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"Praktik Kerja Profesi Apoteker di Rumah Sakit Universitas Indonesia (RS UI) bertujuan agar mahasiswa memahami pelayanan kefarmasian dan peran apoteker di fasilitas pelayanan kesehatan yaitu rumah sakit. Topik tugas khusus yang diangkat pada praktik kerja ini adalah perancangan standar prosedur operasional penanganan obat sitostatika di depo farmasi produksi yang bertujuan untuk menghasilkan suatu standar operasional prosedur penanganan sediaan sitostatika yang dapat digunakan sebagai pedoman oleh apoteker dan tenaga teknis kefarmasian di depo farmasi produksi RS UI dalam melakukan pelayanan permintaan obat sitostatika.

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The purpose of the pharmacy professional internship at the University of Indonesia Hospital (RS UI) is to enable students to understand pharmaceutical services and the role of pharmacists in healthcare facilities, specifically in hospitals. The specific topic of this internship is the designing of standard operational procedures for handling cytostatic drugs in the pharmaceutical production department. This aims to create a standard operational procedure for the handling of cytostatic preparations that can be used as a guideline by pharmacists and pharmaceutical technical staff in the pharmaceutical production department of RS UI when providing cytostatic drug requests."

"Praktik Kerja Profesi Apoteker di PT. SamMarie Tramedifa bertujuan agar mahasiswa memahami peran apoteker dan penerapan Cara Distribusi Obat yang Baik (CDOB) di distributor farmasi. Topik tugas khusus yang diangkat pada praktik kerja ini adalah modifikasi penandaan rak sediaan farmasi yang bertujuan untuk meningkatkan efektivitas distribusi di PT. SamMarie Tramedifa. Modifikasi penandaan rak sediaan farmasi dilakukan dengan memberi penandaan nomor pada setiap rak, memisahkan pemisahan cairan berdasarkan merk, memberi penandaan alfabetis, memberi penandaan produk rThe purpose of the professional pharmacy internship at PT. SamMarie Tramedifa is to enable students to understand the role of pharmacists and the implementation of Good Distribution Practices (GDP) in pharmaceutical distribution. The specific topic of this internship is the modification of the labeling of pharmaceutical storage shelves, with the goal of enhancing distribution effectiveness at PT. SamMarie Tramedifa. The modification of the pharmaceutical storage shelf labeling involves assigning a unique number to each shelf, separating liquids by brand, providing alphabetical labeling, providing cold chain products labeling, providing labeling examples for precursor drugs and specific medications, and categorizing the type of medication on each shelf.

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The purpose of the professional pharmacy internship at PT. SamMarie Tramedifa is to enable students to understand the role of pharmacists and the implementation of Good Distribution Practices (GDP) in pharmaceutical distributors. The specific topic of this internship is the modification of the labeling of pharmaceutical storage shelves, with the goal of enhancing distribution effectiveness at PT. SamMarie Tramedifa. Modification of the labeling of pharmaceutical storage shelves is carried out by marking each shelf with a number, separating the liquid separation based on the brand, providing alphabetical marking, and marking the product. The purpose of the professional pharmacy internship at PT. SamMarie Tramedifa is to enable students to understand the role of pharmacists and the implementation of Good Distribution Practices (GDP) in pharmaceutical distribution. The specific topic of this internship is the modification of the labeling of pharmaceutical storage shelves, with the goal of enhancing distribution effectiveness at PT. SamMarie Tramedifa. The modification of the pharmaceutical storage shelf labeling involves assigning a unique number to each shelf, separating liquids by brand, providing alphabetical labeling, providing cold chain products labeling, providing labeling examples for precursor drugs and specific medications, and categorizing the type of medication on each shelf."

"Pahami pelayanan kefarmasian dan peran apoteker di apotek. Topik tugas khusus yang diangkat pada praktik kerja ini adalah pengkajian resep obat penyakit strok iskemik yang bertujuan untuk menganalisis kesesuaian aspek administrasi, farmasetik, dan klinis dari resep yang diterima di Apotek Kimia Farma 202 Kejayaan. Hasil pengkajian resep menunjukkan tidak adanya drug related problem (DRP) pada resep tetapi masih terdapat ketidaklengkapan aspek administrasi yang perlu ditingkatkan.

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The purpose of the professional pharmacy internship at Apotek Kimia Farma 202 Kejayaan is to enable students to understand pharmaceutical services and the role of a pharmacist in a pharmacy. The specific topic of this internship is the assessment of prescriptions for ischemic stroke prescriptions, aiming to analyze the compliance of the administrative, pharmaceutical, and clinical aspects of the prescriptions received at Apotek Kimia Farma 202 Kejayaan. The assessment of the prescriptions indicates there are no drug-related problems (DRP) in the prescriptions, but there are still incomplete administrative aspects that need to be improved."

