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"Latar Belakang : Kolitis merupakan penyakit gastrointestinal yang banyak ditemukan dan menjadi masalah utama di negara berkembang termasuk Indonesia. Zinc, trace element penting dengan berbagai fungsi diantaranya antimikrobial mukosa intestinal, meningkatkan fungsi barrier gastrointestinal, dan fungsi imun. Kolitis menyebabkan perubahan anatomis saluran gastrointestinal, dianggap dapat menyebabkan defisiensi zinc akibat gangguan penyerapan dan peningkatan ekskresi. Penelitian ini bertujuan mengetahui profil zinc darah dan analisa tinja pada pasien kolitis di RSUPN dr. Cipto Mangunkusumo. Metode : Dilakukan penelitian potong lintang pada bulan Agustus 2019-November 2019. Subjek kolitis diperoleh secara konsekutif dari pasien yang kontrol di poliklinik gastroenterologi atau menjalani kolonoskopi di Pusat Endoskopi Saluran Cerna RSUPN. dr. Cipto Mangunkusumo. Pemeriksaan sampel zinc darah secara spektrofotometri dan analisa tinja subjek kolitis untuk menilai profil zinc darah dan analisa tinja. Kadar zinc darah subjek kolitis dibandingkan dengan kadar zinc darah subjek sehat. Hasil : Terdapat 40 subjek kolitis dan 16 subjek sehat yang disertakan untuk dianalisis pada penelitian ini. Diperoleh 45% pasien kolitis yang defisiensi zinc dengan rerata kadar zinc kelompok kolitis adalah 10,9 ± 1,9 µmol/L dan rerata kadar zinc subjek sehat 12,3 ± 1 µmol/L. Profil analisa tinja kelompok kolitis ditemukan konsistensi lembek 90%, BAB berlendir 17,5%, peningkatan jumlah eritrosit 60%, peningkatan jumlah leukosit 5%, positif amilum 20%, positif lemak 7,5%, pH asam 97,5%, positif darah samar tinja 37,5%, dan jamur di tinja 7,5%. Simpulan : Kadar zinc pada kelompok kolitis lebih rendah bermakna dibanding kadar zinc pada kelompok sehat. Perlu dilakukan penelitian lebih lanjut untuk mempertimbangkan pemberian terapi zinc pada pasien kolitis dengan defisiensi zinc.

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Background: Colitis is a common gastrointestinal disease that is a major problem in developing countries including Indonesia. Zinc, an important trace element with various functions including antimicrobial intestinal mucosa, improves gastrointestinal barrier function, and immune function. Colitis causes anatomical changes in the gastrointestinal tract, considered to cause zinc deficiency due to impaired absorption and increased excretion. This study aims to determine the profile of blood zinc and fecal analysis in colitis patients at RSUPN Dr. Cipto Mangunkusumo. Methods: A cross-sectional study was conducted on 40 colitis and 16 healthy subjects in August 2019-November 2019. Colitis subjects were obtained consecutively from patients who were in the gastroenterology outpatient clinic or underwent colonoscopy at the Gastroenterological Endoscopy Center of RSUPN. dr. Cipto Mangunkusumo. Spectrophotometric examination of blood zinc samples and fecal analysis of colitis subjects to assess blood zinc profile and stool analysis. The level of colitis in the subjects' blood zinc was compared with the level of zinc in the healthy subject. Results: There were 40 colitis subjects and 16 healthy subjects included for analysis in this study. 45% of colitis patients who were deficient in zinc with a mean zinc level in the colitis group were 10.9 ± 1.9 μmol / L and the mean zinc level in healthy subjects was 12.3 ± 1 μmol / L. Fecal analysis profile of colitis group found 90% soft stool consistency, 17.5% slimy stool, increase in erythrocyte count 60%, increase in leukocyte count 5%, positive starch 20%, positive fat 7.5%, acid pH 97.5%, positive Fecal blood feces 37.5%, and fungi in feces 7.5%.

Conclusion: Zinc levels in the colitis group were significantly lower than zinc levels in the healthy group. Further research needs to be done to consider giving zinc therapy to colitis patients with zinc deficiency."

