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"Background: Diabetic kidney disease (DKD), as a common cause of end-stage renal disease (ESRD), is a chronic complication of diabetes mellitus (DM). It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. This study aimed to analyze the association between VDR polymorphisms and DKD in Indonesian population, also risk factors that influence it. Methods: a cross-sectional study was conducted in Type 2 DM patients who visited internal medicine outpatient clinic at Dr. Cipto Mangunkusumo Hospital, Jakarta, from November 2014 until March 2015. Data collection includes characteristics of subjects and laboratory examination, including BsmI polymorphisms in the vitamin D receptor gene. Patients with acute and severe disease were excluded from the study. Bivariate and multivariate analyses were done. Results: of 93 DM subjects, 42 (45.2%) subjects were without DKD and 51 (54.8%) subjects had DKD. Most of the subjects had the Bb genotype (89.2%), with no subject having the BB genotype. The proportions of the B and b alleles were 44.6% and 55.4%, respectively. There is no association between BsmI polymorphisms in the vitamin D receptor gene and DKD (OR = 1.243; CI 95% 0.334-4.621; p value = 0.751). Conclusion: the profile of BsmI polymorphisms in the vitamin D receptor gene in the Indonesian population were genotypes Bb (89.2%) and bb (10.8%). There was no association between BsmI polymorphisms in the vitamin D receptor gene and DKD. Duration of DM more than five years influenced the association between those variables."

"Latar Belakang: Penyakit ginjal diabetik (PGD) merupakan komplikasi mikrovaskular yang paling sering terjadi pada diabetes melitus. Podositopati merupakan kunci utama dari kerusakan glomerular pada PGD. miRNA-21 merupakan regulator epigenetik yang mempunyai peran dalam kerusakan podosit pada PGD, namun hasil dari penelitian yang sudah ada sebelumnya masih menyisakan kontroversi tentang peran miRNA-21 pada patogenesis PGD. Tujuan: Mengetahui korelasi antara kadar miRNA-21 dengan kadar nefrin urin, podosin urin, dan rasio albumin kreatinin urin pada pasien PGD. Metode: Studi potong lintang terhadap 42  pasien PGD di RSUPN Cipto Mangunkusumo Jakarta selama periode April sampai Juli 2023. Uji korelasi dilakukan untuk menilai hubungan miRNA-21 dengan nefrin, podosin, dan rasio albumin kreatinin urin. Regresi linier dilakukan untuk menilai variabel perancu terhadap hubungan tersebut. Hasil: Didapatkan hasil rerata ekspresi relatif miRNA-21 0,069 (0,024) , median nefrin 35,5 (15,75 – 51,25)ng/ml, median podosin 0,501 (0,442– 0,545) ng/mL, dan rasio albumin kreatinin urin 150 (94,56 – 335,75) ng/ml.Ditemukan korelasi antara miRNA-21 dengan nefrin (r = 0,598; p = <0,0001). Ditemukan korelasi antara miRNA-21 dengan rasio albumin kreatinin urin (r = 0,604; p = <0,0001). Tidak didapatkan korelasi antara miRNA-21 dengan podosin. Simpulan: Terdapat korelasi positif antara miRNA-21 dengan nefrin dan rasio albumin kreatinin urin namun tidak didapatkan korelasi yang bermakna antara miRNA-21 dengan podosin urin.