"Praktik Kerja Profesi Apoteker di Puskesmas Kecamatan Pasar Rebo bertujuan agar mahasiswa memahami pelayanan kefarmasian dan peran apoteker di fasilitas pelayanan kesehatan khususnya puskesmas dalam menyelenggarakan upaya kesehatan masyarakat dan upaya kesehatan perorangan. Topik tugas khusus yang diangkat pada praktik kerja ini adalah analisis kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Kecamatan Pasar Rebo yang bertujuan untuk mengetahui gambaran tentang kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Pasar Rebo, khususnya poli non-ISPA. Analisis kepuasan dilakukan dengan melakukan survei menggunakan kuesioner dan diperoleh hasil lebih dari 50% pasien merasa sangat puas terhadap pelayanan kefarmasian di Puskesmas Kecamatan Pasar Rebo pada masing-masing indikator kepuasan.

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The purpose of the professional pharmacy internship at the Puskesmas Kecamatan Pasar Rebo is to enable students to understand pharmaceutical services and the role of pharmacists in healthcare facilities, particularly Puskesmas, in providing public health and individual health efforts. The specific topic of this internship is the analysis of patient satisfaction with pharmaceutical services at the Puskesmas Kecamatan Pasar Rebo. The aim of this analysis is to gain insight into patient satisfaction with pharmaceutical services at the Puskesmas Kecamatan Pasar Rebo, especially in the non-acute respiratory infection (non-ISPA) department. Satisfaction analysis is conducted through a survey using a questionnaire, and the results show that more than 50% of patients are highly satisfied with pharmaceutical services at the Puskesmas Kecamatan Pasar Rebo in each satisfaction indicator."

"Ketoprofen adalah agen antiinflamasi yang digunakan untuk osteoarthritis (OA). Ketoprofen umum diberikan dalam bentuk oral. Namun, pemberian obat secara oral dapat menyebabkan iritasi lambung dan metabolisme obat presistemik. Salah satu upaya untuk mengatasi permasalahan tersebut adalah memberikan ketoprofen melalui rute transdermal, yaitu dissolving microneedle (DMN). Ketoprofen termasuk golongan BCS kelas II yang memiliki kelarutan rendah sehingga harus ditingkatkan kelarutannya dengan metode tertentu, seperti nanosuspensi. Tujuan penelitian ini adalah memformulasikan ketoprofen dalam bentuk nanosuspensi dalam DMN untuk penghantaran transdermal. Nanosuspensi ketoprofen diformulasikan dengan stabilizer PVA dengan konsentrasi 0,5%; 1%; dan 2% serta dilakukan karakterisasi yang meliputi pengamatan organoleptis, analisis ukuran partikel, potensial zeta, serta uji disolusi. Nanosuspensi diformulasikan ke dalam DMN yang dibuat menggunakan polimer kombinasi PVA dan PVP pada berbagai konsentrasi. Evaluasi DMN meliputi evaluasi fisik, mekanis, kehilangan massa, uji kemampuan insersi, uji pelarutan jarum dalam kulit, dan penetapan kandungan ketoprofen. Uji permeasi in vitro dilakukan menggunakan sel difusi Franz. F3-NS (PVA 2%) merupakan formula nanosuspensi terpilih dengan distribusi ukuran partikel paling kecil (dV-90 sebesar 124,3 ± 26,15 nm). Dari hasil evaluasi DMN diperoleh F4-MN (PVA 5%-PVP 10%) dan F5-MN (PVA 5%-PVP 15%) adalah formula yang paling optimal untuk dilakukan uji permeasi. Hasil uji permeasi menunjukkan jumlah kumulatif obat yang terpermeasi ke kompartemen reseptor setelah 24 jam untuk F4-MN dan F5-MN berturut-turut adalah 3,90±0,07 µg dan 3,88±0,46 µg. Penelitian ini menunjukkan bahwa nanosuspensi ketoprofen yang dimuat dalam DMN dapat menghantarkan obat secara transdermal.

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Ketoprofen is an anti-inflammatory agent used for osteoarthritis (OA). Ketoprofen is generally given orally. However, oral administration of the drug can cause gastric irritation and first-pass metabolism. To overcome these limitations, the transdermal route can be considered, namely dissolving microneedle (DMN). Ketoprofen is a BCS class II drug that has low solubility, so its solubility must be increased by certain methods, such as nanosuspension. This study aimed to formulate ketoprofen in the form of nanosuspension in DMN for transdermal delivery. Ketoprofen nanosuspension was formulated with PVA stabilizer with a concentration of 0.5%; 1%; and 2% as well as characterization which includes organoleptic observation, particle size analysis, zeta potential, and dissolution test. The nanosuspension was formulated into DMN which was made using a polymer combination of PVA and PVP at various concentrations. DMN evaluation includes physical and mechanical evaluation, loss of mass, insertion study, in skin dissolution study, and determination of ketoprofen content. In vitro permeation studies were performed using Franz diffusion cells. F3-NS (PVA 2%) is the selected formula of nanosuspension with the smallest particle size distribution (dV-90 of 124,3 ± 26,15 nm). From the results of DMN evaluation, it was found that F4-MN (PVA 5%-PVP 10%) and F5-MN (PVA 5%-PVP 15%) were the most optimal formula for the permeation study. The results of the permeation study show that the cumulative amount of drug permeated into receptor compartment after 24 consecutive hours for F4-MN and F5-MN was 3.90±0, 07 µg and 3.88±0.46 µg, respectively. This study shows that ketoprofen nanosuspension contained in DMN can deliver the drug transdermally."