"Kolitis adalah salah satu penyakit saluran cerna yang sering dijumpai di Indonesia. Peptida antimikroba human beta-defensin 2 (hBD-2) merupakan bagian dari komponen sistem imun alamiah sistem gastrointestinal yang diteliti perannya dalam patofisiologi kolitis. Penelitian ini bertujuan memperoleh kadar hBD-2 feses pada pasien kolitis di RSUPN dr. Cipto Mangunkusumo, serta apakah terdapat perbedaan kadarnya pada kolitis infeksi dan non-infeksi. Penelitian potong lintang ini dilakukan pada subjek kolitis yang direkrut secara konsekutif di poliklinik Gastroenterologi dan Pusat Endoskopi Saluran Cerna RSUPN dr. Cipto Mangunkusumo, pada bulan Juni – Oktober 2020. Sampel feses dari subjek diperiksakan kadar hBD-2 dengan metode ELISA, feses rutin, darah samar, serta biakan di Laboratorium Departemen Patologi Klinik RSUPN dr. Cipto Mangunkusumo. Kadar hBD-2 feses subjek kolitis infeksi dibandingkan dengan kadar hBD-2 feses subjek kolitis non-infeksi. Diperoleh 26 subjek kolitis infeksi dan 20 subjek kolitis non-infeksi dengan median kadar hBD-2 feses berturut-turut adalah 40,39 (5,11 – 555,27) ng/ml dan 36,35 (1,75 – 260,34) ng/ml. Terdapat kecenderungan kadar hBD-2 feses yang tinggi pada subjek kolitis tuberkulosis dan kolitis jamur dengan median berturut-turut 460,55 (30,94 – 555,27) ng/ml dan 340,45 (283,01 – 361,95) ng/ml. Tidak terdapat perbedaan kadar hBD-2 feses yang bermakna antara kolitis infeksi dan non-infeksi (p > 0,05). Perlu dilakukan penelitian lanjutan dengan jumlah subjek lebih banyak untuk kelompok kolitis tuberkulosis dan kolitis jamur.

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Colitis is one of the most common gastrointestinal diseases in Indonesia. Antimicrobial peptide human beta-defensin 2 (hBD-2) is a part of gastrointestinal innate immunity which roles in the pathophysiology of colitis are still being studied. This study aims to determine fecal hBD-2 concentration in colitis at RSUPN dr. Cipto Mangunkusumo, and whether there is significant difference of its concentration in infective and non-infective colitis. A cross-sectional study was conducted on colitis subjects recruited consecutively at Gastroenterology Clinic and Gastroenterology Endoscopy Center of RSUPN dr. Cipto Mangunkusumo, in June - October 2020. Stool samples collected were tested for hBD-2 concentration using ELISA method, routine fecal analysis, fecal occult blood test, and culture at Clinical Pathology Laboratory of RSUPN dr. Cipto Mangunkusumo. Fecal hBD-2 concentration was compared between infective and non-infective colitis. There were 26 subjects with infective colitis and 20 subjects with non-infective colitis. Fecal hBD-2 concentrations of the two groups were 40,39 (5,11 – 555,27) ng/ml and 36,35 (1,75 – 260,34) ng/ml. Fecal hBD-2 concentrations in tuberculous colitis and fungal colitis tended to be high, 460,55 (30,94 – 555,27) ng/ml and 340,45 (283,01 – 361,95) ng/ml. There was no significant difference of fecal hBD-2 concentrations in infective and non-infective colitis (p > 0,05). It is recommended to conduct further study with more subjects regarding group tuberculous colitis and fungal colitis."

"Penderita dengan keganasan seringkali mengalami gangguan sistim kekebalan tubuh, selular dan humoral, baik karena penyakit keganasan sendiri, maupun akibat pengobatan sitostatik dan atau radioterapi. Harryanto (1984) melaporkan, 50,5% dari 99 penderita limfoma Non-Hodgkin yang diteliti menunjukkan uji kulit tuberkulin negatif, dibandingkan dengan kelompok kelola yang berjumlah 83 orang dengan hasil 7,2% yang negatif, yang berarti imunitas selularnya terganggu. Pengobatan sitostatik secara intensif akan menyebabkan keadaan netropenia, yaitu jumlah lekosit polimorfonuklear (PMN) yang kurang dari 500/mm3. Lekosit PMN sebagai bagian terbesar lekosit dalam darah, terdiri atas basopil, eosinopil dan netropil (merupakan jumlah terbesar). Lekosit PMN merupakan pertahanan selular terpenting untuk melawan infeksi bakterial.

