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Daniel Putra
Penyembuhan ulser dengan pemaparan ekstrak etanol kelopak bunga rosella teridentifikasi 7.5% = Healing ulcers with application of standardized ethanol roselle flower petals 7.5%
"Rosella berkhasiat anti-inflamasi dan anti-bakteri.
Tujuan : Mengetahui kondisi makroskopis, mikroskopis ulser mukosa yang diaplikasikan
ekstrak rosella.
Metode : Tiga puluh enam tikus sprague-dawley dibagi, Triamcinolone Acetonide 0.1% sebagai kontrol positif, saline 0.9% sebagai kontrol negatif, ekstrak rosella 7.5% sebagai kelompok perlakuan, selama 1, 3, 7, 14 hari.
Hasil : pada perlakuan 7 hari, selisih diameter awal dan akhir kelompok ekstrak rosella 7.5% lebih besar dibandingkan TA dan saline, skor radang ulser kelompok ektrak rosella 7.5% lebih rendah dibandingkan TA dan saline.
Kesimpulan : Aplikasi ekstrak rosella 7.5% efektif mempercepat penyembuhan ulser pada perlakuan 7 hari.
Roselle have anti-inflammatory, anti-bacteria effect.
Objectives : To determine macroscopic, microscopic condition of ulcers after application of roselle extract.
Methods : thirty six sprague-dawley rats were divided, TA 0.1% as positive control, saline 0.9% as negative control, roselle extract 7.5% as treatment group. healing was observed in the first, third, seventh, and fourteenth day.
Result : In 7 days, the diameter differences of ulcers applied with roselle extract 7.5% is bigger and inflammation score of ulcers is lower than TA and saline.
Conclusion : application of roselle extract 7.5% is effective in accelerating healing in 7 days."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2013
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Anita Erdiani
Efektivitas ekstrak Etanol terstandar kelopak bunga Rosela Tetes terhadap penyembuhan Ulser Mukosa Mulut (in vivo) = Effectiveness of standardized Ethanol extract of Roselle's Calyx drop on healing of Oral Mucous Ulcer (in vivo)
"Pendahuluan: Rosela memiliki khasiat antiinflamasi. Ulser merupakan keadaan inflamasi dalam rongga mulut.
Tujuan: Menganalisis efektivitas ekstrak etanol terstandar kelopak bunga rosela terhadap penyembuhan ulser.
Metode: Penelitian in vivo pada model ulser 12 tikus, dibagi menjadi kelompok kontrol dan perlakuan. Rosela diteteskan 2 kali sehari pada ulser, kemudian hari ke 3 dan 7 dikorbankan. Parameter yang diobservasi adalah kemerahan dan bengkak di sekitar jaringan ulser, diameter ulser, serta skor radang.
Hasil: Rosela 7.5% 7 hari dapat menghilangkan kemerahan, sedangkan 3.75% dan 7.5% menurunkan diameter ulser dan skor radang.
Kesimpulan: Aplikasi tetes ekstrak terstandar rosela efektif dalam mempercepat penyembuhan ulser.
Background: Roselle has antiinflammatory effect. Ulcer is an inflammatory condition in oral.
Objective: Analyze effectiveness of roselle in healing an ulcer.
Methods: This research in vivo on ulcer model 12 rats, divided into control and treatment group. Roselle drops were applied twice a day on ulcer, then day 3 to 7 was sacrificed. Healing process was observed by looking redness and swelling, ulcer diameter, and inflammation score.
Results: Roselle 7.5% 7 days can eliminate redness, while 3.75 % and 7.5% reduced ulcer diameter and inflammation score.
Conclusion: Application drops of standardized ethanol extract of roselle are effective in ulcer healing."
Depok: Universitas Indonesia, 2012
S45513
UI - Skripsi Membership  Universitas Indonesia Library
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Lili Nur Indah Sari
Efektivitas ekstrak Etanol terstandar kelopak bunga Rosela 7,5% dan 15% terhadap Ulser Mukosa Mulut tikus = Effectiveness of Ethanol extract standardized flower petals rosela 7,5% and 15% Mucosa Oral Ulcer of the rat
"Latar Belakang: Rosela dilaporkan memiliki khasiat sebagai antiinflamasi.
