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Raden Roro Galuh Maharani Sukma
Profil Gangguan Psikiatrik dan Hubungannya dengan Kualitas Hidup pada Pasien Kanker Paru di RSUP Persahabatan Jakarta = Profile of Psychiatric Disorders and It`s Correlation to the Lung Cancer Patients` Quality of Life at RSUP Persahabatan Jakarta
"Latar Belakang
Kanker paru merupakan kanker terbanyak pada pria, dan ketiga terbanyak pada wanita, serta merupakan jenis kanker dengan angka mortalitas terbesar. Meskipun tatalaksana kanker paru sudah berkembang, namun angka kesintasan kanker paru masih tergolong kecil dibandingkan jenis kanker lainnya. Hal ini menyebabkan penderita kanker paru rentan mengalami berbagai gangguan psikiatrik selama perjalanan penyakitnya. Kualitas hidup saat ini menjadi salah satu luaran terpenting bagi tatalaksana kanker, dan adanya gangguan psikiatrik akan berdampak pada menurunnya kualitas hidup pasien. Hingga saat ini belum ada penelitian mengenai profil gangguan psikiatrik yang muncul, serta kualitas hidup pada pasien kanker paru di Indonesia.
Metode
Penelitian dilakukan secara potong lintang pada 104 subjek pasien rawat jalan di Poli Onkologi RSUP Persahabatan Jakarta yang diambil secara convenience sampling. Pengambilan data dilakukan dengan wawancara terstruktur menggunakan instrumen The Mini International Neuropsychiatric Interview (MINI ICD-10) untuk menentukan ada atau tidaknya gangguan psikiatrik pada pasien, dan kuesioner World Health Organization Quality of Life - Abbreviated Version (WHOQOL-BREF) untuk menilai kualitas hidup. Data yang diperoleh kemudian dilakukan analisis dengan uji non-parametrik Mann-Whitney U.
Hasil
Ditemukan bahwa gangguan jiwa pada pasien kanker paru yang menjadi subjek penelitian ialah episode depresi (32,7%), risiko bunuh diri (30,8%), distimia (2,9%), gangguan depresi berulang (2,9%), gangguan cemas menyeluruh (5,8%), penggunaan berbahaya dari alkohol (1%), dan gangguan psikotik (16,3%). Didapatkan adanya hubungan yang bermakna antara seluruh ranah kualitas hidup dengan episode depresi (p <0,001 pada ranah fisik, psikologis dan lingkungan; p = 0,013 pada ranah hubungan sosial) ,dan risiko bunuh diri (p <0,001 pada ranah fisik, psikologis, dan lingungan; p = 0,006 pada ranah hubungan sosial).
Introduction
Lung cancer is the most common type of cancer in man, and the third most common type of cancer in woman, also the highest cause of cancer related mortality. Despite the development in lung cancer therapy, the 5-years survival rate for lung cancer remain low compared to other types of cancer. This puts lung cancer patient in a high risk vulnerability in developing psychiatric disorder in the course of the disease.
Quality of life becomes one of the most important outcome in the assessment of lung cancer patient, and the presence of psychiatric disorder could impact the patient’s quality of life.
There hasn’t been any studies that assess the profile of psychiatric disorder and the quality of life among lung cancer patients in Indonesia.
Methods
We conducted a cross-sectional study on 104 subjects from the outpatient oncology clinic at RSUP Persahabatan Jakarta selected by convenience sampling. Data were collected by structured interviews using The Mini International Neuropsychiatric Interview (MINI ICD-10) to determine if the patient suffer from any psychiatric disorder, and the World Health Organization Quality of Life - Abbreviated Version (WHOQOL-BREF) questionnaire to assess the quality of life. Obtained data were analyzed using Mann-Whitney U non-parametric test.
Results
We found that among the study subject, some subject met the diagnostic criteria of depressive episode (32,7%), suicide risk (30,8%), dysthimia (2,9%), recurrent depressive disorder (2,9%), generalized anxiety disorder (5,8%), harmful use of alcohol (1%), and psychotic symptoms (16,3%). There is a significant relationship between all domains in the quality of life with depressive episode (p <0,001 on the physical, psychological, and environmental domains; p = 0,013 on the social relationship domain), and suicide risk (p <0,001 on the physical, psychological, and environmental domains; p = 0,006 on the social relationship domain)."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Alisa Narendraputri
Hasil pemeriksaan lateral flow assay (LFA) cryptococcus dikaitkan dengan profil klinis pasien kanker paru di RSUP Persahabatan = Cryptococcal lateral flow assay (LFA) results associated with clinical profiles of lung cancer patients at Persahabatan Hospital, Jakarta.
"Latar belakang: Kanker paru menduduki peringkat ketiga sebagai penyebab kematian utama akibat keganasan di Indonesia, 85% di antaranya adalah kanker paru karsinoma bukan sel kecil (KPKBSK). Pasien kanker paru rentan terhadap infeksi oportunistik, termasuk kriptokokosis, yaitu infeksi jamur Cryptococcus. Penelitian tentang data klinis dan keberadaan Cryptococcus pada pasien KPKBSK di Indonesia masih terbatas. Salah satu metode untuk mendeteksi keberadaan Cryptococcus adalah pemeriksaan serologi Lateral Flow Assay (LFA).
Tujuan: Penelitian ini bertujuan untuk mengetahui profil klinis pasien KPKBSK dan kaitannya dengan hasil pemeriksaan LFA Cryptococcus di RSUP Persahabatan.
Metode: Penelitian dengan disain potong lintang ini dilakukan pada pasien KPKBSK yang belum dikemoterapi di RSUP Persahabatan yang memenuhi kriteria inklusi. Data klinis pasien diperoleh dari anamnesis dan pemeriksaan fisik yang diambil dari rekam medis, selanjutnya dilakukan pemeriksaan LFA Cryptococcus di laboratorium Parasitologi FKUI.
