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"Latar belakang : Penyakit periodontal disebabkan oleh akumulasi plak mengandung kumpulan mikroorganisme patogen yang memicu respons imun host, menyebabkan pelepasan mediator inflamasi. Peradangan jaringan periodontal yang bersifat kronis menyebabkan inflamasi sistemik derajat rendah dan peningkatan kadar sitokin, seperti Interleukin 1 Beta (IL-1β). Respons imun yang konstan terhadap antigen terus menerus terjadi pada penderita long Covid. Terdapat persamaan respons inflamasi menunjukkan potensi hubungan antara periodontitis dengan infeksi COVID-19. Evaluasi parameter klinis periodontal subjek dengan dengan dan tanpa riwayat COVID-19 memberikan pemahaman dampak COVID-19 terhadap kesehatan periodontal Tujuan: Menganalisis hubungan penyakit periodontal dan riwayat COVID-19 dengan parameter klinis periodontal dan kadar sitokin IL-1β. Metode : Subjek penelitian berjumlah 36 orang terbagi menjadi tiga kelompok yaitu sehat periodontal, gingivitis dan periodontitis dengan parameter klinis periodontal yang diperiksa yaitu kehilangan perlekatan klinis / CAL, indeks plak / PI, perdarahan papila interdental / PBI dan gingival index (GI). Peneliti menganalisis hasil perbandingan nilai CAL, PI, PBI, dan GI pada subjek penyakit periodontal dengan riwayat COVID-19 dan kadar interleukin dengan ELISA. Hasil: Terdapat perbedaan subjek sehat, dan subjek penyakit periodontal dengan parameter klinis periodontal CAL, PI, PBI, GI yang signifikan (p<0.05). Kecenderungan peningkatan parameter klinis periodontal CAL, PI, PBI, GI sesuai keparahan penyakit periodontal. Subjek riwayat COVID-19 memiliki kadar sitokin IL-1β lebih tinggi dibandingkan tanpa riwayat (p<0.05). Terdapat hubungan parameter klinis Gingival Index (GI) pada subjek Gingivitis dan PBI dengan kadar sitokin IL-1β pada subjek riwayat COVID-19. Kesimpulan: Terdapat hubungan penyakit periodontal dan riwayat COVID- 19 dengan parameter klinis periodontal dan kadar sitokin IL-1β. Studi ini menunjukkan bahwa penyakit periodontal merupakan faktor resiko keparahan dari infeksi COVID dan sebaliknya.

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Background: Periodontal disease, including gingivitis and periodontitis, is caused by the

accumulation of plaque containing a group of pathogenic microorganisms that trigger the

host's immune response, leading to the release of inflammatory mediators. Chronic

inflammation of the periodontal tissues causes low-grade systemic inflammation and an

increase in cytokine levels, such as Interleukin 1 Beta (IL-1β). Constant immune

responses to continuous antigen exposure occur in individuals with long Covid. The

similarity in inflammatory responses indicates a potential connection between

periodontitis and COVID-19 infection. Evaluating the clinical parameter periodontal of

subjects with and without a history of COVID-19 provides insights into the impact of

COVID-19 on periodontal health Objective: To analyze the relationship between

periodontal disease and a history of COVID-19 with clinical parameter periodontal and

IL-1β cytokine levels. Methods: The study included 36 participants divided into three

groups: a healthy periodontal group, a gingivitis group, and a periodontitis group. The

clinical parameter periodontal was assessed using clinical attachment loss (CAL), plaque

index (PI), papillary bleeding index (PBI), and gingival index (GI). The researcher

analyzed the mean values of CAL, PI, PBI, and GI in patients with periodontal disease,

considering their history of COVID-19 and interleukin levels using ELISA. Result:

Significant differences were found between subjects with healthy clinical parameter

periodontal and those with periodontal disease, as indicated by the values of CAL, PI,

PBI, and GI (p <0.05). There was a trend of increasing CAL, PI, PBI, and GI values in

line with the severity of periodontal disease. Subjects with a history of COVID-19 showed

higher levels of IL-1β cytokine compared to those without a history (p <0.05). There was

a relationship between clinical parameter periodontal (Gingival Index - GI) in subjects

with gingivitis and PBI with the IL-1β cytokine levels in subjects with a history of

COVID-19. Conclusion: There is relationship between periodontal disease and a history

of COVID-19 with clinical parameter periodontal and IL-1β cytokine levels. This study

suggests that periodontal disease is a risk factor for the severity of COVID-19 infection."

