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Hasil Pencarian

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Henni Qurratul Aini
Analisis penerapan standar kinerja aparatur sipil negara di Badan Kepegawaian Negara = Analysis of the implementation of Civil State Apparatus performance standards in national civil service agency / Henni Qurratul Aini
Abstrak :
Analisis Penerapan Standar Kinerja Aparatur Sipil Negara di Badan Kepegawaian Negara Aparatur Sipil Negara ASN dituntut untuk dapat berkinerja dengan baik agar dapat mewujudkan tujuan organisasi. Badan Kepegawaian Negara BKN selaku instansi pembina manajemen kepegawaian diharapkan dapat menjadi barometer dalam manajemen kepegawaian. Saat ini penilaian kinerja ASN telah menggunakan Penilaian Prestasi Kerja sesuai PP 46 Tahun 2011. Namun penilaian kinerja akan efektif bila terdapat tolak ukur yang jelas yaitu adanya standar kinerja. Sebagaimana Armstrong mengambarkan bahwa sebelum dilakukan penilaian kinerja perlu dibuat standar kinerja oleh sebab itulah penelitian ini bertujuan untuk meneliti penerapan standar kinerja di BKN dan faktor kendala penerapannya. Pendekatan penelitian ini adalah postpositivis karena mengacu pada teori manajemen kinerja Armstrong guna mencari faktor kendala penerapan standar kinerja role definision performance and development agreement. Metode pengumpulan data dilakukan secara kualitatif dan teknik triangulasi diterapkan guna memvalidasi data yang terkumpul. Hasil penelitian menunjukan bahwa saat ini BKN belum memiliki standar kinerja baik standar teknis kegiatan maupun standar perilaku. Faktor kendala penerapan dari aspek role definition adalah analisis jabatan yang ada di BKN belum akurat terutama pada proses analisis dan validasi data. Selanjutnya Performance and development agreement di BKN belum berjalan dengan baik. Pembuatan kontrak kinerja masih lemah pada aspek monitoring, pemahaman pegawai tentang SKP serta komitmen pegawai dan pimpinan. Sementara pengembangan pegawai tidak berbasis kinerja pegawai, belum dapat ditemukannya GAP kompetensi membuat pengembangan hanya sebatas menjawab tuntutan saat ini belum pada merencanakan pengambangan pegawai untuk masa yang akan datang.
Analysis of Application Performance Standards in the National Civil Service Agency Civil ServantApparatus ASN is required to objectives perform well in order to realize an organization. National Civil Service Agency NCSA as an agency personnel management coach expected to be a barometer in personnel management. Currently ASN performance assessment have used Job Performance Assessment in PP 46 of 2011. However, the performance assessment will be effective if there is a clear benchmark, which is the performance standard. Armstrong portrayed that prior to performance assessment,a performance standard needs to be undertaken. Therefore, this study aims at examining performance application standards in NCSA and its implementation constraint factors. This research approach is a postpositivis because it refers to the theory of Armstrong performance management by limiting factor for the adoption of performance standards role definition performance and development agreement . Data collectingmethods used are qualitatively and triangulation techniques applied in order to validate the collected data. The resuls shows that current NCSA has not had a performancestandard either technical standard activities or behavior standard. Constraint factors of the definition aspect implementations is the job analysis in NCSA is not accurate, especially in analysis process and data validation. Furthermore, Performance and development agreement in BKN has not gone well. performance contract manufacturing is still weak on monitoringaspects, employee understanding on SKP and employees and managers commitments. Employee development not has been based on employee performance, a competency GAP that can not be found make a development occurs just to answer the current demand and can not plan future employee enhancement limited to answering the demands of the development is not currently on the planned floating of employees for the foreseeable future.