Tujuan: mengetahui efektivitas rosela terhadap ulser mukosa mulut.
Metode: 12 tikus sprague-dawley dibagi dua; kelompok kontrol dan perlakuan. Triamcinolone diaplikasikan pada kelompok kontrol positif, kelompok perlakuan diberikan aplikasi tetes rosela 7.5% dan 15%, selama 3 atau 7 hari.
Hasil; Hilangnya kemerahan dan pengurangan diameter ulser pada rosela 7 hari (7.5% dan 15%), hilangnya bengkak pada rosela 7 hari (15%) dan penurunan skor radang pada rosela 3 hari (15%) dan 7 hari (7.5% dan 15%).
Kesimpulan: Efektivitas rosela setara Triamcinolone 0.1% pada kemerahan dan penurunan diameter ulser 7 hari.
Backgrounds: Roselle have effect as anti-inflammatory.
Objectives: To determine the effectiveness of roselle towards oral mucosa ulcer.
Methods: 12 sprague-dawley rats were divided into 2 groups; control and treatment. triamnicolone as positive control, treatment group was dropped by 7.5% and 15% roselle. Wound healing was observed in the third or seventh day.
Results; Redness disappearance and ulcer diameter decrease in seventh days (7.5% and 15%). Swelling disappearance in seventh days (15%). Inflammation score decrease in both third days (15%) and seventh days (7.5% and 15%).
Conclusions: roselle is effective for ulcer healing. the Effectiveness is equivalent to Triamcinolone 0.1% in redness disappearance and decreasing of ulcer diameter in seventh days."
Depok: Universitas Indonesia, 2012
S43942
UI - Skripsi Membership  Universitas Indonesia Library
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Molecular mechanism on healing process of peptic ulcer
"Ulcer healing process in an incricate and active process including reconstruction process of mucos through formation of granulation tissue..."
Artikel Jurnal  Universitas Indonesia Library
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Yan Lewis
Penyembuhan ulser dengan pemaparan ekstrak etanol kelopak bunga rosella teridentifikasi 3.75% = Ulcer healing by application of identified ethanol extract of roselle calyx 3.75%
"Ulser sering ditemukan di mukosa mulut. Rosella dilaporkan dapat mempercepat penyembuhan ulser.
Tujuan: Menganalisis efektivitas ekstrak etanol kelopak bunga rosella teridentifikasi 3.75%.
Metode: sebanyak 36 ekor tikus dibagi 3 kelompok paparan saline, triamcinolone acetonide, ekstrak rosella 3.75%. Tikus dikorbankan pada harike 2, 4, 8, dan 15. Spesimen difiksasi dan dilakukan skoring pada sediaan mikroskopik.
Hasil: Pemaparan saline menunjukkan skor radang 3; pemaparan triamcinolone acetonidepada dua ekor tikus menunjukkan skor radang 1, satu ekor tikus menunjukkan skor radang 2; pemaparan ekstrak rosella 3.75% menunjukkan skor radang 2.
Kesimpulan: Pemaparan ekstrak rosella 3.75% kurang efektif menyembuhkan ulser mukosa mulut.
Ulcers are often found in oral mucosa. Roselle has been reported to accelerate wound healing.
Objectives: To analyze the effectiveness of identified ethanol extract of roselle calyx 3.75%.
Methods: A total of 36 rats were divided into 3 groups of application, saline, triamcinolone acetonide, and roselle extract 3.75%. Rats were sacrificed on 2nd, 4th, 8th, and 15th days. Specimens were made and microscopic slide were scored.
Results: Saline application showed inflammation score 3. Triamcinolone acetonide application showed inflammation score 1. Roselle extract application showed inflammation score 2.