"Latar Belakang: Periodontitis merupakan faktor risiko terjadinya Penyakit Jantung Koroner (PJK). Interleukin-1β merupakan sitokin pro-inflamasi utama yang dapat ditemukan pada kedua penyakit ini. Tujuan: Menganalisis hubungan kadar interleukin-1β dalam cairan sulkus gingiva (CSG) penderita PJK dan non PJK dengan status periodontal. Metode: Pemeriksaan klinis 40 subjek PJK dan 40 subjek non PJK, pemeriksaan laboratorium kadar Interleukin-1β dengan ELISA. Hasil : Tidak terdapat perbedaan bermakna Interleukin-1β antara penderita PJK dan non PJK (p>0,05); tidak terdapat perbedaan bermakna antara kadar Interleukin-1β dengan status periodontal penderita PJK dan non- PJK (p>0,05). Kesimpulan: Kadar Interleukin-1β penderita PJK tidak memiliki hubungan dengan status periodontal.

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Background: Periodontitis is a risk factor for coronary heart disease. Interleukin-1β as a pro-inflammatory main cytokine, can be found in this both diseases.

Objective: To analyze the relationship of interleukin-1β levels in CSG CHD and non-CHD patients with periodontal status.

Methods: Clinical Examination for 40 Subject CHD and 40 controls was checked, laboratory test for measured the levels of Interleukin-1β with ELISA.

Results: There were no significant differences between patients Interleukin-1β CHD and non-CHD (p>0.05); there is no significant difference between the levels of Interleukin-1β with periodontal status CHD and control patients (p>0.05).

Conclusions: Levels of Interleukin-1β of CHD patients do not have a relationships with periodontal status."

"ABSTRAKStres faktor risiko penyakit periodontal, yang meningkatkan kadar interleukin-1β yang berperan pada kerusakan jaringan periodontal.Tujuan : analisis hubungan antara stres akademik terhadap kondisi jaringan periodontal dan kadar interleukin-1β dalam cairan krevikular gingiva.Metode : 38 orang subjek mengisi kuasioner GDES, pemeriksaan klinis, pemeriksaan laboratorium kadar interleukin-1β dengan ELISA.Hasil : Terdapat perbedaan bermakna antara tingkatan stres akademik dengan kondisi jaringan periodontal dan kadar interleukin-1β (p<0,05); tidak terdapat perbedaan bermakna antara kadar interleukin-1β dengan kondisi jaringan periodontal (p>0,05).Kesimpulan : Stres faktor risiko penyakit periodontal dengan peningkatan kadar interleukin-1β

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ABSTRACT

Background: Stress is a risk factor for periodontal disease, with increase levels of interleukin-1β that act for periodontal destruction.

Objective: To analyze the relationship between academic stress in dental specialist programme in Dentistry on periodontal tissue conditions and levels of interleukin-1β in gingival fluid krevikular.

Methods: 38 subjects fill the quasioner GDES, periodontal examination and laboratorium examination of interleukin-1β with the ELISA test.

Results: Significant differences between academic stress to periodontal tissue and levels of interleukin-1β (p<0,05); no significant differences between levels of interleukin-1β to periodontal tissues (p>0,05).

Conclusion: Stress is periodontal risk factor with elevated levels of interleukin-1β"

"Latar Belakang: Kerusakan jaringan periodontal terjadi karena inflamasi terhadap invasi bakteri. Human beta defensin-1 adalah peptida antimikroba dan pertahanan pertama terhadap infeksi.Tujuan Penelitian: Membandingkan kadar ekspresi HBD-1 antara kelompok periodontitis kronis, periodontitis agresif dan normalBahan dan Metode: Kadar HBD-1 dari 94 sampel CKG subjek periodontitis kronis, periodontitis agresif dan normal diukur dengan ELISAHasil: Analisis Mann-Whitney menunjukkan perbedaan kadar HBD-1 antara periodontitis kronis dengan normal (p<0,05) dan tidak terdapat perbedaan signifikan (p>0,05) antara periodontitis agresif dengan normal, dan antara periodontitis kronis dengan periodontitis agresif.Kesimpulan: Kadar HBD-1 pada CKG menurun pada kondisi periodontitis kronis dan periodontitis agresif.

