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Abstrak :
Hiperlipidemia merupakan faktor resiko terjadinya aterosklerosis dan penyakit jantung koroner yang berbahaya. Oyong termasuk dalam marga luffa telah diteliti memiliki efek antihiperlipidemia. Penelitian ini bertujuan untuk menguji efek antihiperlipidemia dari ekstrak etanol 70% buah oyong (Luffa acutangula (L.) Roxb). Sebanyak 30 ekor tikus putih jantan galur Sprague Dawley berumur 2 bulan dibagi secara acak ke dalam enam kelompok, yaitu kelompok kontrol normal, induksi, simvastatin (sebagai pembanding), dosis I, II, dan III. Kelompok kontrol normal hanya diberikan larutan CMC 0,5%. Kelompok kontrol induksi, simvastatin, dosis I, II, III diberikan makanan diit tinggi kolesterol dan lemak 2,5 g/200 g bb dengan komposisi kuning telur 80%, lemak hewan 5%, dan larutan sukrosa 15%. Setelah satu jam pemberian ditambahkan berturut-turut CMC 0,5%, simvastatin 1,8 mg/200 g bb, esktrak 20, 40, dan 80 mg/200 g bb. Setelah 8 minggu perlakuan dilakukan pengambilan darah melalui sinus orbital dan penetapan kadar kolesterol total, trigliserida, HDL, dan LDL. Hasil penelitian menunjukkan bahwa ekstrak etanol 70% buah oyong memiliki efek antihiperlipidemia pada dosis 20, 40 dan 80 mg/200 g bb ditinjau dari penurunan kadar kolesterol total, LDL, dan peningkatkan kadar HDL, tetapi penurunan kadar trigliserida hanya terjadi pada dosis 80 mg/200 g bb.

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Hyperlipidemia is a risk factor of atherosclerosis and coronary heart disease. Ridged gourd included in genus Luffa have been researched antihyperlipidemia effect. This research aimed to observe the effect of antihyperlipidemia from 70% ethanol extract of the ridged gourd (Luffa acutangula (L.) Roxb). Thirty male rats Sprague Dawley strain with 2 month were divided randomly into six groups, is : normal control, induction control, simvastatin control (as a comparison), ridged gourd dose I, II, and III. Normal control group only given 0.5% CMC solution. Induction control, simvastatin control, ridged gourd dose I, II, III given high cholesterol and lipid diet (2,5 g/200 g bw) with the composition 80% egg yolk, 5% fat, and 15% sugar solution. After an hour giving, added successively 0,5% CMC, 1,8 mg/200 g bw simvastatin, extracts 20, 40, and 80 mg/200 g bw. After eight weeks of treatment was blood sampling by the orbital sinus and determination of total cholesterol, triglycerides, HDL, and LDL. The results showed that 70% ethanol extract of ridged gourd have antihyperlipidemia effects at doses of 20, 40 and 80 mg/200 g bw in decreased of total cholesterol, LDL and increasing HDL levels, but the decrease in triglyceride levels only at doses of 80 mg/200 g bw.

Abstrak :
Latar Belakang. Pemberian obat anti epilepsi (OAE) generasi pertama dalam jangka waktu lama sering menimbulkan efek samping seperti perubahan kadar lipid plasma yang akan meningkatkan resiko penyakit kardiovaskular dan serebrovaskular. OAE ini banyak digunakan di poli neurologi RSCM. Diharapkan dengan diketahuinya gambaran kadar lipid plasma pada penggunaan OAE generasi pertama tunggal dan prevalensi dislipidemia, dapat dilakukan penapisan dini dan preventif timbulnya penyakit kardio dan serebrovaskular. Metode. Desain penelitian berupa studi potong lintang (cross sectional). Subyek penelitian adalah orang dengan epilepsi yang mendapat karbamazepin, fenitoin, fenobarbital dan valproat tunggal minimal 6 bulan. Subyek diperoleh secara konsekutif, kemudian dilakukan wawancara data medis, recall makanan, pemeriksaan fisik dan kadar lipid darah. Pemeriksaan kadar lipid dilakukan setelah puasa minimal 8 jam. Hasil. Diperoleh 59 subyek, 27 karbamazepin, 16 fenitoin, 10 fenobarbital dan 6 valproat. Prevalensi dislipidemia sebesar 20.3%. Rerata kadar kolesterol total 193.5 ± 31.9; LDL 115.3 ± 23.9; HDL 59.5 ± 18.8 dan trigliserida 117.0 ± 63.6. Rerata kadar kolesterol total, LDL dan trigliserida fenitoin lebih tinggi dari OAE lain. Rerata HDL terendah ditemukan pada valproat. Didapat perbedaan bermakna secara statistik rerata kolesterol total, LDL dan trigliseria berdasarkan jenis OAE. Didapat hubungan bermakna secara stastistik antara durasi penggunaan OAE dengan tingginya kadar HDL pada karbamazepin dan fenobabital. Kesimpulan. Rerata kadar lipid dibawah rerata kadar lipid populasi. Dislipidemia lebih banyak ditemukan pada kelompok fenitoin. Durasi penggunaan OAE berhubungan dengan kadar HDL tinggi. ...... Background. Longterm therapy with first generation of antiepileptic drugs (AED) has been associated with adverse effects, such as serum lipid profile changes which can increase the risk of cardiovaskular and cerebrovascular disease. These AEDs are commonly used in outpatient clinic at Cipto Mangunkusumo hospital. The aim of this study is knowing lipid profile in first generation AEDs consumption. Method. This was cross sectional study. The subjects of this study were epilepsy patiets receiving carbamazepine, phenytoin, phenobarbital and valproate as monotheraphy for more than 6 months. This study used concecutive sampling. All subjects were interviewed, food recalled and underwent physical examination and measurements serum lipid profile. Blood samples for serum lipid profile were collected at least after 8 hours overnight fasting. Result. There were 59 patients, 27 with carbamazepine therapy, 16 phenytoin, 10 phenobarbital, 6 valproate. Prevalence of dyslipidemia is 20.3%. Mean of total cholesterol is 193.5 ± 31.9; LDL 115.3 ± 23.9; HDL 59.5 ± 18.8 and triglyseride 117.0 ± 63.6. Patients with phenytoin showed the highest mean of total cholesterol, LDL and triglyseride. Patients with valpoate showed the lowest mean of HDL. There was significant difference in mean of cholesterol total, LDL and triglyseride according to AEDs. The duration of AEDs therapy was significantly associated with higher HDL in patents with carbamazepine and Phenobarbital. Conclusion. Mean of lipid profile among people with epilepsy was lower than population. Dyslipidemia were more frequent in phenytoin. The duration of AEDs therapy was significantly associated with higher HDL.