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Abstrak :
Latar belakang: Penyakit Kawasaki adalah penyebab utama penyakit jantung didapat pada anak, yang merupakan suatu vaskulitis sistemik akut. Penyakit ini berhubungan dengan luaran aneurisme arteri koroner, yang dapat dicegah dengan pemberian imunoglobulin intravena (IGIV). Terapi baku emas pada penyakit Kawasaki adalah IGIV dosis tinggi (2 g/kgBB). Namun, IGIV dosis medium (1 g/kgBB) merupakan terapi berbiaya lebih rendah dan mungkin memiliki efikasi yang sama. Melalui penelitian ini, kami mengevaluasi keberhasilan terapi IGIV dosis 1 g/kgBB. Metode: Studi kohort retrospektif multisenter dari data rekam medis dengan total 507 pasien dengan penyakit Kawasaki komplit. Penelitian dilakukan di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo dan Kawasaki Center, Indonesia dari Januari 2012 hingga Januari 2022. Pasien yang mendapatkan terapi IGIV dengan dosis 1 g/kgBB didefinisikan sebagai grup A, dan pasien yang mendapatkan terapi IGIV dengan dosis 2 g/kgBB didefinisikan sebagai grup B. Karakteristik dasar subjek dibandingkan antar-kelompok tersebut; demografi, hasil laboratorium, keterlibatan mukokutan, hari demam saat diberikan IGIV, durasi demam pasca-IGIV, lama rawat, dan temuan aneurisme arteri koroner dari ekokardiografi pada periode follow-up. Hasil: Sebanyak 24 pasien (grup A), mendapatkan IGIV dosis medium (1 g/kgBB). Sementara itu, sebanyak 483 pasien (grup B) mendapatkan IGIV dosis tinggi (2 g/kgBB). Distribusi usia dan jenis kelamin, nilai leukosit dan trombosit, hari demam saat diberikan IGIV, durasi demam pasca-IGIV, dan lama rawat tidak berbeda bermakna antar-kelompok (p >0,05). Semua pasien mengalami keterlibatan mukokutan. Berat badan menurut umur (WAZ) dan nilai CRP antar-kelompok bermakna secara statistik (p <0,05). Aneurisme arteri koroner tidak ditemukan pada pasien di grup A dan pada 9 pasien (1,9%) di grup B pada periode follow-up (p >0,05). Simpulan: Terapi dengan dosis inisial IGIV 1 g/kgBB untuk pasien dengan penyakit Kawasaki menunjukkan keberhasilan yang sama dengan IGIV dosis tinggi (2 g/kgBB). Hal ini dapat menjadi opsi terapi bagi negara berkembang. ......Background: Kawasaki disease (KD), the leading cause of acquired heart disease in children, is an acute childhood systemic vasculitis. It is associated with coronary artery aneurysms (CAA), that could be prevented by intravenous immunoglobulin (IVIG) administration. High-dose IVIG (2 g/kg) is usually given in the treatment of Kawasaki disease (KD). However, medium-dose IVIG (1 g/kg) is a low-cost treatment and may have the same efficacy. We aim to determine whether the treatment with IVIG at an initial dose of 1 g/kg is effective for preventing CAA. Methods: A multicenter retrospective cohort study was conducted. A total of 507 patients with complete KD who were treated with high-dose and medium-dose immunoglobulin at Cipto Mangunkusumo Hospital and Kawasaki Center, Indonesia from January 2012 to January 2022 were enrolled. Patients treated with a single infusion of medium-dose IVIG (1 g/kg) were defined as group A, and patients treated with high-dose IVIG (2 g/kg) were defined as group B. Patient characteristics were compared between the two groups; demographic features, laboratory findings, mucocutaneous involvement, day of fever, duration of fever after treatment, length of stay, and rates of CAA from echocardiography during the follow-up period. Results: Medium-dose IVIG was given in 24 patients (group A). High-dose IVIG was given in 483 patients (group B). Age and gender distributions, white blood cell and platelet counts, day of fever when IVIG was administered, duration of fever after IVIG treatment, and length of stay did not differ significantly between the two groups (p >0.05). All patients had mucocutaneous involvement. Median of WAZ was higher in group A (+0,35 vs -0,26; p <0.05). Median of concentrations of C-reactive protein was higher in group B (59,5 mg/L vs 81 mg/L; p <0.05). Coronary artery aneurysms were not found in group A and in 9 patients (1.9%) in group B during the follow-up period (p >0.05). Conclusion: Treatment of KD with IVIG at an initial dose of 1 g/kg could show the same effectiveness as the high-dose IVIG (2 g/kg) and might be an option for low- and middle-income country.