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Background: Periodontal disease is happened because inflammation reaction ro bacterial invasion. Human beta defensin-1 (HBD-1) is antimicroba peptide which regulate the first defense mechanism.

Objectives: To compare level of HBD-1 between chronic periodontitis, aggressive periodontitis, and normal group.

Material and Methods: Level of HBD-1 from GCF sample of chronic periodontitis, aggressive periodontitis, and normal group were assessed with ELISA.

Results: Mann-Whitney analysis show different level of HBD-1 expression between chronic periodontitis and normal (p<0,05) and there was no significant difference (p>0,05) between aggressive periodontitis and normal, and between chronic periodontitis and aggressive periodontitis.

Conclusion: Level of HBD-1 in GCF decreased in chronic periodontitis and aggressive periodontitis."

"Latar belakang: Periodontitis merupakan interaksi kompleks antara sitokin pro-inflamasi dan sitokin anti-inflamasi. Sitokin anti-inflamasi seperti IL-4 pada cairan krevikular gingiva (CKG) dapat menjadi biomarker penyakit periodontal.Tujuan Penelitian: Menganalisis perbedaan kadar IL-4 dalam CKG penderita periodontitis kronis dan periodontitis agresif.Metode dan Bahan: Sampel CKG dikumpulkan dari pasien normal (n=21), periodontitis kronis (n=38) dan periodontitis agresif (n=35) dan dilakukan analisis kadar IL-4 dengan menggunakan ELISA.Hasil: Terdapat perbedaan kadar IL-4 antara periodontitis kronis dengan normal dan antara periodontitis agresif dengan normal (p=0,000). Tidak ada perbedaan kadar IL-4 (p=0,729) antara periodontitis kronis (14,73±0,32 pg/ml) periodontitis agresif (20,58±23,00 pg/ml).Kesimpulan: Kadar IL-4 menurun pada kondisi inflamasi, baik pada periodontitis kronis ataupun periodontitis agresif.

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Background: Periodontitis is a complex interaction between pro-inflammatory and anti-inflammatory cytokine. IL-4 is an anti-inflammatory cytokine in GCF that can be used as a periodontal biomarker.

Objectives: To compare level of IL-4 in GCF of chronic periodontitis and aggressive periodontitis.

Material and Methods: GCF sample were collected from normal (n=21), periodontitis chronic (n=38) and aggressive periodontitis (n=35) group and analysis of level IL-4 was performed with ELISA.

Results: There was a difference level of IL-4 between chronic periodontitis with normal and between aggressive periodontitis with normal (p=0,000). There was no difference level of IL-4 (p=0,729) between chronic periodontitis (14,73±0,32 pg/ml) and aggressive periodontitits (20,58±23,00 pg/ml).

Kesimpulan: Level of IL-4 was decreased in inflammation condition, either chronic periodontitis or aggressive periodontitis."

"ABSTRAKKondisi stres memiliki efek yang buruk terhadap respon imun, sehingga rentan akan infeksi, termasuk penyakit periodontal. Salah satu biomarker yang dapat mengindikasikan penyakit periodontal adalah interleukin-6 (IL-6). Tiga puluh delapan mahasiswa program profesi FKG UI. Subjek diinstruksikan untuk mengusi kuisioner Dental Environment Stress (DES) dan dilakukan pemeriksaan periodontal dan pengambilan sampel cairan krevikular gingiva serta dianalisis untuk mengetahui kadar IL-6 dengan teknik ELISA. Walaupun uji statistik menunjukkan hubungan yang lemah antara tingkatan stres dengan kondisi periodontal dan kadar IL-6, kondisi klinis menunjukkan kecenderungan perburukan kondisi periodontal seiring peningkatan skor stres.

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ABSTRACTStress conditions have a bad effect on the immune response, leading to an imbalance between the host and the parasite so susceptible to infections, including periodontal disease. One biomarker that can indicate periodontal disease is interleukin-6 (IL-6). Thirty eight samples were instructed to filled the Dental Environment Stress (DES) questionnaire, periodontal examination and gingival crevicular fluid were collected. Although statistical tests showed a weak relationship between stress levels and the periodontal condition levels of IL-6, showed a trend of worsening clinical condition of periodontal conditions with increases in stress scores."

