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"Hepatitis C merupakan penyebab penyakit hati kronik yang penting di seluruh dunia termasuk lndonesia. Diperkirakan terdapat 300 juta pembawa virus hepatitis C di seluruh dunia. Pada penelitian yang dilakukan di Indonesia didapatkan prevalensi anti Hepatitis C Virus (anti HCV) berkisar antara 2,1-2,5%.s Penelitian di Jakarta pada tahun 1990 memperlihatkan prevalensi anti HCV pada hepatitis kronik non B sebesar 80,4%. Hepatitis C merupakan jenis hepatitis dengan gejala k1inis yang ringan tapi dengan tingkat kronisitas dan progresifitas yang tinggi ke arah sirosis. Sekitar 70-80% hepatitis C akut akan menjadi kronik dan 20% akan berkembang menjadi sirosis bati.

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Hepatitis C is an important cause of chronic liver disease around the world, including Indonesia. It is estimated that there are 300 million carriers of the hepatitis C virus worldwide. In a study conducted in Indonesia, the prevalence of anti-Hepatitis C Virus (anti-HCV) ranged from 2.1-2.5%.s A study in Jakarta in 1990 showed an anti-HCV prevalence in chronic non-B hepatitis of 80.4%. Hepatitis C is a type of hepatitis with mild k1inis symptoms but with a high degree of chronicity and progression to arabic cirrhosis. About 70-80%. Acute hepatitis C will become chronic and 20% will develop into batic cirrhosis."

"Ruang lingkup dan cara penelitian telah dilakukan studi potong lintang terhadap 33 kasus hepatitis kronik di departemen Patologi Anatomik FKUI-RSUPN Dr.Cipto Mangunkusumo selama periode tabun 2003-2006. Dilakukan penilaian aktivitas proliferasi sel hati dengan pulasan AgNOR serta penilaian indeks aktivitas histologik Metavir yang meliputi penilaian grading (nekroinflamasi) dan staging (fibrosis), kemudian dianalisa secara statistik apakab terdapat hubungan antara proliferasi sel hati dengan indeks aktivitas histologik Metavir. Selain itu ditentukan apakah terdapat perbedaan aktivitas proliferasi sel bati diantara keIompok sirosis dan non SlTOSIS. Basil dan kesimpulan : Berdasarkan indeks aktivitas histologik (IAH), didapatkan 10 kasus ( 30,3%) dengan skor lAB 3, 13 kasus ( 39,39%) dengan skor lAB 2 dan 10 kasus (30,3%) dengan skor IAH 1. Berdasarkan penilaian staging (fibrosis), sebanyak 5 kasus (15,15%) digolongkan sebagai F4, 14 kasus (42,42 %) digolongkan sebagai F3, 12 kasus (36,36%) digolongkan sebagai F2, dan hanya 2 kasus (6,06%) yang digolongkan sebagai Fl. Nilai mAgNOR untuk kelompok IAH 3 adalah 6,66, untuk kelompok IAH 2 didapatkan nilai mAgNOR 5,98 sedangkan untuk kelompok IAH 1 didapatkan nilai mAgNOR 5,92. Uji korelasi dengan Kendall's tau_b menunjukkan adanya korelasi lemah antara nilai mAgNOR dan indeks aktivitas histologik. Uji statistik dengan ANOVA one way test menunjukkan tidak ada perbedaan bermakna untuk nilai pAgNOR pada berbagai derajat lAH. Didapatkan peningkatan nilai mAgNOR sejalan dengan peningkatan derajat piecemeal necrosis dan grading, dan uji korelasi dengan Kendall's tau_b menunjukkan adanya korelasi lemah antara nilai mAgNOR dan piecemeal necrosis pada grading yang berbeda. Berdasarkan staging, untuk kelompok F4, didapatkan nilai mAgNOR 6,77, untuk kelompok F3 didapatkan nilai mAgNOR 5,98, untuk kelompok F2, didapatkan nilai mAgNOR 6,47, dan untuk kelompok Fl, didapatkan nilai mAgNOR 4,075. Uji korelasi dengan Kendall's tau_b menunjukkan tidak ada korelasi antara mAgNOR dan staging. Hasil uji statistik dengan ANOVA one way test menunjukkan nilai pAgNOR untuk kelompok F2-F4 tidak berbeda bermakna, tetapi nilai pAgNOR (>2, >3, >4, >5) untuk kelompok Fl berbeda bermakna dengan nilai pAgNOR pada kelompok F2-F4. Uji statistik dengan t-test menunjukkan babwa nilai mAgNOR tidak berbeda bennakna diantara kelompok sirosis dan non sirosis. Penelitian ini tidak berhasil membuktikan adanya hubungan antara proliferasi sel hati dengan grading dan staging Metavir pada hepatitis kronik.