Hasil: Dari 77 subjek yang memenuhi kriteri inklusi, terdapat 48 (62,3%) pasien laki-laki, dengan rerata usia 59,4 tahun. Data klinis lain menunjukkan IMT 18,5-22,9 kg/m2 (53,2%), status tampilan 1 (42,9%), perokok aktif (61,0%), Indeks Brinkman ringan (42,9%), adenokarsinoma (75,3%), stadium IIIB-IV (79,2%). Riwayat komorbid yang ditemukan adalah TB (13,0%), asma/PPOK (1,3%), DM (16,9%), dan penyakit lainnya (31,2%). Proporsi hasil pemeriksaan LFA Cryptococcus positif adalah 11,7%. Tidak ditemukan hubungan bermakna antara profil klinis dengan keberadaan Cryptococcus pada pasien KPKBSK.
Simpulan: Proporsi keberadaan Cryptococcus pada pasien KPKBSK yang belum dikemoterapi adalah 11,7%. Profil klinis terbanyak berupa IMT 18,5-22,9 kg/m2, status tampilan 1, perokok aktif, Indeks Brinkman ringan, jenis keganasan adenokarsinoma, dan stadium IIIB-IV. Riwayat komorbid meliputi TB, asma/PPOK, DM, dan penyakit lain. Tidak ditemukan hubungan antara profil klinis dengan keberadaan Cryptococcus pada subjek penelitian.
Background: Lung cancer is the third of leading cause of death due to malignancy in Indonesia. Eighty-five percent of them were non-small cell lung cancer (NSCLC). Lung cancer patients are prone to have the opportunistic infections, such as cryptococcosis. However, the clinical data on the exictance of Cryptococcus in NSCLC patients in Indonesia are scarce. One of the methods to detect Cryptococcus in those patients is the Lateral Flow Assay (LFA) serology test.
Aim: The study aimed to determine the association between the clinical profile of NSCLC patients with the Cryptococcal LFA test results at Persahabatan Hospital, Jakarta.
Methods: This cross-sectional study was conducted on naïve NSCLC patients at Persahabatan Hospital Jakarta, who met the inclusion criteria. The clinical data were obtained from history taking and physical examination from the medical records. Furthermore, the Cryptococcal LFA serology test was conducted at laboratory of Parasitology Department, Faculty of Medicine Universitas Indonesia.
Results: Of the 77 subjects, there were 48 male patients (62.3%), and the mean age was 59.4 years old. The most common clinical profile of NSCLC patients were BMI of 18.5-22.9 kg/m2 (53.2%), performance status 1 (42.9%), active smokers (61.0%), mild Brinkman Index (42.9%), adenocarcinoma (75.3%), and cancer stage of IIIB-IV (79.2%). The comorbidities of those patients were TB (13.0%), asthma/COPD (1.3%), DM (16.9%), and other diseases (31.2%). The proportion of positive Cryptococcal LFA test results was 11.7%. There was no significant association between the clinical profiles and the presence of Cryptococcus.
Conclusion: The proportion of the Cryptococcus existance in naïve NSCLC patients was 11.7%. The most common clinical profiles were BMI of 18.5-22.9 kg/m2, performance status 1, active smokers, mild Brinkman Index, adenocarcinoma histology type, and lung cancer stage at IIIB-IV. The comorbidities of those patients were TB, asthma/COPD, DM, and other diseases. No association was found between the clinical profile of those patients and the presence of Cryptococcus."
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Umie Faizah
Gambaran gangguan psikiatri pada pasien TB-MDR (Multi Drug Resistant) dan stres psikososial yang memengaruhi di RSUP Persahabatan = Psychiatric disorders in patients with Multi Drug Resistance Tuberculosis and psychosocial stress influences in RSUP Persahabatan
"[ABSTRAK
Latar Belakang. Pasien TB-MDR sedang menjalankan pengobatan akan memengaruhi kondisi kejiwaan yang dapat disebabkan dari obat-obatan TB-MDR dan atau stres psikososial. Tujuan penelitian adalah mendapatkan gambaran gangguan psikiatri pada pasien TB-MDR dan stres psikososial yang memengaruhi.
Metode. Penelitian ini menggunakan desain potong lintang dengan subjek penelitian berjumlah 50 orang. Pengambilan sampel pada subjek menggunakan metode konsekutif. Instrumen yang digunakan pada penelitian ini adalah MINI ICD-10 dan Life Experiences Survey (LES) dari Irwin G. Sarason yang terdiri dari 60 item yang dinilai dengan skala likert -3 sampai 3. Pada subjek dinilai dampak positif dan negatif stresor menggunakan instrumen LES. Data demografi meliputi usia, jenis kelamin, status pernikahan, jumlah anak, agama, suku, agama, pendapatan, tingkat pendidikan, obat-obatan yang digunakan dan jangka waktu pengobatan. Data dianalisis dengan menggunakan program SPSS untuk windows versi 20. Tingkat kemaknaan yang digunakan untuk uji statistik adalah p < 0,05.
Hasil. Proporsi gangguan psikiatri pada subyek TB-MDR adalah 62%. Proporsi gangguan psikiatri pada subjek TB-MDR terbanyak pada gangguan depresi (32%) diikuti dengan risiko bunuh diri (26%), gangguan panik (24%), gangguan anxietas menyeluruh (20%), gangguan depresi berulang (12%), gangguan psikotik (12%), gangguan agorafobia (8%), gangguan obsesif kompulsif (8%), agorafobia dengan gangguan panik (4%), anorexia nervosa (2%) dan gangguan berkaitan dengan zat psikoaktif (2%). Sebagian besar subjek mendapatkan regimen standar pengobatan TB-MDR mengalami gangguan psikiatri sebesar 58,1%. Terdapat hubungan yang bermakna antara usia subjek dengan gangguan psikiatri sebesar <0,001, antara obat TB-MDR yang didapatkan dengan risiko bunuh diri (p<0,005) dan antara stresor psikososial dengan gangguan psikiatri.
