkan bahwa pencekokan minyak jelantah mengakibatkan perlemakan hati, peningkatan derajat apoptosis zona 1, penipisan miokardium dan hilangnya gelombang sampai putusnya tunika elastika aorta Pemberian vitamin C, vitamin E dan kombinasi keduanya tidak dapat memperbaiki kerusakan akibat pemberian minyak jelantah secara menyeluruh. Daya proteksi vitamin C lebih baik pada jaringan hati dan vitamin E lebih baik pada jantung dan aorta.

Scope of study and method:
In everyday life, re-use cooking oil from hotel or fast food restaurants was commonly used by deep-fried food vendors on the street. Heating of cooking oil caused oxidation and polymerization of its lipid component. This process resulted in lipid peroxide, free radical which produced cell membrane damage. Vitamin C and vitamin E have been known as anti-oxidant that protects cells from free radical destruction. This study was carried to observe the effect of vitamin C and vitamin E or its combination supplementation for 12 weeks on liver, myocardium and aorta from damaging effect of re-use cooking oil intake of 10 ul/g BW with peroxide number 125-130 mEg/kg, in male M musculus strain Swiss-derived. Five groups of 8 mice with standard diet were studied_ control, treated with re-use cooking oil only (MI}, treated with re-use cooking oil with 2.5 mg/day vitamin C supplementation (MJC), treated with re-use cooking oil with 0.1 mg/day vitamin E supplementation (MJE) and treated with combination vitamin C and vitamin E (MICE), in week 13, the mice were sacrificed and histopathological changes in liver, heart and aorta were studied using HE and elastic Verhoeff's staining.
Result and Conclusion
Histopathological changes of venous congestion, increase of apoptotic rate and steatosis were found in liver. Thinning of myocardium, ventricle dilatation, and disruption of elastic fibers of aorta were found. Liver veins congestion were found in all group although in control it was milder (Kruskal Wallis, p=0.048). Central veins dilatation was found in all groups (Ml, MJC, MIE and MJCE) although it was not significantly different. Steatosis were found in all groups, which were more severe in groups MJE and MJCE (Kruskal Wallis, p=0.001), showing that vitamin E did not give protection to liver. There was significant increase of apoptotic rate in zone 3 in all (Kruskal Wallis, p=0.006). Significant thinning of Myocardial was also found in all groups wit or without therapy (Anova, p= 0.011). Significant inverse correlation was found in heart myocardial thinning and ventricle dilatation (Pearson, r==-0,437). Elastic fibers degradation and break-down were found in control and MJ (Kruskal Wallis, pA31.000). In the other groups (MJC, MJE and MICE) degradation of aorta elastic fibers were also found.
From this study, it is concluded that intake of re-use cooking oil contributed to steatosis and increase of zone 3 apoptosis rate in of the liver, and caused thinning of heart myocardium with ventricle dilatation, and degradation of aorta elastic fibers. Vitamin C, vitamin E supplementation or its combination could not protect liver, myocardium or aorta from damaging effect(s) of re-use cooking oil intake.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2005
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Roberts, Sharon L.
New Jersey: Prentice-Hall, 1985
610.73 ROB p
Buku Teks  Universitas Indonesia Library
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