Latar Belakang: Stres faktor risiko penyakit periodontal, yang meningkatkan kadar interleukin-1β yang berperan pada kerusakan jaringan periodontal. Tujuan: analisis hubungan antara stres akademik terhadap kondisi jaringan periodontal dan kadar interleukin-1β dalam cairan krevikular gingiva. Metode: 38 orang subjek mengisi kuasioner GDES, pemeriksaan klinis, pemeriksaan laboratorium kadar interleukin-1β dengan ELISA. Hasil: Terdapat perbedaan bermakna antara tingkatan stres akademik dengan kondisi jaringan periodontal dan kadar interleukin-1β (p<0,05); tidak terdapat perbedaan bermakna antara kadar interleukin-1β dengan kondisi jaringan periodontal (p>0,05). Kesimpulan: Stres faktor risiko penyakit periodontal dengan peningkatan kadar interleukin-1β

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Background: Stress is a risk factor for periodontal disease, with increase levels of interleukin-1β that act for periodontal destruction.

Objective: To analyze the relationship between academic stress in dental specialist programme in Dentistry on periodontal tissue conditions and levels of interleukin-1β in gingival fluid krevikular.

Methods: 38 subjects fill the quasioner GDES, periodontal examination and laboratorium examination of interleukin-1β with the ELISA test.

Results: Significant differences between academic stress to periodontal tissue and levels of interleukin-1β (p<0,05); no significant differences between levels of interleukin-1β to periodontal tissues (p>0,05).

Conclusion: Stress is periodontal risk factor with elevated levels of interleukin-1β