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Patients with malignancies often experience disorders of the immune, cellular and humoral systems, both due to malignant diseases themselves, as well as due to cytostatic treatment and/or radiotherapy. Harryanto (1984) reported, 50.5% of the 99 Non-Hodgkin lymphoma patients studied showed a negative tuberculin skin test, compared to a control group of 83 people with a negative result of 7.2%, which means their cellular immunity is impaired. Intensive cytostatic treatment will lead to a state of netropenia, which is a number of polymorphonuclear lecocytes (PMN) that is less than 500/mm3. PMN lecocytes as the largest part of lekocytes in the blood, consist of basopil, eosinophil and netropil (the largest amount). PMN lecocytes are the most important cellular defense against bacterial infections."

"Penyakit gastroenterologi masih merupakan masalah kesehatan utama di Indonesia, dengan kolitis menempati urutan kelima dari sepuluh penyakit terbanyak pada pelayanan rawat jalan. Kesamaan gambaran klinis dan hasil pemeriksaan diagnostik kolitis TB dan Inflammatory Bowel Disease (IBD) menyebabkan kesulitan diagnosis. Studi ini bertujuan untuk mengetahui peran diagnostik Interferon-Gamma Release Assay (IGRA) metode Elispot pada pasien terduga kolitis tuberkulosis di Indonesia. Dilakukan studi potong lintang dan acak dengan penyajian data deskriptif analitik. Subjek penelitian merupakan 60 pasien terduga kolitis tuberkulosis yang mengunjungi poliklinik gastroenterologi di RSUPNCM bulan April-Oktober 2018. Sampel yang digunakan adalah darah vena. Hasil uji diagnostik IGRA metode Elispot dengan baku emas pemeriksaan histopatologi adalah sensitivitas 83,3%, spesifisitas 57,4%, NPP 17,3%, dan NPN 96,9%. Hasil uji diagnostik IGRA metode Elispot dengan baku emas pemeriksaan kolonoskopi adalah sensitivitas 53,9%, spesifisitas 55,3%, NPP 25%, dan NPN 81,3%. Hasil uji diagnostik IGRA metode Elispot dengan baku emas pemeriksaan kolonoskopi dan histopatologi adalah sensitivitas 57,1%, spesifisitas 60,5%, NPP 28,6%, dan NPN 81,3%. Hasil uji diagnostik IGRA metode Elispot dengan baku emas pemeriksaan histopatologi, kolonoskopi, dan evaluasi klinis akhir adalah sensitivitas 100%, spesifisitas 59,3%, NPP 21,3%, dan NPN 100%. Tes IGRA Metode Elispot dapat digunakan sebagai pemeriksaan penapisan.

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Gastroenterology diseases are still a major health problem in Indonesia, with colitis ranks fifth among the top ten diseases in outpatient care. The similarity of clinical features and diagnostic results of TB and Inflammatory Bowel Disease causes difficulties in diagnosis. This study is aimed to determine the diagnostic value of Interferon-Gamma Release Assay (IGRA) with Elispot Method in patients with suspected tuberculous colitis in Indonesia. It is a cross sectional and randomized study, shown as an analytic descriptive report. There were 60 patients with suspected tuberculosis colitis, visiting gastroenterology polyclinic at RSCM from April-October 2018. The sample was venous blood.  Diagnostic results of IGRA with Elispot Method with histopathology test as the gold standard are sensitivity 83,3%, specificity 57,4%, PPV 17,3%, and NPV 96,9%. As with colonoscopy as the gold standard are sensitivity 53,9%, specificity 55,3%, PPV 25%, dan NPV 81,3%. Meanwhile, with colonoscopy and histopathology test as the gold standard are sensitivity 57,1%, specificity 60,5%, PPV 28,6%, dan NPV 81,3%. And, diagnostic results  of IGRA with Elispot Method with colonoscopy, histopathology test, and final clinical judgement as the gold standard are sensitivity 100%, specificity 59,3%, PPV 21,3%, dan NPV 100%. IGRA with Elispot Method can be used as screening test."