Abstrak :
Pendahuluan: Periodontitis merupakan penyakit keradangan pada jaringan periodontal yang memiliki multifaktor risiko dan dapat memperparah progresifitas periodontitis. Salah satu faktor risiko periodontitis adalahi menopause yaitu kondisi sistemik pada wanita. Keadaan menopause mengacu pada wanita yang telah berhenti menstruasi selama lebih dari setahun. Menopause dapat mempengaruhi kesehatan mulut termasuk sistem kekebalan tubuh, sehingga dapat mempengaruhi pertahanan jaringan periodontal. Penelitian ini dilakukan untuk mengukur tingkat imunoglobulin G dalam cairan crevicular gingiva yang merupakan salah satu bagian dari sistem imun jaringan periodontal. Tujuan: Mendapatkan perbedaan kadar imunoglobulin G pada penderita periodontitis dengan menopause dan tanpa menopause. Metode: Sebanyak total 158 pasien diperiksa untuk diagnosis periodontitis dan diwawancarai untuk status menopause. Setelah diseleksi, studi cross-sectional dilakukan pada 63 subjek (44 subjek pasien menopause dan 19 subjek non-menopause) yang masing-masing kelompok akan diambil sampel CKG nya. Sampel diuji menggunakan ELISA kit untuk imunoglobulin G. Hasil: Rerata kadar IgG pada penderita periodontitis dengan menopause lebih rendah daripada kelompok tanpa menopause, namun pada uji statistik tidak terdapat perbedaan signifikan pada kedua kelompok. Kesimpulan: Tidak terdapat hubungan kadar imunoglobulin G pada penderita periodontitis antara menopause dengan tanpa menopause. ......Introduction: Periodontitis is an inflammatory disease of periodontal tissue that has multifactorial risk and can worsen the progression of periodontitis. One of the risk factors for periodontitis is menopause, which is a systemic condition in women. Menopause refers to women who have stopped menstruating for more than a year. Menopause can affect oral health including the immune system so that it can affect the defense of periodontal tissue. This research was conducted to measure the level of immunoglobulin G in the gingival crevicular fluid which is one part of the immune system of the periodontal tissue. Objective: To find out the difference in immunoglobulin G levels in periodontitis patients with menopause and without menopause. Methods: A total of 158 patients were examined for a diagnosis of periodontitis and interviewed for menopause status. After being selected, a cross-sectional study was carried out on 63 subjects with 44 subjects including menopause patients and 19 non-menopausal subjects for which each group would be sampled from CGK. The sample was tested using an ELISA kit for immunoglobulin G. Results: The mean IgG level in periodontitis patients with menopause was lower than the group without menopause, but in the statistical test there were no significant differences in the two groups. Conclusion: There is no relationship immunoglobulin G levels in periodontitis patients between menopause with no menopause.

