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Utari Oemardy
"Tirosinase merupakan enzim monooksigenase yang berperan dalam katalisis dua reaksi tahap pertama pembentukan melanin. Pigmen melanin melindungi kulit dari radikal bebas yang dapat menyebabkan kerusakan pada kulit, tetapi produksi melanin yang berlebihan dapat mengakibatkan gangguan kulit seperti melasma dan bintik-bintik hitam pada kulit. Oleh Karena itu, saat ini inhibitor tirosinase banyak digunakan dalam dunia kosmetik dan pengobatan. Penelitian ini dilakukan untuk mengetahui adanya potensi penghambatan aktivitas tirosinase dan mengidentifikasi golongan senyawa yang terkandung dalam ekstrak dan fraksi teraktif kulit buah markisa. Ekstraksi dilakukan secara berturut-turut menggunakan pelarut n-heksan, etil asetat, dan metanol. Setiap ekstrak diuji penghambatan aktivitas tirosinase menggunakan spektrofotometer yang dilengkapi dengan microplate reader melalui pengukuran serapan L-dopakrom yang terbentuk pada panjang gelombang 490 nm. Ekstrak teraktif yaitu ekstrak n-heksan dipisahkan menggunakan kromatografi kolom dan dilakukan uji penghambatan tirosinase terhadap fraksi gabungan. Golongan senyawa kemudian diidentifikasi pada ekstrak n-heksan dan fraksi dengan persen penghambatan tertinggi yaitu FG 5. Hasil pengujian menunjukkan bahwa ekstrak n-heksan memiliki potensi penghambatan tirosinase tertinggi dengan IC50 85,46 μg/mL dan mengandung senyawa steroid-terpen; FG 5 juga mengandung senyawa steroid-terpen, namun tidak memiliki potensi penghambatan tirosinase.

Tyrosinase is monooxygenase enzyme that plays an important role in two major reactions of melanin production. Melanin pigment protects skin from free radical that may lead skin damage, but an excessive production of melanin may cause skin disorder such as melasma and freckles. Therefore, nowadays many tyrosinase inhibitor are used in cosmetic and medical field. This study was conducted to find out potential inhibition of tyrosinase activity and to identify compound group in extract and the most active fraction of passion fruit rind. Extraction was carried out sequentially using three solvents with increasing polarity; n-hexane, ethyl acetate, and methanol. Each extract was tested using microplate-reader spectrophotometer by measuring L-dopachrome absorbance at 490 nm. The most active extract, n-hexane extract was separated using column chromatography and tyrosinase inhibition assay was performed in the combined fractions. Compound group then was identified in n-hexane extract and fraction with the highest inhibition percentage, FG 5. The result showed that n-hexane extract had the highest inhibition potential with IC50 value of 85,46 μg/mL and contained steroid-terpene; FG 5 also contained steroid-terpene, but it did not have tyrosinase inhibition potential."
Depok: Fakultas Farmasi Universitas Indonesia, 2014
S55066
UI - Skripsi Membership  Universitas Indonesia Library
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Clements
"Masa-masa awal kehidupan adalah fase krusial dimana sedang terjadi proses pertumbuhan, dan ketika proses ini terganggu dapat terjadi gangguan pertumbuhan. Salah satu bentuk gangguan pertumbuhan adalah stunting. Proses pertumbuhan ini dipengaruhi oleh banyak faktor, dan salah satunya adalah asupan nutrisi. Penelitian ini bertujuan untuk mencari korelasi antara asupan nutrisi yaitu kalsium dengan indikator tinggi badan terhadap usia (TB/U). Penelitian ini menggunakan desain penelitian cross-sectional. Data didapat dari data sekunder penelitian yang dilakukan pada tahun 2011 di beberapa RW di Jalan Kimia, Jakarta Pusat. Metode pengambilan data menggunakan pengukuran antropometri untuk tinggi badan dan food-frequency questionaire untuk pola asupan kalsium. Data yang didapat dianalisis dengan uji spearman menggunakan perangkat lunak SPSS versi 20. Dari penelitian ini didapatkan 15,7% subjek penelitian mengalami stunting, lebih dari 80% subjek penelitian memiliki asupan kalsium harian yang rendah, dan tidak ditemukan korelasi antara asupan kalsium dengan indikator TB/U.

