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"Latar Belakang : Pasien Non-Proliferative Diabetic Retinopathy (NPDR), Proliferative Diabetic Retinopathy (PDR) dengan neuropati kornea akan mengalami terganggunya stabilitas air mata. Penurunan sekresi dan konsituen air mata akan menyebabkan gangguan berupa mata kering. Pada pasien Diabetes dengan retinopati diabetik, gangguan kornea ini berpotensi lebih memperburuk gangguan penglihatan yang terjadi. Tujuan : Menilai stabilitas air mata pada pasien NPDR, PDR dengan neuropati kornea sebelum, sesudah diberikan tetes mata Sodium hyaluronat+Vitamin A,E (HA+Vit A,E) atau Sodium Hyaluronat saja (HA). Metodologi : Penelitian ini merupakan uji eksperimental randomisasi acak terkontrol, dengan dua kelompok utama (NPDR, PDR), kedua kelompok mendapatkan tetes mata HA+Vit A,E atau HA selama 28 hari. Sensitivitas kornea, Skoring Ocular Surface Disease Index (OSDI), Non-Invasive Break Up Time (NIBUT), Schirmer I, jumlah sel goblet konjungtiva dinilai pada 0, 2, 4 minggu. Hasil : 96 subyek berpartisipasi, 65.6% wanita, 34.4% laki-laki (rerata usia 54.4 tahun). Skor OSDI memperlihatkan perbaikan signifikan, nilai terbesar pada kelompok PDR HA+Vit A,E dengan -4.86±5.76 (P= 0.000), NIBUT memperlihatkan perbaikan signifikan, nilai terbesar pada kelompok NPDR HA dengan 4.79±2.63 (P= 0.000), Schirmer I memperlihatkan perbaikan signifikan, hasil terbesar pada kelompok NPDR HA dengan 2.41±2.35 (P= 0.000). Sitologi impressi konjungtiva memperlihatkan perbaikan signifikan, terutama pada kelompok NPDR HA+Vit A,E (66% perbaikan). Seluruh kelompok memperlihatkan perbaikan signifikan, tetapi perbaikan antar kelompok tidak bermakna. Kesimpulan : Parameter seluruh kelompok memperlihatkan perbaikan yang signifikan setelah diberikan tetes mata HA+Vit A,E maupun HA saja, Tetapi jika dibandingkan antar kelompok, tidak terdapat perbedaan perbaikan yang signifikan.

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Background : Patient with Non-Proliferative Diabetic Retinopathy (NPDR), Proliferative Diabetic Retinopathy (PDR) with corneal neuropathy will experiencing disruption in tear film stability. Decrease in tear film secretion and constituent will cause dry eyes. In Diabetic patients with diabetic retinopathy, this corneal disorder has the potential to further worsen visual impairment.

Purpose : To Assess tear film stability in NPDR, PDR patients with corneal neuropathy before, after treatment with topical Sodium hyaluronat+Vitamin A,E (HA+Vit A,E) or Sodium Hyaluronat only (HA).

Method : This study was a double blind experimental randomized control trial with two parallel groups (NPDR, PDR), both group receives HA+Vit A,E or HA for 28 days. Corneal sensitivity, Ocular Surface Disease Index (OSDI), Non-Invasive Break Up Time (NIBUT), Schirmer I, conjungtival goblet cells will be assessed on 0, 2, 4 weeks.

Result : 96 subjects participated, 65.6% female, 34.4% male, mean age 54.4 years old. OSDI score shows significant improvement, highest improvement seen on PDR HA+Vit A,E with -4.86±5.76 (P= 0.000), NIBUT hows significant improvement, highest improvement seen on NPDR HA with 4.79±2.63 (P= 0.000), Schirmer I shows significant improvement, highest improvement seen on NPDR HA with 2.41±2.35 (P= 0.000). Conjungtival goblet cells shows significant improvement, highest improvement seen on NPDR HA+Vit A,E (66% improved). All groups shows shows significant improvement, but between groups the improvement was not statistically significant.