Abstrak :
The smoking habit has been associated with a variety of deleterious changes in the mouth including periodontal tissue. Several studies indicate a relationship between smoking and periodontal disease, including loss of alveolar bone, periodontal attachment as well as periodontal pocket formation. Subjects with a high standard of oral hygiene have been found to have greater bone loss in smokers than non smokers. Generally accepted, periodontal treatment procedures are less efficient in smokers. This holds true for surgical as well as nonsurgical therapy. Therefore, it is concluded that tobacco smoking is associated with an increased risk for destructive periodontal disease. This study is to investigate the effect of smoking on the oral immune response in subjects with periodontal disease by measuring the concentration of IgA in saliva from smokers and non smokers with turbi timer. The results were compared and analyzed by ANOVA. The investigation showed that the level of IgA in saliva from smokers with severe periodontitis (x=39.30 IU/ml) as well as mild periodontitis (x= 84.86 IU/ml) were lower than non-smokers (severe periodontitis x= 51.67 IU/ml; mild periodontitis x=95.41 IU/ml). Furthermore, smokers with gingivitis (x123.76 IU/ml) and healthy gingiva (x=71.55 IU/ml) also had lower IgA levels in saliva compared with the non-smokers (gingivitis, x=145.11 IU/ml; healthy gingiva x=75.19 IU/ml). In conclusion , the investigation showed that all smokers especially smokers with periodontal disease had lower intra oral immune response compared with the non-smokers.

Abstrak :
Pajanan patogen melalui gastrointestinal pada daerah kumuh lebih tinggi dibanding nonkumuh. Hal tersebut mempengaruhi produksi protein globulin yang salah satunya berperan dalam sintesis IgA. Oleh karena itu, peneliti tertarik untuk mengetahui perbandingan kadar IgA pada daerah kumuh dan nonkumuh serta hubungannya dengan rasio albumin terhadap globulin. Pengukuran kadar IgA dilakukan menggunakan metode radial immunodiffusion test (RIDT), sedangkan data rasio albumin terhadap globulin didapatkan dari penelitian sebelumnya. RIDT bekerja dengan prinsip difusi radial sampel antibodi menjauhi sumur berbentuk silindris. Pada kit, terdapat anti terhadap antibodi spesifik yang akan diukur. Hasilnya berupa ikatan antibodi dengan anti-antibodi membentuk cincin dan diukur diameternya. Nilai IgA dikonversi ke dalam satuan mg/L. Hasil analisis kadar IgA menggunakan uji Mann-Whitney menemukan kadar IgA daerah kumuh lebih tinggi dibandingkan nonkumuh namun tidak bermakna secara statistik (p=0,620). Kadar IgA dan rasio albumin globulin ditransformasi menjadi variabel kategorik dan dikelompokkan menjadi 4 zona. Pada zona 3 dimana rasio albumin terhadap globulin tinggi dan kadar IgA rendah, proporsi subjek didominasi oleh penduduk daerah nonkumuh dibandingkan kumuh (47% vs. 14%). Hasil uji Chi Square menunjukkan perbedaan proporsi subjek tersebut bermakna secara statistik (p=0,041). Hubungan antara rasio albumin terhadap globulin dengan ekspresi IgA dianalisis menggunakan uji Pearson dan ditemukan adanya korelasi negatif yang bermakna secara statistik (r= -0,319 dan p= 0,048). Oleh karena itu, dapat disimpulkan tingginya tingkat pajanan patogen melalui gastrointestinal pada daerah kumuh menyebabkan produksi IgA sebagai respon imun mukosa lebih tinggi dibandingkan dengan nonkumuh. Sintesis IgA tersebut berhubungan dengan rasio albumin terhadap globulin karena globulin merupakan komponen penyusun IgA.
Pathogenic exposure in slum is higher compared to nonslum area and mainly occurs through the gastrointestinal. It will affect the rate of globulin production which used as a component to synthesize immunoglobulin A (IgA) Therefore, author is interested to investigate comparison between IgA of people living in slum and non-slum area and the relation IgA expression with albumin globulin ratio. Measurement of the IgA was done using radial immunodiffusion test (RIDT), while the data of albumin globulin ratio was obtained from the previous research. Result of IgA analysis using Mann whitney test shows that IgA level of people living in slum area is higher than non-slum area but not statistically significant (p=0.620). Data of IgA level and albumin globulin ratio was transformed into categoric form and classified into four zones. Zone 3, where the IgA level is low and albumin globulin ratio is high, the subjects proportion found in this zone are dominated by people living in non-slum area (47% vs. 14%). This result is also supported by the Chi-square test that shows a significance difference between proportion of people living in slum and non-slum area found in the zone 3. Next, relation between albumin globulin ratio to the level of IgA was analyzed using Pearson test. The result shows that there is a significant negative correlation between albumin globulin ratio and IgA level (r= -0.319 dan p= 0.048). Therefore, it can be concluded that high level of pathogenic exposure through the gastrointestinal tract in slum area will lead to an increase of IgA production resulting higher level of IgA found in the serum. This IgA production on both populations has a relation with albumin globulin ratio since globulin is one of the constituent component of IgA.

