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"ABSTRAKPenyakit kardiovaskuler adalah penyakit serius yang mematikan di mana seperempat kematian yang terjadi ternyata disebabkan oleh penyakit ini. Sementara itu, di negara berkembang seperti Indonesia kualitas layanan kesehatan masih rendah, ditandai dengan kurangnya tenaga dokter pada daerah-daerah rural dan terpencil. Kondisi ini menjadi motivasi perlunya merancang inovasi teknologi telemedical yang berfungsi membantu dokter melakukan diagnosis dan pengobatan penyakit kardiovaskuler. Penelitian ini mengusulkan sebuah sistem berbasis teknologi machine-to-machine M2M untuk mengecek kesehatan pasien yang akan melaporkan hasilnya ke dokter jantung secara jarak jauh melalui aplikasi website dan aplikasi mobile, yang diberi nama My Kardio. Desain dari sistem ini adalah terdiri dari tiga bagian utama yaitu bagian pasien patient site yang terdiri dari sensor-sensor dan gateway, bagian server server site yaitu server aplikasi web dan mobile yang terletak di cloud internet, dan bagian dokter doctor site yaitu aplikasi web dan mobile untuk dokter agar dokter dapat melakukan pengecekan dan diagnosis terhadap pasien secara online. Sistem ini dilengkapi dengan sistem prediksi auto-rekomendasi untuk memberikan rekomendasi kepada dokter dalam menentukan diagnosis penyakit yang diderita pasien. Sistem auto-rekomendasi ini dibangun dengan algoritma k-Nearest Neighbors kNN yang terbukti cukup baik performansinya dalam hal akurasi dan kecepatan. Uji coba telah dilakukan pada empat lokasi di daerah pinggiran Jakarta yaitu Kampung Banjarsari 10 pasien , Cibubur 15 pasien , Cimanggis 37 pasien , dan Pancoran 23 pasien pada total sejumlah 85 pasien. Evaluasi kuantitatif menghasilkan rata-rata akurasi prediksi sistem auto-rekomendasi adalah 76,47 , waktu pemrosesan sistem auto-rekomendasi 1 detik, dan performansi waktu transfer data dari lokasi pemeriksaan ke server M2M adalah 8,97 detik. Evaluasi secara kualitatif dilakukan melalui wawancara dokter spesialis jantung, dan diperoleh hasil bahwa aplikasi My Kardio sangat membantu terutama untuk daerah-daerah yang kekurangan dokter spesialis jantung; dan juga bermanfaat untuk kota besar di mana akses pasien ke dokter jantung juga terkendala oleh waktu praktek dokter yang terbatas dan kemacetan. Kata kunci:Machine-to-machine, penyakit kardiovaskuler, k-Nearest Neighbors.

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ABSTRACTCardiovascular disease is a deadly disease which one-fourth of deaths are caused by this disease. Meanwhile, in developing country like Indonesia, the quality of health services is still low, marked by the lack of doctors to serve patients. This condition gives the motivation about the need for a new innovation to improve the life expectancy of cardiovascular patients in Indonesia, with the help of technology. This research proposes a machine-to-machine M2M technology-based system to check the health of patients which will report the results to the cardiologist remotely through the web and mobile applications, named My Kardio. The design of this system is composed of three main parts, the first one is patient site consisting of sensors and gateways, then server site which is web and mobile application server located in the Internet cloud, and the last is doctor site: web and mobile application for doctors to enable doctors checking and diagnosing patients online. The system is equipped with an auto - recommendation prediction system to provide recommendations to physicians in determining the diagnosis of illness suffered by the patient. This auto-recommendation system is built on the k-Nearest Neighbors kNN algorithm that has been proven with good accuracy and fast. Trials have been performed in four locations in the suburbs of Jakarta: Kampung Banjarsari 10 patients , Cibubur 15 patients , Cimanggis 37 patients , and Pancoran 23 patients of the total 85 patients. Quantitative analysis results are, first the prediction accuracy of the auto- recommendation system is 76.47 on average, then the processing time of auto- recommendation system is 1 second, and last, the duration of data transfer time from location to M2M server is 8.97 seconds. Qualitative analysis was made with cardiologists interviews, which results that My Kardio application is very helpful especially in remote areas which lacking of cardiologists, even for big cities where patients rsquo; access to cardiologists is a problem due to limited clinic time and traffic jams. "