Kesimpulan. Terdapat gangguan psikiatri pada subjek TB-MDR selama menjalani pengobatan. Kelompok subjek TB-MDR dengan gangguan psikiatri cenderung memiliki skor stres negatif yang lebih tinggi (lebih banyak yang mengalami stresor negatif) dibandingan dengan subjek tanpa gangguan psikiatri.ABSTRACT Background. Patients with Multi Drug Resistance Tuberculosis (MDR-TB) during treatment can influence psychiatric conditions caused by MDR-TB drugs and psychosocial stress. The objective of this research is to describe various psychiatric disorders in patients with MDR-TB and various psychosocial stress during the treatment.
Methods. Design of this study is a cross-sectional design with total 50 subjects. Subjects were selected through consecutive sampling methods. Instruments used in this study were the MINI ICD-10 and Life Experiences Survey (LES) of Irwin G. Sarason which consists of 60 items of Likert scale ranging from -3 to 3. Subjects were assessed using the positive and negative impacts of stressors with LES instrument. Demographic data observed consist of age, gender, marital status, number of children, religion, ethnicity, religion, income, education level, drugs taken and the length of treatment. Data were analyzed using SPSS for Windows version 20. The level of significance used for the statistical tests was p <0.05.
Results. Proportion of psychiatric disorders in subjects with MDR-TB is 62%. Proportion of psychiatric disorders in subjects with MDR-TB are depressive disorders (32%) followed by risk of suicide (26%), panic disorder (24%), anxiety disorder (20%), recurrent depressive disorder (12%), psychotic disorder (12%), agoraphobia disorders (8%), obsessive compulsive disorder (8%), agoraphobia with panic disorder (4%), anorexia nervosa (2%) and psychoactive substances associated disorders (2%). Proportion of psychiatric disorders in subjects getting standard treatment regimen for MDR-TB are 58.1%. A significant relationship is made statistically between age of subjects with psychiatric disorders, MDR-TB drugs with suicide risk and psychosocial stressors with psychiatric disorders.
Conclusions. Psychiatric disorders were found in subjects with MDR-TB during treatment. Subject groups of MDR-TB with psychiatric disorders have higher negative stress score (more likely to have a negative stressor) than subjects without psychiatric disorders. ;Background. Patients with Multi Drug Resistance Tuberculosis (MDR-TB) during treatment can influence psychiatric conditions caused by MDR-TB drugs and psychosocial stress. The objective of this research is to describe various psychiatric disorders in patients with MDR-TB and various psychosocial stress during the treatment.
Methods. Design of this study is a cross-sectional design with total 50 subjects. Subjects were selected through consecutive sampling methods. Instruments used in this study were the MINI ICD-10 and Life Experiences Survey (LES) of Irwin G. Sarason which consists of 60 items of Likert scale ranging from -3 to 3. Subjects were assessed using the positive and negative impacts of stressors with LES instrument. Demographic data observed consist of age, gender, marital status, number of children, religion, ethnicity, religion, income, education level, drugs taken and the length of treatment. Data were analyzed using SPSS for Windows version 20. The level of significance used for the statistical tests was p <0.05.
Results. Proportion of psychiatric disorders in subjects with MDR-TB is 62%. Proportion of psychiatric disorders in subjects with MDR-TB are depressive disorders (32%) followed by risk of suicide (26%), panic disorder (24%), anxiety disorder (20%), recurrent depressive disorder (12%), psychotic disorder (12%), agoraphobia disorders (8%), obsessive compulsive disorder (8%), agoraphobia with panic disorder (4%), anorexia nervosa (2%) and psychoactive substances associated disorders (2%). Proportion of psychiatric disorders in subjects getting standard treatment regimen for MDR-TB are 58.1%. A significant relationship is made statistically between age of subjects with psychiatric disorders, MDR-TB drugs with suicide risk and psychosocial stressors with psychiatric disorders.
Conclusions. Psychiatric disorders were found in subjects with MDR-TB during treatment. Subject groups of MDR-TB with psychiatric disorders have higher negative stress score (more likely to have a negative stressor) than subjects without psychiatric disorders. , Background. Patients with Multi Drug Resistance Tuberculosis (MDR-TB) during treatment can influence psychiatric conditions caused by MDR-TB drugs and psychosocial stress. The objective of this research is to describe various psychiatric disorders in patients with MDR-TB and various psychosocial stress during the treatment.
Methods. Design of this study is a cross-sectional design with total 50 subjects. Subjects were selected through consecutive sampling methods. Instruments used in this study were the MINI ICD-10 and Life Experiences Survey (LES) of Irwin G. Sarason which consists of 60 items of Likert scale ranging from -3 to 3. Subjects were assessed using the positive and negative impacts of stressors with LES instrument. Demographic data observed consist of age, gender, marital status, number of children, religion, ethnicity, religion, income, education level, drugs taken and the length of treatment. Data were analyzed using SPSS for Windows version 20. The level of significance used for the statistical tests was p <0.05.
Results. Proportion of psychiatric disorders in subjects with MDR-TB is 62%. Proportion of psychiatric disorders in subjects with MDR-TB are depressive disorders (32%) followed by risk of suicide (26%), panic disorder (24%), anxiety disorder (20%), recurrent depressive disorder (12%), psychotic disorder (12%), agoraphobia disorders (8%), obsessive compulsive disorder (8%), agoraphobia with panic disorder (4%), anorexia nervosa (2%) and psychoactive substances associated disorders (2%). Proportion of psychiatric disorders in subjects getting standard treatment regimen for MDR-TB are 58.1%. A significant relationship is made statistically between age of subjects with psychiatric disorders, MDR-TB drugs with suicide risk and psychosocial stressors with psychiatric disorders.