"ABSTRAKZinc Zn merupakan mineral yang terkandung dalam salah satu enzim alkaline phosphatase dalam cairan krevikular gingiva. Volume cairan krevikular gingiva ini diketahui berhubungan berat dengan gingivitis. Gingivitis pada anak disebabkan oleh akumulasi plak dan bakteri. Plak merupakan lapisan di permukaan gigi yang mengandung bakteri. Bakteri Streptococcus mutans S. mutans paling banyak ditemukan di plak dan berkoloni pada permukaan gigi. Penelitian ini dilakukan untuk mengetahui hubungan kadar Zn dalam cairan krevikular gingiva dengan terjadinya gingivitis dan pertumbuhan koloni S. mutans pada anak di wilayah DKI Jakarta. Subyek penelitian berusia 12-14 tahun, sebanyak 30 anak. Sampel penelitian berupa kadar Zn yang terdapat di dalam cairan krevikular gingiva. Kadar Zn diukur dengan menggunakan metode spektofotometri serapan atom. Terdapat hubungan lemah dan tidak bermakna dengan arah korelasi positif antara kadar Zn dalam cairan krevikular gingiva dengan terjadinya gingivitis "hr>""b>ABSTRACT"Zinc Zn is a mineral that is contained in one of the enzyme alkaline phosphatase in gingival crevicular fluid. The volume of gingival crevicular fluid are considered to have a relationship with gingivitis. Gingivitis in children is caused by the accumulation of plaque and bacteria. Plaque is a layer on the surface of the tooth that contains bacteria. Streptococcus mutans S. mutans is the most commonly found on plaque and colonize on the tooth surfaces. This research was conducted to determine relationship Zn levels in gingival crevicular fluid to gingivitis and S. Mutans colony growth in children. Subjects aged 12 14 years old, 30 children. Zn levels were measured using atomic absorption spectrophotometry method. There is weak and no significant relationship with positive correlation between Zn levels in gingival crevicular fluid and gingivitis p"

"ABSTRAKPeningkatan prevalensi penyakit periodontal berhubungan dengan faktor peningkatan usia, jenis kelamin, dan kebiasaan merokok. Data epidemiologi dapat menjadi sumber informasi dalam penyusunan rencana strategis dalam penanganan penyakit periodontal. Tujuan: Menganalisis hubungan penyakit periodontal berdasarkan kelompok usia, jenis kelamin dan kebiasaan merokok di RSKGM FKG UI periode 2010-2015. Metode: Penelitian potong lintang dengan subjek 538 rekam medik. Hasil: Penyakit periodontal yang paling banyak diderita oleh seluruh kelompok usia adalah periodontitis kronis dengan mayoritas pasien wanita dan kebiasaan tidak merokok. Kesimpulan: Uji chi-square menunjukkan.

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ABSTRAKBackground Prevalence of periodontal disease increasing by several factor such as age, gender, smoking habit. Epidemiology data of periodontal disease can be a source to create strategic plan to decrease the prevalence of the disease. Objective analyze relationship of periodontal disease by age, gender and smoking habit in RSKGM FKG UI period 2010 2015. Method The study design is cross sectional using 538 medical records. Result The most common periodontal disease in every age group is chronic periodontitis with majority of women and non smoking habit. Conclusion Chi Square test showed "

"Tubuh akan mengalami penurunan kemampuan menghadapi berbagai stimulus dan stres dari lingkungan saat lansia. Penurunan respons imun merupakan bentuk kemunduran fungsi pada lansia sehingga lansia menjadi lebih rentan terpapar patogen. Periodontitis merupakan penyakit pada jaringan periodontal yang sering terjadi pada lansia. Periodontitis terjadi ketika terdapat interaksi antara respons imun dan patogen. Penelitian ini bertujuan untuk membandingkan status periodontal dan kadar sitokin antara lansia dengan dewasa penderita periodontitis, serta menganalisis hubungan status periodontal dengan kadar sitokin. Subjek penelitian berjumlah 40 orang penderita periodontitis yang terdiri dari 20 lansia dan 20 dewasa. Pengukuran klinis status periodontal mencakup Indeks Plak dan Indeks Perdarahan Papila. Pemeriksaan sitokin mencakup sitokin pro-inflamasi Interleukin 1 Beta (IL-1β), Tumour Necrosis Factor Alpha (TNF-α), dan sitokin anti-inflamasi Interleukin 10 (IL-10) yang diambil dari cairan krevikular gingiva (CKG). Pengambilan CKG diperoleh dari gigi yang memiliki kedalaman poket 5-7 mm. Kadar sitokin IL-1β, IL-10 dan TNF-α dalam CKG diukur menggunakan tes ELISA. Rerata nilai Indeks Plak dan Indeks Perdarahan Papila pada lansia lebih tinggi dibandingkan dengan dewasa. Kadar sitokin pada lansia lebih tinggi pada lansia dibandingkan dewasa, meskipun tidak signifikan secara statistik. Terdapat korelasi yang kuat antara status periodontal dan kadar sitokin dalam CKG. Studi ini menunjukkan penuaan memengaruhi respons peradangan.