"Penyakit kardiovaskuler merupakan penyebab kematian utama penduduk dunia (30%). Untuk menghadapi masalah ini perlu diketahui distribusi penyakit kardiovaskuler terhadap faktor-faktor risikonya secara lebih spesifik. Penelitian ini bertujuan untuk mengetahui gambaran penyakit kardiovaskuler pada pasien rawat inap di Rumah Sakit Jantung dan Pembuluh Darah (RSJPD) Harapan Kita Tahun 2012. Penelitian ini menggunakan data sekunder dari rekam medik RSJPD Harapan Kita menggunakan desain studi cross sectional dengan jumlah sampel 339 orang dianalisis secara univariat. Hasil menunjukkan Ischemic Heart Diseases merupakan penyakit dengan proporsi terbesar yaitu 43,36%. Berdasarkan letak lesi, penyakit jantung memiliki proporsi terbesar yaitu 87,02%. Penyakit kardiovaskuler cenderung mengenai kelompok usia 51-60 tahun dengan proporsi 29,79%. Penyakit kardiovaskuler cenderung menyerang laki-laki dan orang dengan tingkat pendidikan menengah. Diketahui bahwa proporsi pasien hipertensi dan diabetes mellitus cenderung lebih besar di antara pasien penyakit pembuluh darah otak daripada pada pasien penyakit jantung ataupun pasien penyakit pembuluh darah perifer.

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Cardiovascular disease is the most common death cause (30%) . To face the problem it’s necessary to know the distribution of cardiovascular disease specifically to its risk factors. This research aims to describe the cardiovascular disease among the hospitalized patients in Harapan Kita Cardiovascular Hospital in 2012. This research uses the secondary data from Harapan Kita Cardiovascular Disease medical record and also uses cross sectional design with 339 sample and analyzed in univariate.

The results show that among the cardiovascular diseases in inpatient unit in Harapan Kita Cardiovascular Hospital, Ischemic Heart Diseases is the diseases with the biggest proportion which is 43,36%. According to lesion location, heart disease has the biggest proportion which is 87,02%. Cardiovascular diseases tend to affect the 51-60 years old group of age by 29,79% among other age groups. Cardiovascular diseases tend to affect men and those who have middle educational level. The results also show that proportion of patients with hypertension and Diabetes Melitus tends to be bigger among cererovascular diseases patients than heart diseases patients or peripheral vascular diseases patients."

"Kejadian penyakit kelainan katup masih menjadi masalah dan angka kejadiannya terus mengalami peningkatan di negara berkembang termasuk di Indonesia Dari tahun ke tahun angka kesakitan dan kematian terus mengalami peningkatan seiring dengan tingginya angka kejadian demam rematik di negara dengan iklim tropis dan subtropis Selain itu karena berbagai faktor lainnya seperti ekonomi dan lingkungan Kelainan katup stenosis mitral dapat menyebabkan berbagai komplikasi termasuk diantaranya gagal jantung dan edema paru Perawat sebagai salah satu tenaga kesehatan yang paling penting di unit pelayanan kesehatan diharapkan mampu mendeteksi secara dini timbulnya komplikasi yang akan muncul akibat penyakit jantung Sedangkan perawat spesialis sangat berperan penting dalam memberikan asuhan keperawatan kepada pasien terutama pasien dengan penyakit kardiovaskular yang kompleks Praktik residensi keperawatan medikal bedah bertujuan untuk melaksanakan peran perawat spesialis yang mencakup pemberian asuhan keperawatan dengan pendekatan konsep konservasi Myra Estrin Levine pada pasien dengan gangguan sistem kardiovaskular terutama pada pasien dengan stenosis katup mitral penerapan tindakan pemberian latihan aktifitas fisik rehabilitasi jantung fase 1 untuk mempercepat proses penyembuhan dan stabilisasi status hemodinamik serta berperan aktif dalam program inovasi pengembangan media edukasi pada pasien dengan pemasangan alat medis Hasil analisis praktik menunjukkan bahwa model konservasi Levine dapat diterapkan pada pasien dengan gangguan kardiovaskular untuk mengoptimalkan derajat kesehatan pasien pemberian latihan aktifitas fisik rehabilitasi jantung fase 1 menunjukkan tidak ada perubahan yang signifikan dalam perubahan hemodinamik dan pengembangan media edukasi pada pasien dengan pemasangan alat medis membantu pasien dalam meningkatkan pengetahuan mengenai alat medis.