Conclusions. Psychiatric disorders were found in subjects with MDR-TB during treatment. Subject groups of MDR-TB with psychiatric disorders have higher negative stress score (more likely to have a negative stressor) than subjects without psychiatric disorders. ]"
Fakultas Kedokteran Universitas Indonesia, 2015
MK-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Hapsari Retno Dewanti
Profil dan angka tahan hidup 1 tahun kanker paru bukan sel kecil (kpkbsk) jenis adenokarsinoma paru dengan mutasi epidermal growth factor receptor (egfr) exon 20 t790m primer di rsup persahabatan = The characteristics and one year survival of lung adenocarcinoma patients with primary exon 20 t790m epidermal growth factor receptor mutation treated at persahabatan hospital Jakarta, Indonesia
"Latar Belakang: Kanker paru menjadi penyebab kematian utama akibat keganasan pada laki-laki sebesar 31% dan perempuan sebesar 27%. Pada pasien adenokarsinoma paru dengan mutasi pada exon 20 T790M memberikan respons yang buruk terhadap terapi EGFR-TKI generasi pertama maupun generasi kedua.
Tujuan: Mengetahui profil serta angka tahan hidup 1 tahun pasien kanker paru jenis Adenokarsinoma dengan mutasi exon 20 T790M primer.
Metode: Penelitian menggunakan desain kohort terhadap pasien-pasien adenokarsinoma paru stadium IV dengan mutasi exon 20 T790M primer dari bulan September 2015 sampai Desember 2017 di RSUP Persahabatan. Variabel yang diteliti adalah karakteristik klinis dan angka kesintasanberdasarkan kurva Kaplan Meier. Hasil analisis dinyatakan berbeda bermakna apabila nilai p<0,05.
Hasil: Didapatkan 27 subjek penelitian dengan rerata usia 58,5 tahun dan berjenis kelamin laki-laki (70,6%). Keluhan utama berupa sesak napas (73,5%) dan nyeri dada (55,9%). Mutasi genetik tunggal pada Exon 20 T790M (64,7%), sedangkan mutasi Exon 20 T790M dengan Exon 21 L858R (11,8%) dan mutasi Exon 20 T790M dengan 21 L861Q (8,8%). Organ target metastasis adalah efusi pleura (73,5%), tulang (26,5%) dan otak (20,6%). Angka kesintasan 360 dan 990 hari sebesar 35% dan 20% dengan median kesintasan sebesar 213 hari.
Kesimpulan: Mutasi exon 20 T790M pada adenokarsinoma paru memegang peranan penting terhadap kesintasan dan prediktor responsterhadap terapi yang diberikan.
Background: Lung cancer causes mortality in men (31%) and in women (27%). Lung adenocarcinoma patients with exon 20 T790Mepidermal growth factor receptor(EGFR) mutation showed poor response to the first generation and second generation of EGFR tyrosine kinase inhibitor (TKI) therapy.
Purpose: This study aims to reveal the characteristics and one year survival rate of lung adenocarcinoma patients with primary exon 20 T790M EGFR mutations treated at Persahabatan Hospital Jakarta, Indonesia.
Methods: The cohort study involved patients with primary exon 20 T790M EGFR mutation between September 2015 to December 2017 in Persahabatan Hospital Jakarta, Indonesia. The survival rate was observed from Kaplan Meier estimator curve and was statistically analyzed.
Results: There were 27 subjects with mean age of 58.5 years and were predominated male (70.6%). The most common chief complaints were shortness of breath (73.5%) and chest pain (55.9%). The EGFR mutations detected were exon 20 T790M (64.7%), exon 20 T790M with exon 21 L858R (11.8%) and exon 20 T790M with exon 21 L861Q (8.8%). Metastatic target organs were pleural effusions (73.5%), bone (26.5%) and brain (20.6%). Survival rate of 360 and 990 days was 35% and 20% respectively with median survival rate was 213 days.
Conclusion: Exon 20 T790M EGFR mutation in lung adenocarcinoma was revealed to be an important factor in survival and in predicting response to EGFR TKI chemotherapy."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Ayuningtyas Setyoreni
Manfaat klinis pemberian ibandronic acid pada pasien kanker paru bermetastasis tulang di RSUP Persahabatan Jakarta Indonesia = The implication of ibandronic acid in treatment on bone metastatic disease in lung-cancer patients at the National Respiratory Referral Hospital Persahabatan Jakarta Indonesia
"Latar Belakang : Metastasis tulang merupakan masalah pada pasien kanker paru karena memperburuk prognosis dan kualitashidup. Nyeri merupakan salah satugejala yang paling umum. Tatalaksana metastasis tulang pada pasien kanker paru meliputi terapi pada tumor primer, radioterapi pada lesi metastasis dan pemberian ibandronic acid.
Metode : Penelitian ini merupakan studi retrospektif. Kami mencatat pasien kanker paru bermetastasis tulang dan dirawat di rumah sakit pusat rujukan respirasi nasional Persahabatan Jakarta dari tanggal 1 Januari 2016 sampai 30 Juni 2018. Tujuan penelitian ini untuk mengevaluasi penurunan nyeri kanker yang berhubungan dengan metastasis tulang. Semua pasien menerima terapi ibandronic acid 6 mg intravena setiap bulan dan diukur skala nyerinya dengan menggunakan Visual Analogue Scale (VAS). Selain mendapat terapi ibandronic acid, setiap pasien juga mendapatkan modalitas terapi nyeri kanker lain seperti analgetik, radioterapi atau kombinasi keduanya.
