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"Particulate Matter 2,5 (PM 2,5) adalah partikel halus memiliki diameter aerodinamis kurang dari 2,5 μm, partikel ini terbentuk dari gas dan kondensasi uap suhu tinggi selama pembakaran. Sumber partikel berasal dari alam dan antropogenik. Beberapa partikel bebas dapat juga masuk ke dalam saluran limfa. Partikel-partikel yang dapat larut mungkin diserap lewat epitel ke dalam darah. Testosteron adalah hormon steroid yang diproduksi di testis pada pria dan di ovarium pada wanita (dalam jumlah yang terbatas testosteron pada wanita juga diproduksi dalam kelenjar adrenal). Pengukuran partikel PM 2,5 dilakukan di dalam dan di luar gardu tol menggunakan pompa leland legacy. subyek penelitian ini adalah para pekerja gerbang tol dengan pengambilan sampel darah. Jumlah sampel 45 orang pekerja dan 15 orang bukan pekerja gerbang tol. Hasil pengukuran PM 2,5 dihitung menggunakan rumus dari leland legacy. Berdasarkan hasil penelitian nilai rata-rata konsentrasi PM 2,5 di dalam gardu 316,35 μg/m3 dan di luar gardu sebesar 152,11 μg/m3. Hasil uji statistik menunjukkan tidak ada perbedaan antara konsentrasi PM 2,5 baik di dalam maupun di luar gardu dengan nilai P value > 0,05 Rata-rata kadar plasma testosteron pekerja gerbang tol adalah 604,67 ng.dl, sedangkan untuk bukan pekerja gerbang tol adalah 750,30 ng/dl. Hasil uji statistik menunjukkan nilai P value > 0,05 berarti tidak ada perbedaan antara kadar plasma testosteron pekerja gerbang tol dan bukan pekerja gerbang tol. Tidak ada hubungan yang signifikan antara testosteron dengan faktor usia, perilaku merokok, dan status gizi baik pekerja gerbang tol maupun bukan pekerja gerbang tol. Walaupun demikian perlu dilakukan pemeriksaan kesehatan secara rutin untuk mencegah pajanan.

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Particulate Matter (PM 2.5) are fine particles having an aerodynamic diameter of less than 2.5 lm, these particles are formed from gas and high temperature steam condensation during combustion. Particles derived from natural sources and anthropogenic. Some free particles can also enter into the lymph channels. The particles may be absorbed through soluble epithelium into the blood. Testosterone is a steroid hormone produced in the testes in men and ovaries in women (a limited amount of testosterone in women is also produced in the adrenal glands). Measurement of PM 2.5 particles carried inside and outside the toll booth using a pump leland legacy. This research is the subject of the toll gate workers with blood sampling. Number of samples 45 and 15 workers not tollgate workers.

The results of measurements of PM 2.5 was calculated using the formula of leland legacy. Based on the results of the study the average value of the concentration of PM 2.5 in the substation 316.35 μg/m3 and outside the substation was 152.11 μg/m3. Statistical test results showed no difference between PM 2.5 concentrations both within and outside the substation with P value> 0.05 Average plasma levels of testosterone tollgate workers are ng.dl 604.67, while not working toll booths is 750.30 ng / dl. Statistical test results show the value of the P value> 0.05 means that there is no difference between plasma testosterone levels toll gate workers and not the toll gate workers. There is no significant relationship between testosterone with age, smoking behavior, and nutritional status of both workers and non-workers tollgate tollgate. Nevertheless, health checks need to be done regularly to prevent exposure"