"Latar belakang: Leukemia limfoblastik akut LLA merupakan jenis kanker tersering pada anak. Faktor penyakit dan kemoterapi dapat menyebabkan ketidakseimbangan nutrisi makro maupun mikro. Zinc adalah salah satu nutrien mikro yang memiliki banyak peran fisiologis dalam tubuh, namun kadarnya berkurang pada penyakit limfoproliferatif. Defisiensi zinc cenderung meningkatkan morbiditas pada anak LLA, salah satunya infeksi. Tujuan: Penelitian ini bertujuan untuk mencari proporsi defisiensi zinc pada LLA anak serta hubungannya dengan kejadian infeksi. Pasien dan metode: Disain penelitian potong lintang deskriptif-analitik, tempat pelaksanaan di Departemen Patologi Klinik dan Departemen Ilmu Kesehatan Anak RSUPN Dr. Cipto Mangunkusumo, Jakarta. Jumlah subjek 81 anak LLA, yang terdiri dari 26 pasien baru dan 55 pasien pada berbagai fase kemoterapi. Kadar zinc diukur menggunakan prinsip kolorimetri dengan alat spektrofotometer otomatis. Hasil: Proporsi defisiensi zinc pada pasien yang baru terdiagnosis sebesar 65.4 n= 26 dan pada pasien kemoterapi sebesar 49 n= 55 . Terdapat hubungan bermakna antara defisiensi zinc dengan kejadian infeksi p= 0.003; RR= 3.2, 95 CI 1.33 ndash; 7.69 Kesimpulan: Defisiensi zinc ditemukan pada anak dengan LLA sebelum kemoterapi dimulai, maupun pada berbagai fase kemoterapi. Risiko infeksi lebih besar pada anak LLA yang mengalami defisiensi zinc. Suplementasi zinc dapat dipertimbangkan untuk meningkatkan prognosis, namun perlu dilakukan penelitian lebih lanjut mengenai efektivitasnya.

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Background: Acute lymphoblastic leukemia ALL is a most common malignancy in children. Disease factors and chemotherapy effects may cause both macro or micro nutritional imbalance. Zinc is one of the micro nutrients that has many physiological roles in the body, but the levels may decrease in ALL. Zinc deficiency tend to increase morbidity in children with ALL, including infection.

Objective: The present study was done in order to find the proportion of zinc deficiency in pediatric ALL patients and to identify its relationship with the incidence of infection.

Patients and methods: This cross sectional study was carried out in the Departement of Clinical Pathology and Department of Paediatric Health, RSUPN Dr. Cipto Mangunkusumo, Jakarta. We conducted 81 paediatric ALL patients, consisted of 26 newly diagnosed and 55 in various phases of chemotherapy. Zinc levels were measured using colorimetric method by an automatic spectrophotometer.

Results: The proportion of zinc deficiency is 65.4 in newly diagnosed patients and 49 in children with various chemotherapy phases. There is a significant association between zinc deficiency and the incidence of infection p 0.003 RR 3.2, 95 CI 1.33 ndash 7.69.

Conclusion: zinc deficiency was found in children with LLA, and has significant association with the risk of infection. Zinc supplementation may be considered to improve the prognosis, however futher study of safety and side effect is necessary. "

"ABSTRAKPsoriasis merupakan kelainan kulit yang diakibatkan oleh disregulasi sistem imun yang berdampak sangat besar terhadap kualitas hidup pasien. Sindrom metabolik, di antaranya termasuk obesitas dan hipertensi, diduga memiliki hubungan yang kuat dengan psoriasis. Tujuan dari penelitian ini adalah untuk mengetahui apakah terdapat hubungan antara Indeks Massa Tubuh IMT dan tekanan darah dengan tingkat keparahan psoriasis yang diukur dengan skor Psoriasis Area and Severity Index PASI . Penelitan dilakukan di Unit Rekam Medis Rumah Sakit dr. Cipto Mangunkusumo RSCM dan melibatkan 63 pasien psoriasis yang berobat di RSCM pada tahun 2015 dan 2016. Dari 63 pasien yang ikut serta dalam penelitian ini, tingkat keparahan psoriasis terbagi 18 orang untuk kategori ringan dan 45 orang untuk kategori sedang berat. Terdapat 35 pasien yang dikategorikan obese dan 16 pasien yang dikategorikan mengalami hipertensi. Analisis statistik yang dilakukan pada penelitian ini yaitu berupa uji Chi-Square menunjukkan beberapa hubungan statistik yang signifikan yaitu hubungan antara tingkat keparahan psoriasis dengan IMT p=0,025 dan tekanan darah p=0,026 . Oleh karena itu, dapat disimpulkan bahwa terdapat hubungan yang signifikan antara obesitas dan hipertensi dengan tingkat keparahan psoriasis.

