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"Alarm symptoms for dyspepsia, such as anemia, evidence of gastrointestinal bleeding, weight loss, dysphagia, odynophagia and new onset at age > 50 years are associated with an increase risk of cancer. Most guidelines for the management of dyspepsia emphasize that patients with alarm symptoms should undergo aggressive evaluation including endoscopy.We reported a case of 65 years old female with several alarm symptoms that suggesting of malignancy, but endoscopy finding revealed gastroduodenitis erosive NSAID due to the pain killer herbal medicine use."

"Penelitian ini bertujuan untuk menjelaskan bentuk gastrodiplomasi Jepang di Indonesia melalui program JETRO Japan Food Festival (JFF) 2016, dan menjelaskan pandangan orang Indonesia terhadap gastrodiplomasi Jepang di Indonesia melalui program JETRO JFF 2016. Metode yang digunakan dalam penelitian ini adalah metode kuantitaif dan kualitatif. Teknik pengumpulan data dilakukan dengan cara mengumpulkan data dari buku atau jurnal artikel yang membahas tentang gastrodiplomasi secara umum maupun yang dilakukan oleh Jepang, data hasil wawancara dari perwakilan pihak JETRO Jakarta, dan data melalui penyebaran angket sebagai data primer.Berdasarkan hasil analisis data, gastrodiplomasi Jepang melalui program JETRO, yakni JFF 2016 ini disimpulkan sebagai bentuk keseriusan/kesungguhan pemerintah Jepang dalam melaksanakan gastrodiplomasi, dengan acara ini akan ada atau banyak restoran Jepang di Indonesia. Pandangan orang Indonesia terhadap gastrodiplomasi Jepang melalui program JETRO JFF 2016 adalah belum banyak orang Indonesia, khususnya di wilayah Jabodetabek yang mengetahui washoku dan wagashi yang dijual di JFF 2016. Orang Indonesia lebih memilih untuk menikmati washoku dan wagashi di restoran Jepang di wilayah Jabodetabek, khususnya yang ada di dalam mall. Selain itu, gastrodiplomasi juga dapat meningkatkan softpower atau pandangan yang baik tentang Jepang dan minat untuk berwisata ke Jepang, serta dapat meningkatkan penjualan ekspor bahan-bahan dari Jepang ke restoran yang ada di Indonesia

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This study aims to explain the form of Japanese gastrodiplomacy in Indonesia through the JETRO Japan Food Festival (JFF) 2016 program, and to explain the views of Indonesians on Japanese gastrodiplomacy in Indonesia through the JETRO JFF 2016 program. The methods used in this research are quantitative and qualitative methods. The data collection techniques are carried out by collecting data from books or journal articles that discuss gastrodiplomacy in general and those carried out by Japan, data from interviews from representatives of JETRO Jakarta, and carried out by distributing questionnaires as primary data.

Based on the results of data analysis, Japanese gastrodiplomacy through the JETRO program, namely JFF 2016, is concluded as a form of seriousness of the Japanese government in carrying out gastrodiplomacy, with this event there will be or many Japanese restaurants in Indonesia. The view of Indonesians on Japanese gastrodiplomacy through the JETRO JFF 2016 program is that not many Indonesians, especially in the Jabodetabek area, known that washoku and wagashi are sold at JFF 2016. Indonesians prefer to eat washoku and wagashi at Japanese restaurants in the Jabodetabek area, especially those in the malls. Therefore the Japanese government made a Japanese food expo with the aim of opening a Japanese restaurant in Jabodetabek due to the high number of Jabodetabek people eating washoku and wagashi in Japanese restaurants, especially those in malls. In addition, gastrodiplomacy can also increase softpower or a good view of Japan and interest in traveling to Japan, and can increase export sales of Japanese ingredients to restaurants in Indonesia"