"ABSTRAKPenyuntikan secara intramuskular dua dosis kombinasi northisteron enanthat (NE) dan testosteron enanthat (TE) dosis tunggal (long-acting), bertujuan untuk menurunkan kesuburan mencit (Kus musculus L.) jantan strain CER tanpa menurunkan libido dan potensi seks. Parameter kesuburan yang diukur adalah jumlah spermatozoa total, persentase spermatozoa motil, dan jumlah fetus. Jumlah korpus luteum, perubahan berat badan, dan perbandingan jenis kelamin fetus merupakan data tambahan.Mencit kelompok Eksperimen 1 (E1 ) disuntik dengan kombinasi 0,004 mg/0,01 ml NE per gram berat badan (BB) mencit dan 0,005 mg/0,01 ml TE per gram BB mencit, E2 disuntik dengan 0,008 mg/0,01 ml NE per gram BB mencit dan 0,005 mg/0,01 ml TE per gram BB mencit. Kontrol 1 (K1) disuntik dengan kombinasi pelarut NE dan pelarut TE, sedangkan K2 tidak diberi perlakuan apapun. Hasil uji ANAVA menunjukkan tidak ada pengaruh perlakuan terhadap jumlah spermatozoa total, persentase spermatozoa motil, jumlah fetus, dan perubahan berat badan. Hasil uji Chi-kuadrat menunjukkan tidak ada pengaruh perlakuan terhadap perbandingan jenis kelamin fetus. Kesimpulan, penyuntikan dua dosis kombinasi northisteron enanthat dan testosteron enanthat dosis tunggal, untuk jangka waktu 45 hari tidak menurunkan kesuburari mencit (Mus musculus L.) strain CBR.ABSTRACT"

"Latar belakang: Pengembangan kontrasepsi hormonal pria didasarkan pada penekanan gonadotropin sehingga mengbnmbat spermatogenesis dan berdampak pada penurunan konsentrasi spermatozoa. Pemberian depot medroksiprogesteron aselat (DMPA) efektif mengbambat spermatogenesis dan sekresi testosteron namun berakibat menurunnya libido dan potensi seksual. Berbagai tanaman yang dapat menstimulasi pembentukan androgen endogen telah ditemukan di dalam tanaman obat, salah satunya adalah cabe jawa (Piper retrofractum Vahl.). Secara tradisional buah cabe jawa digunakan untuk obat lemah syahwat dan telah terbukti dapat meningkatkan kadar hormon testosteron darah. Tujuan: Mengetahui pengaruh komhinasi DMPA dan ekstrak cabe jawa terbadap konsent:rasi serta viabUitas spermatozoa vas deferenskadar hormon testosteron darah, berat badan, hernarologi, dan biokimia darah tikos (Rattus norvegicus L.). Metode: Penelitian ini menggunakan rancangan acak 1engkap (RAL), equal size sample yaitu terdiri dari satu kelompok kontrol dan dua kelompok perlakuan yang menggunakan tikus jantan galur Sprague Dawley sebagal model. Kelompok perlakuan pertama adalah tikus kastrasi yang dicekok dengan ekstrak cabe jawa dosis 0 mg (plasebo), 0,94 mg, 1,88 mg, 2,82 mg, dan 3,76 mg. Kelompok perlakuan kedua adalah tikos yang disuntik dengan doais 1,25 mg DMPA dan dicekok dcngan ekstrak cabe jawa dosis 0 mg (plasebo), 0,94 mg, 1,88 mg, 2,82 mg, dan 3,76 mg. Penyuntikan DMPA dilakukan pada minggu ke-0 dan minggu ke-12 perlakuan, sedangkan pencekokan ekstrak cabe jawa dilakukan setiap hari dimulai dari minggu ke-7 sampai minggu ke-18 perlakuan.Hasil: Terjadi penurunan konsentrasi spermatozoa yang siguifikan dibanding kontrol (p<0,05) pada kelompok DMPA + cabe jawa (0,94 mg dan 1,88 mg). Penurunan konsentrasi spermatozoa kelompok DMPA + cabe jawa (2,82 mg dan 3,76 mg) tidak berbeda signifikan dibanding kontrol (p>0,05). Terjadi penurunan viabililas spennatozoa pada kelompok DMPA + berbagai dosis ekstrak cabe jawa. Kadar hormon testosteron darah kelompok DMPA + cabe jawa 3,76 mg lebih tinggi dibandingkan kontrol (p>0,05) antara praperlakuan dan selama perlakuan. Penyuntikan dosis minimal DMPA dan pencekokan berbagai dosis ekstrak cabe jawa tidak mempengaruhi hemotologi dan biokimia darah tikus.

