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"Drawing on the author's collective experience of over 75 years, this book accurately and easily breaks down the latest soy research, details how using soy can markedly improve your health, and includes dozens of delicious, easy recipes guaranteed to make you a soy lover! no matter how much you may have heard about soy, this book will provide answers to all your questions concerning soy's health benefits, safety and proper use"

"This manual for women gives an in-depth holistic approach to herbal treatments. Over 70 different herbs and their uses are described. A ready reference to diet, nutrition, essential oils, Bach Flower Remedies, and a chart for matching herbs with ailments are also included."

"This self-help text for women offers natural strategies for combatting the physical and emotional stresses of modern life. It explores the whole care of mind, body and spirit and offers herbal treatment plans for a comprehensive range of physical ailments and emotional crises."

"Latar Belakang: Sel punca kanker merupakan populasi sel minor yang memiliki kemampuan self-renewal dan proliferasi tak terbatas sehingga bersifat tumorigenik dan diduga berperan dalam penurunan sensitivitas terhadap berbagai terapi kanker. Tamoksifen merupakan terapi lini pertama pada kanker payudara ER positif namun penggunaan jangka panjangnya menimbulkan masalah resistensi. Beberapa faktor yang diduga berperan dalam penurunan sensitivitas sel terhadap Tamoksifen yakni modulasi pensinyalan estrogen melalui ER?66; dan ER?36 (yang diketahui memperantarai pensinyalan non-genomik), serta ekspresi transporter effluks seperti MRP2 yang berperan dalam penurunan kadar Tamoksifen intraseluler. Penelitian ini bertujuan untuk menganalisis efek pemaparan Tamoksifen berulang pada sel punca kanker payudara CD24-/CD44+, dalam kaitannya mengenai sensitivitas terapi melalui perubahan ekspresi estrogen reseptor alfa dan transporter efluks MRP2.Metode: Selpunca kanker payudara CD24-/CD44+ dipaparkan Tamoksifen 1 ?M selama 21 hari dengan DMSO sebagai kontrol negatif. Viabilitas sel setelah pemaparan Tamoksifen diuji dengan metode trypan blue exclusion. Sifat tumorigenik sel setelah pemaparan (CD24-/CD44+(T)) diuji dengan mammossphere formation assay dan dibandingkan dengan sel CD24-/CD44+(0) yang belum dipaparkan Tamoksifen. Ekspresi mRNA Oct4, c-Myc, ER?66, ER?36 dan MRP2 dianalisis dengan one step quantitative RT-PCR.Hasil: Terjadi penurunan sensitivitas sel punca kanker payudara CD24-/CD44+(T) yang dipaparkan Tamoksifen selama 21 hari yang ditunjukkan dengan kenaikan viabilitas sel hingga 125,2%. Tamoksifen tidak dapat menekan sifat tumorigenik sel CD24-/CD44+(T) yang dibuktikan melalui jumlah mammosfer yang tidak berbeda bermakna dibandingkan dengan CD24-/CD44+(0). Penurunan sensitivitas sel CD24-/CD44+(T) juga dibuktikan melalui peningkatan ekspresi Oct4 dan c-Myc; keduanya merupakan petanda pluripotensi dan c-Myc juga dikenal sebagai petanda keganasan. Parameter penurunan sensitivitas seperti ER?66, ER?36 dan MRP2 juga menunjukkan peningkatan ekspresi pada hari ke-15 namun menurun kembali pada hari ke-21 yang menunjukkan adanya mekanisme regulasi lain yang mungkin terlibat dalam penurunan sensitivitas sel punca kanker payudara terhadap Tamoksifen.Kesimpulan: Pemaparan Tamoksifen berulang dapat menurunkan sensitivitas sel punca kanker payudara CD24-/CD44+ melalui perubahan ekspresi estrogen reseptor alfa dan transporter efluks MRP2.