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ABSTRACTPsoriasis is a skin disorder caused by immune disregulation which impacts the quality of life of the patient. Metabolic syndrome, which includes obesity and hypertension, was suspected to have a strong association with psoriasis. The purpose of this research is to find out the association between Body Mass Index BMI and blood pressure to psoriasis severity which was measured using the Psoriasis Area and Severity Index PASI score. The research was done at the Medical Record Unit of dr. Cipto Mangunkusumo Hospital RSCM and includes participation of 63 psoriasis patient who was seeking medical care at year 2015 and 2016. Of all 63 patients participated in this research, the psoriasis severity was divided into 18 patients in mild category and 45 patients in moderate to severe category. There are 35 patients who are categorized as obese and 16 patients that are categorized in hypertensive. Statistical analysis that was done in this research shows some statistically significant association between psoriasis severity and BMI p 0,025 and blood pressure p 0,026 . This concludes that there are significant associations between obesity and hypertension to psoriasis severity. "

"Latar Belakang: Tuberkulosis (TB) merupakan masalah kesehatan utama di dunia, khususnya di Indonesia. Tuberkulosis umumnya menyerang paru (TB paru), namun bisa juga menyerang organ lain (TB ekstraparu), seperti kolitis TB. Diagnosis kolitis TB menjadi tantangan karena klinis dan hasil pemeriksaannya menyerupai penyakit lain, seperti inflammatory bowel disease (IBD). Studi ini bertujuan untuk mengetahui proporsi hasil PCR-TB feses pada pasien teduga kolitis TB dan uji diagnosis pemeriksaan PCR-TB feses jika dibandingkan dengan hasil kolonoskopi, histopatologi, dan evaluasi klinis. Metode: Dilakukan studi uji diagnostik pada 60 subjek terduga kolitis TB di RSCM yang menjalani pemeriksaan kolonoskopi pada bulan Februari-April 2019. Ekstraksi DNA dari feses dilakukan dengan menggunakan QIAamp® Fast Stool DNA Mini Kit dan PCR dilakukan dengan kit artus® M. tuberculosis RG dengan target gen 16s rRNA. Hasil pemeriksaan PCR-TB feses dibandingkan dengan hasil kolonoskopi, histopatologi, dan evaluasi klinis. Hasil: Terdapat 60 subjek terduga kolitis TB yang disertakan dan dianalisis dalam penelitian ini. Diperoleh 26 (43,3%) hasil PCR-TB feses positif, yang terdiri atas 7/8 subjek kolitis TB dan 19/52 subjek bukan kolitis TB. Dari hasil penelitian ini, didapatkan nilai diagnostik PCR-TB feses dibandingkan hasil kolonoskopi, histopatologi, dan evaluasi klinis memiliki sensitivitas 87,5%, spesifisitas 63,5%, NPP 26,9%, dan NPN 97,1%. Simpulan: Pemeriksaan PCR-TB feses memiliki sensitivitas baik namun spesifisitas yang rendah untuk diagnosis kolitis TB sehingga lebih baik sebagai pemeriksaan penyaring untuk kolitis TB.

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Background: Tuberculosis (TB) is a major health problem in the world, particularly in Indonesia. Tuberculosis commonly affects lung (pulmonary TB), but it can also affect other organs (extrapulmonary TB), such as TB colitis. The diagnosis of TB colitis has become a challenge because the clinical manifestation and its tests result can mimic other diseases, such as inflammatory bowel disease (IBD). This study was aimed to find the proportion of stool TB-PCR result in patients which suspected with TB colitis and the diagnostic value of stool TB-PCR if compared to colonoscopy, histopathology, and clinical evaluation. Methods: Diagnostic study was done in 60 subjects suspected for TB colitis in RSCM which underwent colonoscopy and histopathology examination in February-April 2019. The DNA extraction from the stool was done by using QIAamp® Fast Stool DNA Mini Kit and TB-PCR was done with artus® M. tuberculosis RG PCR kit which targeting 16s rRNA gene. The result of stool TB-PCR then was compared to the result of colonoscopy, histopathology, and clinical evaluation. Results: There were 60 subjects suspected with TB colitis recruited and analyzed in this study. There were 26 (43,3%) positive stool TB, consist of 7/8 subjects with TB colitis and 19/52 subjects with non-TB colitis. From this study, the diagnostic value of stool TB-PCR that was compared to combination of colonoscopy, histopathology, and clinical evaluation were: sensitivity 87,5%, specificity 63,5%, positive predictive value (PPV) 26,9% and negative predictive value (NPV) 97,1%. Conclusion: Stool TB-PCR has good sensitivity but low specificity for diagnosing TB colitis. Therefore, stool TB-PCR is better utilized for TB colitis screening."