Depok: Fakultas Ilmu Sosial dan Ilmu Politik Universitas Indonesia, 2017
T46865
UI - Tesis Membership  Universitas Indonesia Library
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Marlina Qurratul Aini
Pengaruh Indeks Massa Tubuh Terhadap Respon Klopidogrel pada Pasien Sindrom Koroner Akut dengan Intervensi Koroner Perkutan di RSUPN Dr. Cipto Mangunkusumo Jakarta = Impact of Body Mass Index on Clopidogrel Responses After Percutaneous Coronary Intervention at RSUPN Dr. Cipto Mangunkusumo Jakarta
Abstrak :
Klopidogrel, agen antiplatelet pasca Intervensi Koroner Perkutan (IKP), merupakan obat yang profil farmakokinetik dan farmakodinamiknya dipengaruhi oleh Indeks Massa Tubuh (IMT). Penelitian ini bertujuan untuk mengetahui pengaruh IMT terhadap respon klopidogrel pada pasien Sidrom Koroner Akut (SKA) setelah IKP. Penelitian ini menggunakan desain studi potong lintang terhadap 143 rekam medis pasien SKA dengan IKP di RSUPN Dr. Cipto Mangunkusumo Jakarta pada tahun 2018. Subyek dikelompokkan berdasarkan IMT, yakni kategori berat badan berlebih dan kategori berat badan tidak berlebih. Respon klopidogrel dinilai menggunakan luaran Major Adverse Cardiac Event (MACE) dalam tiga puluh hari pertama. Hasil dari penelitian adalah (a). Secara signifikan subyek dengan berat badan berlebih memiliki risiko terjadi MACE lebih tinggi dibanding subyek dengan berat badan tidak berlebih (PR = 6,792, CI 1(1,498 – 30,805). (b). Tidak ada variabel perancu yang berhubungan dengan MACE kecuali jenis klopidogrel. Subyek dengan klopidogrel generik bersifat proteksi terhadap MACE dibanding subyek dengan klopidogrel paten (Plavix) (PR 0,098, CI 0,013 -0,753). Kesimpulan dari penelitian ini adalah IMT berpengaruh secara signifikan terhadap MACE.
Clopidogrel, antiplatelet agent after Percutaneous Coronary Interventions (CPI), is  drug with high individual pharmacokinetic and pharmacodynamic variability interfered by Body Mass Index (BMI). The aim of this study is to assess  impact of BMI on clopidogrel responses after PCI. This comparative cross-sectional study was conducted in RSUPN Dr. Cipto Mangunkusumo Jakarta using 143 Acute Coronary Syndrome (ACS) patient health record years of 2018. Patients were randomly assigned into two groups based on BMI, overweight and normal weight groups. Results of this study are: (a). Overweight patient have higher MACE risk than normalweight patient (PR = 6,792, CI 1(1,498 – 30,805). (b) . No confounding variables are associated with MACE, except type of clopidogrel. Generic clopidogrel have protective effect of MACE ((PR 0,098, CI 0,013 -0,753).
Depok: Fakultas Farmasi Universitas Indonesia, 2019
T53367
UI - Tesis Membership  Universitas Indonesia Library
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Qurratul Aini
Tingkat Efisiensi Penerimaan Negara Bukan Pajak (PNBP) Keimigrasian di Indonesia: Peran Teknologi Informasi = The Efficiency of Immigration Non-Tax State Revenue in Indonesia: The Role of Information Technology
Abstrak :
Penelitian ini bertujuan untuk mengukur tingkat efisiensi PNBP 126 kantor imigrasi (kanim) selama periode 2019-2022 dan menganalisis hubungan antara tingkat efisiensi tersebut dengan penggunaan teknologi informasi. Dengan menggunakan metode data envelopment analysis (DEA), tingkat efisiensi sebesar 0,470 menandakan rata-rata efisiensi penggunaan input adalah sebesar 47%. Skor efisiensi relatif meningkat tiap tahun dengan nilai rata-rata secara berurutan dari tahun 2019 hingga tahun 2022 adalah sebesar 0,402, 0,470, 0,635 dan 0,371. Estimasi DEA juga menunjukkan bahwa kanim yang menjadi tempat pemeriksaan imigrasi (TPI) memiliki nilai rata-rata efisiensi lebih tinggi dibandingkan dengan kanim non TPI dan kelas kanim kelas dengan lokasi lebih strategis memiliki nilai efisiensi lebih rendah. Hasil estimasi menunjukkan bahwa pemanfaatan teknologi informasi pada kantor imigrasi belum memiliki pengaruh terhadap tingkat efisiensi PNBP keimigrasian. Selain itu, sub-sample analysis pada kelas kanim juga memiliki nilai yang beragam. ......This study aims to measure efficiency level of Non-Tax State Revenue on 126 immigration offices in 2019-2022 and analyze its relationship with information technology utilization. Using the data envelopment analysis (DEA) method, the efficiency level is 0,470, indicating that the average input efficiency is 47%. The relative efficiency score increases yearly ??from 2019 to 2022 with average values 0,402, 0,470, 0,635 dan 0,371 respectively. DEA estimates that immigration offices with checkpoint services have higher average efficiency score than non-checkpoints one and the more strategic immigration offices’ location tends to lower the efficiency level. The empirical method used is panel data regression with fixed effect model. The estimation results show that the use of information technology at the immigration office has no effect on the efficiency level of immigration Non-Tax State Revenue. In addition, sub-sample analysis on immigration office’ class shows mixed results.