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Material and method : Cross sectional study was carried out in 33 cases of chronic hepatitis in the department of pathology Dr. Cipto Mangunkuswno Hospital during year 2003-2006. Proliferative rate of hepatocytes was detennined by AgNOR staining method. Histologic activity Index (HAl) by Metavir (grading and staging) was also determined. The correlation between proliferative rate of hepatocytes and grading-staging Metavir was evaluated in this study. The differerence of hepatocytes proliferative rate between cirrhotic and non cirrhotic chronic hepatitis was also determined. Results and conclusion: From 33 cases of chronic hepatitis 10 cases (30,3%) were grouped as HAl score 3, 13 cases (39,39%) were HAl 2, and 10 cases (30,3%) were HAl 1. Based on fibrosis/staging 14 cases (42,42 %) were grouped as F3, 12 cases ( 36,36%) were grouped as F2, and only 2 cases (6,06%) were grouped as F1. mAgNOR's value for IAH 3 was 6,66, mAgNOR's value for IAH 2 was 5,98, mAgNOR's value for IAH 1 was 5,92. Correlation test with Kendall's tau_b showed a weak correlation between mAgNOR's value and HAl score. ANOVA one way test showed there was no statistically different for pAgNOR values among different HAl groups. Correlation test with Kendall's tau_b showed weak correlation between mAgNOR's value and piecemeal necrosis. Based on staging, mAgNOR's value for F4 was 6,77, mAgNOR's value for F3 was 5,98, mAgNOR's value for F2 was 6,47, and mAgNOR's value for Fl was 4,075. Correlation test with Kendall's tau_b showed no correlation between mAgNOR's value dan staging. ANOVA one way test showed there was no statistically different for pAgNOR's values among F2-F4 group, but there was statistically different for pAgNOR's values between Fl and F2- F4 group. T-test showed no statistically difference for mAgNOR's value between cirrhotic and non cirrhotic group. This study failed to show correlation between liver cell proliferative rate and grading-staging Metavir"

"Ruang lingkup dan cara penelitian : Telah dilakukan studi retrospektif terhadap 20 karsinoma adenoid kistik hasil operasi dari Bagian Patologi Anatomik FKUI / RSUPN Dr. Cipto Mangunkusumo selama 8 tahun (1991-1998) dengan melihat tipe histologik, derajat histologik dan invasi perineural serta melakukan penghitungan AgNOR. Selanjutnya dicari hubungan antara AgNOR dengan tipe histologik, derajat histologik dan invasi perineural karsinoma adenoid kistik kelenjar liur mayor dan minor. Hasil dan kesimpulan : Dari 20 kasus karsinoma adenoid kistik kelenjar liur mayor dan minor, diperoleh 4 kasus dengan satu tipe histologik (20%) dan 16 kasus dengan tipe campuran (80%). Berdasarkan kriteria derajat histologik menurut Szanto dkk didapatkan 6 kasus dengan tumor derajat I (30%), 10 kasus dengan tumor derajat II (50%) dan 4 kasus dengan tumor derajat III (20%). Invasi perineural ditemukan 11 kasus (55%). Nilai AgNOR meningkat berurutan pada tipe tubular, kribriform dan solid. Nilai AgNOR juga meningkat berurutan pada KAK derajat I, Il dan III. Nilai AgNOR menunjukkan perbedaan bermakna antara KAK derajat IIl dengan derajat I dan II. Tidak ditemukan perbedaan bermakna antara nilai AgNOR dengan lokasi tumor (kelenjar liur mayor dan minor) atau ada tidaknya invasi perineural. Dari penelitian retrospektif ini dapat disimpulkan bahwa terdapat peningkatan bermakna jumlah AgNOR antara tumor derajat III dengan derajat I dan II, sehingga dengan demikian nilai AgNOR dapat digunakan dalam meramalkan prognosis KAK kelenjar liur mayor dan minor."

"We report three rare cases of mucosal-associated lymphoid tissue (MALT) lymphoma. Two cases are of gastric MALT lymphoma and one is a case of transverse colon MALT lymphoma. The two cases of gastric MALT lymphoma were diagnosed by endoscopy which demonstrated an ulcer in the cardia and another in the corpus. The first case is in a 62-year-old male. The patients medical history revealed upper GI tract bleeding with melaena in 1993. At the time no diagnosis was made on endoscopy In August 2000, melaena recurred and endoscopy showed an ulcer in the cardio. Histology showed high-grade gastric MALT lymphoma. Based on Ann Arbor classification, the patient was classified as stage IE gastrointestinal lymphoma. H. pylori was negative. The patient received chemotherapy The second case is in a 53-year-old male. He suffered from gastric lymphoma for 3 years. He complained of annually recurring haematemesis before a definitive diagnosis was finally established. He suffered jiom stage IE low-grade well-differentiated lymphocytic MALT lymphoma. H. pylori was negative. Endoscopic procedure after H. pylori eradication showed ulcer regression though histology still showed low-grade MALT lymphoma and H. pylori as positive. The third case is in a 46-year-old male with a complaint of haematochezia. Colonoscopy showed intususception due to tumor in the transverse colon. Histologic examination showed chronic colitis and granulomatosa. lnvagination due to colon tumor was reported. Histologic examination of the biopsy specimen showed low-grade small cell lymphocyte-plasmocytoid lymphoma. "

"Benign recurrent intrahepatic cholestasis (BRIC) or idiopathic recurrent intrahepatic cholestasis is a rare case. It is familial and autosomal recessive. The etiology of BRIC is still unknown. We report the case of of patient with BRIC who suffered recurrent jaundice 7 times in 7 years that occurred for 1-3 months with spontaneous resolution. This patient received ursodeoxycholic acid, cholestiramine and prednisone. And within 2 months, the jaundice resolved together with other complaints."