Conclusion: Application of roselle extract 3.75% less effective to accelerate wound healing."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2013
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Rina Yulia
Uji validitas muka dan konstruk instrumen cardiff wound impact pada pasien dengan ulkus diabetikum = Face and construct validity cardiff wound impact instrument on the patients with diabetic foot ulcers / Rina Yuliaty
"ABSTRAK
Ulkus diabetikum merupakan salah satu komplikasi dari diabetes mellitus yang
berdampak terhadap kehidupan pasien. Cardiff Wound Impact merupakan salah satu
instrument untuk mengukur dampak dari luka. Penelitian ini bertujuan untuk
mengetahui apakah instrument Cardiff Wound Impact ini merupakan pengukuran
yang baik dan layak digunakan jika dikaitkan dengan budaya yang ada di Indonesia.
Disain penelitian ini adalah deskriptif kuantitatif dengan pendekatan potong lintang
(cross-sectional) menggunakan sampel pasien ulkus diabetikum di RSPI Sulianti
Saroso dan Klinik Wocare Center sebesar 51 pengukuran yang dipilih dengan
teknik purposive. Instrumen yang digunakan adalah Cardiff Wound Impact
Questionaire . Pada uji validitas muka tidak ada masalah yang bermakna dari segi
bahasa dan makna kalimat. Uji validitas konstruk dilakukan dengan analisis faktor
dan didapatkan bahwa nilai Kaiser-Meyer-Olkin Measure of sampling Adequacy
(KMO) dan Bartlet Test tiap komponen CWI berada pada rentang 0,741-0,834.
Hasil penelitian ini juga menunjukkan ada hubungan yang kuat antara skala kualitas
hidup dengan kepuasan kualitas hidup (p=0005; r=0,764). Penelitian ini telah
menunjukkan bahwa CWI merupakan alat yang valid dan reliable dalam mengkaji
dampak dari luka ulkus diabetikum di Indonesia karena sudah teruji melalui
validitas muka dan konstruk. Penelitian ini merekomendasikan perlu dilakukan
penelitian ulang dengan proporsi yang merata antar ruang rawat jalan dan ruang
rawat inap
ABSTRACT
Diabetic foot ulcer is one of the diabetes mellitus complications that impact on the
patients life. Cardiff Wound Impact is one of instrument that can measure the
impact of chronic wounds. The purpose of this study was to evaluate and validate
the Cardiff Wound Impact in diabetic foot ulcer in Indonesia population. This
research was used cross-sectional method and used 51 sample of diabetic foot
ulcers patients in Sulianti Saroso hospital, Wocare Clinic and Husada hospital.
The respondents filled the Cardiff Wound Impact Questionar. In the face validity
there was no significant problems in terms of language and meaning of a sentence.
Construct validity was performed by factor analysis and found that the value of
Kaiser-Meyer-Olkin Measure of Sampling Adequacy (KMO) and Bartlet Test of
each component of CWI are in the range 0.741 to 0.834. The results of this study
also showed a strong correlation between the scale of quality of life and
satisfaction of quality of life (p = 0005; r = 0.764). This study has shown that the
CWI is a valid and reliable tools to assess the impact of the diabetic foot ulcer in
Indonesia because it has been tested through the face and construct validity.
Researcher suggested for this research need to be done again with the same
proportion between outpatients and inpatients wards"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2014
S57543
UI - Skripsi Membership  Universitas Indonesia Library
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Rizky Amaliah, supervisor
Karakteristik pasien ulkus peptikum perforasi dan kaitannya dengan morbiditas dan mortalitas di Rumah Sakit Cipto Mangunkusumo periode Januari 2006 - Maret 2012 = Characteristic of perforated peptic ulcer patient and correlation in morbidity and mortality in Cipto Mangunkusumo Hospital 2006 January - 2012 March
"[ABSTRAK