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Incidence of cardiac valve abnormalities still a problem and the number of events is increasing in developing countries including Indonesia From year to year the morbidity and mortality continues to increase in line with by a high incidence of rheumatic fever in countries with tropical and subtropical climates Moreover because of many other factors such as the economy and environment Abnormalities of the mitral valve stenosis can cause a variety of complications including heart failure and pulmonary edema The nurse as one of the most important health personnel in the health care unit is expected to detect early onset of complications that would arise as a result of valve disease Meanwhile nurse specialist plays an important role in providing nursing care to patients especially patients with complicated cardiovascular disease

The practice of medical surgical nursing residency aimed to carry out the role of nurse specialist includes providing nursing care by implementing the concept of conservation of Myra Estrin Levine to patients with cardiovascular disorders especially those with mitral valve stenosis The implementation of measures to provide cardiac rehabilitation exercise physical activity to accelerate the phase 1 healing process and stabilization of hemodynamic status as well as an active role in the development of educational media innovation program in patients with implanted medical devices

Results of the analysis showed that the model of conservation practices Levine can be applied in patients with cardiovascular disorders to optimize the health status of patients provision of cardiac rehabilitation exercise physical activity Phase 1 showed no significant changes in hemodynamic changes and the development of educational media in patients with implanted medical devices help patients to improve knowledge of medical devices."

"ABSTRAKNama : Alifiah RachmaProgram Studi : Ilmu Kesehatan MasyarakatJudul : Pengembangan Aplikasi Daring Sistem Monitoring dan Evaluasi FaktorRisiko Penyakit Jantung dan Pembuluh DarahPembimbing : Dr. Artha Prabawa, SKM, M.SiPenyakit jantung dan pembuluh darah PJPD , salah satu Penyakit Tidak Menular,merupakan penyebab kematian terbesar secara global di seluruh negara. Prevalensi PJPDdi Indonesia tergolong tinggi. Akan tetapi skrining atau deteksi dini faktor risiko PJPDmasih rendah. Oleh karena itu, penelitian ini bertujuan untuk membangun pengembanganaplikasi daring dalam jaringan sistem monitoring dan evaluasi faktor risiko penyakitjantung dan pembuluh darah yang terintegrasi dengan surveilans dan sistem informasiPTM dan memudahkan penduduk Indonesia melakukan deteksi dini faktor risiko PJPD.Pengembangan sistem pada penelitian ini menggunakan System Development Life Cycle SDLC metode Rapid Application Development dengan model sistem pengembanganiterative penambahan .Hasil penelitian ini adalah Prototype aplikasi daring sistem monitoring dan evaluasifaktor risiko penyakit jantung dan pembuluh darah PJPD yang bernama SEHATJANTUNGKU. Prototype sistem ini berbasis website responsive online yangmemudahkan pengguna aplikasi mengakses sistem ini dimana saja dan melalui berbagaijenis platform. Kesimpulan dari penelitian ini adalah pengembangan aplikasi daringsistem monitoring dan evaluasi membantu pengelola program PTM dan stakeholderuntuk monitoring, evaluasi, dan membuat kebijakan.Kata kunci:Penyakit Tidak Menular, faktor risiko PJPD, deteksi dini, RAD, monev

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ABSTRACTName Alifiah RachmaStudy Program Public Health ScienceTitle Online Application Development of Monitoring and EvaluatingSystem of the Cardiovascular Disease Risk FactorCounsellor Dr. Artha Prabawa, SKM, M.SiBackground Cardiovascular Disease CVD is one of Non communicable Diseaseswhich cause the biggest number of death all over the world. The prevalence ofcardiovascular disease in Indonesia is high, but the screening or earlier detection of riskfactor of CVD is still low. In this context, this research is aimed to build online applicationdevelopment of monitoring and evaluating system of the CVD risk factor which isintegrated with the surveillance and NCD information system to facilitate Indonesian tohave earlier detection of CVD risk factor. Method System development in research usingSystem Development Life Cycle SDLC method of Rapid Application Development withchoice of iterative system model. Results the prototype of online application developmentof monitoring and evaluating system of the CVD risk factor is named SEHATJANTUNGKU. This prototype is online responsive web based which facilitate the usersto access this system anywhere and by using many platforms. Conclusions the onlineapplication development of monitoring and evaluating system of the CVD risk factor willhelp the NCD program manager and stakeholders to monitor, evaluate, and createrelated policies.Keywords NCD, CVD risk factor, early detection, RAD, monitoring and evaluating"