Childhood is a crucial phase of life where the process of growth is ongoing, and when this process is interrupted, the end result will be a growth disorder. Stunting is an example of such a condition. The process of growth is influenced by numerous factors and one of them is nutrient intake. This research aimed to find out the correlation between the level of nutrient intake and height-for-age indicator. The nutrient discussed in this research is calcium. This research used a cross-sectional research design. Data of this research used a secondary data from a research conducted in 2011 in several RW on Jalan Kimia, Central Jakarta. The primary research used anthropometric measurements to obatain height data and food frequency questionaire to obtain the calcium intake patterns. Data that have been obtained then were analyzed with the Spearman test using SPSS version 20 software. This research conclude that 15.7% of the research subjects are stunted, over 80% of the research subjects had a low daily calcium intake and no correlation is found between daily calcium intake and the indicator of height-for-age.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Prinka Diaz Adyta
"Pendahuluan: Malnutrisi dan hipoksia merupakan faktor yang mempengaruhi kegagalan terapi pada KNF stadium lokal lanjut. Kadar albumin merupakan salah satu pemeriksaan status nutrisi. Hipoksia menyebabkan radioresistensi terhadap radiasi.Tujuan dari penelitian ini adalah mengetahui korelasi antara kadar albumin praradiasi, hipoksia terhadap respon radiasi.
Metode penelitian: Penelitian ini merupakan studi kohort retrospektif menggunakan data sekunder terhadap 40 pasien kanker nasofaring stadium lokal lanjut yang memenuhi kriteria inklusi di Departemen Radioterapi dan Departemen Patologi Anatomi RSUP Dr Cipto Mangunkusumo dari Desember 2012 sampai Agustus 2013. Dilakukan pencatatan kadar albumin praradiasi, berat badan serta CT scan sebelum dan sesudah radiasi. Kemudian dilakukan analisa HIF1α dengan pulasan imunohistokimia. Sel yang positif hipoksia dihitung per 10 lapang pandang besar. Setelah itu, dilakukan penilaian respon radiasi berdasarkan kriteria Recist.
Hasil: Rerata kadar albumin praradiasi sebesar 3,9 +/- 0,5 g/dL, dan median persentase hipoksia sel yaitu 24,7(1-100)%. Tidak terdapat hubungan yang bermakna antara kadar albumin praradiasi terhadap respon radiasi (p≥0,05). Terdapat hubungan yang bermakna anatara hipoksia terhadap respon radiasi (p<0,05). Korelasi antara kadar albumin praradiasi dan hipoksia menunujukkan korelasi yang lemah dan tidak bermakna (r=-0,24, p=0,324).
Kesimpulan: Hasil penelitian ini memperlihatkan bahwa albumin praradiasi tidak berhubungan dengan respon radiasi pada KNF stadium lokal lanjut. Terbukti bahwa hipoksia meningkatkan radioresistensi dan menurunkan respon radiasi. Tidak terdapat korelasi antara albumin praradiasi dan hipoksia.

Introduction: Malnutrion and hypoxia had been shown to cause irradiation failure. Albumin is one of the nutritional status examination. Hypoxia caused radioresistance to irradiation. The purpose of this study was to evaluate the correlation of albumin, hypoxia towards radiation response in locally advanced nasopharyngeal carcinoma.
Methods: This is a retrospective cohort study using secondary data from Departement of Radiotheraphy and Departement of Pathology Cipto Mangunkusomo hospital of 40 patients locally advanced nasopharyngeal cancer who meet the inclusion criteria from December 2012 to August 2013. Albumin preirradiation, body weight and CT scan before and after radiation were recorded. We examined the expression of HIF1 α by immunohistochemistry staining. Hypoxia cell was asessed by cell counting. Radiation response was determined by Recist criteria.
Results: The mean of serum albumin is 3.9 + / - 0.5 g /dL, and the median percentage of hypoxia was 24,7(1-100)%. There was no statistically significant relationship between albumin and radiation response (p≥0.05). There was a statistically significant relationship between hypoxia and radiation response (p<0,05). There were no correlation between albumin and hypoxia (r=-0,24, p=0,324).