Ulkus peptikum perforasi merupakan salah satu kasus bedah gawat darurat yang cukup sering di RSCM. Perkembangan medikamentosa dalam tatalaksana ulkus peptikum telah berkembang pesat sehingga menurunkan angka tindakan bedah secara elektif. Studi ini bertujuan untuk melihat karakteristik dan faktor risiko pasien dengan morbiditas dan mortalitas ulkus peptikum perforasi. Seluruh pasien ulkus peptikum perforasi yang dilakukan tindakan pembedahan emergensi di Instalasi Gawat Darurat Rumah Sakit Cipto Mangunkusumo periode Januari 2006 sampai dengan Maret 2012 dievaluasi secara retrospektif. Empat puluh delapan pasien ulkus peptikum perforasi telah dilakukan tindakan pembedahan di IGD RSCM yang terdiri dari 36 pasien laki-laki dan 12 pasien perempuan dengan usia berkisar antara 17 ? 97 tahun. Faktor risiko terbanyak adalah pemakaian obat-obatan ulserogenik (NSAID dan jamu) sebanyak 70.83%. Sebanyak 52.08% pasien dengan ulkus peptikum perforasi datang dengan keluhan yang dirasakan >24 jam dengan rerata durasi 42 jam. Lokasi perforasi tersering adalah prepilorus sebanyak 66.7% dengan median diameter perforasi 10 mm. Tindakan tersering yang dilakukan adalah penjahitan primer dengan omental patch sebanyak 93.75%. Komplikasi tersering adalah acute kidney injury, sepsis dan infeksi luka operasi sebanyak 45.83%, 31.25% dan 14.58%. Angka morbiditas dan mortalitas pasien ulkus peptikum perforasi adalah 68.75% dan 33.3%. Pada studi ini tidak ditemukan hubungan yang bermakna antara karakteristik pasien dengan morbiditas dan mortalitas. Angka morbiditas dan mortalitas pasien ulkus peptikum perforasi masih tinggi. Faktor risiko yang ada dapat digunakan untuk meningkatkan pilihan tindakan dan menurunkan morbiditas dan mortalitas pasien ulkus peptikum perforasi. ABSTRACT Perforated peptic ulcer is one of the most common emergency case in RSCM. Development medicine treatment in peptic ulcer treatment had developed hence had decreased number of elective surgical treatment. This study was aimed to identify patients? characteristic and risk factor in perforated peptic ulcer in morbidity and mortality. All of the patient of perforated peptic ulcer that was done emergency laparotomy in emergency operating room of Cipto Mangunkusumo Hospital since 2006 January until 2012 March was evaluated retrospectively. Fourty eight percent of perforated peptic ulcer patients had been done surgery in Emergency Operating Room of Cipto Mangunkusumo Hospital that consist of 36 male and 12 female with age range 17 ? 97 years old. The most common risk factor is ulcerogenic drug using (70.83%). Patients came to hospital >24 hours (52.08%) after felt complaint with mean duration 42 hours. The most common location of perforation was prepiloric with median of diameter was 10 mm. The most common surgical treatment was primary suturing with omental patch (93.75%). The common complication were acute kidney injury, sepsis and surgical wound infection around 45.83%, 31.25% and 14.58%/. Morbidity rate was 68.75%. Mortality rate was 33.3%. There were no relation between patients? characteristic with morbidity and mortality. Morbidity and mortality rate in perforated peptic ulcer were still high. Risk factor that still be used to increase more choice for surgical treatment and decrease morbidity and mortality rate in perforated peptic ulcer., Perforated peptic ulcer is one of the most common emergency case in RSCM. Development medicine treatment in peptic ulcer treatment had developed hence had decreased number of elective surgical treatment. This study was aimed to identify patients’ characteristic and risk factor in perforated peptic ulcer in morbidity and mortality. All of the patient of perforated peptic ulcer that was done emergency laparotomy in emergency operating room of Cipto Mangunkusumo Hospital since 2006 January until 2012 March was evaluated retrospectively. Fourty eight percent of perforated peptic ulcer patients had been done surgery in Emergency Operating Room of Cipto Mangunkusumo Hospital that consist of 36 male and 12 female with age range 17 – 97 years old. The most common risk factor is ulcerogenic drug using (70.83%). Patients came to hospital >24 hours (52.08%) after felt complaint with mean duration 42 hours. The most common location of perforation was prepiloric with median of diameter was 10 mm. The most common surgical treatment was primary suturing with omental patch (93.75%). The common complication were acute kidney injury, sepsis and surgical wound infection around 45.83%, 31.25% and 14.58%/. Morbidity rate was 68.75%. Mortality rate was 33.3%. There were no relation between patients’ characteristic with morbidity and mortality. Morbidity and mortality rate in perforated peptic ulcer were still high. Risk factor that still be used to increase more choice for surgical treatment and decrease morbidity and mortality rate in perforated peptic ulcer.]"