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Diabetic kidney disease (DKD) is the most common microvascular complication in diabetes mellitus. Podocytopathy is a key component of glomerular damage in DKD. miRNA-21 is an epigenetic regulator that plays a role in podocyte damage in DKD, however, the results of previous studies have not resolved the controversy about the role of miRNA-21 in the pathogenesis of DKD. Objective: The aim is to investigate the correlation between miRNA-21 levels and the urinary nephrin, urinary podosin, and urinary albumin-creatinine ratio (uACR) in patients with DKD.  Methods: A cross-sectional study of 42 patients with DKD was conducted at Cipto Mangunkusumo Hospital Jakarta from April to June 2023. A correlation test was performed to assess the association of miRNA-21 with the nephrin, podosin, and uACR. A linear regression test was performed to assess the confounding variables in these relationships. Results: The mean relative expression of miRNA-21 was 0.069 (0.024), the median nephrin was 35.5 (15.75 - 51.25) ng/ml, the median podocin was 0.516 (0.047 - 0.620) ng/ml, and the uACR was 150 (94.56 - 335.75) ng/ml. There was a correlation between miRNA-21 and nephrin (r = 0.598; p = <0.0001). There was a correlation between miRNA-21 and the uACR (r = 0.604; p = <0.0001). No correlation was found between miRNA-21 and podocin. Conclusions: There was a positive correlation between miRNA-21 and nephrin and urinary albumin-creatinine ratio, but no significant correlation between miRNA-21 and urinary podocin."

"ABSTRAKTujuan penelitian ini adalah untuk mengembangkan model perilaku adaptasi pasien penyakit ginjal kronis pre dialisis serta mengidentifikasi efektifitas model terhadap respon adaptasi fisiologi, perilaku adaptasi psikologi, pengetahuan dan sikap. Penelitian ini merupakan riset development yang dilakukan dalam dua tahap. Tahap satu mengidentifikasi masalah melalui penelitian kualitatif dengan pendekatan fenomenologi deskriptif tentang pengalaman hidup pasien dengan penyakit ginjal kronis pre dialisis, dilanjutkan membuat solusi dengan mengembangkan model perilaku adaptasi pasien penyakit ginjal kronis pre dialisis. Penelitian tahap dua quasi eksperimen dengan desain pre-test-post-test with control group untuk melihat efektifitas model pada 70 pasien penyakit ginjal kronis pre dialisis 38 orang kelompok intervensi dan 32 orang kelompok kontrol . Hasil penelitian tahap satu berupa buku model dan panduan implementasi, materi pembelajaran perilaku adaptasi untuk perawat pelaksana, serta booklet perilaku adaptasi untuk pasien penyakit ginjal kronis pre dialisis. Hasil penelitian tahap dua membuktikan kelompok intervensi memiliki respon adaptasi fisiologi, perilaku adaptasi psikologi, serta pengetahuan dan sikap yang lebih baik dibanding kelompok kontrol. Kesimpulan hasil penelitian ini adalah model perilaku adaptasi pasien penyakit ginjal kronis pre dialisis efektif terhadap respon adaptasi fisiologi, perilaku adaptasi psikologi, pengetahuan dan sikap. Saran melakukan sosialisasi model, advokasi ke unit terkait, aplikasi dalam asuhan keperawatan pada pasien penyakit ginjal kronis pre dialisis. Kata kunci: model perilaku adaptasi, respon adaptasi fisiologi, perilaku adaptasi psikologi, penyakit ginjal kronis pre dialisis

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ABSTRACTThe purpose of this study is to develop a model of adaptation behaviors for patients with chronic kidney disease pre dialysis and identify the effectiveness of the model towards physiological adaptation response, psychological adaptation behavior, knowledge and attitude of the patients. The study is a development research done in two stages. Stage one is identification of the issues through qualitative study according to descriptive phenomenology approach related to patients rsquo life experiences with chronic kidney disease pre dialysis, continued by the development of a model of adaptation behaviors for patients with chronic kidney disease pre dialysis as a solution to the issue. Stage two is a quasi experiment according to pre test post test with control group design to observe the effectiveness of the model in 70 patients with chronic kidney disease pre dialysis 38 subjects in the intervention group and 32 subjects in control group . The result of stage one study is a model book and implementation guideline, adaptation behaviors learning material for caregiver nurse and basic adaptation behaviors booklet for patients with chronic kidney disease pre dialysis. The result of stage two study proved that the intervention group has a physiological adaptation response, psychological adaptation behavior, knowledge and attitude better than the control group. In conclusion, the constructed model of adaptation behaviors for patients with chronic kidney disease pre dialysis is effective towards physiological adaptation response, psychological adaptation behavior, knowledge and attitude of the patients. Suggestions for model dissemination, advocacy to related units, application in nursing care in patients with chronic kidney disease pre dialysis. Keywords Model of adaptation behaviors, physiological adaptation response, psychological adaptation behavior, chronic kidney disease pre dialysis"