"ABSTRAKDewasa ini, jumlah populasi usia lanjut di Indonesia semakin meningkat. Jumlah ini diiringi dengan semakin banyaknya masalah-masalah yang menyertai seseorang dengan usia lanjut, seperti menurunnya mobilitas fungsional. Penurunan mobilitas fungsional ini akan berpengaruh terhadap menurunnya pula kualitas hidup terkait kesehatan HRQoL . Belum ada penelitian yang mengetahui korelasi antara mobilitas fungsional dengan HRQoL, jika diukur menggunakan European Quality of Life-5 Dimension EQ-5D yang memiliki keunggulan. Sebanyak 70 pasien usia lanjut di Poliklinik Geriatri, RSCM dilakukan pengukuran TUGT mengukur mobilitas fungsional dan EQ-5D mengukur HRQoL . Didapatkan nilai median untuk TUGT adalah 12,335 7-30,9 detik, EQ-5D TTO 0,777 0,532-1 , dan EQ-5D VAS 70,0 30-100 . Dengan menggunakan analisis korelasi, didapatkan hasil bahwa terdapat korelasi negative antara TUGT dengan EQ-5D TTO p= 0,006; r= -0,324 dan EQ-5D VAS p= 0,037; r= -0,254 . Dari penelitian ini didapatkan bahwa TUGT orang usia lanjut di Indonesia lebih rendah jika dibandingkan di negara lain. Penelitian ini juga sejalan dengan penelitian-penelitian terkait mobilitas fungsional dan HRQoL. Penelitian lanjutan tentang hubungan kausalitas kedua variabel perlu dilakukan.

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ABSTRACTRecently, total population of eldery in Indonesia is growing in number. This number accompanied by problems among elderly, as decrese in functional mobility. The decrease of functional mobility will affect to health related quality of life HRQoL . There is still no study knowing correlation between functional mobility and HRQoL, if assessed using European Quality of Life 5 Dimension EQ 5D which has its own excellence. As many as 70 elderly patients in Geriatric Policlinic was tested for timed up and go test TUGT for assessing functional mobility and EQ 5D for assessing HRQoL . The median of TUGT was 12,335 7 30,9 second, EQ 5D TTO was 0,777 0,532 1 , and EQ 5D VAS was 70,0 30 100 . From bivariate analysis, there was a correlation between TUGT with EQ 5D TTO p 0,006 r 0,324 and TUGT with EQ 5D VAS p 0,037 r 0,254 . From this study, it is known that TUGT of elderly patient in Indonesia is lower if compared to another counties rsquo references value. This study is also suit with another studies about functional mobility and HRQoL. Advanced study to know causality association between variables needs to be done. "

"Kualitas hidup merupakan tujuan penting dari keseluruhan perawatan pasien dengan gagal ginjal terminal yang menjalani hemodialisis. Studi terbaru menunjukkan bahwa parameter subyektif lebih penting dalam mengukur kualitas hidup dibandingkan parameter obyektif seperti biokimia darah. Instrumen pengukuran kualitas hidup memiliki varian yang cukup banyak, namun belum ada instrumen yang sederhana, mudah diisi dan nyaman untuk diterapkan. Modified ESAS merupakan salah satu instrumen pengkajian beban gejala yang menurut hasil penelusuran ilmiah mampu mempredikasi kualitas hidup. Tujuan dari penerapan EBN ini adalah teridentifikasinya instrumen kualitas hidup yang valid, reliabel, sensitif dan spesifik serta mudah diterapkan di tatanan klinik. Proses pelaksanaan EBN ini terdiri dari penelusuran ilmiah menggunakan pertanyaan klinis dan dilanjutkan dengan implementasi EBN terhadap 54 pasien GGT yang menjalani hemodialisis. Hasil penerapan menunjukkan modified ESAS merupakan instrumen yang valid, reliabel, memiliki sensitivitas dan spesifisitas dalam mengukur kualitas hidup. Selain iu, secara teknis instrumen ini mudah diterapkan baik ditinjau dari aspek perawat maupun pasien.

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Quality of life is an important goals for patients undergoing hemodialysis. Recent studies showed that the subjective parameters are more important in measuring the quality of life than objective parameters such as blood biochemistry. The quality of life instrument is still many variants and there is no simple, easy to filled and comfortable instrument to apply. Based on scientific research, modified ESAS is one of the instruments that can predict the quality of life.

The implementation of evidence based nursing was aimed to identify the validity, reliability, sensitivity, specificity and applicability instrument of quality of life patients undergoing hemodialysis in clinical settings. The process EBN implementation consist of searching scientific clinical question and followed by 54 patients undergoing hemodialysis.