Conclusion : Parameters on all groups shows statistically significant improvement after topical HA+Vit A,E or HA. But, if compared between groups, the improvement was not significantly differed."

"Tujuan: menilai prevalensi katarak terinduksi radiasi, serta menghubungkannyadengan dosis paparan radiasi dan penggunaan perlengkapan proteksi radiasi.Metode: Studi potong lintang dan studi kasus-kontrol. Seratus delapan puluh subyekberpartisipasi dalam penelitian. Prevalensi katarak terinduksi radiasi dinilaimenggunakan analisis Scheimpflug pada alat Pentacam®-Oculus. Dosis paparanradiasi kumulatif dan penggunaan perlengkapan proteksi radiasi pada subyekdiidentifikasi melalui kuesioner dan personal dosimeter.Hasil: Prevalensi katarak terinduksi radiasi sebanyak 16.7%. Median dosis radiasikumulatif berdasarkan kuesioner menunjukkan median 0,8 (0.1- 35.6) Gy. Hubungankorelasi positif didapatkan antara dosis radiasi kumulatif dengan densitas lensa (RSpearman= 0.64). Sebanyak 83.9% subyek menggunakan tabir pada 71-100% masakerjanya, tetapi mayoritas subyek penelitian (40.6%), tidak menggunakan kacamatapelindung. Peningkatan risiko katarak terinduksi radiasi meningkat secara bermaknaseiring dengan kepatuhan penggunaan proteksi radiasi yang kurang. Subyek denganproteksi tabir radiasi 31-50% dari masa kerjanya meningkatkan risiko katarak 10.80kali lipat (IK 95% 1.05-111.49, p=0.044). Sementara itu, kelompok proteksi tabirradiasi 51-70% meningkatkan risiko katarak 8.64 kali lipat (p=0.001). Subyek yangtidak memakai kacamata pelindung memiliki OR 164.3 (IK 95% 19.81-1363)dibandingkan dengan kelompok pengguna kacamata pelindung.Kesimpulan: Katarak terinduksi radiasi pada pekerja radiasi bidang kardiologiintervensi tergantung pada dosis paparan radiasi dan penggunaan proteksi radiasi.Oleh karena itu, kepatuhan pekerja radiasi perlu ditingkatkan sesuai ketentuanproteksi radiasi.

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Objectives: to determine the prevalence of radiation-induced cataract and correlatewith radiation exposure dose and radiation protection use among radiation workers ofinterventional cardiology.Methods: A cross-sectional and retrospective case-control study. One hundred andeighty subjects were included. Prevalence of radiation-induced cataract was assessedusing Scheimpflug analysis on the Pentacam®-Oculus. Individual cumulativeradiation exposure dose and radiation protection use of subjects were identified fromquestionnaire and personal dosimeter.Results: The prevalence of radiation-induced cataract was 16.7%. Median cumulativeradiation dose was 0.8 (0.1-35.6) Gy. A positive correlation was found betweencumulative radiation dose and lens density (RSpearman=0.64). This study showed that83.9% of subjects used ceiling-suspended shield in 71-100% of their working period,however the majority of subjects (40.6%) did not wear protective eyewear.Statistically significant increasing risk of cataract was found along with unresponsiveuse of radiation protection. The subjects using ceiling-suspended shield in 31-50% oftheir working period were increasing their cataract risk by 10.80 times (95% CI 1.05-111.49, p=0.044). Meanwhile, the subjects using protective eyewear in 51-70% oftheir working period were increasing their cataract risk by 8.64 times (p=0.001).Subjects who did not wear protective eyewear had an OR 164.3 (95% CI 19.81-1363)compared to those who wore protective eyewear.Conclusion: Radiation-induced cataract among radiation workers of interventionalcardiology was depend on radiation exposure dose and radiation protection.Therefore, the compliance of radiation safety recommendation should be improved."