"Latar Belakang: Pruritus menjadi salah satu gejala yang dialami oleh pasien dengan penyakit ginjal kronik (PGK). Pruritus yang berasosiasi dengan PGK mayoritas terjadi pada pasien yang menjalani hemodialisis (HD) dan dapat terjadi pada resipien transplantasi ginjal (RTG). Gejala pruritus yang tidak ditangani dengan baik dapat memberikan dampak terhadap kualitas hidup. Belum terdapat penelitian yang membandingkan proporsi derajat keparahan pruritus, kualitas hidup, dan korelasi berbagai faktor biokimia antara pasien HD dengan RTG di Indonesia. Tujuan: Membandingkan derajat keparahan pruritus, kualitas hidup, serta korelasi kadar hs-CRP, kalsium, fosfat, dan e-GFR antara pasien PGK yang menjalani HD dengan RTG. Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Setiap SP dilakukan anamnesis, pemeriksaan fisis, dan pemeriksaan laboratorium. Skala gatal 5 dimensi (5-D) digunakan untuk evaluasi derajat keparahan pruritus dan Indeks Kualitas Hidup Dermatologi (IKHD) digunakan dalam menilai kualitas hidup. Analisis statistik yang sesuai dilakukan untuk membuktikan hipotesis penelitian dengan nilai kemaknaan yang digunakan adalah p <0,05. Hasil: Dari 30 SP di masing-masing kelompok, proporsi pruritus derajat sedang-berat sebesar 76,7% pada kelompok HD sedangkan pada kelompok RTG sebanyak 83,3% mengalami pruritus derajat ringan (RR = 4,6; IK 95% = 2,02–10,5; p <0,001). Median skor IKHD pada kelompok HD adalah sebesar 5 (3–6) sedangkan pada kelompok RTG sebesar 3 (2–4) (p <0,001). Terdapat korelasi positif yang bermakna antara hs-CRP dengan skor skala gatal 5-D pada kelompok HD (r = 0,443; p <0,05). Terdapat korelasi negatif yang bermakna antara e-GFR dengan skor skala gatal 5-D pada RTG (r = -0,424; p <0,05). Tidak terdapat korelasi yang bermakna secara statistik antara kadar kalsium dan fosfat dengan skor skala gatal 5-D pada kedua kelompok. Kesimpulan: Pasien HD lebih banyak mengalami pruritus derajat sedang-berat dibandingkan pada RTG. Pruritus pada kelompok HD berdampak ringan hingga sedang terhadap kualitas hidup sedangkan pada kelompok RTG pruritus berpengaruh ringan terhadap kualitas hidup. Pada pasien HD, semakin tinggi kadar hs-CRP maka semakin meningkat skor skala gatal 5-D. Pada pasien RTG, semakin menurun nilai e-GFR maka semakin meningkat skor skala gatal 5-D.