The EBN results showed that ESAS was a valid, reliable, sensitive and specific instrument to measure the quality of life. In addition, this instrument is easy applied both of nurses and patients. "

"Gagal jantung merupakan penyakit kronis dengan angka re-hospitaliasi dan angka mortalitas yang tinggi. Pasien gagal jantung masih mengalami berbagai masalah terkait symptom burden dan distress psikologis yang mempengaruhi kualitas hidup. Tujuan dari penelitian ini adalah untuk mengidentifikasi hubungan symptom burden dan distress psikologis pasien gagal jantung dengan kebutuhan perawatan paliatif di ruang rawat inap. Metode penelitian ini menggunakan metode studi deskriptif analitik korelasional dengan pendekatan cross sectional. Ukuran sampel sebanyak 120 pasien ditetapkan dengan purposive sampling. Responden diberikan tiga kuesioner yaitu Edmonton Symptom Assessment Scale (ESAS), Hospital Anxiety and Depression Scale (HADS), Problems and Needs in Palliative Care (PNPC). Hasil riset menunjukkan symptom burden (70%) dan distress psikologis (82,5%) pasien gagal jantung tahap lanjut berasa pada tingkat ringan. Dan seluruh responden (100%) menyatakan memiliki masalah perawatan paliatif dan sebanyak (92,5 %) yang membutuhkan perawatan paliatif. Hubungan yang signifikan antara symptom burden dengan masalah dan kebutuhan perawatan paliatif dengan dengan p value <0,0001. Terdapat hubungan antara distress psikologis dengan masalah perawatan paliatif dengan p value <0,0001, namun tidak ada hubungan antara distress psikologis dengan kebutuhan perawatan paliatif dengan p value 0,211. Rekomendasi dari hasil penelitian ini adalah perlunya pendekatan paliatif dalam melakukan intervensi psikologis dan pentingnya edukasi terhadap pasien dan keluarga terkait dengan efek samping dari pengobatan dan progresivitas penyakit.

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Heart failure is a chronic disease with a high rehospitalization rate and mortality rate. Heart failure patients still experience various problems related to symptom burden and psychological distress that affect their quality of life. The purpose of this study was to identify the relationship between symptom burden and psychological distress in heart failure patients with a need for palliative care in the inpatient unit. This research method uses a correlational analytic descriptive study method with a cross-sectional approach. The sample size of 120 patients was determined by purposive sampling. Respondents were given three questionnaires, namely the Edmonton Symptom Assessment Scale (ESAS), the Hospital Anxiety and Depression Scale (HADS), and Problems and Needs in Palliative Care (PNPC). The results of the research showed that the symptom burden (70%) and psychological distress (82.5%) of advanced heart failure patients were at a mild level. And all respondents (100%) said they had palliative care problems, and as many (92.5%) needed palliative care. There is a significant relationship between symptom burden with problems and the need for palliative care, with a p value of 0.0001. There is a relationship between psychological distress and palliative care problems with a p value of 0.0001, but there is no relationship between psychological distress and the need for palliative care with a p value of 0.211. Recommendations from the results of this study include the need for a palliative approach to conduct psychological intervention and the importance of educating patients and their families regarding the side effects of treatment and disease progression."

"ABSTRAKNama : Ayatun Fil IlmiProgram studi : Ilmu Kesehatan MasyarakatJudul : Faktor Dominan Gejala Premenstrual Syndrome padaMahasiswi Universitas IndonesiaPremenstrual syndrome merupakan kumpulan gejala fisik, psikologis, dan emosi,yang dialami wanita pada 7-14 hari sebelum mentruasi akibat perubahanhormonal yang berhubungan dengan siklus ovulasi. Tujuan penelitian ini adalahmengetahui faktor dominan yang berhubungan dengan gejala premenstrualsyndrome. Desain studi dalam penelitian ini adalah cross sectional dengan tekniksampling consecutive sampling. Sampel penelitian berjumlah 130 mahasiswi yangberasal dari S1 reguler Fakultas Kesehatan Masyarakat dan Departemen ArsitekFakultas Teknik angkatan 2015/2016. Variabel yang diteliti terdiri dari gejalapremenstrual syndrome, tingkat stres, aktivitas fisik, asupan gizi mikro piridoksin, vitamin D, kalsium dan magnesium , pola tidur, dan status gizi. Hasilpenelitian menunjukan sebanyak 36,9 mahasiswi mengalami premenstrualsyndrome gejala sedang hingga berat. Terdapat hubungan yang signifikan antaratingkat stres p=0,001 , asupan piridoksin p=0,003 , asupan magnesium p=0,044 , pola tidur p=0,006 dengan gejala premenstrual syndrome. Faktoryang paling dominan terhadap premenstrual syndrome adalah pola tidur OR=3,580 , diikuti tingkat stres dan asupan piridoksin. Mahasiswi dengan polatidur yang buruk berisiko mengalami premenstrual syndrome 3,580 kali lebihtinggi dibandingkan dengan mahasiswi yang memiliki pola tidur yang baik.Disarankan pihak kampus dapat memberikan promosi kesehatan yangberhubungan dengan gejala premenstrual syndrome, pentingnya pola tidur yangbaik dan cukup, pengendalian stress, dan pentingnya asupan gizi mikro.Kata kunci : premenstrual syndrome, tingkat stress, aktivitas fisik, asupan gizimikro, pola tidur, status gizi