Conclusion: This study showed that there was no correlation between albumin preirradiation and response in locally advanced nasopharyngeal cancer. It was proven that hypoxia increased radioresistance in locally advanced nasopharyngeal cancer. There was no correlation between albumin preirradiation and hypoxia.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T59152
UI - Tesis Membership  Universitas Indonesia Library
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Sazkia Febradhany Tania
"Latar Belakang: Metilasi di area promoter berpotensi mengakibatkan gene silencing pada gen CDH1 yang berperan penting dalam adhesi antarsel dan morfogenesis kraniofasial.
Tujuan: Mengetahui distribusi metilasi antara individu cleft dan non-cleft.
Metode: 24 sampel DNA penderita orofacial cleft dan 24 sampel kontrol dianalisis menggunakan teknik methylation-specific PCR (MSP).
Hasil: Dari kelompok cleft didapatkan 5 sampel (20,83%) berstatus fully methylated dan 19 sampel (79,17%) berstatus partially methylated, sedangkan dari kelompok kontrol didapatkan 24 sampel (100%) berstatus partially methylated.
Kesimpulan: Terjadi metilasi CDH1 pada penderita orofacial cleft, namun secara statistik tidak terdapat perbedaan bermakna pada distribusi status metilasi CDH1 antara individu cleft dan non-cleft (p=0,05).

Background: Methylation at promoter area potentially results in silencing of CDH1 gene which plays important role in cell adhesion and craniofacial morphogenesis.
Objective: To obtain the distribution of CDH1 methylation in cleft and non-cleft individuals.
Methods: 24 DNA samples of individuals with orofacial cleft and 24 control samples were analyzed with methylation-specific PCR (MSP) technique.
Results: From cleft group, 5 (20.83%) were fully methylated and 19 (79.17%) were partially methylated; while from control group, 24 (100%) were partially methylated.
Conclusion: CDH1 methylation was observed in orofacial cleft affected individuals but there is no significant difference in CDH1 methylation status between cleft and non-cleft individuals (p=0.05).
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2014
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Nunung Nurjanah
"Kadar gula darah yang tidak normal menjadi masalah kesehatan yang penting, tak terkecuali pada penderita hipertensi yang mengarah pada komplikasi penyakit yang serius seperti diabetes. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kadar gula darah pada penderita hipertensi ysng dilakukan di Puskesmas Bojonggede, Kabupaten Bogor, Jawa Barat menggunakan desain studi cross sectional dan metode purposive sampling, dengan jumlah sampel sebanyak 105 orang yang terdiri dari laki-laki dan perempuan berusia 30-65 tahun yag termasuk kelompok usia dewasa dan lansia. Hasil penelitian ini menunjukkan bahwa 30,2% responden memiliki kadar gula darah tinggi. Terdapat hubungan bermakna antara usia (OR = 3,5 95% CI 1,361-8,890), jenis kelamin (OR = 5,1 95% CI 1,655-15,570), indeks glikemik (OR = 2,587 95% CI 1,089-6,141), dan lingkar pinggang terhadap kejadian kadar gula darah. Modifikasi gaya hidup dianjurkan seperti rutin melakukan olahraga dan konsumsi makanan sesuai dengan pedoman gizi seimbang. Selain itu, konsumsi makanan dan minuman dengan IG rendah dan sedang, monitoring berat badan dan lingkar pinggang, serta pemeriksaan gula darah secara rutin sangat dianjurkan untuk mencegah peningkatan kadar gula darah.