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Background: The development of hormonal male contraception retied on suppression of gonadotropin so that inhibit spermatogenesis and reduced sperm concentration. 1njection of DMPA will inhibit spermatogenesis and testosterone secretion but also cause degradation of sexual potency and libido. Various plants able to stimulate forming of androgen endogen. one of them is javanese long pepper (Piper retrofractum Vahl.). Traditionally, the fruits of javanese long pepper was used to cure weaken lust and have been proven to improve blood testosterone level.

Purpose: Knowing the effect of combination of DMPA and javanese long pepper extract on concentration and viability of sperm in was deferens, blood testosterone level, haematology and blood chemistry level of rat (Rattus norvegicus L.).

Method: This research is using complete random device, equal size sample that is consisting of one group of control and two groups of treatment which is taking male rat strain Sprague-Dawley as a model. The fast group of treatment is castration rat that feed with javanese long pepper exiract dosis 0 mg (placebo), 0.94 mg, 1.88 mg, 2.82 mg and 3.76 mg. The second group of treatment is injected rat with DMPA dosis 1.25 mg and also feed with javaoese long pepper extract dosis 0 mg (placebo), 0.94 mg, 1.88 mg, 2.82 mgand 3.76 mg. Injection of DMPA done at week 0 aod 12 oftrealment while feed ofjavanese long pepper extract done every day started from week 7 until week 18 of treatment.

Result: There was decreasing of spenn concentrstion significantly (p<0.05) at group of DMPA + (0.94 mg and 1.88 mg) of javanese long pepper extract which compered to controL Sperm concentration in group ofDMPA + (2.82 mg and 3.76 mg) of javanese long pepper extract was decreased but not significantly differ to control (p>O,OS). The sperm viability was decreased in group of DMPA + various dosis of javanese long pepper extract. The blood testosterone level was higher than control in group of DMPA + 3.76 mg of javanese long pepper extract (p>0.05). The body mass index was increased significantly (p<0.05) between before and during treatment. In general, injection of minimal dosis of DMPA and feeding various dosis of javanese long pepper extract do not influence to the rat haemotology and blood chemistry level."

"Kadar testosteron pada penyalahguna narkotika lebih kecil 43 dari padalaki-laki yang bukan penyalahguna narkotika, kadar testosteron yang rendahberpotensi menimbulkan masalah fisik, psikis dan sosial.Tujuan penelitian untuk mengetahui perubahan kadar hormon testosteronpada program rehabilitasi medis penyalahguna narkotika di Balai BesarRehabilitasi Badan Narkotika Nasional Indonesia, Lido-Bogor. Desain penelitianini adalah longitudinal dengan analisis GLM-RM Generalized Linear ModelsRepeated Measure.Hasil penelitian adalah program rehabilitasi medis pada penyalahgunanarkotika meningkatkan kadar hormon testosteron tidak dapat dibuktikan. Saranpenelitian ini adalah masih perlu penelitian lanjut dengan membutuhkan waktuyang lebih lama, bukan dilakukan pada awal rehabilitasi dan tidak setiap minggutetapi setiap bulan. Program yang dilakukan lebih bertumpu pada aktifitas fisikyang disesuaikan dengan perilaku agresif dan menyenangkan.

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Testosterone levels in narcotics abusers are 43 smaller than males whoare not narcotics abusers, low testosterone levels potentially cause physical,psychological and social problems.The purpose of this research is to know the changing of testosterone levelin medical rehabilitation program of narcotics abuser in Central RehabilitationAgency of National Narcotics Board of Indonesia, Lido-Bogor. The design of thisstudy is longitudinal with GLM-RM Generalized Linear Models RepeatedMeasure analysis.The results of study for medical rehabilitation programs on narcoticsabusers raise the testosterone levels was not proven. This study result is suggestfor the future research needed more longer time, not start from the beginning ofrehabilitation and also not every week examination but every month. The programis based on more physical activity suitable to aggressive behavior and more fun."

