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"Tujuan : Membandingkan dan menentukan perbedaan kadar homosistein dalam darah dan zalir folikel pada wanita infertil dengan dan tanpa endometriosis, kemudian menganalisis pengaruh kadar homosistein tersebut dengan mutu oosit.Metode : Penelitian ini merupakan penelitian potong lintang (cross sectional). Lima puluh sembilan subjek mengikuti program fertilisasi in-vitro yang masuk dalam kriteria penerimaan dibagi menjadi dua kelompok sama besar, yaknikelompok endometriosis dan tanpa endometriosis secara konsekutif (consecutive sampling). Masing-masing subjek diambil percontoh dari darah dan zalir folikel kemudian diukur kadar homosisteinnya dengan metode teraimun CMIA. Rerata masing-masing kelompok diuji statistik dengan uji t independen.Hasil : Rerata kadar homosistein dalam darah pada kelompok endometriosis lebih tinggi dibandingkan dengan tanpa endometriosis dan secara statisik berbeda bermakna (8,34 ±2,68 vs 6,71 ±1,56, p=0.007;95%CI: 0,02417-0,14657).Demikian pula dengan kadar homosistein dalam zalir folikel, kelompok endometriosis lebih tinggi dan secara statistik berbeda bermakna (6,19 ±1,67 vs 3,46 ±1,03; p= 0,000; 95% CI : 0,19310-0,32353). Semua mutu oosit baik padakedua kelompok, yakni derajat 3. Terdapat korelasi antara kadar homosistein di dalam darah dan zalir folikel pada kelompok endometriosis dan dinilai dengan uji Pearson didapatkan bermakna (p = 0,002) dan nilai korelasi 0,553 (kekuatan korelasi sedang) dan arah korelasi positif.Kesimpulan : Rerata kadar homosistein dalam darah dan zalir folikel pada wanita infertil dengan endometriosis lebih tinggi dibandingkan dengan tanpa endometriosis dan secara statistik berbeda bermakna. Kadar homosistein ini tidakberpengaruh terhadap mutu oosit. Terdapat korelasi positif antara kadar homosistein dalam darah dan zalir folikel pada kelompok endometriosis.

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Purpose : Compare and determine the differences in levels of homocysteine in

the blood and follicular fluid in infertile women with and without endometriosis, then analyze the effect of homocysteine levels with oocyte quality.

Method : This study was cross-sectional study. Fifty-nine subjects following the

in-vitro fertilization program are included in the admission criteria were divided into two equal groups, ie groups of endometriosis and without endometriosis consecutively (consecutive sampling). Each subject taken from the blood and follicular fluid then measured the levels of homocystein levels with immuoassay

method : The mean of each group was statistically tested with an independent t

test.

Results : The mean levels of homocysteine in the blood is higher in the endometriosis group than without endometriosis group and it was statisticaly significance (8,34 ±2,68 vs 6,71 ±1,56, p=0.007;95%CI: 0,02417-0,14657).

Similarly, the levels of homocysteine in follicular fluid , the endometriosis group

is higher and statisticaly significance (6,19 ±1,67 vs 3,46 ±1,03; p= 0,000; 95% CI : 0,19310-0,32353). All oocytes are in good quality in both groups, maturation grade 3. There is a correlation between the levels of homocysteine in the blood and follicular fluid in the endometriosis group and assessed with Pearson test, and it found significant (p = 0.002) and the correlation value 0.553 (moderate correlation strength) and direction of a positive correlation.

Conclusion : The mean levels of homocysteine in the blood and follicular fluid in infertile women with endometriosis is higher than without endometriosis and were statistically significantly different. These homocysteine levels does not affect the quality of oocytes. There is a positive correlation between the levels of homocysteine in the blood and follicular fluid in endometriosis group."

"Membandingkan dan menentukan rerata kadar AMH serum pada wanita infertil dengan tanpa endometriosis serta mengetahui rerata kadar AMH serum pada masing-masing derajat endometriosis. Metode: Penelitian ini merupakan penelitian potong lintang (cross sectional). Enam puluh delapan subjek yang menjalani laparoskopi, yang masuk dalam kriteria penerimaan dibagi menjadi dua kelompok sama besar, yakni kelompok endometriosis dan tanpa endometriosis secara konsekutif (consecutive sampling). Masing-masing subjek diambil percontoh dari darah sebelum dilakukan laparoskopi kemudian diukur kadar AMH serum. Rerata masing-masing kelompok diuji statistik dengan uji Mann-Whitney. Hasil: Rerata kadar AMH serum pada kelompok endometriosis lebih rendah dibandingkan dengan tanpa endometriosis dan secara statistik berbeda bermakna (2,30+1,8 ng/ml vs 3,75+2,13 ng/ml; p=0,005). Dengan uji Kruskal-Wallis, didapatkan perbedaan bermakna secara statistik pada subjek kelompok endometriosis berdasarkan derajat endometriosis (p=0,005). Bila dilakukan pengelompokkan kelompok endometriosis minimal-ringan dan kelompok endometriosis sedang-berat dibandingkan dengan kelompok tanpa endometriosis, maka hasilnya menunjukkan tidak adanya hubungan yang bermakna antara kadar AMH serum pada kelompok endometriosis minimal-ringan dengan kelompok tanpa endometriosis (p=0,34), sedangkan pada kelompok endometriosis sedang-berat dengan kelompok tanpa endometriosis terdapat hubungan yang bermakna (p<0,005).

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To compare and to determine the differences in levels of serum AMH in infertile women with and without endometriosis, and also to determine the mean levels of serum AMH in every grade of endometriosis.

Methods: This study is a cross-sectional study. Sixty-eight subjects who have undergone laparoscopy fulfilled the inclusion criteria are included and divided into two groups, i.e groups of endometriosis and without endometriosis consecutively (consecutive sampling). Blood samples are taken from each subject before laparoscopy which is then measured the levels of serum AMH. The mean levels of each group are tested with an Mann-Whitney test.

Results: The mean levels of serum AMH were lower in the endometriosis group than that group without endometriosis and it was statistically significance ( 2,30+1,8 ng/ml vs 3,75+2,13 ng/ml; p=0,005). With Kruskal-Wallis test, it was found that there was statistically significant difference among endometriosis group based on grading. There was no different at the mean levels of serum AMH between the minimal-mild endometriosis group and without endometriosis group (p=0,34), but the mean levels of serum AMH was lower in the moderate-severe endometriosis compare to the group without endometriosis and it was statistically significance (p<0,005).

Conclusions: The mean levels of serum AMH in infertile women with endometriosis were lower than that group without endometriosis and were statistically significantly different. There was no different between the mean levels of serum AMH in minimal-mild endometriosis group and that group without endometriosis, while in moderate-severe endometriosis group, it was lower than without endometriosis and it was statistically significance."