Depok: Fakultas Ekonomi dan Bisnis Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Desna Qurratul Aini
Uji inhibisi dan profil pelepasan nanopartikel ekstrak daun keji beling (strobilanthes crispus) untuk sediaan obat antihiperkolesterolemia = Inhibition and released profile assay of nasty shard nanoparticle leaves extract strobilanthes crispus as drug dosage formulation of antihypercholesterolemia
Abstrak :
[ ABSTRAK
Keji Beling (Strobilanthes crispus) merupakan salah satu tanaman yang dapat dimanfaatkan sebagai antihiperkolesterolemia dengan senyawa aktif fitosterol. Pembuatan nanopartikel keji beling sebagai penghantar obat dilakukan untuk mencapai efektivitas obat menuju organ target. Penelitian ini bertujuan mendapatkan gambaran profil pelepasan nanopartikel keji beling pada media fluida sintetik dengan variasi konsentrasi penyalutnya serta pengujian inhibisi ekstrak keji beling dalam menghambat enzim HMG KoA Reduktase. Penelitian terdiri atas 4 tahap yaitu ekstraksi keji beling, pembuatan nanopartikel, uji profil pelepasan serta uji inhibisi enzim HMG koA Reduktase. Penelitian ini menghasilkan nanopartikel dengan efisiensi penyalut terbesar(94,64%) pada Kitosan 1% : STPP 1%, dan loading capacity terbesar (31,28%) diperoleh pada variasi Kitosan 1% :1,5%. Profil pelepasan dengan karakter penyalut yang resisten pada kondisi lambung diperoleh oleh variasi Kitosan 1%:1,5%. Determinasi analitis secara FTIR membuktikan bahwa ekstrak telah tersalut dalam penyalutnya yang dibuktikan dengan adanya gugus alkohol. Morfologi FESEM dengan ukuran partikel terkecil diperoleh pada variasi kitosan 1%: STPP 1% dengan ukuran terkecil 132 nm. Penurunan kadar kolesterol oleh daun keji beling terjadi melalui penghambatan enzim HMG KoA Reduktase. Penelitian ini membuktikan bahwa ekstrak keji beling mampu berperan sebagai inhibitor dalam menghambat enzim HMG-KoA dengan persentase inhibisi 15%-17,8%.
ABSTRACT Nasty Shard (Strobilanthes crispus) is one of herbs that utilized as antihypercholesterolemia with phytosterol as active compound. Producing nanoparticle of nasty shard as drug delivery is to obtain efectiveness drug to released target. This research was design to obtain released profile assay of nasty shard nanoparticle in simulated digestive fluid with concentration variation of nanoparticle and inhibition assay of nasty shard extract to inhibit HMG CoA Reductase.This resarch consist of 4 stages those are extraction of nasty shard leaves, nanoparticle designed, release profile assay and inhibition assay of HMG CoA Reductase. This research produce nanoparticle with highest encapsulation efficiency (94,64%) obtained by chitosan concentration 1% and STPP 1%, while the highest loading capacity (31,28%) was obtained by chitosan concentration 1% and STPP 1,5%. Released profile assay show nanoparticle characteristic which resistant in gastric condition with chitosan consentration 1% and STPP 1,5%. FTIR analysis show extract has encapsulated by alcohol group. Morphology by FESEM of smallest particle sized (132 nm) Obtained by chitosan concentartion 1% and STPP 1,5%. The decreasing of cholesterol by extract through inhibit HMG CoA Reductace. This research shown nasty shard leaves extract is capabable of acting as inhibitor of HMG CoA Reductase enzime with percentage inhibition from15%-17,8% ;Nasty Shard (Strobilanthes crispus) is one of herbs that utilized as antihypercholesterolemia with phytosterol as active compound. Producing nanoparticle of nasty shard as drug delivery is to obtain efectiveness drug to released target. This research was design to obtain released profile assay of nasty shard nanoparticle in simulated digestive fluid with concentration variation of nanoparticle and inhibition assay of nasty shard extract to inhibit HMG CoA Reductase.This resarch consist of 4 stages those are extraction of nasty shard leaves, nanoparticle designed, release profile assay and inhibition assay of HMG CoA Reductase. This research produce nanoparticle with highest encapsulation efficiency (94,64%) obtained by chitosan concentration 1% and STPP 1%, while the highest loading capacity (31,28%) was obtained by chitosan concentration 1% and STPP 1,5%. Released profile assay show nanoparticle characteristic which resistant in gastric condition with chitosan consentration 1% and STPP 1,5%. FTIR analysis show extract has encapsulated by alcohol group. Morphology by FESEM of smallest particle sized (132 nm) Obtained by chitosan concentartion 1% and STPP 1,5%. The decreasing of cholesterol by extract through inhibit HMG CoA Reductace. This research shown nasty shard leaves extract is capabable of acting as inhibitor of HMG CoA Reductase enzime with percentage inhibition from15%-17,8% , Nasty Shard (Strobilanthes crispus) is one of herbs