Blood sugar levels are not normal become important health problem, not least in patients with hypertension leading to serious complications of the disease such as diabetes. This study aims to determine the factors associated with blood sugar levels in patients with hypertension. This research was conducted at the health center Bojonggede, Bogor, West Java using cross sectional study design and purposive sampling method with a total sample of 105 people consisting of men and women aged 30-65 years including age group adults and elderly. The results showed that 30.2% of respondents have high blood sugar levels. There is a significant relationship between age (OR = 3.5 95% CI 1.361 to 8.890), gender (OR = 5.1 95% CI 1.655 to 15.570), the glycemic index (OR = 2.587 95% CI 1.089 to 6.141), and waist circumference on the incidence of blood sugar levels. Lifestyle modification is recommended such as exercise frequently and food consumption suitable with the guidelines of balanced nutrition. In addition, the consumption of foods and beverages with low and medium GI, monitoring body weight and waist circumference, and blood sugar tests are routinely highly recommended to prevent an increase in blood sugar levels."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2015
S58929
UI - Skripsi Membership  Universitas Indonesia Library
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"[Hiperkolesterolemia merupakan suatu kondisi dimana terjadi peningkatan
kolesterol plasma dan lipoprotein. Hiperkolesterolemia dapat menimbulkan
berbagai komplikasi apabila tidak ditatalaksana dengan baik. Pengobatan utama
yang umum digunakan untuk mengatasi hiperkolesterolemia adalah simvastatin.
Namun, pada penggunaannya, apabila dikonsumsi pada dosis tinggi dan
berkepanjangan simvastatin dapat menyebabkan toksisitas pada hati. \Pada
penelitian ini dilakukan studi eksperimental untuk menguji pengobatan alternatif
hiperkolesterolemia dengan menggunakan ekstrak akar akar kucing (Acalypha
Indica) pada tikus hiperkolesterolemia. Tikus Sprague-Dawley jantan dibagi ke
dalam empat kelompok yang terdiri atas diit tinggi fruktosa-kolesterol,
simvastatin, ekstrak akar Acalypha Indica dan kelompok normal. Kolesterol total
dan LDL diolah dengan uji Kruskal Wallis dan post hoc Mann-Whitney. Dari
hasil penelitian ini, didapatkan perbedaan yang bermakna pada uji kolesterol total
(p < 0,05) dan kolesterol LDL (p < 0,05) terhadap kelompok kontrol. Sementara
itu, kolesterol HDL dan trigliserida diolah dengan uji One Way ANOVA dimana
ditemukan perbedaan yang bermakna pada percobaan kadar trigliserida (p < 0,05)
dan tidak bermakna pada percobaan HDL (p > 0,05). Hasil dari penelitian ini
menunjukkan bahwa ekstrak akar Acalypha Indica bermanfaat sebagai terapi
alternatif untuk hiperkolesterolemia, Hypercholesterolemia is a condition in which the lipoproteins and cholesterol
plasma levels increase. Untreated hypercholesterolemia can cause several
complications such as myocardial infarction, stroke, and insulin resistance.
Simvastatin is a first line drug commonly used to treat this lipid abnormality.
Long-term use of simvastatin can cause hepatotoxicity. The aim of this study is to
determine the alternative treatment for hypercholesterolemia using the extract of
Acalypha Indica roots in hypercholesterolemia rats. Male Sprague-Dawley rats
were assigned to four groups (n=6) and give the intervention for 4 weeks. One
normal group receive normal feed, one group receive high fructose-cholesterol
diet, while the others were supplemented with 250 mg/kgBW ethanol extract of
Acalypha Indica roots and 10 mg/kgBW simvastatin. Total cholesterol and LDL
level were analyzed by using Kruskal Wallis test and post hoc Mann-Whitney
test. The results showed that total cholesterol (p < 0,05) and LDL level (p < 0,05)
are significantly different compared to the normal group. Meanwhile, HDL and
triglycerides were analyzed by using One Way ANOVA test. There is
significantly different results in triglycerides level (p < 0,05) and no different
results in HDL level ( p > 0,05) compared to the control groups. In conclusion, the
result of this study indicated that the extract of Acalypha Indica roots can be used
as alternative therapy for hypercholesterolemia]"
[Fakultas Kedokteran Universitas Indonesia, ], 2015
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Linda Yulianti W.
"Pendahuluan: Aktivitas proliferasi, sintesis kolagen, dan hidrasi kulit akan menurun seiring proses penuaan kulit, sehingga kulit menua menjadi kusam, kendur, dan kering. Aquaporin-3 (AQP3) adalah protein kunci yang berperan pada proliferasi dan hidrasi keratinosit, sekarang menjadi target inovasi pengembangan kosmetika pelembab anti penuaan kulit. Penelitian ini bertujuan menganalisis kombinasi dua bahan alam yaitu ekstrak etanol Centella asiatica dan nanopartikel kitosan (EECA+NPK) terhadap proliferasi sel fibroblast dan keratinosit, sintesis kolagen I dan III serta ekspresi protein aquaporin-3 (AQP3) secara in vitro.
