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Abstrak :
[ABSTRAK
Latar Belakang: Minosiklin merupakan antibiotik dengan sifat bakteriostatik yang potensial mengeliminasi bakteri patogen periodontal. Kesembuhan perawatan periodontitis kronis umumnya ditunjukkan secara klinis dan mikrobiologis. Tujuan: Menganalisis parameter klinis (penurunan kedalaman poket dan indeks perdarahan gingiva, peningkatan perlekatan klinis) dan jumlah T. forsythia sebelum dan sesudah aplikasi gel Minosiklin HCl 2%. Metode: Empat puluh dua subjek menerima aplikasi gel Minosiklin HCl 2% sebanyak empat kali, kemudian dievaluasi parameter klinis dan T. forsythia dengan Real- Time Polymerase Chain Reaction (RT-PCR). Hasil: Terdapat perbedaan bermakna dari parameter klinis dan T. forsythia antara pemeriksaan awal dan kontrol bulan ke-6 (p<0,05). Terdapat perbedaan bermakna antara hubungan penurunan indeks perdarahan gingiva dengan jumlah T. forsythia (p<0,05). Kesimpulan: Aplikasi gel Minosiklin HCl 2% secara klinis dan mikrobiologis efektif dalam perawatan periodontitis kronis.

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ABSTRACT
Background: Minocycline is known as one of the antibiotics with great bacteriostatic effect to eliminate periodontal pathogen. Healthier periodontal environment is usually shown with better clinical and microbiological response. Objective: To clinically and microbiologically (T. forsythia) analyze the effect of Minocycline HCl 2% for treatment of chronic periodontitis within six months. Methods: Forty-two subjects applied with Minocyline HCl 2% for four times. Clinical and microbiological examinations were evaluated on baseline, month-2, month-3, and month-6. T. forsythia was examined with Real-Time Polymerase Chain Reaction (RT-PCR) techniques. Result: There were significant differences between Probing Pocket Depth, Papilla Bleeding Index, Clinical Attachment Level, and amount of T. forsythia in baseline compare to six months period (p<0.05). There was an association between the amount of T. forsythia and Papilla Bleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effective clinically and microbiologically in chronic periodontitis therapy.;Background: Minocycline is known as one of the antibiotics with great bacteriostatic effect to eliminate periodontal pathogen. Healthier periodontal environment is usually shown with better clinical and microbiological response. Objective: To clinically and microbiologically (T. forsythia) analyze the effect of Minocycline HCl 2% for treatment of chronic periodontitis within six months. Methods: Forty-two subjects applied with Minocyline HCl 2% for four times. Clinical and microbiological examinations were evaluated on baseline, month-2, month-3, and month-6. T. forsythia was examined with Real-Time Polymerase Chain Reaction (RT-PCR) techniques. Result: There were significant differences between Probing Pocket Depth, Papilla Bleeding Index, Clinical Attachment Level, and amount of T. forsythia in baseline compare to six months period (p<0.05). There was an association between the amount of T. forsythia and Papilla Bleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effective clinically and microbiologically in chronic periodontitis therapy., Background: Minocycline is known as one of the antibiotics with great bacteriostatic effect to eliminate periodontal pathogen. Healthier periodontal environment is usually shown with better clinical and microbiological response. Objective: To clinically and microbiologically (T. forsythia) analyze the effect of Minocycline HCl 2% for treatment of chronic periodontitis within six months. Methods: Forty-two subjects applied with Minocyline HCl 2% for four times. Clinical and microbiological examinations were evaluated on baseline, month-2, month-3, and month-6. T. forsythia was examined with Real-Time Polymerase Chain Reaction (RT-PCR) techniques. Result: There were significant differences between Probing Pocket Depth, Papilla Bleeding Index, Clinical Attachment Level, and amount of T. forsythia in baseline compare to six months period (p<0.05). There was an association between the amount of T. forsythia and Papilla Bleeding Index (p<0.05). Conclusion: Minocycline HCl 2% was effective clinically and microbiologically in chronic periodontitis therapy.]

Abstrak :
ABSTRAK
Mayoritas penelitian menemukan hubungan periodontitis dengan stres, namun hubungannya dengan hormon kortisol pada cairan krevikular gingiva belum diteliti. Tujuan: Mengevaluasi pengaruh stres pada mahasiswa program akademik FKGUI terhadap kondisi periodontal dan kadar kortisol dalam CKG. Pemeriksaan Dental Environtmental Stress, indeks periodontal (OHIS, BOP, PPD, CAL), dan kadar kortisol terhadap 39 subjek, ditemukan perbedaan OHIS (p=0,023), BOP (p=0,000), PPD (p=0,004), dan CAL (p=0,004), namun tidak ada perbedaan kadar kortisol (p=0,456) diantara tingkatan stres. Tidak ada perbedaan kadar kortisol pada OHIS (p=0,587), BOP (p=0,470), PPD (p=0,863), dan CAL (p=0,863). Tidak ada perbedaan bermakna antara stres akademik dan kadar kortisol, dengan kondisi periodontal.

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ABSTRACT
Majority of investigations associating chronic periodontitis with stress found positive correlation, but no investigations correlating with cortisol in gingival crevicular fluid. Purpose: To evaluate the relationship between stress experienced by academic students FKGUI, periodontium, and cortisol. Survey using Dental Environtmental Stress (DES), clinical examinations (OHIS, BOP, PPD, and CAL), and cortisol level. 39 subjects show differences in OHIS (p=0.023), BOP (p=0.000), PPD (p=0,004), and CAL (p=0,004) between stress level and no differences in cortisol level (p=0,456). No differences in cortisol level between OHIS (p=0,587), BOP (p=0,470), PPD (p=0,863), and CAL (p=0,863). No significant differences between stress, cortisol level and periodontium.