Hasil : Lokasi lesi kanker paru bermetastasis ke tulang paling sering (dari 51/71 pasien) adalah vertebra 74 (43,79%), toraks 55 (32,54%) dan pelvis 28 (17,75%). Rerata jumlah pemberian ibandronic acid adalah 8 kali pemberian. Rentang waktu pemberian ibandronic acid dari tegak jenis adalah 6 bulan. Nyeri VAS setelah pemberian ibandronic acid berturut-turut nyeri VAS ringan (VAS 1-3) 14 (27,54%), nyeri VAS sedang (VAS 4-6) 37 (72,46%) dan nyeri berat (VAS 7-10) 0 (0%). Total waktu penurunan nyeri setelah pemberian ibandronic acid adalah 4 bulan. Rerata penurunan nyeri VAS pada grup nyeri VAS ringan-sedang terjadi setelah 5 kali pemberian sedangkan rerata penurunan grup nyeri VAS berat setelah 1 kali pemberian (p = 0.0001). Terdapat beberapa kejadian efek samping setelah pemberian ibandronic acid yang ditemukan pada 9 dari 51 subjek antara lain 2 (3,9%) ruam kulit, 3 (5,9%) mual dan muntah, 3 (5,9%) sakit kepala dan 1 (2,0%) demam.
Kesimpulan : Terapi ibandronic acid sangat bermanfaat untuk menurunkan nyeri kanker pada pasien kanker paru bermetastasis ke tulang
Background: Bone metastasis (BM) is one of the problems in lung cancer because it affects the prognosis and quality of life. Pain is most common symptom. The management of bone metastasis (BM) in lung cancer are treatment of primary cancer lesion, radiotherapy on the metastatic lesions and ibandronic acid.
Method : In this retrospective study, lung cancer patients with BM and treated in Persahabatan National Respiratory Referral Hospital, Jakarta, between January 1st 2016 and June 30th 2018 were enrolled. The aim of study was to evaluate the efficacy of ibandronic acid in the treatment of cancer pain caused by BM. All of patients received ibandronic acid 6 mg (intravenously) monthly and Visual Analogue Scale (VAS) was used to evaluate pain. All patients received other management cancer pain such as analgesics, radiotherapy or combination.
Results : Most BM lesions (51/71 cases) were located in vertebra 74 (43,79%), thoracic cage 55( 32,54%) and pelvic 28 (17,75%). The averages of administration of ibandronic acid 6 mg iv was 8 times. The mean time-to-treat of ibandronic acid since the first time of lung cancer diagnosis was 6 months. VAS pain scale after administration of ibandronic acid was classified to mild pain (VAS 1-3) 14 cases (27,54%), moderate pain (VAS 4-6) 37 cases (72,46%) and severe pain (VAS 7-10) 0 cases. Overall the decrease in VAS scale was seen after 4 times ibandronic acid administration. Pain was significantly improved after the fifth administration in patients which initially suffered from moderate to mild pain and was significantly improved immediately after the first administration in patients which initially suffered from severe pain (p=0,0001). The side effects caused by ibandronic acid was observed in 9 patients, in which 2 subjects (3,9%) had a rash skin, 3 subjects (5,9%) suffered nausea and vomiting, 3 subjects (5,9%) had headache, and 1 subject (2,0%) fever.
Conclusion : Ibandronic acid treatment was useful to relieve metastatic bone pain in lung cancer patients."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T55538
UI - Tesis Membership  Universitas Indonesia Library
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Jennifer Sahira Sunukanto
Kualitas Hidup Pasien Kanker Paru pada Pandemi COVID-19 = Quality of Life of Lung Cancer Patients during COVID-19 Pandemic
"Latar belakang: Situasi pandemi COVID-19 membawa dampak terhadap berbagai aspek kehidupan, terutama pada masyarakat dengan penyakit kronis seperti kanker paru. Perubahan akibat pandemi memengaruhi tingkat kualitas hidup pasien yang penting untuk kesejahteraan hidup mereka. Penelitian ini bertujuan untuk memberikan gambaran kualitas hidup pasien kanker paru pada pandemi COVID-19.
Metode: Studi dengan metode potong-lintang dilakukan di Poli Rawat Jalan Onkologi Toraks RSUP Persahabatan, Jakarta. Sampel diambil menggunakan metode consecutive sampling. Tingkat kualitas hidup dinilai menggunakan kuesioner European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (EORTC QLQ-C30) versi Bahasa Indonesia. Penelitian ini juga menilai karakteristik sosiodemografis dan klinis pasien, serta faktor terkait COVID-19 yang meliputi kekhawatiran akan terhambatnya pengobatan, paparan informasi mengenai COVID-19, hambatan akses menuju fasilitas kesehatan, hambatan kelanjutan pengobatan, tekanan mental yang dialami, serta hubungan dengan keluarga dan teman selama pandemi COVID-19.
Hasil: Sebanyak 94% dan 6% pasien kanker paru memiliki tingkat kualitas hidup sedang dan buruk selama pandemi COVID-19. Keseluruhan pasien mengalami gangguan kualitas hidup selama pandemi, tetapi tidak ditemukan adanya hubungan yang bermakna secara statistik pada tingkat kualitas hidup dengan karakteristik subjek, maupun dengan pandemi COVID-19. Sebagian besar pasien mengkhawatirkan keterlambatan pengobatan dan mengalami tekanan psikologis, namun hanya sedikit pasien yang mengalami hambatan pengobatan selama pandemi.
Kesimpulan: Studi ini menunjukkan adanya gangguan kualitas hidup pada pasien kanker paru selama pandemi COVID-19. Diperlukan adanya penelitian lebih lanjut serta pengembangan intervensi yang lebih holistik dan komprehensif untuk pasien kanker paru, terutama selama pengobatan jarak jauh.