"[ABSTRAKPendahuluan : Glioma adalah jenis tumor yang paling umum dari neoplasma intraserebralprimer. Tumor ganas primer sistem saraf pusat (SSP) mencapai sekitar 2% dari semua kankerdan high grade glioma adalah jenis yang paling banyak ditemukan. High grade gliomamenyebabkan tingkat morbiditas dan mortalitas yang tinggi. Saat ini belum ada data yangmenggambarkan profil pasien glioma yang menjalani radioterapi di Indonesia.Metode penelitian : Penelitian ini merupakan penelitian retrospektif deskriptif analitikterhadap 121 pasien glioma yang mendapat radiasi di departemen Radioterapi RSUPN Dr.Cipto mangunkusumo dari Januari 2009 sampai Januari 2014. Data diperoleh dari catatanmedisdan hasil penelusuran melalui telepon terhadap pasien atau keluarganya. Respon tumordianalisa terhadap 22 pasien yang mempunyai CT scan atau MRI pre dan post radiasi denganmenggunakan kriteria RECIST.Hasil : Sebagian besar pasien adalah laki-laki (53,7%), dengan usia rata-rata 45 tahun.Histopatologi yang paling banyak ditemukan adalah astrositoma. Prosedur bedah yang palingbanyak ditemukan pada penelitian ini adalah craniotomi removal tumor (70%). Teknik 3DCRT paling banyak digunakan yaitu pada 77,7% pasien. Nimotuzumab sebagai antibodimonoklonal digunakan pada 9% pasien. Respon parsial ditemukan 59,1%. Analisis kesintasanhidup tiga tahun dari seratus sebelas pasien yang memenuhi kriteria didapatkan angkakesintasan yaitu 46,15%. Analisis kaplan meyer menunjukkan overall treatment timemerupakan faktor prognostik untuk kesintasan hidup (p = 0,016).Kesimpulan : Teknik operasi terbanyak pada pasien glioma yang menjalani radiasi didepartemen radioterapi RSUPN DR. Cipto Mangunkusumo adalah kraniotomi removal tumor(70,9%). Teknik 3D CRT adalah teknik radiasi yang paling banyak digunakan. Responparsial ditemukan 59,1%. Kesintasan hidup tiga tahun pasien glioma yaitu 46,2% dan overalltreatment time merupakan faktor prognostik yang bermakna untuk kesintasan hidup