Fakultas Kedokteran Universitas Indonesia, 2013
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Nila Indrayati
Efektifitas Penyembuhan Ulkus Kaki Diabetik menggunakan Telehealth Nursing = The Effectiveness of Healing Diabetic Foot Ulcers using Telehealth Nursing
"Telehealth nursing adalah layanan berbasis teknologi informasi yang diharapkan dapat menjadi sarana untuk mempermudah komunikasi antara pasien dan perawat dalam merawat luka terutama pada saat kondisi pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui efektifitas telehealth nursing terhadap penyembuhan ulkus kaki diabetik. Desain penelitian menggunakan quasi eksperimen dengan pre-post test with control group. Jumlah responden dalam penelitian ini sebanyak 46 orang diperoleh melalui teknik consecutive sampling. Kelompok eksperimen diberikan telehealth nursing yang berisi kombinasi edukasi dan monitoring perawatan luka mandiri dan kelompok kontrol diberikan edukasi dan perawatan luka secara langsung di klinik luka. Penyembuhan luka diukur dengan menggunakan Bates Jensen Wound Assessment Tool (BWAT). Hasil penelitian menunjukkan bahwa telehealth nursing memiliki efektifitas yang signifikan yaitu sebesar p=0,873 (α>0.05) pada proses penyembuhan luka. telehealth nursing adalah pilihan terbaik dalam merawat ulkus kaki diabetik pada pasien yang mengalami kesulitan atau dengan kondisi yang tidak memungkinkan untuk perawatan luka secara langsung ke layanan kesehatan.
Telehealth nursing as an information technology-based service is expected to be a means to facilitate communication between patients and nurses in caring for wounds, especially during the COVID-19 pandemic. This study aims to identify the effectiveness of telehealth nursing in healing diabetic foot ulcers.This study was a quasi-experimental with a pre-post test with a control group. The study was conducted on 46 people using consecutive sampling. The intervention group was given telehealth nursing which contained a combination of education and self manage wound care monitoring and the control group was given education and wound care at the wound clinic. Wound healing was measured using the Bates Jensen Wound Assessment Tool (BWAT). The results showed that telehealth nursing had significant effectiveness of p=0.873 (α>0.05) in the wound healing process. telehealth nursing is the best choice in treating diabetic foot ulcers in patients who have difficulty or with conditions that do not allow direct wound care to health services."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Darwin Yunaidy
Efektivitas pasta gigi propolis terhadap penyembuhan ulser traumatik termal pada mukosa bukal mus musculus (Swiss Webster) = Efficacy of propolis-based toothpaste towards the healing of thermal traumatic ulcer in the buccal mucosa of mus musculus (Swiss Webster)
"Ulser adalah masalah yang sering ditemukan pada rongga mulut. Keluhan sakit seringkali menimbulkan rasa tidak nyaman pada penderita yang dapat memengaruhi kualitas hidupnya, sehingga penderita cenderung mencari pengobatan untuk menangani hal tersebut. Propolis merupakan bahan alami yang memiliki kandungan flavonoid yang dapat bertindak sebagai anti-inflamasi dalam menangani ulser. Mengetahui efektivitas pasta gigi propolis sebagai pengobatan ulserasi traumatik termal pada mukosa bukal. Penelitian dilakukan secara in vivo dengan menggunakan model ulser traumatik termal pada mukosa bukal 16 ekor Mus musculus (SwissWebster) yang terbagi dalam penelitian pendahuluan dan penelitian lanjutan. Penelitian menggunakan 3 kelompok dengan kelompok pasta gigi propolis, pasta gigi kontrol dan larutan saline (NaCl 0,9%). Dilakukan pemaparan trauma termal dengan ballpointed bersuhu 80oC selama 5 detik. Pengamatan dilakukan secara klinis berupa perubahan diameter ulser, pembengkakan dan kemerahan di sekitar ulser, berat badan serta persentase penyembuhan ulser, dan secara histopatologis berupa perubahan skor radang. Mus musculus kemudian dikorbankan pada hari pertama terbentuk ulser, hari puncak ulser dan hari sembuhnya ulser pada setiap kelompok. Pada pengamatan makroskopis, persentase penyembuhan kelompok pasta gigi propolis lebih cepat dibanding kelompok pasta gigi kontrol dan saline, serta rata-rata waktu penyembuhan ulser juga lebih cepat, yaitu sembuh pada hari ke-8. Pada pengamatan mikroskopis, semua kelompok perlakuan mengalami perubahan skor radang dibandingkan ketika hari pertama terbentuknya ulser. Pasta gigi propolis efektif terhadap penyembuhan ulser traumatik termal pada mukosa bukal Mus musculus (Swiss Webster).
