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Abstrak :
Prevalensi kanker payudara semakin meningkat. Proses penyakit dan pengobatannya berdampak pada fisik dan psikologis sehingga menyebabkan perubahan kualitas hidup bahkan dapat menjadi perburukan. Faktor yang dapat memperbaiki kualitas hidup tersebut diantaranya adalah self- compassion dan hope, penelitian ini bertujuan untuk mengetahui hubungan self-compassion, hope dengan kualitas hidup pada pasien kanker payudara yang menjalani kemoterapi. Metode yang digunakan pada penelitian ini adalah cross sectional pada 130 pasien kanker payudara dari dua Rumah Sakit Kanker, analisis data dengan regresi logistik untuk mengetahui hubungan dari 3 variabel tersebut. Kuesioner yang digunakan adalah self-compassion scale untuk menilai self- compassion, Hert Hope Index untuk menilai hope serta FACT-B menilai kualitas hidup. Hasil penelitian ini menunjukkan bahwa self-compassion dan hope berhubungan signifikan dengan kualitas hidup dengan p-value ≤0,05 dan Odds Ratio 5,965 dan 2,604. Simpulan: Terdapat hubungan self-compassion dan hope dengan kualitas hidup pada pasien kanker payudara. Rekomendasi: penting bagi perawat onkologi untuk mengetahui tentang self-compassion dan hope sehingga dapat melakukan asuhan keperawatan untuk meningkatkannya yang berdampak pada peningkatan kualitas hidup pasien kanker payudara. ......The prevalence of breast cancer is increasing. The disease process and its treatment have an impact on physical and psychological aspects, causing changes in quality of life and can even worsen. Factors that can improve quality of life include self-compassion and hope, this study aims to determine the relationship between self-compassion, hope and quality of life in breast cancer patients undergoing chemotherapy. The method used in this study was cross-sectional in 130 breast cancer patients from two Cancer Hospitals, data analysis with logistic regression to determine the relationship between the 3 variables. The questionnaire used was the self- compassion scale to assess self-compassion, the Hert Hope Index to assess hope and FACT-B to assess quality of life. The results of this study indicate that self-compassion and hope are significantly related to quality of life with a p-value ≤0.05 and Odds Ratio 5.965 and 2.604. Conclusion: There is a relationship between self-compassion and hope and quality of life in breast cancer patients. Recommendation: It is important for oncology nurses to know about self-compassion and hope so that they can provide nursing care to improve them, which will have an impact on improving the quality of life of breast cancer patients.

Abstrak :
Summary: "The most comprehensive, widely used, and evidence-based pharmacotherapy text available Hailed by Doody's Review Service as "one of the best in pharmacy" Pharmacotherapy: A Pathophysiologic Approach is unmatched in its ability to help students develop a mastery of evidence-based medicine for optimum patient outcomes. The eighth edition will feature the addition of SI units throughout and an increased number of global examples and clinical questions. Features Unparalleled guidance in the development of pharmaceutical care plans Full-color presentation Key Concepts in each chapter Critical Presentation boxes summarize common disease signs and symptoms Clinical Controversies boxes examin complicated issues you face when providing drug therapy NEW material added to the online learning center EXPANDED evidence-based recommendations EXPANDED coverage of timely issues such as palliative care and pain medicine Therapeutic recommendations in each disease-specific chapter"

Abstrak :
Siklofosfamid merupakan senyawa antineoplastik golongan pengalkilasi yang banyak digunakan untuk mengobati penyakit keganasan. Alkilasi yang terjadi pada posisi N7 basa guanin di kedua untai rantai DNA mengakibatkan kegagalan replikasi sel yang berguna untuk terapi kanker. Kesalahan posisi alkilasi, salah satunya pada posisi O6 basa guanin, ternyata dapat memberikan efek mutagenik dan bahkan karsinogenik, yang dapat memicu kanker sekunder. Oleh karena itu, addition product (adduct) yang terbentuk akibat alkilasi tersebut, yaitu O6-metilguanin, dapat menjadi penanda biologis terhadap risiko terbentuknya kanker sekunder. Pada penelitian ini, dilakukan identifikasi senyawa O6-metilguanin dalam darah pasien kanker yang mendapatkan siklofosfamid dalam regimen kemoterapi selama minimal 4 siklus. Sampel yang digunakan adalah DNA yang diisolasi dari darah pasien kanker. Isolat DNA kemudian dihidrolisis dan dianalisis menggunakan metode Kromatografi Cair Kinerja Tinggi penukar kation kuat dengan fase gerak amonium format 30 mM pH 3,95 - metanol (94:6), suhu kolom 30°C, laju alir 1,2 ml/menit, dengan sistem deteksi fluoresensi menggunakan panjang gelombang eksitasi 300 nm dan emisi 370 nm. Penentuan O6-metilguanin dalam sampel dilakukan dengan membandingkan data waktu retensi sampel dengan standar, yaitu menit ke 7,600 dengan batas deteksi sebesar 20,74 ng/ml (setara dengan 128813,52 μV/s). Sampling dilakukan terhadap 27 pasien, tetapi hanya 17 sampel DNA pasien yang dapat teranalisis dan O6-metilguanin terdeteksi dalam 1 sampel DNA pasien.

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Cyclophosphamide is one of alkylating agent which widely use in chemotherapy. Alkylation occurred in N7-guanine position in both DNA strand causes the cancer cell failed to replicate, hence gives the cytotoxic effects which is beneficial for the cancer therapy. Contrary, if the alkylation occurres in O6-guanine position, the drug gives mutagenic and carcinogenic properties which vulnerably leads to secondary cancer. Therefore, detection of the adduct formed, O6-methylguanine, is able to become a biomarker for the risk of secondary cancer?s development. In this research, O6-methylguanine was identified from patient which had been receiving cyclophosphamid in their chemotherapy for minimum 4 cycles. Patient?s DNA which isolated from their blood, were being hydrolized and identified. Analytical method which use in this research was High Performance Liquid Chromatography with strong cation exchange column, mobile phase consisted of 30 mM ammonium formate pH 3,95-methanol (94:6), flow rate 1,2 ml/min, column temperature 30°C and detected at excitation wavelength 300 nm and emission wavelength 370 nm. Standart of O6-methylguanine in samples was conducted with comparing retention time data from sample and standar, which was eluted in 7.600 minute and with limit of detection as 20,74 ng/ml (equals to 128813,52 μV/s). Sampling was conducted in 27 patients but only 17 patient?s DNA samples were able to be analyzed and O6-methylguanine was detected in 1 sample.

Abstrak :
Buku yang berjudul "Pharmacotherapy handbook" ini ditulis oleh Barbara G. Wells, Joseph T. Dipiro, Terry L. Schwinghammer, dan Cindi W. Hammilton. Buku ini membahas tentang penyakit dan gangguan kesehatan, seperti gangguan dermatologis, gangguan gastrointestinal, dan gangguan endokrinologis.

Abstrak :
Provides an explanation of the essential pharmacoeconomics topics outlined by The Accreditation Council for Pharmacy Education (ACPE). This title defines terminology used in research and covers the application of economic-based evaluation methods to pharmaceutical products and services