Kata kunci: Kanker Paru, Kualitas Hidup, COVID-19
Introduction: The COVID-19 pandemic has affected various aspects of life, especially for people with chronic diseases such as lung cancer. The changes due to the pandemic impact their quality of life (QoL) which is important for their well-being. This study aimed to provide an overview of lung cancer patients’ QoL during the COVID-19 pandemic.
Method: A cross-sectional study was conducted in the Thoracic Oncology Outpatient Clinic of Persahabatan National Respiratory Referral Hospital, Jakarta. Patients were recruited using consecutive sampling methods. QoL was assessed using the Indonesian version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (EORTC QLQ-C30). This study also assessed the patients’ sociodemographic and clinical characteristics and the factors related to COVID-19, including concerns about treatment delays, exposure to COVID-19 information, barriers to access to healthcare facilities and treatment continuation, psychological pressure, and interpersonal relationships with family and friends.
Results: 94% and 6% of lung cancer patients have moderate and poor QoL during the COVID-19 pandemic. All patients have impaired QoL, but no statistically significant relationship was found between QoL and the subjects’ characteristics or the factors related to the pandemic. Most patients are concerned about treatment delays and experiencing psychological pressure, but only a few patients experience treatment barriers during the pandemic.
Conclusion: This study showed an impaired QoL in lung cancer patients during the COVID-19 pandemic. Further research and development of more holistic and comprehensive interventions for lung cancer patients, particularly during remote treatment, are needed."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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UI - Skripsi Membership  Universitas Indonesia Library
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Inggar Pertiwi
Analisis waktu tunggu dan biaya penegakan diagnosis kanker paru di RSUP Persahabatan = Diagnostic time and cost of lung cancer in Persahabatan hospital
"ABSTRAK
Latar Belakang : Pasien kanker paru umumnya datang pada stage yang sudah lanjut. Keterlambatan bisa diakibatkan oleh pasien itu sendiri, dokter dan sistem kesehatan. Sejak diberlakukan Jaminan Kesehatan Nasional, RSUP Persahabatan sebagai rujukan penyakit paru mengalami peningkatan jumlah pasien kanker paru. Diagnosis kanker paru ditargetkan tegak dalam dua minggu. Namun, selama ini ini belum ada data berapa lama diagnosis kanker paru dapat ditegakan dan berapa biaya yang dikeluarkan serta faktor-faktor apa saja yang mempengaruhinya.Metode : Penelitian ini merupakan studi observasional. Sebanyak 110 subjek terdapat pada penelitian ini. Kami mengevaluasi berapa waktu dan biaya yang dibutuhkan sejak subjek datang ke RSUP Persahabatan sampai diagnosis histopatologi kanker paru didapat. Kami juga mengevaluasi beberapa faktor yang menentukan lama dan besarnya biaya penegakan diagnosis kanker paru.Hasil : Sebanyak 110 subjek terdapat dalam penelitian ini. Delapan puluh empat 76,36 subjek laki-laki dan 26 23,64 perempuan. Nilai tengah umur subjek adalah 57 tahun dengan kisaran 26 sampai 86 tahun. Sebanyak 53 48,2 mendapatkan diagnosis dalam waktu le; dan 57 51,8 subjek mendapatkan diagnosis lebih dari 2 minggu. Nilai tengah penegakan diagnosis adalah 15 hari dengan kisaran 1 ndash;68 hari. Pasien dengan stage lanjut, tampilan status yang jelek dan dirawat dengan pembiayaan umum memiliki waktu tunggu yang lebih singkat. Biaya penegakan diagnosis kanker paru di RSUP Persahabatan memiliki nilai tengah Rp. 13.025.381,- dengan kisaran Rp. 1.083.000,- hingga Rp156.285.000,-. Subjek dengan stage lanjut, tampilan status yang buruk, memiliki penyulit dan dirawat di kelas non JKN memiliki biaya yang lebih besar.Kesimpulan : Nilai tengah waktu penegakan diagnosis kanker paru pada penelitian ini adalah 15 hari dengan kisaran 1-86 hari. Waktu tunggu berhubungan dengan stage pada saat datang, tampilan status, kelas perawatan. Biaya penegakan diagnosis kanker paru di RSUP Persahabatan memiliki nilai tengah Rp. 13.025.381,- dengan kisaran Rp. 1.083.000,- hingga Rp156.285.000,-. Biaya penegakan diagnosis berhubungan dengan stage pada saat datang, tampilan status, penyulit dan kelas perawatan.Kata Kunci : Kanker paru, diagnosis, keterlambatan diagnosis
ABSTRAK
Background and aim Most lung cancer patients had been diagnosed in advanced stage. Most reasons for the delay of the diagnosis, might be from patients and or health system. Currently, in Indonesia has National Health Insurance System Jaminan Kesehatan Nasional . That situation made an increasing numbers of patients who come to referral hospital. In Persahabatan Hospital the National Referral for Respiratory Diseases, the maximum time interval for lung cancer diagnosis was set not more than two weeks, however several cases were delayed. We had been conducting a study to evaluate time diagnostic time and cost for diagnose lung cancer.Method We performed bservational study in Persahabatan Hospital Jakarta. One hundred an ten new patients was recruited in this study. We evaluated how long the time was and how much was needed from the first visit until the initial diagnosis by histopatology obtained. We also evaluated the factors that have correlated with time and cost of diagnosis.Results One hundred and ten patients were enrolled in this study. Eighty four 76,36 were male and 26 23,64 were female. The median age was 57 years old with range 26 to 86 years old. Data had shown that 53 48,2 patient were diagnosed under target time 2 weeks but 57 51,8 had diagnostic time more than 2 weeks. The median time of diagnostic was 15 days with range 1 ndash 68 days. Diagnostic delay was correlated with early stage of the diseases, good performance status, financial resource. The median cost of diagnosis was Rp. 13.025.381, with range Rp. 1.083.000, to Rp156.285.000, . Subject who came with late stage, poor performance status, had complication of lung cancer and hospitalized in private area had higher cost of diagnostic. Conclusion Median diagnostic time of lung cancer in RSUP Persahabatan is 15 days range from 1 to 86 days. Diagnostic time correlates with stage at admission, performance status at admission and source of financial. The median cost of diagnosis is Rp. 13.025.381, with range Rp. 1.083.000, to Rp156.285.000, . Cost of diagnosis correlates with stage at admission, performance status at admission, source of financial and complication related with lung cancer."