"Latar Belakang: Penyakit jantung merupakan penyebab kematian nomor satu dari kelompok Penyakit Tidak Menular (PTM) dan berdasarkan studi epidemiologi di Asia Tenggara, prevalensi gagal jantung di Asia Tenggara memiliki presentase yang lebih tinggi dibandingkan dengan negara lainnya. Gagal Jantung Dekompensasi Akut (GJDA) menjadi indikasi utama terjadinya admisi pada pasien dengan gagal jantung, khususnya gagal jantung dengan fraksi ejeksi rendah. Adanya kondisi hiponatremia dan hipokloremia pada pasien fraksi ejeksi rendah diharapkan dapat meningkatkan kewaspadaan bagi klinisi sebagai prediktor admisi akibat GJDA. Metode : Studi kohort retrospektif dengan menelusuri rekam medis pasien GJDA pada populasi fraksi ejeksi rendah berusia>18 tahun yang dirawat inap di RSUPN Cipto Mangunkusumo sejak tahun 2020 sampai dengan tahun 2023, dan menelusuri data elektrolit 90 hari sebelum admisi pasien dengan diagnosis GJDA pada pasien dengan fraksi ejeksi rendah. Dilakukan analisis bivariat dan juga multivariat prediktor admisi dengan diagnosis GJDA pada pasien dengan fraksi ejeksi rendah.Hasil : Dari total 265 subjek penelitian yang diletiti, analisis bivariat yang menunjukkan hiponatremia dan hipokloremia dapat menjadi prediktor admisi akibat GJDA pada pasien dengan fraksi ejeksi rendah, dengan analisis multivariat menunjukkan keduanya tetap merupakan prediktor yang baik secara statistik terkait admisi akibat GJDA pada pasien dengan fraksi ejeksi rendah dengan RR hiponatremia 1,729 (IK95% 1,367-2,179) dengan nilai P<0,001 dan OR hipokloremia 1,181 (IK95% 1,064-1,311) dengan nilai P 0,002.Kesimpulan : Hipontaremia ataupun hipokloremia pada pasien gagal jantung dengan fraksi ejeksi rendah dapat menjadi prediktor admisi akibat GJDA.

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Background : Cardiovascular disease remains the foremost cause of mortality within the spectrum of Non-Communicable Diseases (NCDs). Epidemiological studies within Southeast Asia have illuminated a notably elevated prevalence of heart failure compared to other global regions. Acute Decompensated Heart Failure (ADHF) serves as a primary catalyst for hospital admissions, particularly among patients exhibiting diminished left ventricular ejection fraction. The identification of hyponatremia and hypochloremia in individuals with reduced ejection fraction holds promise in enhancing clinicians' vigilance as predictive markers for ADHF admissions.

Methodology : This retrospective cohort study delved into the medical records of individuals with ADHF within the low left ventricular ejection fraction cohort, aged >18 years, admitted to Dr. Cipto Mangunkusumo National Central General Hospital from 2020 to 2023. Electrolyte profiles from the 90-day period preceding ADHF diagnosis among patients with reduced ejection fraction were scrutinized. Both bivariate and multivariate analyses were conducted to delineate predictors of ADHF admissions in this subgroup.

Results : Among the 265 subjects scrutinized, bivariate analysis revealed that both hyponatremia and hypochloremia could function as robust predictors for ADHF admissions in patients displaying diminished ejection fraction. Multivariate analysis solidified their statistical significance as predictors of ADHF admissions in individuals with reduced ejection fraction. Hyponatremia exhibited an relative risk (RR) of 1.729 (95% CI 1.367-2.179) with a P-value of <0.001, while hypochloremia demonstrated an RR of 1.181 (95% CI 1.064-1.311) with a P-value of 0.002.

Conclusion : The presence of hyponatremia and hypochloremia in patients with heart failure and reduced left ventricular ejection fraction stands as a clinically significant predictive factor for ADHF admissions."