Abstrak :
Latar belakang: Karsinoma nasofaring (KNF) merupakan keganasan daerah kepala dan leher terbanyak di Indonesia (60%) dan endemik di Asia Tenggara dan Timur Tengah. Virus Epstein-Barr (EBV) terlibat langsung dalam patogenesis KNF dan sekitar 90% individu dunia telah terinfeksi oleh EBV namun hanya beberapa yang berlanjut menjadi KNF. Komponen imun mukosa nasofaring, polymeric immunoglobulin receptor (plgR) yang terlibat dalam infeksi EBV diduga sebagai faktor genetik diteliti dalam penelitian ini. Penelitian ini menguji polimorfisme plgR yaitu pada nukleotida PIGR1739C->T dan hubungannya dengan suseptibilitas KNF di Indonesia. Metode: Penelitian dilakukan dengan metode kasus-kontrol dari Mei 2010 sampai Juni 2010 di Departemen Biologi Kedokteran Fakultas Kedokteran Universitas Indonesia. Pengambilan sampel dilakukan secara konsekutif. Peneliti mengisolasi DNA darah tepi sampel, mengamplifikasi dengan Polymerase Chain Reaction (PCR), melakukan Restriction Fragment Length Polymorphism (RFLP), dan menginterpretasi genotip plgR. Hasil: Dari 50 pasien KNF dan 50 kontrol didapatkan frekuensi alotip C 35 % dan T 65 % pada kelompok KNF; C 34 % dan T 66 % pada kelompok kontrol. Distribusi alotip antara kelompok kasus dan kontrol tidak berbeda bermakna secara statistik (*z= 0,227, df = 1, p = 0,882, OR = 1,045, IK 95% = 0,959-1,139). Kesimpulan: Tidak ada hubungan berbeda bermakna secara statistik antara polimorfisme (alotip) gen plgR dengan suseptibilitas individu terhadap KNF di Indonesia.

Abstrak :
Pada penelitian ini dilakukan kepada pada Anak dengan Gangguan Spektrum Autisme (GSA) yang mempunyai tujuan untuk mengetahui perbedaan penurunan tingkat stress yang diintervensi video modeling dan modul pedagogi visual berkunjung ke dokter gigi melalui analisis kadar immunoglubulin A saliva. Studi ini merupakan penelitian cross- sectional-eksperimental klinis dan laboratoris dilakukan pengambilan saliva sebelum dan setelah intervensi untuk diukur kadar salivary immunoglobulin A (SIgA). Subjek adalah 16 anak GSA berusia 6-10 tahun yang telah memiliki diagnosa dari dokter anak atau psikiater, tidak memiliki kelainan pada penglihatan dan pendengaran, maupun pernah menjalani koreksi pada penglihatan dan pendengaran sehingga tidak mengganggu kemampuan melihat dan mendengar, dapat mengikuti instruksi sederhana, belum pernah berkunjung ke dokter gigi. Subjek dibagi menjadi 2 kelompok yaitu kelompok intervensi Video modeling dan kelompok intervensi Modul PV-BDG, masing-masing kelompok terdiri dari 8 anak GSA. Analisis data menggunakan uji normalitas Shapiro-Wilk. Terdapat kenaikan kadar SIgA setelah intervensi Video PV- BDG. Rata-rata kadar SIgA setelah intervensi Video modeling dan modul PV-BDG adalah 35,35±22,67 dan -38,67±11,07. Video modeling lebih efektif dalam menurunkan stress pada saat perawatan gigi yang diukur dari perubahan kadar salivary immunoglobulinA ......The research is conducted on children with Autism Spectrum Disorder (ASD) with aim is to determine the difference of stress level reduction which intervened by video modeling and the module of ”Pedagogi visual berkunjung ke dokter gigi” through analyis of salivary Immunoglobulin A level. This study is a cross-sectional- experimental and laboratory research that carried out salivary collection before and after the intervention to obtain the level of Salivary Immunoglobulin A (SIgA). The subjects are 16 children with ASD aged 6-10 years old who have had diagnosed by pediatrician or psychiatrist, neither have any