2016
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UI - Tugas Akhir  Universitas Indonesia Library
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Hasanah
Proporsi tuberkulosis paru pada pasien terduga kanker paru yang menjalani bronkoskopi di RSUP Persahabatan = Proportion of pulmonary tuberculosis in patients who underwent bronchoscopy for suspected lung cancer at Persahabatan Hospital National Respiratory Center
"Latar belakang: Tuberkulosis (TB) dan kanker paru merupakan dua masalah kesehatan dunia dengan angka kematian yang tinggi. Risiko TB meningkat pada pasien dengan keganasan termasuk kanker paru dengan prevalensi 0,7% - 18,7%. Tuberkulosis paru dan kanker paru memiliki gejala yang mirip sehingga diagnosis keduanya sering kali terlambat menyebabkan prognosis yang lebih buruk. Bronkoskopi merupakan suatu tindakan efektif untuk mendiagnosis TB dan kanker paru. Penelitian ini bertujuan untuk mengetahui proporsi TB paru pada pasien terduga kanker paru melalui pemeriksaan tes cepat molekular (TCM) bilasan bronkus.
Metode: Penelitian ini menggunakan metode potong lintang dengan subjek terduga kanker paru yang akan menjalani bronkoskopi di RSUP Persahabatan dan berusia minimal 18 tahun pada periode Maret sampai Juli 2024. Bilasan bronkus dilakukan pemeriksaan TCM menggunakan InaTB-Rif untuk mendiagnosis TB.
Hasil: Sebanyak 104 subjek memenuhi kriteria inklusi dan ekslusi dengan karakteristik usia berada pada median 60 tahun (18-80 tahun), jenis kelamin laki-laki (61,5%), status gizi baik dengan indeks massa tubuh normal (60,6%), memiliki riwayat merokok (54,8%) dan bekas TB (21,2%). Subjek penelitian yang memiliki komorbid paling banyak adalah diabetes melitus (DM) tipe 2 yaitu 20,2%. Sebagian besar mengeluhkan batuk, gambaran radiologi mayoritas tampak massa dan kompresi serta massa infiltratif pada temuan bronkoskopi. Proporsi TB paru pada pasien yang menjalani bronkoskopi dengan terduga kanker paru yaitu 22,12% dengan dua pasien terdeteksi resisten rifampisin (8,67%). Analisis bivariat menunjukkan bahwa fibrosis dan ratio neutrofil limfosit memiliki hubungan yang bermakna secara statistik dengan hasil TCM.
Kesimpulan: Diagnosis TB pada pasien terduga kanker paru perlu dipertimbangkan terutama pada negara dengan beban TB yang tinggi seperti Indonesia sehingga tata laksana dapat diberikan secara optimal.
Background: Tuberculosis (TB) and lung cancer are two global health problems with high mortality rates. The risk of TB increases in patients with malignancies including lung cancer with a prevalence ranging from 0.7% to 18.7%. Pulmonary tuberculosis and lung cancer have similar symptoms, often leading to delayed diagnosis and resulting in a worse prognosis. Bronchoscopy is an effective procedure for diagnosing TB and lung cancer. This study aims to determine the proportion of pulmonary TB in suspected lung cancer patients through the examination of bronchial washing using a rapid molecular test (RMT).
Method: This was a cross-sectional study with suspected lung cancer patients who would undergo bronchoscopy at Persahabatan Hospital National Respiratory Center and at least 18 years old in the period from March to July 2024. Bronchial washing was examined by RMT using InaTB-Rif to diagnose TB.
Results: A total of 104 subjects met the inclusion and exclusion criteria, with a median age of 60 years (range 18 to 80 years), predominantly were male (61.5%), and demontrated good nutritional status with a normal body mass index (60.6%), had a history of smoking (54.8%), and former TB (21.2%). The most common comorbidity among the subjects was type 2 diabetes mellitus, accounting for 20.2%. Most participants reported cough and radiological findings predominantly revealed masses, compression, and infiltrative masses in bronchoscopy results. The proportion of pulmonary tuberculosis in patients who underwent bronchoscopy for suspected lung cancer was 22.12%, with two patients detected as resistant to rifampicin (8.67%). Bivariate analysis revealed that fibrosis and neutrophil-lymphocyte ratio had a statistically significant with RMT.