"Penyakit kardiovaskular merupakan penyebab kematian utama di Malaysia baik di kota dan pedesaan. Untuk pencegahan dan penanggulangan masalah ini perlu disusun menurut prioritas beberapa faktor risiko. Tujuan artikel ini ialah untuk mengidentifikasi beberapa faktor risiko penyakit kardiovaskular yang dominan. Satu penelitian potong lintang komunitas dilakukan pada Maret 2000 ? Juni 2001 terhadap 8159 penduduk pinggiran kota dan pedesaan yang berusia 18 tahun ke atas untuk melihat prevalensi faktor risiko utama penyakit kardiovaskular. Faktor risiko yang diteliti adalah tekanan darah sistolik, tekanan darah diastolik, kadar kolesterol dan glukosa darah, indeks massa tubuh, kebiasaan merokok, aktivitas fisik, dan tingkat ketegangan mental. Prevalensi faktor risiko utama penyakit kardiovaskular pada umumnya tinggi yang didominasi oleh kurang aktivitas fisik (65.7%), peningkatan kolesterol ? TC:HC (62.3%), ketegangan mental (55.5%), obesitas (53.7%), dan merokok (49.9%) terutama di antara lelaki. Beberapa prevalensi meskipun meningkat menurut umur akan tetapi relatif rendah: prevalensi tekanan darah sistolik (23.7%) dan diastolik (19.2% serta penyakit kencing manis (6.3%). Faktor risiko kardiovaskular yang berkaitan gaya hidup ternyata jauh lebih prevalens dibandingkan dengan faktor risiko akibat pengaruh biologi. Oleh karena itu inisiatif upaya kesehatan masyarakat harus dipacu untuk mencegah dan mengontrol faktor risiko yang berkaitan gaya hidup.

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AbstractCardiovascular problem is one of the leading cause of death in Malaysia and now invaded to the sub-urban and rural areas. To prevent and control of this problem, several main risk factors needed to be known and shall be reexamined and ranked according to the priority. The objectives of this research paper was to identify several dominant risk factor related to cardiovascular problem. A cross sectional study was carried out from March 2000 ? June 2001 on a total of 8159 rural population aged 18 and above to measure the prevalence of the common cardiovascular risk factors. Those risk factors are systolic blood pressure, diastolic blood pressure, serum cholesterol level, obesity index, blood glucose level, smoking, physical activity and mental stress. Overall prevalence of common cardiovascular risk factors were higher, dominated by physical inactivity (65.7%), hypercholesterolemia ? TC:HC (62.3%), mental stress (55.5%) and obesity (53.7%). Smoking was also high at 49.9% especially among men. However systolic hypertension, diastolic hypertension and diabetes mellitus; although increased by age, its prevalence is relatively low at 23.7%, 19.2%, and 6.3% respectively. Cardiovascular risk factors related to lifestyle are much evidenced as compared to risk factors related to the biological influence. Therefore, all initiatives in community health intervention should be mobilized specifically on prevention and control of lifestyle-related risk factors. "