Metode: Dilakukan uji proliferasi sel fibroblas dan keratinosit yang dianalisis dengan uji Microculture Tetrazolium (MTT), analisis sintesis kolagen I dan III menggunakan Enzyme Linked Immunosorbent Assay (ELISA) kit (COL1A1 dan COL3A1) setelah dipajankan dengan ekstrak etanol Centella asiaticadalam nanopartikel kitosan (EECA + NPK) pada beberapa konsentrasi selama 24, 48, dan 72 jam dibandingkan dengan asam retinoat, selanjutnya ekspresi aquaporin-3 (AQP3) dianalisis dengan teknik Imunositokimia menggunakan antibodi anti-aquaporin3 ab125219, kemudian dianalisis secara kuantitatif menggunakan ImageJ software.
Hasil: EECA + NPK dapat meningkatkan proliferasi fibroblas 1.6 kali lipat dibandingkan kontrol. Optimal pada konsentrasi 6.25 mg/mL dan proliferasi sel keratinosit optimal pada konsentrasi 3.125 mg/mL, secara statistic tidak berbeda bermakna dengan AR. (EECA + NPK) dapat meningkatkan sintesis kolagen I setelah pajanan 72 jam dan kolagen III setelah pajanan 48 jam, secara statistic tidak berbeda bermakna dengan AR. Uji imunositokimia dengan antibodianti-aquaporin3 ab125219 (EECA + NPK) dapat meningkatkan ekspresi aquaporin 3 (AQP 3) pada sel fibroblas optimal pada konsentrasi 12.5 mg/mL dan sel keratinosit pada konsentrasi3.125 mg/mL setelah pajanan selama 24 jam, secara statistik berbeda dengan AR.
Kesimpulan: Ekstrak etanol Centella asiatica dalam nanopartikel kitosan (EECA + NPK) dapat meningkatkan proliferasi fibroblas dan keratinosit, meningkatkan sintesis kolagen I dan III, serta ekspresi protein AQP3 pada sel fibroblas dan sel keratinosit.

Introduction: Proliferation activity, collagen synthesis, and hydration of the skin will decrease with the process of aging, therefore, skin looks dull, sagging, and dry. Aquaporin-3 (AQP3) is a key protein that plays a role in keratinocyte proliferation and hydration, recently becomes the target of innovation development of anti-aging cosmetic moisturizer. This research aims to analyze a combination of two natural ingredients, Centella asiaticaethanolic extractand chitosan nanoparticles (EECA + NPK) to increased proliferation fibroblast cell and keratinocyte, synthesis type I and III collagen, and the expression of AQP3 in vitro.
Methods: Microculture Tetrazolium Test was conducted to analyze the proliferation of fibroblast and keratinocyte. The synthesis of type I and III collagen in fibroblast were analyzed using Ezyme Linked Immunosorbent Assay (ELISA) kit (COL1A1 and COL3A1) after the exposure of CAEE + CNP in several concentrations for 24, 48, 72 hours and compared to Retinoic acid (RA). The expression of AQP 3 on fibroblast and keratinocyte was analyzed using antibody anti-aquaporin 3 ab125219 immunocytochemistry technique, then quantitively analyzed using Image-J software.
Results: CAEE+ CNP increased the proliferation of fibroblas optimal result at 6.25mg/mL concentration and the proliferation of keratinocyte increased 1.5 time than control, optimal result at 3.125 mg/mL concentration, statistically were not significant different with RA.CAEE + CNP increased the synthesis collagen type I optimal after incubated for 72hours and the synthesis collagen type III optimal 48 hours, statistically were not significant different with RA.Using antibody anti-aquaporin 3 ab125219 immunocytochemistry examination indicated CAEE+ CNP increased the expression of AQP 3 on fibroblast and keratinocyte, optimal results at 12.5 mg/mL and 3.125 mg/mL respectively after 24 hours exposure.
