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"Penelitian mengenai LD50 serai wangi telah dilakukan, namun pengaruh dosis serai wangi yang biasa digunakan dalam pengobatan belum banyak diketahui. Penelitian bertujuan untuk mengetahui pengaruh pemberian infus serai wangi (Cymbopogon nardus (L.) Rendle) terhadap organ hati mencit. Penelitian dilakukan dengan cara memberikan infus serai wangi secara oral terhadap 28 ekor mencit jantan (Mus musculus L.) yang dibagi ke dalam 1 kelompok kontrol dan 3 kelompok perlakuan dengan masing-masing perlakuan terdiri dari 7 ulangan. Kelompok perlakuan masing-masing diberi infus serai wangi dengan dosis 2% (b/v), 4% (b/v), dan 8% (b/v), sedangkan untuk kelompok kontrol diberi akuades. Pemberian infus serai wangi dilakukan selama 5 hari, dan 2 jam setelah pemberian infus terakhir mencit dikorbankan. Organ hati mencit diisolasi untuk dibuat preparat dengan metode parafin dan pewarnaan Haematoksilin Eosin (HE). Pengamatan organ hati dilakukan secara makroskopik dan mikroskopik. Berdasarkan data makroskopik berupa warna organ hati dan berat basah tidak ditemukan adanya perbedaan nyata antara kelompok perlakuan. Data mikroskopik terdiri dari data kuantitatif dan semikuantitatif. Hasil analisis data kuantitatif berupa diameter vena sentralis menunjukkan bahwa tidak ada pengaruh perlakuan diameter vena sentralis antara kelompok perlakuan. Data semikuantitatif berupa derajat kerusakan organ menunjukkan bahwa pada pemberian dosis 8% ditemukan adanya kerusakan ringan berupa penimbunan limfosit dan pembendungan darah pada vena sentralis.

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The research about LD50 of Citronella has been done, but the effect of citronella doses that commonly used as medical treatment not much known yet. The aims of this research were to know the effect of using citronella (Cymbopogon nardus (L.) Rendle) infuse to mice?s liver organ.The research was conducted by giving citronella infuse orally to 28 male mice (Mus musculus L.) which divided into 1 control group and 3 experimental groups with 7 repeated for each group. Tree of experimental groups were given citronella infusion in doses 2% (w/v), 4% (w/v), and 8% (w/v), while the control group was given akuades.Citronellainfusion were given for 5 days, and 2 hours after the last infusion was given mices were sacrificed. Liver organ of mices were isolated and histopathology slides were made with parrafin method and using Haematoksilin Eosin (HE) for staining.

Observation liver organ were done macroscopic and microscopic. Based on macroscopic analysis with organ color and wet weight data showed that the treatment has no significant impact to organ color and wet weight among the groups. Microscopic data which divided to quantitative and semiquantitative data showed that quantitatively the treatment has no effect tovena central diamater among the groups, but semiquantitative data which is damaged degree showed that at the doses 8% that was found mild damaged including lymphocytes stuck and blood dammed in central vein."

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"Keong tutut (Bellamya javanica) telah lama dikenal oleh masyarakat tradisional di Indonesia sebagai alternatif untuk mengobati penyakit kuning yang merupakan gejala penyakit hati, terutama karena kandungan asam amino yang diduga terdapat dalam keong tutut, khususnya asam amino glutamat, glisin, dan sistein. Tujuan penelitian ini adalah untuk melihat pengaruh pemberian daging keong tutut sebagai hepatoprotektor melalui pengamatan histopatologi hati dan pengukuran aktivitas alkali fosfatase (ALP) dalam serum menggunakan spektrofotometer UV-Vis. Sejumlah 36 ekor tikus putih jantan Sprague-Dawley dibagi menjadi 6 kelompok perlakuan, yaitu kontrol normal, kontrol negatif, kontrol positif, dosis 1, dosis 2, dan dosis 3. Kelompok kontrol normal dan kontrol negatif diberikan CMC 0,5%, kontrol positif diberikan silymarin dosis 9,45 mg/200 g bb tikus sedangkan untuk kelompok dosis diberikan serbuk daging keong tutut dengan dosis berturut-turut 56 mg/200 g bb tikus, 112 mg/200 g bb tikus, dan 224 mg/200 g bb tikus selama 14 hari. Pada hari ke-15, semua kelompok kecuali kelompok kontrol normal diinduksi hepatotoksik dengan CCl4 untuk mendapatkan kondisi kerusakan hati kemudian semua tikus dipuasakan makan dengan tetap diberikan minum. Setelah 24 jam induksi CCl4, dilakukan pengukuran aktivitas ALP serum dan pembedahan untuk mengambil organ hati. Hasil yang didapatkan menunjukkan bahwa pemberian daging keong tutut dosis 112 mg/200 g bb tikus dan 224 mg/200 g bb tikus mempunyai efek hepatoprotektor dalam mencegah kerusakan hati dibandingkan dengan kontrol negatif. Selain itu, terdapat perbedaan efek pada pemberian tiga varian dosis serbuk daging keong tutut. Dosis yang memiliki efek potensial sebagai hepatoprotektor adalah dosis 224 mg/200 g bb tikus (p < 0.05).

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Fresh water snail (Bellamya javanica) has been known by traditional communities in Indonesia as an alternative to treat jaundice which is a liver disease symptoms, especially because its amino acid compounds, in particular, glutamic acid, glysine, and cysteine that can be found in tutut snail. This study aimed to observe the effect of fresh water snail flesh as hepatoprotector through liver histopathology and alkaline phosphatase (ALP) activities measurements in serum using UV-Vis spectrophotometer. A total of 36 white male rats of Sprague-Dawley were divided into 6 groups: normal control, negative control, positive control, dose 1, dose 2, and dose 3. Normal and negative control groups were received CMC 0,5%, positive control group were received silymarin dose 9,45 mg/200g bw rats and for dose groups were received fresh water snail flesh powder, consecutively, dose 56 mg/200g bw rats, dose 112 mg/200 g bw rats, and dose 224 mg/200 g bw rats for 14 days. On day-15, all groups, except normal control group, are hepatotoxicity induced by CCl4 to obtain liver damage in rats and were not allowed to eat for 24 hours. After 24 hours of CCl4 induced, ALP activities in serum was measured and the rats were being dissected to take the liver. The results showed that fresh water snail flesh powder at a dose of 112 mg/200 g bw and 224 mg/200 g bw give a hepatoprotective effect when being compared to negative control. In addition, there are variance effect in 3 doses and the potential effect as a hepatoprotector is given by dose 224 mg/200 g bw (p < 0.05)."

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