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ABSTRACTName Ayatun Fil IlmiStudy Program Public HealthTitle The Dominant Factor of Premenstrual Syndrome Symptomin Female Student of Universitas IndonesiaPremenstrual syndrome is a complex of symptoms, including physic, phsycology,and emotion that is experienced by some women, 7 14 days before women rsquo speriod, it is cause by hormonal changes related to ovulation. The purpose of thisstudy was to determine the risk factors related to PMS. The research used crosssectional study design with sampling technique used consecutive sampling. Asample of this study was 130 student at FKM and Architecture Departement ofUniversitas Indonesia. Data collected include PMS occurrence, stress level,phsycal activities, intake of micronutrient pyridoxine, vitamin D, Ca, Mg , sleeppattern and nutritional status. The result showed 36,9 of subject had moderat tosevere PMS level. There was relationship between stress level p 0,001 ,pyridoxine intake p 0,003 , Mg intake p 0,044 , sleep patern p 0,006 withPMS. Sleep pattern OR 3,580 was the most dominant influence of premenstrualsyndrome followed by stress level and pyridoxine intake. Student with poor sleeppattern had experience PMS 3,580 higher than student with good sleep pattern.Researcher recommend to The University able to give health promotion related toPMS, the importance of good sleeping pattern, stress management, the importanceof micronutrient intake.Keyword premenstrual syndrome, stress level, phsycal activity, micronutrientintake, sleep pattern, nutritional status"

"Inflammatory mediators, such as prostaglandins and histamines can cause pain. Non steroid anti-inflammatory drugs (NSAIDs) have been indicated to reduce pain on inflammatory conditions. Pharmacologically, NSAIDs inhibit prostaglandins which are synthesized from arachidonic acid by blocking cyxlooxygenase-1 and 2 enzymes. Prostaglandins are known to be overexpressed on inflammatory, premalignant and malignant conditions. The prostaglandins promote tumour development by enhancing tumour cells proliferation, tumour angiogenesis, and tumour cell metastatic opportunity, and by inducing antiapoptotic gene expression. Epidemiological and biomedically, there is significant evidence that NSAIDs could inhibit tumour development. NSAIDs inhibit expression transcription factors, angiogenic factors of tumour angiogenesus, tumour metastasis and depresse expression of antiapoptotic genes. The avidence suggest that potentially NSAIDs could prevent tumour development, besides being analgetic-antiinflammatory drugs."

"ABSTRACTAcquired hemophilia A (AHA) is a blood clotting disorder caused by the presence of autoantibodies (inhibitors) against factor VIII. The typical symptom of this disorder is bleeding under the skin and soft tissue (rarely in the joints), with no family or personal previous history of bleeding. This case reports is tended to build up awareness for better diagnosis and therapy. Woman, 39 years old, bruises on both forearms are intermittent for 2 months with a history of long term drug consumption for headache treatment. Hemostatic test showed the elongation of activated partial thromboplastin test (APTT) to 87,1 (normal 24,4-44,4 seconds) and the decreament of factor VIII (FVIII) activity to 5% (normal 60-150%). Provision of recombinant factor VIII lowered factor VIII activity to 2%. Factor VIII inhibitor titer was 21,12 BU and diagnosis AHA was made. Inhibitor eradication by methylprednisolone tablet 3x16mg which was given for 2 months, improved the APPT to 46,7 seconds and factor VIII activity to 36%. Acquired Hemophilia A should be suspected in an adult bleeding patient with history of taking a long time non-steroidal anti-inflammatory drugs (NSAIDs). This case is a rare case in Indonesia and therefore the procedure for diagnosis needs to be improved in order to avoid errors in delivering a therapy which can cause the decreament of factor VIII activity."