"ABSTRAK Latar belakang: disglikemia adalah keadaan intoleransi glukosa berupa peningkatan kadar gula darah yang berhubungan dengan risiko penyakit kardiovaskular. Seiring dengan waktu, pada akhirnya diabetes akan menimbulkan kerusakan pada target organ, salah satu yang penting adalah pada sistem organ kardiovaskular, dapat berupa penyakit jantung koroner, kardiomiopati diabetes, penyakit serebrovaskuler, dan penyakit arteri perifer. Diabetes juga meningkatkan risiko terjadinya gagal jantung. Pada kardiomiopati diabetes, proses fibrosis yang masih reversibel sudah mulai terjadi bahkan ketika penderita masih asimtomatik. Pemeriksaan baku emas untuk mendeteksi terjadinya fibrosis miokard secara dini adalah pemeriksaan histopatologi jaringan miokardium melalui biopsi. Akan tetapi pemeriksaan ini sangat invasif dan tidak nyaman bagi subjek. Pemeriksaan yang kemudian berkembang adalah pencitraan menggunakan Cardiac Magnetic Resonance Imaging (CMRI). Akan tetapi pemeriksaan ini cukup mahal, dan tidak tersedia pada semua fasilitas kesehatan. Sementara itu, ST2 adalah penanda enzim jantung yang menggambarkan derajat proses fibrosis yang sedang terjadi pada miokard, terutama pada keadaan gagal jantung. Pemeriksaan menggunakan penanda enzim dapat menjadi alternatif dengan keuntungan lebih murah, dapat terjangkau luas dan mudah tersedia. Tujuan: Mengetahui hubungan antara kadar ST2 serum dengan fibrosis miokard interstisial pada penderita disglikemia. Metode: Pasien disglikemia yang lolos kriteria eksklusi berupa komorbid kardiovaskular akan menjalani pemeriksaan kadar ST2 serum dan T1 relaxation time menggunakan Cardiac MRI. Selanjutnya dilakukan analisis hubungan antara kadar ST2 serum dan T1 relaxation time. Hasil penelitian: Sebanyak 34 pasien diikutsertakan ke dalam penelitian ini. Didapatkan kisaran nilai kadar ST2 serum antara 12.40-53.22 ng/dL (median 19.95 ng/dL). Rerata nilai T1 relaxation time didapatkan sebesar 443.39 ± 113.35 ms. Terdapat korelasi bermakna antara kadar ST2 serum dengan fibrosis diffuse miokardium (Spearman correlation r = -0,547, p < 0.01). Pada analisa multivariat hubungan antara kadar ST2 serum dan T1 relaxation time tidak dipengaruhi oleh faktor perancu yang telah ditetapkan (r = -0,44, p = 0,033). Kesimpulan: Hasil penelitian ini menunjukkan kadar ST2 serum berkolerasi dengan fibrosis diffuse miokardium pada populasi disglikemia.ABSTRACT Background: disglycemia is a state of glucose intolerance include increased blood sugar levels associated with risk of cardiovascular disease. Over time, eventually diabetes will cause damage to the target organ, especially the cardiovascular system, which include coronary heart disease, diabetic cardiomyopathy, diabetes, cerebrovascular disease, and peripheral arterial disease. Diabetes also increases the risk of heart failure. The clinical appearance of the disease is wide ranging from asymptomatic to symptomatic heart failure. Gold standard examination to detect the occurrence of early myocardial fibrosis is histopathological examination of myocardial tissue via biopsy. However, these tests are very invasive and uncomfortable for the subject. Examination which later evolved is imaging using cardiac magnetic resonance imaging (CMRI). However, these tests are quite expensive, and not available at all health facilities. Meanwhile, ST2 is a cardiac enzyme marker that describes the degree of fibrosis process in the myocardium, especially in the state of heart failure. Examination using enzyme markers can be a cheaper alternative, widely accessible and readily available. Aim: Knowing the relationship between serum levels of ST2 with myocardial interstitial fibrosis in disglycemic patients. Methods: Disglycemic patients who passed from the exclusion criteria (cardiovascular comorbid), will undergo a serum ST2 levels and T1 relaxation time using cardiac MRI. Then we analyzed the relationship between serum levels of ST2 and T1 relaxation time. Results: A total of 34 patients were included in this study. The range values of serum ST2 levels were between 12.40-53.22 ng/dL (median 19.95 ng/dL). The mean value of T1 relaxation time were 443.39 ± 113.35 ms. There is a significant correlation between serum levels of ST2 with diffuse myocardial fibrosis (Spearman correlation r = -0.547, p <0:01). Multivariate analysis showed the relationship between serum levels of ST2 and T1 relaxation time is not influenced by confounding factors (r = -0.44, p = 0.033). Conclusion: ST2 serum levels correlates with diffuse myocardial fibrosis on disglycemic population.;Background: disglycemia is a state of glucose intolerance include increased blood sugar levels associated with risk of cardiovascular disease. Over time, eventually diabetes will cause damage to the target organ, especially the cardiovascular system, which include coronary heart disease, diabetic cardiomyopathy, diabetes, cerebrovascular disease, and peripheral arterial disease. Diabetes also increases the risk of heart failure. The clinical appearance of the disease is wide ranging from asymptomatic to symptomatic heart failure. Gold standard examination to detect the occurrence of early myocardial fibrosis is histopathological examination of myocardial tissue via biopsy. However, these tests are very invasive and uncomfortable for the subject. Examination which later evolved is imaging using cardiac magnetic resonance imaging (CMRI). However, these tests are quite expensive, and not available at all health facilities. Meanwhile, ST2 is a cardiac enzyme marker