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Background: Cancer stem cells are minor population of cells possessing self-renewal and unlimited proliferation abilities which support their tumorigenicity and role in decreased sensitivity to many cancer therapies. Tamoxifen is a first line therapy for breast cancer patients with positive ER status. Nonetheless, after 5 years of its long term use eventually leads to recurrence and resistance in 50% of patients receiving tamoxifen therapy. Among some factors that might play role in decreased sensitivity to tamoxifen are modulation of estrogen signaling through ER?66 and ER?36 (the latter known for its non-genomic estrogen signaling), and expression of efflux transporter such as MRP2 responsible for decreased intracellular tamoxifen level. The objective of this study is to analyze the effects of long term tamoxifen exposure toward decreased sensitivity of the breast cancer stem cells CD24-/CD44+ through changes in expression of estrogen receptor alpha and efflux transporter MRP2.

Methods: Breast cancer stem cells CD24-/CD44+ were exposed to 1 ?M tamoxifen for 21 days with DMSO as negative control. After exposure with 1 ?M tamoxifen, the cell viability were tested by the trypan blue exclusion method. Cell tumorigenicity of tamoxifen-exposed CD24-/CD44+(T) and CD24-/CD44+(0) (before treatment) were tested by the mammosphere formation assay. The expression of Oct4, c-Myc, ER?66, ER?36 andMRP2 mRNAs were analyzed by one step quantiative RT-PCR.

Results: A decreased sensitivity of the breast cancer stem cells CD24-/CD44+ exposed with 1 ?M tamoxifen for 21 days was observed as indicated by an increased cell viability up to 125.2%. In the presence of tamoxifen, breast cancer stem cells CD24-/CD44+(T) exhibited tumorigenic properties as indicated in no significant difference in the formation of mammosphere unit compared to those of CD24-/CD44+(0). After exposure with 1 ?M tamoxifen for 21 days, an elevated level of Oct4 and c-Myc expressions were observed; both are known as pluripotency markers and the latter also known as marker of aggresiveness. Parameters for a decreased sensitivity such as ER?66, ER?36 and MRP2 also exhibited an elevated expression after 15 days of exposure, but the decreased expression after 21 days of exposure suggests that there might be another mechanism involved in decreased sensitivity of the breast cancer stem cells toward tamoxifen.

Conclusion: Long term tamoxifen exposure may decrease the sensitivity of the breast cancer stem cells CD24-/CD44+ through changes in expression of estrogen receptor alpha and efflux transporter MRP2."

"Pendahuluan: Asam galat adalah salah satu senyawa aktif yang dapat menyebabkan apoptosis pada sel kanker paru manusia. Aktivitas antikanker paru yang mengesankan dari asam galat mendorong dilakukannya penelitian untuk menguji aktivitas sitotoksik senyawa turunan asam galat (alkil amida galat) terhadap sel kanker paru A549. Metode: Enam senyawa alkil amida galat hasil sintesis, yaitu Senyawa metil amida galat, etil amida galat, butil amida galat, sek-butil amida galat, ters-butil amida galat, dan heksil amida galat diuji aktivitas sitotoksiknya terhadap sel kanker paru A549 dengan metode MTT Proliferation assay. Data yang dihasilkan dianalisa menggunakan analisis regresi linear untuk mendapatkan nilai IC50. Hasil uji aktivitas sitotoksik senyawa alkil amida galat hasil sintesis dibandingkan dengan hasil uji aktivitas sitotoksik asam galat sebagai senyawa asli dan doxorubicin selaku kontrol positif. Hasil: Jika dibandingkan dengan asam galat (IC50: 23.2 μM) dan doxorubicin (IC50: 31.1 μM), keenam senyawa alkil amida galat, yaitu metil amida galat, etil amida galat, butil amida galat, sek-butil amida galat, ters-butil amida galat, dan heksil amida galat memperlihatkan sitotoksisitas yang lebih kuat terhadap sel kanker paru A549 dengan nilai IC50 berkisar dari 5.4 μM hingga 30.0 μM. Kesimpulan: Enam senyawa alkil amida galat berpotensi dikembangkan lebih lanjut sebagai agen antikanker paru.