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Aging can change the ability to respond to various stimuli and stress. The decreased immune response is a form of deterioration of function in the elderly. Periodontitis is an abnormality of periodontal tissue that often occurs in the elderly. Periodontitis occurs when there is an interaction between the host immune system and the pathogen. The aim of this study is to compare periodontal status and cytokine levels between elderly and adults with periodontitis, and to analyze the relationship between periodontal status and cytokines level. This clinical study examined 40 subjects with periodontitis, consisting of 20 adult and 20 elderly. Clinical measurement of periodontal status included Plaque Index (PlI) and Papilla Bleeding Index (PBI). Cytokines examination included proinflammatory cytokine Interleukin 1 Beta (IL-1β), Tumor Necrosis Factor Alpha (TNF-α), and anti-inflammatory cytokine Interleukin 10 (IL-10) from gingival crevicular fluid (GCF). GCF collection was obtained from teeth with a probing depth of 5-7 mm. Cytokine levels of IL-1β, IL-10 and TNF-α in GCF were quantified using ELISA kits. The mean value of PI and PBI in the elderly was higher than in adults. Cytokine levels in the elderly were higher than in adults, although there was no statistical difference. There was a strong correlation between periodontal status and cytokines level in GCF. This study indicates aging affects the inflammation response."

"Patogenesis terjadinya aterosklerosis pada penyakit jantung koroner telah meluas dari suatu pandangan yang semula etiologi utama karena lemak yang abnormal menjadio proses inflamasi termasuk periodontitis. Tannerella forsythia adalah bakteri negatif Gram, anaerob, berbentuk batang fusiform yang diduga berperan pada kedua penyakit tersebut. Tujuan: Menganalisis perbedaan kuantitatif T.forsythia pada plak gigi dengan status periodontal pada penderita PJK dan non PJK. Metode: 66 pasien PJK dan 40 kontrol diperiksa status periodontal dan diambil sampel plak subgingiva dan kuantitatif T.forsythia dihitung dengan menggunakan metode real time polymerase chain reaction. Hasil: Kuantitatif T.forsythia PJK tidak berbeda dengan non PJK. Tidak terdapat hubungan antara T.denticola dengan perdarahan gingival, kedalaman poket, dan kehilangan perlekatan klinis pada penderita PJK dan non PJK. Kesimpulan: Kuantitatif T.forsythia penderita PJK tidak berbeda dengan penderita non PJK. Kuantitatif T.forsythia tidak berhubungan dengan status periodontal.

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The pathogenesis of the development of atherosclerosis in subjects with coronary heart disease has evolved to the extent where abnormal fat accumulation was no longer the culprit, but rather a certain inflammatory process, including periodontitis. Tannerella forsythia is a Gram-negative anaerobic bacteria, with fusiform rod shape, that has played a role in inducing the development of both diseases. Objective : The aim of this study was to analyze the difference in quantitative measurement of Tannerella forsythia accumulated in the plaque and the periodontal status of subjects with and without coronary heart disease. Tannerella forsythia was counted by utilizing the Real-Time Polymerase Chain Reaction (RT-PCR). Methods: Periodontal status of 66 CHD patients and 40 controls was obtained. Subgingival plaque was isolated. Tannerella forsythia level were measured using real-time PCR. Result: Tannerella forsythia level of CHD patients (-6,29 log10 CFU/ml) was significantly different from control (-19,63 log10 CFU/ml). Tannerella forsythia was not significntly associated with any periodontal status (p<0.05). Conclusion: Tannerella forsythia levels of CHD patients were higher than control. Tannerella forsythia was not associated with any periodontal status."