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Background: Pruritus is one of the symptoms experienced by patients with chronic kidney disease (CKD). Most patients with chronic kidney disease-associated pruritus (CKD-aP) occur in dialysis patients and could also happen in kidney transplant (KT) recipients. Inappropriate management of pruritus could impact the quality of life (QoL). No studies have compared the severity of pruritus, QoL, and the correlation of various biochemical factors between hemodialysis (HD) and KT recipients in Indonesia. Objective: To compare the severity of pruritus, QoL, and the correlation of hs-CRP, calcium, phosphate, and e-GFR levels between HD and KT recipients. Methods: This is a cross-sectional analytic observational study. Medical history, physical examination, and laboratory examination were conducted on each subject. The 5-dimensional (5-D) itch scale was used to evaluate the severity of pruritus. Dermatology Life Quality Index (DLQI) was used to assess the QoL. Appropriate statistical analysis was conducted to prove the research hypothesis with a significance value of p <0.05. Results: Out of 30 subjects in each group, the proportion of moderate to severe pruritus was 76.7% in the HD group. In the KT group, 83.3% experienced mild pruritus (RR = 4.6; CI 95% = 2.02– 10.5; p <0.001). The median DLQI score in the HD group was 5 (3–6), while in the KT group was 3 (2–4) (p <0.001). There was a significant positive correlation between hs-CRP and the 5-D itch scale in the HD group (r = 0.443; p <0.05). The KT group had a significant negative correlation between e-GFR and the 5-D itch scale (r = -0.424; p <0.05). Both groups had no statistically significant correlation between calcium and phosphate levels and the 5-D itch scale. Conclusion: Moderate-to-severe pruritus was more common in HD patients than in KT recipients. Pruritus in HD patients had a mild to moderate effect on QoL, whereas pruritus in KT recipients had a mild impact on QoL. A higher level of hs-CRP in HD patients results in a higher 5-D itch scale. In KT recipients, the lower the e-GFR value, the higher the 5-D itch scale."

"Kebiasaan dalam jangka waktu yang lama akan pola diet yang tidak sehat pada masyarakat perkotaan menjadi salah satu faktor resiko terjadinya hipertensi. Penyakit ini menjadi salah satu faktor penyebab kerusakan ginjal yang dapat mengakibatkan gagal ginjal kronik. Pasien gagal ginjal kronik sering terjadi kelebihan volume cairan akibat kerusakan fungsi filtrasi glomerolus. Oleh karena itu perlu dilakukan pembatasan cairan yang ketat, efektif dan efesian untuk mencegah terjadinya komplikasi dengan upaya pemantauan intake dan output cairan. Penulisan karya ilmiah ini menggunakan metode studi kasus dengan menggunakan fluit intake output chart dan dibuktikan bahwa pemantauain ini efektif untuk menangani kelebihan volume cairan dibuktikan dengan tidak bertambahnya komplikasi yang terjadi pada pasien.

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Long lasting habits of unhealthy diet in urban society is becoming one of hypertension risk factor. This disease has become a factor causing kidney damage, which can lead to chronic kidney failure. Chronic kidney failure patients commonly experience volume overload due to damage in glomerular filtration function. Hence, fluid restriction is needed as effective and efficient to prevent complication by monitoring fluid intake and output. This scientific writing uses case study method by using fluid intake-output chart to prove that this monitoring method is effective in handling fluid overload by looking at the occurrence of complication in patient."

"Analisis praktik residensi spesialis Keperawatan Medikal Bedah dengan kekhususan pada sitem nefrologi bertujuan mengaplikasikan peran perawat sebagai pemberi asuhan, pengelola, pendidik, dan peneliti. Peran pemberi asuhan dan pendidik diaplikasikan saat perawatan pasien kelolaan utama dengan kasus Chronic Kidney Disease dan 30 pasien dengan masalah nefrologi melalui pendekatan teori Virginia Henderson. Peran perawat sebagai pengelola dan peneliti (case manager) dibuktikan saat penyusunan evidence based nursing (EBN) mengenai penerapan hand and foot massage dalam mengurangi fatigue pasien hemodialisis dan proyek inovasi mengenai “Buku Harian Pasien HD” dalam mengontrol Interdyalitic Weight Gain (IDWG). Seluruh rangkaian praktik tersebut merupakan perwujudan asuhan keperawatan holistik untuk mencapai kualitas pelayanan prima.