"Dalam rangka mencari altematif kontrasepsi untuk pria, telah dilakukan berbagai penelitian mengenai tanaman-tanaman yang diduga mengandung zat-zat antifertilitas. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak cairan perasan (juice) buah paria (Momordica charantia L) terhadap kesuburan dan kadar hormon testosteron dalam darah mencit jantan strain AJ. Pemberian ekstrak dilakukan dengan dosis 800 mg/ml, 900 mg/ml, dan 1000 mg/ml selama 40 hari. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok dengan 5 macam perlakuan yakni dosis 800 mg/ml, 900 mg/ml, 1000 mg/ml, kontrol dengan perlakuan, dan kontrol tanpa perlakuan, dan masing-masing perlakuan dengan 6 kali ulangan. Ekstrak buah paria diperoleh dengan cara penguapan cairan perasan (juice) buah paria menggunakan penangas air bersuhu 50 ° C. Kemudian dibuat dosis ekstrak 800 mg, 900 mg, dan 1000 mg dalam aquabides. Cairan ekstrak diberikan pada mencit secara oral dengan menggunakan spuit khusus sebanyak ± 0,5 ml dua kali sehari (pagi dan sore) selama 40 hari. Setelah masa pemberian selesai mencit dikawinkan dengan betina dewasa fertil untuk mengetahui jumlah anak yang dilahirkan. Setelah 5 hari dicampur dengan betina, mencit dikorbankan untuk meniiai beberapa parameter kesuburan dan kadar hormon testosteron dalam darah. Parameter kesuburan yang diteliti antara lain : A. Jumlah anak B. Konsentrasi spermatozoa vas deferens C. Jumlah sel-sel spermatogenik yakni : 1. Spermatogonium 2. Spermatosit preleptoten 3. Spermatosit primer pakhiten 4. Spermatid"

"Telah dilakukan penelitian yang bertujuan melihat pengaruh penyuntikan dua dosis kombinasi ethinyl estradiol dan testosteron enanthat terhadap kesuburan mencit jantan. Mencit yang digunakan berumur 2 sampai 3 bulan, berat antara 20 sampai 30 gram disuntik secara infra muskular dengan ethinyl estradiol (EE) dosis tunggal 0,2 atau 2 mg/kg berat badan (bb) ditambah testosteron enanthat (TE) sebanyak 5 mg/kg bb. Untuk kontrol hanya diberi pelarut sebanyak 1 ml/100 g bb. Pengambilan data dilakukan pada hari ke 39 setelah penyuntikan, yaitu satu siklus spermatogenesis ditambah 5 hari masa perkawinan dengan betina. Hasil yang didapat menunjukkan bahwa tidak ada pengaruh terhadap jumlah sperma total, jumlah sperma abnormal, berat testis, berat epididimis, berat vesika seminalis, diameter tubulus seminiferus, dan jumlah anak yang dihasilkan. Kesimpulan, penyuntikan dua dosis kombinasi EE dan TE yang diberikan hanya sekali tidak berpengaruh terhadap kesuburan ataupun libido mencit jantan galur CBR."