Conclusion: The diagnosis of tuberculosis in suspected lung cancer patients needs to be considered especially in high TB burden countries such as Indonesia so the management could be given optimally."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tugas Akhir  Universitas Indonesia Library
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Hera Afidjati
Faktor risiko yang berhubungan dengan terjadinya kanker paru pada perempuan di RSUP Persahabatan = Risk factors associated with the occurence of lung cancer in women in Persahabatan Hospital
"ABSTRAK
Kanker paru merupakan penyebab kematian terbanyak kedua karena kanker pada perempuan di Indonesia dan insidensinya terus meningkat dari tahun ke tahun. Penyebab utama kanker paru adalah merokok, namun hal ini tidak berlaku pada perempuan, terutama di Asia dan Indonesia. Kanker paru terjadi karena multifaktor, dan sekitar 10 -15 kasus kanker paru di dunia dijumpai pada bukan perokok. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berkaitan dengan terjadinya kanker paru pada perempuan di RSUP Persahabatan. Penelitian ini menggunakan desain kasus kontrol dan melibatkan 46 subjek pada kelompok kasus serta 62 subjek pada kelompok kontrol di Poli Paru RSUP Persahabatan. Hasil analisis bivariat menunjukkan bahwa terdapat hubungan yang bermakna antara perokok pasif p=0,038; OR=2,613; 95 CI: 1,038-6,575 dan usia p=0,002; OR=5,378; 95 CI: 1,698-17,029 . Tidak terdapat hubungan yang bermakna antara perilaku merokok p = 0,569; OR = 0,889; 95 CI: 0,236-3,351 , riwayat kanker di keluarga p = 0,858; OR = 0,917; 95 CI: 0,354-2,373 , dan riwayat penyakit paru kronis p = 0,231; OR = 0,508; 95 CI: 0,165-1,560 terhadap kejadian kanker paru pada perempuan. Dari analisis multivariat didapatkan bahwa terdapat hubungan bermakna antara perokok pasif p=0,047; aOR=2,639; 95 CI: 1,012-6,878 dan usia p=0,005; aOR=5,417; 95 CI: 1,685-17,412 . Dari hasil tersebut dapat disimpulkan bahwa usia di atas 40 tahun dan perokok pasif merupakan faktor yang paling berhubungan dengan terjadinya kanker paru pada perempuan.
ABSTRACT
Lung cancer is the second leading cause of cancer specific death among women in Indonesia and the incidence increases continuously from year to year. The main cause of lung cancer is smoking, but it is unlikely occured in women, especially in Asia and Indonesia. Lung cancer is caused by multifactor, and about 10 15 of lung cancer in the world are found in nonsmokers. This study aims to determine the risks factors associated with the occurence of lung cancer in women in Persahabatan Hospital. A case control study was done and involved 46 subjects with lung cancer as well as 62 subjects with no lung cancer at Poli Paru Persahabatan Hospital. The result of bivariate analysis showed that there is a significant association between passive smoker p 0.038, OR 2.613 95 CI 1.038 6.575 and age p 0.002 OR 5.378 95 CI 1.698 17.029 . There are no significant association between active smoking p 0.569 OR 0.889 95 CI 0.236 3.351 , family history of cancer p 0.858 OR 0.917 95 CI 0.354 2.373 , and history of chronic lung disease p 0.231 OR 0.508 95 CI 0.165 1.560 with lung cancer in women. From multivariate analysis, it was found that there was a significant association between passive smoker p 0.047, aOR 2.639, 95 CI 1.012 6.878 and age p 0.005 aOR 5.417 95 CI 1.685 17.412 . From these results it can be concluded that age above 40 years and passive smoker are the factor most associated with the occurrence of lung cancer in women."
2017
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UI - Skripsi Membership  Universitas Indonesia Library
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Aulya Fairuz
Faktor-faktor risiko kejadian kanker paru pada laki-laki bukan perokok di RSUP Persahabatan = Risk factors of lung cancer in male never-smokers in RSUP Persahabatan
"ABSTRAK
Kanker paru merupakan salah satu jenis kanker yang paling membunuh di dunia, dengan 1,8 juta kasus dan 1,59 juta kematian pada tahun 2012. Proporsinya pun lebih banyak pada laki-laki. Walaupun rokok adalah faktor penyebab utama kanker paru, sekitar 25 kasus kanker paru di dunia tidak disebabkan oleh perilaku merokok. Di Asia Tenggara sendiri, diperkirakan sekitar 50 kejadian kanker paru terjadi pada bukan perokok. Penelitian ini berusaha mencari tahu faktor-faktor risiko kanker paru pada laki-laki bukan perokok. Studi kasus-kontrol dilakukan dengan melibatkan 45 subjek: 27 subjek kelompok kasus dan 18 subjek kelompok kontrol. Hasil uji bivariat menunjukkan adanya hubungan antara environmental tobacco smoke ETS OR=6,914; CI 1,78-26,853 dan riwayat kanker pada keluarga OR=8,5;CI 0,971 ndash; 74,424 dengan kejadian kanker paru pada laki-laki bukan perokok. Analisis multivariate menunjukkan adanya hubungan dengan peningkatan risiko kanker paru baik faktor ETS maupun riwayat kanker pada keluarga, dengan ETS menjadi faktor yang paling berpengaruh dimana individu yang terekspos pada ETS memiliki kemungkinan 8,479 kali lebih besar berisiko kanker paru dibandingkan yang tidak.
ABSTRACT
Lung cancer is one of world rsquo s deadliest cancer, with 1,8 million new cases and 1,59 million deaths caused by lung cancer in 2012. Lung cancer is also known to be more prevalent in males than in females. Although active smoking is already known to have causative relationship with lung cancer, about 25 of lung cancer cases worldwide are not associated with active smoking. In Southeast Asia, approximately 50 of lung cancer cases are thought to have nothing to do with active smoking. This study was aimed to find the risk factors of lung cancer in male never smokers. This study is a case control study with 45 subjects in total 27 with lung cancer and 18 with no lung cancer. Results from bivariate analysis showed that environmental tobacco smoke ETS OR 6,914 CI 1,78 26,853 and family history of cancer OR 8,5 CI 0,971 ndash 74,424 were associated with increased risk in lung cancer in male never smokers. Multivariate analysis showed both ETS and family history of lung cancer were associated with risk of lung cancer in male never smokers, with ETS being the most associated factor having individuals with expousure to ETS to have 8,479 more likely odds of developing lung cancer."
2017
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UI - Skripsi Membership  Universitas Indonesia Library
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