abnormalities in vision and hearing nor have undergone correction in vision and hearing, so that they can follow simple instructions. They should also have never been visited the dentist before. Subjects are divided into 2 groups, they are the video modeling intervention group and the PV-BDG Module intervention group. Each group consists of 8 children with ASD. The data analysis utilizes Shapiro-Wilk normality test. It is found that SIgA level is increased after PV- BDG video intervention. The average level of SIgA after intervention of video modeling and PV-BDG module are 35.35±22.67 and -38.67±11.07. It is concluded that video modeling method is more effective in reducing stress level in dental care as measured by the changes of salivary Immunoglobulin Alevel.

Abstrak :
Early childhood caries ECC merupakan keadaan terdapatnya satu atau lebih gigi karies, hilang atau ditambal pada anak dengan usia kurang dari 71 bulan. Streptococcus mutans serotype c merupakan bakteri utama penyebab ECC. Imunoglobulin A dan saliva berperan pada pencegahan terbentuknya biofilm pada permukaan gigi. Tujuan: Menganalisis level IgA anti-Streptococcus mutans serotype c serta korelasinya dengan viskositas dan skor dmft pada saliva pasien ECC. Metode: Level IgA anti-S. mutans serotype c dari 11 sampel saliva pasien ECC di ukur menggunakan metode ELISA. Nilai absorbansi dibaca pada panjang gelombang 405 nm. Level IgA anti-S. mutans serotype c kemudian dikorelasikan dengan data skor dmft dan viskositas saliva pasien ECC. Hasil: Level IgA anti-S. mutans serotype c saliva terstimulasi adalah 4,6 sedangkan saliva tidak terstimulasi adalah 6. Level IgA anti-S. mutans serotype c pada saliva kental dan encer berturut turut adalah 6 dan 3,5. Peningkatan skor dmft tidak di ikuti dengan penurunan level IgA anti-S. mutans serotype c. Kesimpulan: Pada pasien ECC, tidak terdapat perbedaan bermakna antara level IgA anti-S. mutans serotype c saliva terstimulasi dan tidak terstimulasi. Terdapat korelasi positif antara level IgA anti-S.mutans serotype c dengan viskositas saliva pasien ECC, sedangkan dengan skor dmft pasien ECC diperoleh korelasi negatif. ...... Background: Early Childhood Caries is the presence of one or more decayed, missing or filled tooth in a child 71 months of age or younger. Streptococcus mutans serotype c is the main causes of ECC. Salivary Immunoglobulin A inhibit the biofilm formation of S. mutans serotype c on the tooth surface. Objective: To analyze Immunoglobulin A anti Streptococcus mutans serotype c level and the correlation towards saliva viscosity and dmft score of ECC patients. Methods: Levels of IgA anti Streptococcus mutans serotype c calculated from 11 saliva sample of ECC patients using ELISA methods. Absorbance readings conducted at 405 nm wavelength. Levels of IgA anti Streptococcus mutans serotype c then correlated with saliva viscosity and dmft score of ECC patients. Result: Levels of IgA anti Streptococcus mutans serotype c in stimulated saliva is 4.6, while unstimulated saliva is 6. Levels of IgA anti S. mutans serotype c in high and low saliva viscosity. The escalation of dmft score causes a decrease in the levels of IgA anti Streptococcus mutans serotype c. Conclusion: There's no significant differences of IgA anti S.mutans serotype c level in stimulated and unstimulated saliva. There is a positive correlation between IgA anti Streptococcus mutans serotype c levels with saliva viscosity of ECC patients, while dmft score of ECC patients has negative correlations.