Ulcer is a problem which is mainly found in the oral cavity. The pain resulted often causes discomfort towards the patients hence affecting their life quality. As a result, they tend to seek treatment to deal with it. Propolis is a natural ingredient that contains flavonoid which can act as an anti-inflammatory to treat the ulcer. To determine the efficacy of propolis toothpaste as a treatment for thermal traumatic ulcer of the buccal mucosa. The study was conducted in vivo by using the thermal traumatic ulcer model of the buccal mucosa of 16 Mus musculus (Swiss Webster) and divided into preliminary test and continuous test. There are 3 groups in the study, using propolis toothpaste, control toothpaste and saline (NaCl 0,9%) groups. The thermal trauma is exposed by a 80oC ballpointed for 5 seconds. Observations are made clinically (difference in ulcer diameter, swelling and redness around the ulcer, weight and percentage of ulcer healing) and histopathologically in the form of changes in inflammation score. Mus musculus was then sacrificed on the first day of ulcer formation, ulcer peak day and ulcer healing day in each group. In the macroscopic observation, the ulcer healing percentage in propolis toothpaste group was faster than the control groups, and the ulcer healing time was also faster, which was healed on the 8 day. In the microscopic observation, all treatment groups show changes in inflammation score compared to the first day of ulcer formation. Propolis toothpaste is effective towards the healing of thermal traumatic ulcer in the buccal mucosa of Mus musculus (Swiss Webster)."
Depok: Universitas Indonesia, 2018
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Dwi Agustina
Pengalaman kenyamanan pada pasien dengan ulkus diabetikum studi fenomenologi = Experiences of comfort in patients with diabetic ulcers study of phenomenology
"Ulkus Diabetik merupakan penyakit komplikasi dari diabetes melitus. Kondisi ulkus diabetikum dapat menimbulkan komplikasi fisik, psikologis, sosial serta lingkungan yang menyebabkan munculnya ketidaknyamanan. Tujuan dari penelitian ini adalah menggambarkan pengalaman ketidaknyamanan pasien dengan ulkus diabetikum. Penelitian ini menggunakan metode kualitatif fenomenologi dekskriptif, dimana dilakukan dengan indepth interview. Didapatkan delapan partisipan, yaitu tiga laki laki dan lima perempuan. Didapatkan hasil sembilan tema, yaitu pemahaman diabetes melitus, pengalaman terjadinya ulkus diabetikum, pengalaman nyeri ulkus diabetikum, pemahaman kenyamanan, perubahan dalam kehidupan, dukungan sosial yang diterima, pengalaman spiritual saan memiliki ulkus diabetikum, dukungan tenaga kesehatan dan pengalaman psikologis. Penelitian ini merekomendasikan untuk dilakukan penelitian serupa pada rumah sakit yang berbeda.
Diabetic ulcers is the complication of diabetes mellitus disease. Diabetic ulcers can cause physical, psychological, social and environment that cause the appearance of discomfort. The purpose of this study is to describe the experience of discomfort of patients with diabetic ulcers. This study used qualitative methods dekskriptif phenomenology, which is done by in-depth interview. Obtained eight participants, three men and five women. This research found nine themes, there are understanding of diabetes mellitus, diabetic ulcers experience, diabetic ulcer pain experience, understanding of comfort, changes in life, received social support, spiritual experience in diabetic ulcers, support health professionals and psychological experience. The study recommends to similar studies conducted in different hospitals."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2014
T42065
UI - Tesis Membership  Universitas Indonesia Library
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