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"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 84-86The progressiveness of malignant tumors is influenced by various complex factors. One of the important factor is Tenascin-C (Tn-C) protein, which can interact with fibronectin as an anti adhesive of anti modulation protein. Tenascin-C is an extra cellular matrix glyco protein (EMG) which can be found in the oral tissue also as an up regulator. They can be associated with EMG, and strongly influenced promotion of the stromal cell as cell growth, migration, differentiation, angiogenesis, and apoptosis in cancer. Alternative splicing of fibronectin-like type III (FN lll) repeats of Tn-C generates a number of splice variants, and influences tumor progressiveness. The conclusion of Tn-C role in tumor progressiveness depends on the molecular weight and alternative splicing of FN lll. ;Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 84-86;Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 84-86"

"Latar Belakang: Perubahan genetik pada p53 menyebabkan imortalisasi dan kecenderungan sel bertransformasi menjadi neoplasma. Imortalisasi ini berhubungan dengan pemeliharaan panjang telomer oleh telomerase. hTERT adalah komponen kunci telomerase yang aktivitasnya ditekan oleh p53.Tujuan: Menganalisis profil protein hTERT pada sel galur KSSRM HSC-3 dan HSC-4 serta jaringan mukosa mulut normal. Metode: Profil protein hTERT dianalisis menggunakan teknik SDS-PAGE dan Gel Doc, Quantity One.Hasil: Protein hTERT diekspresikan oleh sel galur KSSRM mulut tipe HSC 3 dan HSC 4 serta 2 dari 17 sampel protein jaringan mukosa mulut normal.Simpulan: Protein hTERT yang diekspresikan oleh sel galur KSSRM berhubungan dengan kondisi mutan p53. Adanya ekspresi protein hTERT pada jaringan mukosa mulut normal diperkirakan karena adanya sel keratinosit dan infiltrasi sel hematopoietik.

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Backround: Genetic alteration on p53 allows cellular immortalization and predisposes cells to neoplastic transformation. This immortalization is related to telomere length maintenance by telomerase. hTERT is a key component of telomerase, which activity is suppressed by p53.Objectives: To analyze the hTERT protein profile in HSC-3 and HSC-4 OSCC cell lines and normal human oral mucosa tissue. Methods: SDS-PAGE and Gel Doc, Quantity One were used for analyzing hTERT protein profile.Results: hTERT protein expressed in HSC-3 and HSC-4 OSCC cell lines and 2/17 protein samples of normal human oral mucosal tissues.Conclusion: hTERT protein that was expressed by OSCC cell lines is related to their status of mutant p53. The existing of hTERT protein on normal human oral mucosas tissue may be caused by keratinocyte cells and infiltrated hemapoietic cells."

"Oral mucous inflammation is common in our community. Therefore we need an anti-inflammatory medicine with affordable price, relative low adverse effects, and easily obtained in our environment. Sweet fennel is a plant that widely used in our community as a decorating plant, food flavouring and herbal medicine for various diseases. The affectivity for fennel has not been clinically examined. Therefore we are interested in finding our the affectivity of sweet fennel as an alternative anti-inflammatory. The aim of this research is to examine and compare reaction of both crushed and distilled fennel fruit on inflamed oral mucosa caused by hydrogen peroxide 10%. 14 rats were used and divided into 4 groups, and controls (6 rats). They received hydrogen peroxide 10% applications on vestibulum mucosa for there days to make the inflammation. After that they received crushed and distilled fennel. There days later they were killed and the vestibulum mucosa was excised for microscopic slides. The results show that the crushed the redness of oral mucosa. The conclusion is fennel could reduce an inflammation and there is no difference of healing either by crushed or distilled fennel."

"ABSTRAKEfek samping gastroduodenal sering terjadi pada pengunaan aspirin jangka panjang, bahkan pada dosis yang sangat rendah (10 mg/hari). Saat ini angka kejadian kerusakan mukosa gastroduodenal akibat penggunaan aspirin dosis rendah jangka panjang di Indonesia belum diketahui. Tujuan: Mengetahui prevalensi dan gambaran endoskopi kerusakan mukosa gastroduodenal pada pengguna aspirin dosis rendah jangka panjang pada pasien yang berobat di RSCM, serta faktor-faktor yang mempengaruhi. Metode: Penelitian ini menggunakan desain potong lintang pada pasien poliklinik dan ruang perawatan RSCM usia ≥ 18 tahun yang mengkonsumsi aspirin dosis rendah (75-325 mg) lebih dari 28 hari. Didapatkan 95 subjek penelitian melalui metode konsekutif dalam periode Desember 2015 ? April 2016. Temuan endoskopi berupa erosi mukosa dan ulkus peptikum dimasukkan ke dalam kelompok kerusakan mukosa. Hasil: Kerusakan mukosa gastroduodenal ditemukan pada pada 49 subjek (51,6% (95% IK 41,6-61,7%)), dengan gambaran erosi mukosa pada 38 subjek (40% (95% IK 30,2-49,9%)) dan ulkus peptikum pada 11 subjek (11,6% (95% IK 5,2-18,0%)). Hanya 44,9% pasien dengan kerusakan mukosa gastroduodenal memiliki keluhan dispepsia. Kombinasi antitrombotik meningkatkan risiko terjadinya kerusakan mukosa (OR 3,3 (95% IK 1,3 ? 8,5)). Sedangkan penggunaan obat golongan proton pump inhibitors (PPI) menurunkan risiko (OR 0,2 (95% IK 0,04 ? 0,60)). Kesimpulan: Kerusakan mukosa gastroduodenal terjadi pada lebih dari separuh pasien yang menggunakan aspirin dosis rendah jangka panjang. Kombinasi aintitrombotik meningkatkan risiko kerusakan mukosa. Sedangkan penggunaan PPI efektif dalam menurunkan risiko tersebut.