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Objective: Gallic acid has shown its potential to induce apoptosis in lung cancer cells. Its impressive anti-lung cancer agent prompted us to conduct research that is aimed to evaluate six alkyl amide derivatives of gallic acid against lung cancer A549 cells.

Methods: six synthesized compounds of alkyl amide gallate, which are methyl amide gallate, ethyl amide gallate, butyl amide gallate, sec-butyl gallate, ters-butyl gallate and hexyl amide gallate, will be evaluated their cytotoxicities agains lung A549 cells by MTT Proliferation assay. Linear regression analysis is used to analyzed the data to generate IC50 value. Cytotoxicity results of alkyl amide gallates will be compared with cytotoxicity result of gallic acid as an original compound and with doxorubicin as positive control.

Results: Compared with gallic acid (IC50 23.2 μM) and doxorubicin (IC50 31.1 μM), six derivatives of aklyl amide gallates (methyl-, butyl-, sec-butyl-, ters- butyl, and hexyl amide gallate) shows better cytotoxic activity against lung A549 cells, with IC50 value range from 5.4 μM to 30.0 μM.

Conclusion: Six compounds of Alkyl amide gallate could be further developed as anti-lung cancer agent."

"Pengaruh medan listrik terhadap sel kanker ada dua macam yaitu menghambat pertumbuhan tumor dan menghancurkan sel kanker yang sedang mengalami pembelahan. Penelitian ini menggunakan Electro Capacitive Cancer Treatment (ECCT) vest tipe A dan tipe B dengan frekuensi 50 - 500 KHz dari sumber arus listrik bolak-balik dengan tegangan 2,4 ? 3 V. Pemberian medan listrik dilakukan secara in vivo selama 16 jam secara kumulatif terhadap pasien bersel kanker payudara stadium II dengan atau tanpa metastase ke axilla dengan posisi sel kanker di lima kuadran yang berbeda pada payudara, yaitu medial superior, medial inferior, central, lateral superior dan lateral inferior. Hasil penelitian menunjukkan bahwa alat terapi Electro Capacitive Cancer Treatment sangat efektif untuk menghambat pembelahan sel kanker dan membunuh sel kanker yang terletak pada kuadran lateral superior.

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AbstractThe influence of an electric field of cancer cell there are two kinds of which inhibits tumor growth and destroy cancer cells that are undergoing fission. This research uses Electro Capacitive Cancer Treatment (ECCT) vest type A and type B with frequency of 50 - 500 KHz of the electric current source back and forth with voltage 2,4 - 3 volt. Award of the electrical field conducted in in vivo for 16 hours cumulatively on patients with breast cancer-celled ferocity stadium level II with or without metastase to the axilla to the position of cancer cells in five different quadrants of breast medial superior, inferior, medial, central, lateral superior and inferior lateral. The results showed that Electric therapy very effective Capacitive Cancer Treatment to inhibit cell division and cancer kill cancer cells that are located on the superior lateral quadrant."