that describes the degree of fibrosis process in the myocardium, especially in the state of heart failure. Examination using enzyme markers can be a cheaper alternative, widely accessible and readily available. Aim: Knowing the relationship between serum levels of ST2 with myocardial interstitial fibrosis in disglycemic patients. Methods: Disglycemic patients who passed from the exclusion criteria (cardiovascular comorbid), will undergo a serum ST2 levels and T1 relaxation time using cardiac MRI. Then we analyzed the relationship between serum levels of ST2 and T1 relaxation time. Results: A total of 34 patients were included in this study. The range values of serum ST2 levels were between 12.40-53.22 ng/dL (median 19.95 ng/dL). The mean value of T1 relaxation time were 443.39 ± 113.35 ms. There is a significant correlation between serum levels of ST2 with diffuse myocardial fibrosis (Spearman correlation r = -0.547, p <0:01). Multivariate analysis showed the relationship between serum levels of ST2 and T1 relaxation time is not influenced by confounding factors (r = -0.44, p = 0.033). Conclusion: ST2 serum levels correlates with diffuse myocardial fibrosis on disglycemic population.;Background: disglycemia is a state of glucose intolerance include increased blood sugar levels associated with risk of cardiovascular disease. Over time, eventually diabetes will cause damage to the target organ, especially the cardiovascular system, which include coronary heart disease, diabetic cardiomyopathy, diabetes, cerebrovascular disease, and peripheral arterial disease. Diabetes also increases the risk of heart failure. The clinical appearance of the disease is wide ranging from asymptomatic to symptomatic heart failure. Gold standard examination to detect the occurrence of early myocardial fibrosis is histopathological examination of myocardial tissue via biopsy. However, these tests are very invasive and uncomfortable for the subject. Examination which later evolved is imaging using cardiac magnetic resonance imaging (CMRI). However, these tests are quite expensive, and not available at all health facilities. Meanwhile, ST2 is a cardiac enzyme marker that describes the degree of fibrosis process in the myocardium, especially in the state of heart failure. Examination using enzyme markers can be a cheaper alternative, widely accessible and readily available. Aim: Knowing the relationship between serum levels of ST2 with myocardial interstitial fibrosis in disglycemic patients. Methods: Disglycemic patients who passed from the exclusion criteria (cardiovascular comorbid), will undergo a serum ST2 levels and T1 relaxation time using cardiac MRI. Then we analyzed the relationship between serum levels of ST2 and T1 relaxation time. Results: A total of 34 patients were included in this study. The range values of serum ST2 levels were between 12.40-53.22 ng/dL (median 19.95 ng/dL). The mean value of T1 relaxation time were 443.39 ± 113.35 ms. There is a significant correlation between serum levels of ST2 with diffuse myocardial fibrosis (Spearman correlation r = -0.547, p <0:01). Multivariate analysis showed the relationship between serum levels of ST2 and T1 relaxation time is not influenced by confounding factors (r = -0.44, p = 0.033). Conclusion: ST2 serum levels correlates with diffuse myocardial fibrosis on disglycemic population.;Background: disglycemia is a state of glucose intolerance include increased blood sugar levels associated with risk of cardiovascular disease. Over time, eventually diabetes will cause damage to the target organ, especially the cardiovascular system, which include coronary heart disease, diabetic cardiomyopathy, diabetes, cerebrovascular disease, and peripheral arterial disease. Diabetes also increases the risk of heart failure. The clinical appearance of the disease is wide ranging from asymptomatic to symptomatic heart failure. Gold standard examination to detect the occurrence of early myocardial fibrosis is histopathological examination of myocardial tissue via biopsy. However, these tests are very invasive and uncomfortable for the subject. Examination which later evolved is imaging using cardiac magnetic resonance imaging (CMRI). However, these tests are quite expensive, and not available at all health facilities. Meanwhile, ST2 is a cardiac enzyme marker that describes the degree of fibrosis process in the myocardium, especially in the state of heart failure. Examination using enzyme markers can be a cheaper alternative, widely accessible and readily available. Aim: Knowing the relationship between serum levels of ST2 with myocardial interstitial fibrosis in disglycemic patients. Methods: Disglycemic patients who passed from the exclusion criteria (cardiovascular comorbid), will undergo a serum ST2 levels and T1 relaxation time using cardiac MRI. Then we analyzed the relationship between serum levels of ST2 and T1 relaxation time. Results: A total of 34 patients were included in this study. The range values of serum ST2 levels were between 12.40-53.22 ng/dL (median 19.95 ng/dL). The mean value of T1 relaxation time were 443.39 ± 113.35 ms. There is a significant correlation between serum levels of ST2 with diffuse myocardial fibrosis (Spearman correlation r = -0.547, p <0:01). Multivariate analysis showed the relationship between serum levels of ST2 and T1 relaxation time is not influenced by confounding factors (r = -0.44, p = 0.033). Conclusion: ST2 serum levels correlates with diffuse myocardial fibrosis on disglycemic population."