Abstrak :
ABSTRAK
Penduduk permukiman kumuh tinggal di lingkungan yang kotor sehingga terpapar patogen yang tinggi, yang ditunjukkan dengan status infeksi yang lebih tinggi dibandingkan di kawasan non kumuh. Perbedaan tingkat pajanan patogen menyebabkan respon imun yang berbeda terlihat dari perbedaan rasio albumin globulin. IgM adalah respon antibodi yang pertama kali disintesis melawan patogen. Penelitian ini dilakukan untuk mengetahui apakah terdapat perbedaan kadar IgM antara kedua pengendapan tersebut dan untuk mengetahui apakah rasio albumin globulin memiliki korelasi dengan kadar IgM. Penelitian ini menggunakan desain potong lintang. Sampel permukiman kumuh adalah penduduk wilayah Bantargebang (n = 20) sedangkan civitas akademika YARSI (n = 20) mewakili permukiman non-kumuh. Kadar IgM merupakan data primer yang diukur dengan metode uji imunodifusi radial. Analisis data menggunakan uji parametrik T tidak berpasangan dan uji korelasi Pearson. Hasil kadar IgM di kawasan kumuh adalah 2.11 (1.82-2.41) g / L lebih tinggi dari pada di kawasan non-kumuh 2.07 (1.65-2.49 g / L tetapi perbedaannya tidak signifikan (p = 0.872) Hal ini dikarenakan penduduk Daerah Bantargebang secara terus menerus terpapar patogen karena tinggal di dekat TPA. Paparan berulang terhadap patogen menyebabkan respon imun lanjutan (sekunder, tersier, dll atau respon amnestik) teraktivasi secara dominan sehingga berdasarkan kinematika respon imun IgG disintesis lebih dominan daripada Ketekunan IgM juga dapat menjawab bahwa tidak ada korelasi antara rasio albumin globulin dengan IgM di kedua wilayah tersebut (r = 0.102, p = 0.535) Hal ini disebabkan tingginya sintesis globulin di kawasan kumuh yang mengarah pada sintesis IgG. Fraksi gamma globulin (6%) menyebabkan perubahan kadar IgM tidak menyebabkan perubahan kadar globulin yang bermakna.

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ABSTRACT
Slum residents live in dirty environments so they are exposed to high pathogens, which is indicated by a higher infection status than in non-slum areas. The difference in the level of exposure to pathogens causes different immune responses seen from differences in the albumin globulin ratio. IgM is an antibody response that is first synthesized against a pathogen. This study was conducted to determine whether there was a difference in IgM levels between the two precipitations and to determine whether the albumin globulin ratio had a correlation with IgM levels. This study used a cross sectional design. The sample of slum settlements is residents of the Bantargebang area (n = 20) while the YARSI academic community (n = 20) represents non-slum settlements. IgM levels are primary data measured by the radial immunodiffusion test method. Data analysis used unpaired parametric T test and Pearson correlation test. The result of IgM levels in slum areas was 2.11 (1.82-2.41) g / L higher than in non-slum areas 2.07 (1.65-2.49 g / L but the difference was not significant (p = 0.872) This is because the population of Bantargebang area continues Continuous exposure to pathogens due to living near the TPA.Repeated exposure to pathogens causes the advanced immune response (secondary, tertiary, etc. or amnestic response) to be activated predominantly so that based on the IgG immune response kinematics synthesized more dominantly than the persistence of IgM can also answer that there is no correlation between the ratio of albumin globulin to IgM in the two regions (r = 0.102, p = 0.535) This is due to the high synthesis of globulin in the slum area which leads to IgG synthesis.The gamma globulin fraction (6%) causes changes in IgM levels that do not cause changes in globulin levels meaningful.