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The analysis of the practice of medical-surgical nursing specialist residency with specialization in the nephrology system aims to apply the role of nurses as caregivers, managers, educators, and researchers. The role of caregivers and educators was applied when treating primary patients with Chronic Kidney Disease cases and 30 patients with nephrological problems through Virginia Henderson's theoretical approach. The role of nurses as managers and researchers (case managers) was proven during the preparation of evidence based nursing (EBN) regarding the application of hand and foot massage in reducing fatigue in hemodialysis patients and in the innovation project "HD Patient Diary" in effort to control Interdyalitic Weight Gain (IDWG). This whole series of practices is the embodiment of holistic nursing care to achieve excellent service quality."

"Penyakit ginjal kronik merupakan penyakit kronik yang bersifat irreversible dan progresif yang disebabkan oleh kerusakan vaskular seperti pada hipertensi dan diabetes mellitus. Kerusakan vaskular pada penyakit ginjal kronik dapat menyebabkan masalah kelebihan volume cairan tubuh yang dapat mengakibatkan komplikasi sistemik. Penulisan karya ilmiah ini menggunakan studi kasus dengan tujuan menganalisis intervensi pemantauan cairan pasien penyakit ginjal kronik dengan menggunakan lembar pemantauan intake dan output. Intervensi pemantauan cairan dilakukan selama 5 hari di ruang rawat gedung A lantai 7 zona A RSUPN. Dr. Ciptomangun Kusumo Jakarta. Rekomendasi dari kasus ini adalah penggunaan lembar pemantauan pada pasien yang beresiko mengalami ketidakseimbangan cairan seperti pada pasien penyakit ginjal kronik. Sehingga intervensi penggunaan lembar pemantauan efektif untuk mengatasi kelebihan volume cairan.

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Chronic kidney disease is  a chronic, irreversible, and progressive disease resulting from vascular impairment such that occurs in hypertension and diabetes mellitus condition. Vascular impairment in chronic kidney disease may result in excess fluid volume which leads to systemic complications. The study design was case study and aimed to analyze fluid monitoring intervention in patient with chronic kidney disease by employing intake and output monitoring sheet. The intervention was conducted in Zone A ward of 7th floor Building A of RSUPN Dr. Cipto Mangunkusumo for 5 days long. The study recommends the use of fluid monitoring sheet in patient with risk for fluid imbalance such as in chronic kidney disease. Therefore, use of intake and output monitoring sheet is effective in managing excess fluid volume."

"Background: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. Methods: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox's Proportional Hazard Regression. Results: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15-4.05; p = 0.017). Conclusion: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect."

"ABSTRAKNama : Imam Kurniawan RizalProgram Studi : Ilmu KeperawatanJudul : Analisis Massase dengan Menggunakan VCO Pada Pasien Chronic Kidney Disease CKD dengan Penurunan Kesadaran Di Ruang Anak, Lantai 1 Gedung A, RSUP Cipto Mangunkusumo Luka tekan merupakan kerusakan integritas kulit yang mengalami tekanan berkepanjangan dan terus menerus. Luka tekan berada di peringkat ketiga yang membutuhkan biaya perawatan besar dan penyebab kematian tertinggi. Dalam mengantisipasi semakin tinggi angka kematian yang diakibatkan oleh luka tekan, perawat harus lebih sadar dan memberikan perhatian khusus untuk menangani masalah ini. Salah satu upaya pencegahan luka tekan dapat dilakukan dengan massase menggunakan VCO. Karya Ilmiah Akhir Ners ini bertujuan untuk menganalisis intervensi massase dengan menggunakan VCO untuk mencegah terjadi luka tekan pada pasien CKD dengan penurunan kesadaran. Metodologi yang digunakan adalah metode studi kasus dan analisa penelitian yang telah ada. Hasil analisa yang didapat menunjukkan bahwa intervensi ini terbukti efektif karena dapat mencegah luka tekan dengan tanda tidak terjadi kemerahan pada kulit pasien. Kata kunci: Virgin Coconut Oil, Luka tekan, Massase