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ABSTRACTBackground: Long-term aspirin therapy can induces gastroduodenal mucosal injury, even in a very low dose (10 mg daily). The frequency of gastroduodenal injuries among long-term low-dose aspirin users in Indonesia is currently unknown.Aim: To determine the gastroduodenal mucosal injury prevalence, endoscopic findings, and influencing factors among long-term low-dose aspirin users in RSCM. Methods: This study was a cross-sectional study conducted in Cipto Mangunkusumo Hospital, Jakarta. Subjects were ≥ 18 years old patients that have been using low-dose aspirin (75-325 mg) for at least the preceding 28 days. Ninety five subjects were recruited consecutively in the period of December 2015 ? April 2016. Endoscopic findings such as erosions and ulcers were assessed as mucosal injuries. Results: Mucosal injury was found in 49 subjects [51.6% (95% CI 41.6?61.7%)]; mucosal erosion in 38 subjects [40% (95% CI 30.2?49.9%)] and ulcers in 11 subjects [11.6% (95% CI 5.2?18.0%)]. Only 44.9% patients with mucosal injury had dyspepsia symptoms. Double antiplatelet therapy increases the risk of mucosal injury [OR 3.3 (95% CI 1.3?8.5)]. However, proton pump inhibitor (PPI) decreases the risk [OR 0,2 (95% IK 0,04 ? 0,60)]. Conclusions: Gastroduodenal mucosal injury was found in more than half of long-term low-dose aspirin users. Double antiplatelet therapy increases the risk of mucosal injury, while PPI effectively reduced the risk.;"

"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 215-220The purpose of this study was to disclose one of the etiopathogenesis of recurrent aphthous stomatitis (RAS) at molecular level by analyzing the expression of protein anomaly in oral mucosa. This was a cross-sectional explorative and analytic observational study. Samples, who met inclusion and exclusion criteria, were taken from total population. Samples of protein swab were obtained from oral mucosa, serum weretaken from 15 patients with major RAS, 20 patients with minor RAS and 15 were control. The characterization of protein anomaly expressed on the surface of oral mucosa epithelium was carried out using SDS-PAGE 12% and Westemblot methods. The result of oral mucosa protein anomaly expression analysis in patients with major RAS using SDS-PAGE 12% revealed five protein bands with molecular weights of 87,65, 30, 25, and 20 kDa. In minor RAS cases with protein anomaly expression there were four proteins with molecular weights of 87, 65, 25, and 20 kDa, and the protein in remission RAS had four proteins bands with molecular weight of 87, 65, 25 and 20 kDa. The band disappearances by using Westemblot test, of 30 kDa of major cases, 87 and 20 kDa of minor cases and 20 and 25 kDa of remission cases, indicated that those patients were not reacted with polyclonal antibodies of rabbit serum; therefore they had no role in the induction of RAS. ln conclusion, the antigenic protein expressed in oral mucosa of major, minor, and remission RAS was predominantly 65 kDa molecular weight."

"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 435-438Heat Shock Protein (HSP) is a molecular chaperone that prevents stress induced aggregation of partially denatured proteins and promotes their return to native confimations when the condition is favorable. Asmolecular chaperones, the HSP protect protein structure and activity, thereby preventing disease, but they may contribute to cell malfunction if they are perturbed. In inracellular quantities and cellular localizalion of HSP was changed in response to anoxia/hypoxia, heat and oxidation, and in relation to pathological status. This review discuses the role of HSP in several human medical condition particularly in oral mucosa."

"Oral lichen planus (OLP) is a chronic inflammatory condition that effects oral mucous membranes with a variety of clinical presentations including reticular, atrophic, plaque and ulcerative lesions. Corticosteroid is one of the effective therapy for OLP in reducing the sign and symptoms of this disease, but this therapy have a serious side effect, therefore to administering one must consider the patient?s systemic condition. We reported a case of OLP in 52 years old female patient who has no history of diabetes mellitus and unknown glucose level. Management of this patient included application of corticosteroid swish, topical 0.05% clobetasol propionate and 0,1% triamcinolone acetonide, antimycotics, improvement the oral hygiene status and referral to internal medicine specialist. The next treatments plan challenging because unstable blood glucose level which in turn effects the drug choice and teeth extraction plan. We concluded that the treatment of OLP requires a complete assessment of medical status and lab studies specially on the first visit so the drug selection with corticosteroid therapy and the treatment planning of predisposing factor are effective in reducing the sign and symptoms of OLP with minimum systemic side effect."