"Telah dilakukan penelitian tentang pengaruh pemberian ekstrak buah pare terhadap kesuburan dan kadar testosteron serum tikus Jantan strain IMF,. Sebanyak 24 ekor tikus jantan dibagi secara acak dalam 3 kelompok, masing-masing terdiri dari 8 ekor. Tiap kelompok diberi ekstrak buah pare secara oral mulai dari dosis 750 mg; 1000 mg; 1250 mg; 1500 mg; 1750 mg dan 2000 mg/kgBB. Kelompok lain diberi larutan CMC sebagai kelnmpok placebo dan sate kelompok sebagai kontrol (tanpa perlakuan.).Pemberian ekstrak buah pare dilakukan setiap pagi selama 50 hari. Pada hari ke 50 tikus perlakuan dicampur dengan betina fertil sampai terjadi kopu1asi. Tujuh hari setelah dicampur, tikus jantan dibunuh dengan eter. Tikus jantan yang telah dibunuh dengan eter diambil darahnya dari jantung danjaringan testis. Parameter yang dianalisis yaitu kadar testosteron serum, berat testis, jumlah spermatozoa, persentase metilitas, persentase bentuk kepala abnormal dan jumlah anak.Hasil yang diperoleh menunjukkan bahwa pemberian ekstrak buah pare dosis 750 mg/kg SR sampai dosis 2000 mg/kg SS dapat meningkatkan kadar testosteron serum tikus dan persentase kelainan bentuk kepala spermatozoa. Selain itu juga dapat menurunkan berat testis, jumlah spermatozoa, persentase motilitas dan jumlah anak yang dihasilkan."

"Pada usia subur, wanita akan mengalami berbagai perubahan hormonal, baik yang bersifat fisiologis ataupun patologis. Perubahan ini berpengaruh terhadap kesiapan organ reproduksi untuk memasuki menstruasi, implantasi, kehamilan, dan paskapersalinan. Perubahan kadar hormon yang bersifat patologis, misalnya pada hormon testosteron yang berfungsi sebagai prekursor langsung estradiol, dapat bermanifestasi sebagai gangguan menstruasi. Penelitian ini bertujuan untuk mengetahui perbandingan kadar hormon testosteron berdasarkan usia pada perempuan usia subur yang mengalami gangguan menstruasi. Penelitian ini merupakan studi comparative cross-sectional analitik yang melibatkan 80 perempuan usia subur (15 - 45 tahun) yang mengalami gangguan menstruasi. Data merupakan bagian dari penelitian yang dilakukan di Klinik Yasmin RSUPN Cipto Mangunkusumo pada tahun 2009 hingga 2011. Data pada penelitian ini diambil dari data sekunder hasil pemeriksaan laboratorium dan kuesioner SCL-90 pada penelitian ?Peranan Adiponektin terhadap Polycystic Ovary Syndrome (PCOS) dan Hubungannya dengan Faktor Genetik, Endokrin, dan Metabolik?. Data dianalisis dengan analisis bivariat uji Mann-Whitney. Penelitian menunjukkan kadar hormon testosteron pada usia kurang dari 35 tahun lebih tinggi dengan median 26,67 ng/dl (min. 2,85 ng/dl; maks. 133,2 ng/dl) dibandingkan kadar hormon testosteron pada usia lebih dari atau sama dengan 35 tahun dengan median 16,19 ng/dl (min. 5,59 ng/dl; maks. 58,13 ng/dl) yang secara statistik bermakna (p=0,049). Hasil lain didapatkan kadar hormon testosteron pada subyek dengan kadar insulin puasa normal lebih tinggi dengan median 30,96 ng/dl (min. 2,85 ng/dl; maks. 133,2 ng/dl) dibandingkan kadar hormon testosteron pada subyek dengan kadar insulin puasa abnormal dengan median 20,06 ng/dl (min. 5,6 ng/dl; maks. 61,08 ng/dl) yang secara statistik bermakna (p=0,018). Tidak terdapat perbedaan bermakna pada kadar testosteron berdasarkan jenis pekerjaan, gizi, dan gejala mental emosional. Dapat disimpulkan bahwa terdapat peran usia dan kadar insulin puasa terhadap kadar hormon testosteron.

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In reproductive age, women will experience various hormonal changes, which happen physiologically or pathologically. These changes affect the preparation of reproductive organ in order to undergo menstruation, implantation, pregnancy, and postpregnancy. The pathologic changes of hormone level, such as testosterone as the direct precursor of estradiol, could be manifested as menstrual disorders.