that utilized as antihypercholesterolemia with phytosterol as active compound. Producing nanoparticle of nasty shard as drug delivery is to obtain efectiveness drug to released target. This research was design to obtain released profile assay of nasty shard nanoparticle in simulated digestive fluid with concentration variation of nanoparticle and inhibition assay of nasty shard extract to inhibit HMG CoA Reductase.This resarch consist of 4 stages those are extraction of nasty shard leaves, nanoparticle designed, release profile assay and inhibition assay of HMG CoA Reductase. This research produce nanoparticle with highest encapsulation efficiency (94,64%) obtained by chitosan concentration 1% and STPP 1%, while the highest loading capacity (31,28%) was obtained by chitosan concentration 1% and STPP 1,5%. Released profile assay show nanoparticle characteristic which resistant in gastric condition with chitosan consentration 1% and STPP 1,5%. FTIR analysis show extract has encapsulated by alcohol group. Morphology by FESEM of smallest particle sized (132 nm) Obtained by chitosan concentartion 1% and STPP 1,5%. The decreasing of cholesterol by extract through inhibit HMG CoA Reductace. This research shown nasty shard leaves extract is capabable of acting as inhibitor of HMG CoA Reductase enzime with percentage inhibition from15%-17,8% ]
Depok: Fakultas Teknik Universitas Indonesia, 2015
S59792
UI - Skripsi Membership  Universitas Indonesia Library
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Qam Qam Qurratul Aini
Efektivitas ekstrak daun delonix regia dan ekstrak biji delonix regia terhadap densitas parasit dengan uji in vivo pada hewan coba mencit swiss webster terinfeksi plasmodium berghei = Effectiveness of delonix regia leaf extract and delonix regia seed extract against density of parasit with in vivo test on experimental animal swiss webster mice infected by plasmodium berghei
Abstrak :
Malaria adalah penyakit menular yang disebabkan infeksi Plasmodium sp. Malaria adalah penyakit yang tersebar di dunia serta memiliki tingkat mortalitas yang tinggi. Penurunan efikasi obat pilihan utama disebabkan resistensi parasit terhadap obat malaria. Tujuan penelitian ini adalah untuk memahami efek ekstrak daun dan ekstrak biji Delonix regia terhadap densitas parasit pada binatang percobaan mencit Swiss Webster yang terinfeksi Plasmodium berghei dan untuk mengetahui kandungan fitokimia ekstrak daun Delonix regia dan ekstrak biji Delonix regia sebagai antiplasmodium. Penelitian ini dibagi menjadi delapan kelompok perlakuan, yaitu kontrol negatif dengan air, kontrol positif dengan klorokuin dosis 0.52 mg/20 gr mencit, ekstrak daun Delonix regia dosis 2.8 mg/20 gr mencit, 8.4 mg/20 gr mencit, dan 14 mg/20 gr mencit, ekstrak biji Delonix regia dosis 2.8 mg/20 gr mencit, 8.4 mg/20 gr mencit, dan 14 mg/20 gr mencit. Perlakuan dimulai pada hari ke-0 pada mencit terinfeksi Plasmodium berghei dan observasi parasitemia dilakukan pada hari ke-0 sebelum pemberian perlakuan dan hari ke-3. Uji Statistik One Way Anova menunjukkan bahwa ekstrak daun Delonix regia dan ekstrak biji Delonix regia tidak memiliki aktivitas yang berbeda jika dibandingkan kontrol negatif (p=0.139). Hasil penelitian menunjukkan ekstrak daun Delonix regia dan ekstrak biji Delonix regia tidak bisa menghambat pertumbuhan Plasmodium berghei. ......Malaria is an infectious disease caused by infection of Plasmodium sp. Malaria is world wide disease which a high mortality rate. The decreasing of efficacy of its firstline drugs is caused by the parasite?s resistance to malaria drugs. The aims of the research were to understand the effect of Delonix regia leaf extract and seed extract against the parasite density on experimental animal Swiss Webster mice infected by Plasmodium berghei and to know the content of phytochemystry of Delonix regia leaf extract and Delonix regia seed extract as antiplasmodium. This research was divided into eight treatment groups, namely negative control by water, positif control by cloroquin of dose 0.52 mg/20 gr mice, Delonix regia leaf extract of dose 2.8 mg/20 gr mice, 8.4 mg/20 gr mice, and 14 mg/20 gr mice, Delonix regia seed extract of dose 2.8 mg/20 gr mice, 8.4 mg/20 gr mice, and 14 mg/20 gr mice. The treatments were started on day 0 on where the mices were infected by Plasmodium berghei and the observation of parasitemia carried out on day 0 before giving the treatments and day 3. One Way Anova statistical test showed that Delonix regia leaf extract and Delonix regia seed extract did not have different activity against negative control (p=0.139). The results showed Delonix regia leaf and Delonix regia seed extract could not inhibit the growth of Plasmodium berghei.
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library