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ABSTRACTIntroduction : Glioma is the most common type of primary intracerebral neoplasms. Highgrade glioma being the most frekuent type found (70,9%) causes a high morbidity andmortality rate. There is currently no data describing the profile management of patientsundergoing radiotherapy glioma in Indonesia.Methods : This study Retrospective analytic descriptive study of 121 glioma patients fromjanuari 2009 until december 2014. The data was obtained from medical records and indivualcontact via telephone. Tumor response was evaluated in 22 patients with pre and postirradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECISTcriteria.Results : Most of our patients were male (53,7%), with median age 45 years old.Astrocytoma was the most histopathological type found. 70.9% of Patients who receivedradiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3DConformal technique was used in 81.0% of patients. Seventy nine point three had a two graydose perfraction. Provision of chemotherapy in patients undergoing radiation still only at7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The medianoverall treatment time was 45 days and delay treatment time 38 days. Fifty nine point onepercent of partial respon was found. Local recurrences were found throughout the follow-upof 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factorfor overal survival rate (p=0,016).Conclusions : : Almost seventy one percent of glioma patients who received radiotherapyhad craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty ninepoint one percent of partial respon founded. Three years overall survival was 46,2% andoverall treatment time was found as a factor that significantly affects overall survivalprognosis.;Introduction : Glioma is the most common type of primary intracerebral neoplasms. Highgrade glioma being the most frekuent type found (70,9%) causes a high morbidity andmortality rate. There is currently no data describing the profile management of patientsundergoing radiotherapy glioma in Indonesia.Methods : This study Retrospective analytic descriptive study of 121 glioma patients fromjanuari 2009 until december 2014. The data was obtained from medical records and indivualcontact via telephone. Tumor response was evaluated in 22 patients with pre and postirradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECISTcriteria.Results : Most of our patients were male (53,7%), with median age 45 years old.Astrocytoma was the most histopathological type found. 70.9% of Patients who receivedradiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3DConformal technique was used in 81.0% of patients. Seventy nine point three had a two graydose perfraction. Provision of chemotherapy in patients undergoing radiation still only at7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The medianoverall treatment time was 45 days and delay treatment time 38 days. Fifty nine point onepercent of partial respon was found. Local recurrences were found throughout the follow-upof 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factorfor overal survival rate (p=0,016).Conclusions : : Almost seventy one percent of glioma patients who received radiotherapyhad craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty ninepoint one percent of partial respon founded. Three years overall survival was 46,2% andoverall treatment time was found as a factor that significantly affects overall survivalprognosis.;Introduction : Glioma is the most common type of primary intracerebral neoplasms. Highgrade glioma being the most frekuent type found (70,9%) causes a high morbidity andmortality rate. There is currently no data describing the profile management of patientsundergoing radiotherapy glioma in Indonesia.Methods : This study Retrospective analytic descriptive study of 121 glioma patients fromjanuari 2009 until december 2014. The data was obtained from medical records and indivualcontact via telephone. Tumor response was evaluated in 22 patients with pre and postirradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECISTcriteria.Results : Most of our patients were male (53,7%), with median age 45 years old.Astrocytoma was the most histopathological type found. 70.9% of Patients who receivedradiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3DConformal technique was used in 81.0% of patients. Seventy nine point three had a two graydose perfraction. Provision of chemotherapy in patients undergoing radiation still only at7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The medianoverall treatment time was 45 days and delay treatment time 38 days. Fifty nine point onepercent of partial respon was found. Local recurrences were found throughout the follow-upof 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factorfor overal survival rate (p=0,016).Conclusions : : Almost seventy one percent of glioma patients who received radiotherapyhad craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty ninepoint one percent of partial respon founded. Three years overall survival was 46,2% andoverall treatment time was found as a factor that significantly affects overall survivalprognosis., Introduction : Glioma is the most common type of primary intracerebral neoplasms. Highgrade glioma being the most frekuent type found (70,9%) causes a high morbidity andmortality rate. There is currently no data describing the profile management of patientsundergoing radiotherapy glioma in Indonesia.Methods : This study Retrospective analytic descriptive study of 121 glioma patients fromjanuari 2009 until december 2014. The data was obtained from medical records and indivualcontact via telephone. Tumor response was evaluated in 22 patients with pre and postirradiation imaging (CT or MRI) using 3D volumetric data and assessed via RECISTcriteria.Results : Most of our patients were male (53,7%), with median age 45 years old.Astrocytoma was the most histopathological type found. 70.9% of Patients who receivedradiotherapy in Cipto Mangunkusumo hospital were post craniotomi tumor removal. 3DConformal technique was used in 81.0% of patients. Seventy nine point three had a two graydose perfraction. Provision of chemotherapy in patients undergoing radiation still only at7.4% of patients. Nimotuzumab as a monoclonal antibody used on 9% patient. The medianoverall treatment time was 45 days and delay treatment time 38 days. Fifty nine point onepercent of partial respon was found. Local recurrences were found throughout the follow-upof 6.6%. Analysis kaplan meyer showed that overall treatment time was a prognostic factorfor overal survival rate (p=0,016).Conclusions : : Almost seventy one percent of glioma patients who received radiotherapyhad craniotomy removal tumor. 3D Conformal techniques is the most widely used. Fifty ninepoint one percent of partial respon founded. Three years overall survival was 46,2% andoverall treatment time was found as a factor that significantly affects overall survivalprognosis.]"

"End-stage kidney disease (ESKD) pada anak berdampak tidak terbatas pada aspek kesehatan fisik, tetapi juga perubahan emosi dan perilaku. Namun, kondisi ini seringkali diabaikan. Di Indonesia, data mengenai gangguan emosi dan perilaku khususnya pada pasien ESKD anak yang menjalani hemodialisis (HD) jumlahnya pun terbatas. Studi potong lintang ini dilakukan untuk mengetahui prevalensi, jenis gangguan, dan asosiasi faktor-faktor yang berhubungan terhadap gangguan emosi dan perilaku pada pasien ESKD anak yang menjalani HD. Total 28 pasien ESKD anak di RSCM usia 4-18 tahun yang menjalani hemodialisis minimal 1 bulan diikutkan dalam penelitian. Skrining gangguan emosi dan perilaku diukur menggunakan PSC-17. Analisis bivariat dilakukan menggunakan uji Chi-Square/Fisher. Studi ini menemukan prevalensi gangguan emosi dan perilaku pada pasien ESKD anak yang menjalani HD di RSCM sebesar 32%, dengan persentase abnormal tertinggi pada subskala internalisasi (21,4%). Variabel jenis kelamin menunjukkan hubungan signifikan (p<0,05) terhadap gangguan emosi dan perilaku.