The purpose of this study is to compare testosterone level by age in women of reproductive age with menstrual disoders. This is an analytic comparative cross-sectional study which included 80 women of reproductive age (15 ? 45 years old) with menstrual disorders. The data used on this study was collected from Klinik Yasmin RSUPN Cipto Mangunkusumo from 2009 until 2011.

This study used secondary data which was resulted from laboratory examination and SCL-90 questionnaire from the research ?Role of Adiponectin on Polycystic Ovary Syndrome (PCOS) Related to Genetics, Endocrine, and Metabolic Factors?. Data is analyzed with Mann-Whitney test bivariat analytic.

This study suggested that testosterone level in women under 35 years old is higher with median 26,67 ng/dl (min. 2,85 ng/dl; max. 133,2 ng/dl), compared to testosterone level in women aged 35 years old or above with median 16,19 ng/dl (min. 5,59 ng/dl; max. 58,13 ng/dl), which is statistically significant (p=0,049).

Another result is that the testosterone level in group with normal level of fasting insulin is higher with median 30,96 ng/dl (min. 2,85 ng/dl; max. 133,2 ng/dl), compared to testosterone level in subject with abnormal fasting insulin level with median 20,06 ng/dl (min. 5,6 ng/dl; max. 61,08 ng/dl) which is statistically significant (p=0,018). There is no significant difference in testosterone level by occupational status, nutritional status, and mental emotional symptoms. In conclusion, age and fasting insulin level have roles for testosterone level."

"[ABSTRAKLatar Belakang. Penderita HIV/AIDS di Indonesia semakin meningkat, sedangkan infeksi HIV/AIDS maupun terapi ARV dapat menyebabkan penurunan kadar testosteron yang sangat memengaruhi kualitas hidup penyandang HIV/AIDS. Gejala dan tanda penurunan kadar testosteron pada pria dengan HIV sangat tidak spesifik, sedangkan pemeriksaan laboratorium sangat mahal, sehingga perlu diketahui faktor-faktor pada pasien yang dapat memprediksi penurunan kadar testosteron.Tujuan. Mengetahui apakah jumlah CD4 awal, lamanya terapi ARV, jenis ARV, lipodistrofi dan besarnya lingkar pinggang memengaruhi kadar testosteron bebas pada pria dengan HIV yang mendapat ARV.Metode. Penelitian potong lintang dilakukan pada bulan Maret 2015 di Unit Pelayanan HIV Terpadu RSCM, Jakarta. Subjek adalah pria dengan HIV berusia 18-40 tahun, mendapat ARV teratur sekurangnya dalam 1 tahun terakhir. Pemeriksaan meliputi anamnesis, pengukuran lingkar pinggang dan lipodistrofi, pemeriksaan kadar testosteron total, SHBG dan testosteron bebas (Free Testosteron Index: FTi). Uji regresi linier digunakan untuk menilai faktor-faktor yang berhubungan dengan kadar testosteron bebas pada penelitian ini.Hasil. Dari 54 subjek, didapatkan median usia 35,11 tahun (21-40), median lamanya ARV 59 bulan (16-129), median CD4 awal 57/mm3 (3-443), rerata lingkar pinggang 82,4cm (SB 10,33). Subjek yang mengalami lipodistrofi sebanyak 17 orang (32%). Subjek yang menggunakan ARV lini pertama 48 orang. Median kadar testosteron bebas 30,87% (9,78-85,64) dan subjek yang memiliki kadar testosteron bebas rendah sebanyak 32 orang(59%). Terdapatnya lipodistrofi (p=0,003, OR= -12,25) dan lamanya menggunakan ARV (p=0,002, OR=-0,182) berhubungan dengan kadar testosteron bebas pada penelitian ini.Simpulan : Pada pria dengan HIV yang mendapat terapi ARV, adanya lipodistrofi dan lamanya terapi ARV berhubungan dengan kadar testosteron bebas. Kadar CD4 awal, jenis ARV dan lingkar pinggang tidak berhubungan dengan kadar testosteron bebas.

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ABSTRACTBackground. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels., Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.]"