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ABSTRACTName Imam Kurniawan RizalStudy program NursingTitle Massage Analysis Using VCO in Chronic Kidney Disease CKD Patients With Decreased Awareness in Child Room, 1st Floor of Building A, RSUP Cipto Mangunkusumo Pressure ulcers is a malfunction integrity skin because have pressure prolonged and continuous. Pressure ulcers is ranked third which requires the greatest care costs and the highest cause of death. In anticipation of the higher mortality caused by the pressure ulcers, the nurse must be more aware and pay special attention to handle this problem. One of prevention pressure ulcers can be done by massase using Virgin Coconut Oil VCO . This Final Scientific Work of Ners aims to analyze the interventions of massase by using Virgin Coconut Oil VCO to prevent pressure ulcers on patients Chronic Kidney Disease CKD with impairment of consciousness. The methodology used is the case study method and the existing research analysis. The results obtained showed this intervention proved to be effective as it can prevent pressure ulcers with no signs of redness on the patients skin. Keyword Virgin Coconut Oil, Pressure ulcers, Massage "

"ABSTRAKPasien Penyakit Ginjal Kronik (PGK) memerlukan hemodialisis akibat mengalami gangguan fungsi endokrin, metabolic, cairan elektrolit serta asam basa. Tindakan hemodialisis tersebut dapat berdampak terhadap kualitas hidup responden. Berbagai faktor yang diduga berhubungan dengan kualitas hidup pada responden hemodialisis diantaranya faktor demografi, lama menjalani hemodialisis, kadar hemoglobin, tekanan darah, adekuasi hemodialisis dan akses vaskuler.Tujuan penelitian untuk mengidentifikasi dan menjelaskan faktor yang berhubungan dengan kualitas hidup pada responden yang menjalani hemodialisis.Desain penelitian cross sectional deskriptif korelasi dengan jumlah sampel 95 orang yang menjalani hemodialisis di RSI Fatimah Cilacap dan RSUD Banyumas. Hasil penelitian menunjukkan bahwa responden yang berkualitas hidup baik (52.6%) dengan rata-rata usia 44.82±11.57 tahun. Tidak ditemukan hubungan antara kualitas hidup dengan faktor demografi, kadar hemoglobin, akses vaskuler, dan adekuasi hemodialisis. Kualitas hidup memiliki hubungan dengan tekanan darah (hipertensi) dengan p value 0.02 ; OR: 4.5 , dan lama waktu menjalani hemodialisis (≥11 bulan) dengan p value 0.035; OR:2.6. Penelitian ini menyimpulkan bahwa tekanan darah dan lama menjalani hemodialisis merupakan faktor independen yang berhubungan dengan kualitas hidup. Pada penelitian selanjutnya diharapkan meneliti tentang adekuasi nutrisi, kontrol Calcium & Phospat. Diperlukan konseling tentang nutrisi, farmakologi dan exercise untuk responden hemodialisis.

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ABSTRACT

Patients with Chronic Kidney Disease (CKD) requiring hemodialysis due to malfunctioning endocrine, metabolic, electrolyte and acid-base fluids. Hemodialysis may have an impact on respondents quality of life. Various factors are thought to relate to quality of life in hemodialysis respondents include demographic factors, duration undergoing hemodialysis, hemoglobin, blood pressure, adequacy hemodialysis and vascular access.

The aim is to identify and explain factors related to quality of life in respondents who underwent hemodialisis.Desain cross sectional descriptive correlation study with a sample of 95 people who underwent hemodialysis in RSI Fatimah Cilacap and Banyumas Hospital. Results showed that respondents who live good quality (52.6%) with an average age of 44.82 years ± 11:57. No relationship was found between quality of life by demographic factors, levels of hemoglobin, vascular access and hemodialysis adequacy. Quality of life has a relationship with blood pressure (hypertension) with p value 0:02; OR: 4.5, and the length of time undergoing hemodialysis (≥11 months) with a p value of 0035; OR: 2.6. This study concluded that blood pressure and duration of hemodialysis undergo an independent factor associated with quality of life. In further studies are expected to examine the adequacy of nutrition, calcium and phosphate control. Required counseling about nutrition, pharmacology and exercise for the respondent hemodialysis."