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Children with end-stage kidney disease (ESKD) have behavioral and emotional difficulties in addition to physical health problems. But this condition is frequently disregarded. Data on emotional and behavioral issues among pediatric ESKD patients in Indonesia, especially those receiving hemodialysis (HD), is still scarce. The purpose of this cross-sectional study is to identify the prevalence, type, and correlation of variables associated with emotional and behavioral issues in pediatric hemodialysis patients. There were a total of 28 pediatric ESKD patients at RSCM, ages 4 to 18, who received hemodialysis treatment for at least one month included in this study. The children were screened for emotional and behavioral problems using PSC-17 questionnaire. Bivariate analysis was measured using Chi-Square/ Fisher test. This study discovered the prevalence of behavioral and emotional issues in children with ESKD receiving HD in RSCM is 32%, high proportion found in internalization subscale (21.4%). The risk of emotional and behavioral issues was shown to be significantly correlated with gender (p<0.05)."

"Preeklampsia masih menimpakan penyakit obstetrik peringkat atas di RSUPN Dr Cipto Mangunkusumo Jakarta. Penatalaksanaan preeklampsia meliputi pemberian obat, diet dan istirahat. Prinsip diet preeklampsia antara lain tinggi energi dan tinggi protein. Telah dilaporkan bahwa asupan energi dan protein pasien preeklampsia masa antenatal yang dirawat adalah Kurang dari kebutuhan dan ternyata tidak berhubungan dengan perubahan albumin darah dan kejadian edema. Penelitian ini bertujuan untuk memperoleh gambaran kehutuhan energi dan protein, serta mengetahui hubungan antara asupan energi dan protein dengan albumin darah dan kejadian edema. Metoda: Jenis disain penelitian adalah cross sectional dengan populasi dan sampel adalah ibu hamil dengan preeklampsia yang dirawat dan besar sampel 90. Semua sampel mendapat diet preeklampsia sesuai standar RSCM. Asupan makanan sebelum dirawat menggunakan metoda Semi quantitative food frequency dan selama dirawat dengan metoda penimbangan. Analisa zat gizi menggunakan program Food Processor 2. Dilakukan pemeriksaan albumin darah, proteinuria dan kejadian edema Analisa data secara univariat.bivariat dan multivariat menggunakan program Epi info 6, dengan menggunakan uji perbedaan t dan regresi multiple. Hasil dan pembahasan: Rerata kebutuhan energi responder adalah 1852 kalori dan kebutuhan protein 61.5 gram. Sebelum dirawat, rerata asupan energi dan protein masih dahlia batas normal yaitu 110.6% dan 94.5% .Ternyata tidak ada hubungan antara asupan energi dan protein dengan albumin darah sebelum dirawat yang kemungkinan disebabkan karena jumlah subyek terbatas dan homogen, serta perbedaan tingkat kerusakan endotel pembuluh darah Selma dirawat rerata asupan energi dalam batas normal (91.2% kebutuhan) dan protein termasuk defisit kurang (86.3%). Faktor gangguan fisik berhubungan dengan asupan energi dan protein tetapi faktor pengetahuan gizi tidak berhubungan. Kejadian edema dan tingkat proteinuria tidak berhubungan dengan asupan energi dan protein. Diperlukan standar diet preeklarnpsia berdasarkan tinggi badan yang dilengkapi dengan suatu pedoman untuk kemudahan pemesanan dan distribusinya. Parameter pre albumin dapat digunakan untuk melihat penibahan status protein selama perawatan 2 - 3 hari. Saran: Preskepsi diet dapat dikelompokkan rnenjadi 1700 kalori, 1900 kalori dan 2100 kalori. Anggota tim kesehatan perlu meningkatkan motivasi kepada pasien, baik dalam penyuluhan maupun pemberian bantam saat makan. Sedangkan parameter prealbumin dapat digunakan untuk menentukan kasus dan control dalam penelitian lebih lanjut."