Conclusion: CAEE + CNP increased the proliferation of fibroblast and keratinocyte, synthesis of type I and III collagen, and the expression of AQP3 in fibroblast and keratinocyte;Introduction: Proliferation activity, collagen synthesis, and hydration of the skin will decrease with the process of aging, therefore, skin looks dull, sagging, and dry. Aquaporin-3 (AQP3) is a key protein that plays a role in keratinocyte proliferation and hydration, recently becomes the target of innovation development of anti-aging cosmetic moisturizer. This research aims to analyze a combination of two natural ingredients, Centella asiaticaethanolic extractand chitosan nanoparticles (EECA + NPK) to increased proliferation fibroblast cell and keratinocyte, synthesis type I and III collagen, and the expression of AQP3 in vitro."
Depok: Universitas Indonesia, 2016
D-Pdf
UI - Disertasi Membership  Universitas Indonesia Library
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"For those involved in the identification and management of patients with inborn errors of metabolism, this book is now recognised as the standard textbook in this interdisciplinary field. It has proved to be indispensable for professionals in specialities ranging from pediatrics, neonatology, pathological biochemistry and genetics to neurology, internal medicine, nursing, dietetics and psychology. This 5th edition has been extensively revised and updated.
What´s new
- Additional chapter focusing on inborn errors affecting adults, particularly the late neurological presentations
- Numerous updates on diagnostic procedures and treatment
- Newly discovered disorders.
As with previous editions, the book opens with a section presenting the clinical approach to inborn metabolic diseases for those cases in which a diagnosis is being sought. This now includes a chapter on the clinical presentation of metabolic diseases in the older age range, using an analogous structure. If a particular diagnosis is already suspected, the reader may refer to the following sections of the book containing general chapters on diagnostic procedures and treatment, and on specific groups of disorders. "
Berlin : Springer, 2012
e20426451
eBooks  Universitas Indonesia Library
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Hery Sudarno
"ABSTRAK
Penduduk bumi telah mencapai lebih dari 7 milyar jiwa dan pertumbuhannya
terus meningkat. Kondisi ini menimbulkan tekanan pada penyediaan pangan
terutama sumber protein. Peternakan konvensional banyak menyebabkan
terjadinya degradasi dan pencemaran lingkungan. Masyarakat kawasan karst
Gunung Sewu (KKGS) dikenal sejak lama memanfaatkan serangga sebagai
sumber protein, namun tidak ada data penelitian tentang pemanfaatan serangga.
Tujuan penelitian ini adalah mengumpulkan data jenis serangga yang
dimanfaatkan sebagai sumber protein pada masyarakat KKGS, menganalisis
faktor yang mempengaruhi konsumsi serangga pada masyarakat KKGS, dan
mengkaji dampak pemanfaatan serangga sebagai sumber protein pada masyarakat
di KKGS. Penelitian ini menggunakan pendekatan kuantitatif. Pengumpulan data
dilakukan dengan observasi lapangan, penyebaran kuesioner, dan wawancara
kemudian dilakukan telaah pustaka. Hasil penelitian menunjukkan masyarakat di
kawasan Karst Gunung Sewu memanfaatkan 18 jenis serangga yang sebagian
besar berasal dari ordo Coleoptera (kumbang), Orthoptera (belalang dan jangkrik),
dan Lepidoptera (kupu-kupu dan ngengat) sebagai sumber protein, karena pada
musim tertentu memiliki kelimpahan yang sangat tinggi. Faktor Internal (serangga
mempunyai rasa yang enak dan lezat) dan faktor eksternal (lingkungan, ekonomi,
dan sosial) mempengaruhi dan saling berkaitan dalam membentuk perilaku
konsumsi serangga pada masyarakat di kawasan karst. Pemanfaatan serangga
sebagai sumber protein pada masyarakat di kawasan karst Gunung Sewu
mempunyai dampak yang positif terutama pada aspek lingkungan dan ekonomi
yaitu dapat membantu menggantikan peran predator alami serangga yang hilang
dan juga mampu meningkatkan perekonomian masyarakat setempat

ABSTRACT
Earth's population has reached more than 7 billion people and its growth continues
to increase. These conditions led to pressure on the provision of food, especially
protein sources. Many conventional farms cause environmental degradation and
pollution. The community of Gunung Sewu karst area (GSKA) known since long