Abstrak :
Abstrak
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation and activation of eosinophils, whether they induce eosinophilic skin inflammation, independent of the IgE-mediated pathway has been unclear. To address the functional role of T cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or naive DO11.10 T cells into unprimed BALB/c mice. Ovalbumin-specific Th2 cells, as well as eosinophils, accumulated in the skin upon antigen challenge, despite the absence of antigen-specific IgE. Neither antigen-specific Th1 nor naive T cells induced eosinophil accumulation, although Th1 cells by themselves migrated into the skin. Interleukin (IL)-4, IL-5, and eotaxin were specifically produced in the skin of antigen-challenged, Th2 cell-transferred mice, whereas interferon (IFN)-γ and regulated on activation, normal T cell expressed and secreted (RANTES) were preferentially produced in Th1 cells-transferred mice. Production of monocyte chemoattractant protein (MCP)-1 and MCP-3 was enhanced by both Th1 and Th2 cells. The accumulation of eosinophils and Th2 cells in the skin was suppressed by both dexamethasone and FK506, indicating an essential role of Th2 cells in eosinophil recruitment. We conclude that Th2 cells can induce eosinophilic infiltration into the skin in the absence of antigen-specific IgE.

Abstrak :
Latar Belakang: Karies yang menyerang anak-anak dibawah 71 bulan dikenal dengan Early childhood caries ECC . Salah satu bakteri yang mendominasi penyebab ECC adalah Streptococcus mutans dan sistem imun yang berperan dalam pencegahan karies adalah IgA. Tujuan: Menganalisis hubungan level IgA anti Streptococcus mutans serotype f dengan viskositas dan dmft pada stimulated saliva dan unstimulated saliva pasien ECC. Metode: Level IgA anti-S. mutans serotype f di ukur menggunakan metode ELISA. Hasil: Analisis stastistik dengan uji Spearman didapatkan korelasi negatif antara level IgA anti-S. mutans serotype f dan indeks dmft, pada stimulated saliva r= -0.471; p=0.286 dan pada unstimulated saliva r= -0.529; p=0.408 , hasil korelasi antara level IgA anti-S. mutans serotype f dan viskositas stimulated saliva adalah korelasi positif r=0,417; p=0.352 . Level IgA anti-S. mutans stimulated saliva lebih rendah daripada unstimulated saliva P=0.127. Kesimpulan: Terdapat hubungan negatif antara level IgA anti-S.mutans serotype f dengan indeks dmft pada stimulated saliva dan unstimulated saliva pasien ECC, serta terdapat korelasi positif antara level IgA anti-S.mutans serotype f dengan viskositas saliva pada stimulated saliva, tetap secara statisik tidak bermakna. Level IgA anti-S. mutans stimulated saliva lebih rendah daripada unstimulated saliva tetapi tidak terdapat perbedaan bermakna antara level IgA anti-S. mutans serotype f stimulated saliva dan unstimulated saliva. ...... Background: Early childhood caries ECC is caries which affects in children aged 71 months or younger. One of the bacteria that dominates the formation of ECC is Streptococcus mutans. The immune system that plays a role in the formation of caries is IgA. Objective: To analyze the correlation between level of IgA anti Streptococcus mutans serotype f with viscosity and dmft in stimulated saliva and unstimulated saliva of ECC patients. Methods: Level of IgA anti S. mutans serotype f was measured using ELISA method. Results based on Spearman test, there was a negative correlation between level of IgA anti S. mutans serotype f and dmft index in stimulated saliva r 0.471 p 0.286 and unstimulated saliva r 0.529 p 0.408. Results: The result correlation levels of IgA anti S. mutans serotype f and viscosity of saliva was positive r 0.417 p 0.352 . Level of IgA anti S. mutans serotype f in stimulated saliva was lower than unstimulated saliva p 0.127. Conclusion: There was a negative correlation between the levels of IgA anti S. mutans serotype f and dmft index in saliva stimulated and unstimulated saliva of ECC patients and positive correlation between the levels of IgA anti S. mutans serotype f and viscosity of stimulated saliva. However, there were no significantly difference. The levels of IgA anti S. mutans serotype f stimulated was lower than unstimulated saliva, but not significantly difference.