"Oral lichen planus (OLP) is a chronic inflammatory condition that affects the oral mucous membranes with a variety of clinical presentations, including reticular, atrophic (desquamative gingivitis) and ulcrative lesions. Treatment aims primarily to reduce the length and severity of symptomatic outbreaks. We report a case of OLP in 53 years old female patient with hypertension as underlying disease. The patient had been treated with nifedipine and reserpine for twelve years. Management of the patient included the application of 0.05% clobetasol propionate in a custom tray for erosive gingival lesions, nutritional supplementation, oral hygiene promotion and consultation to internal medicine specialist. The improvement of OLP requires a complete assessment of the medical status and elimination of local exacerbating factors. Systemic drug therapy is needed if OLP is suspected as the cause of oral lichenoid lesion. Changing to other drug regimes may also become necessary for improved immune status."

"Aloe vera has been proven as anti inflammatory effect, but the lowest concentration and the shortest time of Aloe vera which could decrease inflammatory has not been known exactly. The aims of this research is to find the lowest concentration on 1 day application of Aloe Vera which could decrease inflammatory on rat oral mucosa after it has been applied by H2O2 10% for 3 days. 12 rats that has been applied by H2O2 10% were divided into 4 groups, which are : applied Aloe vera 10% substrate for 1 day (3 rats), applied Aloe vera 25% substrate for 1 day (3 rats), control group 1 which applied Aloe vera 10% substrate for 3 days (3 rats), and control group 2 which applied Aloe vera 25% substrate for 3 days (3 rats). The score of inflammatory is determined using modification the method of Eda S and Fuyama. The obtained data were analyzed with Kolmogorov - Smirnov (p<0,05). In conclusion, Aloe vera substrate 10% applied for 1 day could decrease oral mucosa inflammatory."

"ABSTRAKMucocele adalah lesi jinak yang terdapat pada mukosa mulut dan merupakan gangguan yang sering terjadi pada kelenjar saliva minor. Mucocele termasuk dalam 17 lesi yang sering terjadi pada rongga mulut yang disebabkan oleh trauma dan obstruksi pada kelenjar saliva. Mucocele dapat terjadi pada berbagai kelompok usia, namun pada umumnya terjadi pada anak-anak, remaja, dan dewasa muda. Penelitian mengenai distribusi dan frekuensi mucocele perlu dilakukan untuk mengetahui epidemiologi dari mucocele, sehingga dapat memberikan informasi berupa prognosis dan kesuksesan perawatan berdasarkan kondisi yang dialami oleh pasien di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo periode 2016-2017. Penelitian ini menggunakan studi deskriptif retrospektif dengan menggunakan rekam medik pada pasien di RSUPN Dr. Cipto Mangunkusumo. Analisis 8 kasus mucocele berdasarkan umur, jenis kelamin, jenis pekerjaan, lokasi terjadinya lesi, ukuran lesi, kondisi lesi, etiologi, jenis perawatan, dan kasus rekurensi. Sebagian besar pasien berumur 11-20 tahun (37,5%) dengan pekerjaan sebagai pelajar (50%). Rasio antara pasien laki-laki dan perempuan adalah 1:3. Lesi paling banyak ditemukan pada bibir bawah (50%) dengan ukuran 6-10 mm (50%) dalam keadaan yang tidak pecah. Etiologi berasal dari trauma dan kebiasaan menggigit bibir. Pilihan perawatan yang sering dilakukan adalah eksisi, yaitu sebanyak 4 kasus. Terdapat 4 kasus rekurensi pada mucocele setelah dilakukan perawatan.

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ABSTRACTMucocele is a benign lesion found in the oral mucosa and it is a disorder that often occurs in minor salivary glands. Mucoceles are included in 17th common lesions in the oral cavity caused by trauma and obstruction in the salivary glands. Mucocele can occur in various age groups but usually in children, adolescents, and young adults. Research on the distribution and frequency of mucocele needs to be done to determine the epidemiology of mucocele, so it can provide the information of prognosis and success of treatment based on the conditions that experienced by patients at National Hospital Dr. Cipto Mangunkusumo from 2016-2017. The method of this research is retrospective descriptive study from medical records of National Hospital Dr. Cipto Mangunkusumo patients. 8 cases of mucocele was analyzed based on age, gender, occupation, location of the lesion, size of lesion, condition of lesion, etiology, type of treatment, and recurrence cases. Most of the patients were 11-20 years old (37.5%) and most of them were students (50%). The ratio between male and female patients is 1:3. Most of the lesions are found in the lower lip (50%) in sizes 6-10 mm (50%) in a non-ruptured condition. The etiology of mucocele are trauma and lip biting habits. The choice of treatment that is often done in 4 cases of mucocele is excision. There were 4 cases of recurrence in mucocele after treatment."