time been using edible insects as a protein source, but there is no research data on
the use of insects. The purpose of this study is to collect data species of insect
used as a protein source on GSKA community, to analyze factors influencing the
consumption of edible insects on GSKA community, and examines the impact use
of edible insects as a protein source on GSKA community. This study uses a
quantitative approach. The data collection is done by field observations,
questionnaires and interviews later conducted literature review. The results
showed people in the Gunung Sewu Karst Area use of 18 species of insects are
largely derived from the order Coleoptera (beetles), Orthoptera (grasshoppers and
crickets), and Lepidoptera (butterflies and moths) as a protein source because in a
particular season has an abundance of very high. Environmental factors and
economic factors, has the highest influence on the consumption of insects in
GSKA community. Internal factors (insect has a good flavor and delicious) and
external factors (environmental, economic, and social) influence and interrelated
in the consumption activities of insects. Utilization of insects as a protein source
in the GSKA community has a positive effect especially on environmental and
economic aspects, which can help replace the role of natural predators of insects
were lost and also able to improve the local economy"
2016
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Stefanus Agung Budianto
"ABSTRAK
Laserpunktur merupakan salah satu tindakan akupunktur untuk penanganan kasus nyeri. Penelitian ini bertujuan untuk mengetahui pengaruh laserpunktur pada titik LI4 Hegu terhadap kadar β-endorfin plasma darah subjek sehat. Uji acak tersamar ganda dengan kontrol plasebo dilakukan pada 29 subjek sehat yang dialokasikan ke dalam kelompok laserpunktur (n=15) dan kelompok laserpunktur plasebo (n=14). Kadar β-endorfin plasma darah digunakan untuk mengukur keluaran penelitian yang dinilai sebelum perlakuan, dan pasca perlakuan. Terdapat perbedaan bermakna secara statistik pada rerata kadar β-endorfin plasma darah sebelum dan sesudah perlakuan dalam kelompok laserpunktur, perubahan nilai rerata dari 0,22±0,06 ng/ml menjadi 0,29±0,07 ng/ml dengan nilai p=0,005 (p<0,05). Tidak terdapat perbedaan bermakna secara statistik pada rerata kadar β- endorfin plasma darah sebelum dan sesudah perlakuan pada kelompok laserpunktur plasebo, perubahan nilai rerata dari 0,22±0,06 ng/ml menjadi 0,26±0,09 ng/ml dengan nilai p=0,195 (p>0,05). Pada rerata selisih kadar β- endorfin plasma darah antara kelompok laserpunktur dengan kelompok laserpunktur plasebo juga tidak terdapat perbedaan bermakna secara statistik (p=0,183, p>0,05). Kesimpulan penelitian ini laserpunktur dapat mempengaruhi kadar β-endorfin plasma darah subjek sehat, namun tidak berbeda bermakna secara statistik pada rerata selisih kadar β-endorfin plasma darah antar kelompok perlakuan.

ABSTRACT
Laserpuncture is one of acupuncture method for pain management. This study
aims to determine the effect laserpuncture at LI4 Hegu point on plasma levels of β-endorphin in healthy subjects. A randomized double-blind controlled trials with placebo controls carried out on 29 healthy subjects, they were allocated into laserpuncture group (n=15) and laserpuncture placebo group (n=14). Plasma levels of β-endorphin is used to measure the output of the study assessed both before treatment and post-treatment. There are statistically significant in the mean plasma levels of β-endorphin before and after treatment in the laserpuncture group, changes in mean value from 0.22±0,06 ng/ml to 0.29±0,07 ng/ml with a p value=0,005 (p<0,05). There are no statistically significant in the mean plasma levels of β-endorphin before and after treatment in the laserpuncture placebo group, changes in mean value from 0,22±0,06 ng/ml to 0,26±0,09 ng/ml with p values=0,195 (p>0,05). Between groups, there were no statistically significant in the mean difference of plasma levels of β-endorphin (p=0,183, p>0,05). The conclusion of this study laserpuncture can affect the plasma levels of β-endorphin in healthy subjects, but no statistically significant in the mean difference of plasma levels of β-endorphin between groups"
2016
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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