"ABSTRAKIndonesia adalah negara dengan jumlah perokok tertinggi di Asia Tenggara. Perokok perempuan di Indonesia mengalami peningkatan. Merokok pada perempuan memiliki banyak dampak pada kesehatan seperti risiko terkena penyakit kronis, penyebab kematian hingga menambah beban masalah kesehatan masyarakat Indonesia di masa yang akan datang. Penelitian ini bertujuan untuk melihat gambaran perokok perempuan di Indonesia tahun 2012 dan faktor-faktor apa saja yang berhubungan denganya yang bersifat kuantitatif dengan desain studi potong lintang menggunakan analisis chi-square dan regresi logistik sederhana. Populasi pada penelitian ini adalah wanita usia subur usia 19-49 tahun di Indonesia tahun 2012 yang berjumlah 45.607 responden dengan jumlah sampel 44.501 responden yang datanya lengkap dan menggunakan data sekunder yaitu data SDKI tahun 2012.Hasil penelitian menemukan bahwa ada hubungan yang signifikan secara statistik antara umur, status pendidikan, wilayah tempat tinggal, status pekerjaan, status perkawinan, dan paparan media massa dengan perilaku merokok responden. Responden umur 45-49 tahun memiliki POR 95 CI = 3,272 2,693-3,975 , tidak sekolah dengan POR 95 CI = 9,321 7,123-12,198 dan kuintil kekayaan terbawah POR 95 CI = 2,542 2,091-3,091 terhadap perilaku merokok.

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ABSTRAKIndonesia is the country with the highest number of smokers in Southeast Asia. Female smokers in Indonesia have increased. Smoking in women has many health effects such as the risk of chronic illness, the cause of death so that it can increase the burden of health problems of Indonesian society in the future. This study aims to examine the description of female smokers in Indonesia in 2012 and what factors relate to them that are quantitative with cross sectional study design using chi square analysis and logistic regression. The population in this study were women aged 19 49 years old in Indonesia in 2012 which amounted to 45,607 respondents with a total sample of 44,501 respondents whose data is complete and using secondary data SDKI 2012. The results of the study found that there was a statistically significant relationship between age, education status, residence area, employment status, marital status, and exposure to mass media with respondents 39 smoking behavior. Respondents age 45 49 years have POR 95 CI 3,272 2,693 3,975 , not school with POR 95 CI 9,321 7,123 12,198 and lowest wealth quintile POR 95 CI 2,542 2,091 3,091 to smoking behavior."

"Pasien kanker yang sedang menjalani pengobatan berupa kemoterapi sering sekali mengalami nyeri dan kecemasan. Penelitian ini bertujuan untuk mengidentifikasi pengaruh akupresur terhadap nyeri dan kecemasan akibat kemoterapi pada pasien kanker payudara di RSUD Jend. Ahmad Yani Kota Metro Lampung. Penelitian ini menggunakan desain Randomized Controlled Trial (RCT) dengan randomisasi alokasi yang menggunakan cara randomisasi blok. Sampel dalam penelitian ini berjumlah 48 responden yang dibagi menjadi 24 responden kelompok intervensi yang mendapatkan perlakuan akupresur pada titik LI4, LR3, PC6 dan ST 36. Selanjutnya 24 responden kelompok kontrol yang mendapatkan perlakuan akupresur pada titik placebo. Semua kelompok tetap mendapatkan terapi standar. Hasil penelitian menunjukkan penurunan rata-rata nyeri dan kecemasan setelah akupresur pada kelompok intervensi lebih tinggi secara bermakna dibandingkan kelompok kontrol (p value 0,001). Penelitian ini merekomendasikan bahwa akupresur merupakan salah satu terapi komplementer yang dapat diterapkan untuk membantu menangani permasalahan nyeri dan kecemasan.

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Cancer patients who are undergoing chemotherapy often experience pain and anxiety. This study aims to identify the effect of acupressure on pain and anxiety due to chemotherapy in breast cancer patients at RSUD Jend. Ahmad Yani, Metro City, Lampung. This study used a Randomized Controlled Trial (RCT) design with randomized allocation using block randomization. The sample in this study is 48 respondents who were divided into two groups, group one 24 respondents in the intervention who received acupressure treatment at the LI4, LR3, PC6 and ST 36 points, and another 24 respondents in the control group received acupressure treatment at the placebo point. All groups continued to receive standard therapy. The results showed that the average reduction in pain and anxiety after acupressure in the intervention group was significantly higher than the control group (p value 0.001). This study recommends that the complementary therapies: acupressure can be applied to decrease pain and anxiety level"