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Abstrak :
Secara umum industri petrokimia merupakan industri dengan tingkat potensi bahaya kecelakaan proses sangat berbahaya bagi para pekerja, masyarakat dan lingkungan sekitar. PT. XYZ sebagai perusahaan produsen Pupuk Urea (NH₂)₂CO merupakan salah satu pabrik petrokimia di Indonesia dimana dalam menjalankan proses bisnis PT XYZ tidak terlepas dari berbagai ancaman risiko bahaya proses yang tinggi baik dari hulu (proses pengolahan bahan baku gas alam menjadi bahan baku setengah jadi) hingga hilir (proses produksi Pupuk). Maka dari itu dibutuhkan suatu sistem manajemen khusus untuk mengidentifikasi, mitigasi, mengendalikan hingga merepson bahaya dari semua aktifitas maupun proses produkti di tempat kerja. Process Safety Management (PSM) merupakan suatu sistem manajemen keselamatan berbasis proses proaktif dalam mengidentifikasi, mitigasi, mengendalikan serta merespon bahaya dari semua aktifitas ataupun proses produksi di tempat kerja yang banyak digunakan industry petrokimia yang diimplementasikan PT XYZ di salah satu pabriknya yaitu pabrik 2B. Tujuan dari penelitian ini untuk menganalisis tingkat maturitas penerapan PSM pada pabrik 2B PT XYZ yang terdiri dari 14 elemen yaitu Process Safety Information (PSI), Process Hazard Analysis (PHA), Operating Procedure (OP), Employee Participation (EP), Training (TRA), Contractor (CTR), Pre Startup Safety Review (PSSR), Mechanical Integrity (MI), Permit To Work (PTW), Management Of Change (MOC), Incident Investigation (II), Emergency Response and Planning (ERP), Compliance Audit (CA), dan Trade Secret (TS) dimana tingkat maturitas penerapan PSM penting bagi organisasi agar dapat mengetahui kelemahan dan kelebihan dari setiap elemen yang telah mereka terapkan agar dapat mengidentifikasi dan menetapkan tindakan yang dapat dilakukan untuk meningkatkan penerapan elemen PSM sehingga dapat menurunkan potensi kecelakaan proses. Dalam melakukan penilaian tingkat maturitas PSM penelitian menggunakan metode mix methode analisis deskriptif semi kualitatif dengan melakukan pendekatan sumber informasi kunci yang diperoleh melalui kuesioner, wawancara, observasi lapangan dan tinjauan dokumen perusahaan dengan jumlah sample 93 orang. Hasil penelitian didapatkan penilaian terhadap 14 elemen PSM di pabrik 2B PT XYZ berada pada commited to excellence dimana dari 14 elemen tersebut hanya terdapat 4 elemen berada pada level compliant. ......Commonly, petrochemical industry is the type of industry with a high level of potential process accident hazards that can affect workers, the community and the surrounding environment. PT. XYZ as a producer of Urea Fertilizer (NH₂)₂CO is one of the petrochemical industry in Indonesia and their business processes cannot be separated from upstream process hazards (processing natural gas raw materials into semi-finished raw materials) to downstream process hazards (fertilizer production process). Therefore, a special management system is needed to identify, mitigate, control and respond to hazards from all products and processes activity in the workplace. Process Safety Management (PSM) is a proactive process-based safety management system in identifying, mitigating, controlling and responding to hazards from all activities or production processes in the workplace that are widely used by the petrochemical industry which is implemented by PT XYZ in one of its factories, it’s 2B plants. The purpose of this study is to analyze the maturity level of PSM implementation at PT XYZ's 2B plants which consists of 14 elements, namely Process Safety Information (PSI), Process Hazard Analysis (PHA), Operating Procedure (OP), Employee Participation (EP), Training (TRA). ), Contractor (CTR), Pre Startup Safety Review (PSSR), Mechanical Integrity (MI), Permit To Work (PTW), Management Of Change (MOC), Incident Investigation (II), Emergency Response and Planning (ERP), Compliance Audit (CA), and Trade Secret (TS) where the maturity level of PSM implementation is to be able to identify the advantages and disadvantages of each element implemented in order to identify and determine actions that can be taken to improve the implementation of PSM elements so as to reduce the potential for the accident process. In conducting research to assess PSM implementation maturity level, the research uses a mixed method of semi-qualitative descriptive analysis by approaching the sources of information obtained through questionnaires, interviews, and observations field and research company documents with a sample of 93 people. The results of the assessment research on 14 PSM elements at PT XYZ's 2B factory are committed to excellence where from these 14 elements there are only 4 elements at the compliant level.

Abstrak :
Hipertensi merupakan penyakit penyerta yang paling umum ada pada penderita COVID-19. Faktor risiko seperti genetik, sosiodemografi, dan kondisi klinis awal diduga dapat memengaruhi kerentanan individu terhadap hipertensi dan COVID-19. Salah satu gen yang berhubungan dengan hipertensi adalah gen ACE. Penelitian ini bertujuan untuk mengkaji variasi genetik gen ACE dalam hubungannya dengan risiko kerentanan dan penanganan penyakit hipertensi dan COVID-19 menggunakan model populasi Palu-Sulawesi Tengah. Penelitian ini merupakan studi observasional dengan desain cross-sectional. Data faktor non-genetik diperoleh dari rekam medis dan kuesioner. Identifikasi variasi genetik dilakukan pada 4 lokasi pada gen ACE, yaitu rs1799752 (I/D) dengan metode PCR, dan rs4331 (A/G), rs4341 (G/C), dan rs4343 (G/A) dengan rhAmp SNP genotyping. Data faktor genetik dan non-genetik kemudian disusun menjadi model instrumen translasional. Studi melibatkan 136 subjek, dan analisis variasi genetik menunjukkan genotipe dominan untuk rs1799752 adalah II (50%), rs4331 adalah GG (51%), rs4341 adalah GG (100%), dan rs4343 adalah AA (65%). Varian alel D rs1799752, alel A rs4331, dan alel G rs4343 menunjukkan hubungan dengan kerentanan terhadap hipertensi, COVID-19, dan keparahan COVID-19. Analisis regresi menunjukkan bahwa jenis kelamin, usia, riwayat hipertensi, LDL, asam urat, glukosa darah, dan variasi genetik gen ACE adalah prediktor dalam menilai tingkat risiko hipertensi. Sementara itu, jenis kelamin, trigliserida, HDL, komorbiditas hipertensi, dan variasi genetik gen ACE adalah prediktor dalam menilai risiko terhadap kejadian COVID-19, sementara komorbiditas hipertensi, IMT, asam urat, dan variasi genetik gen ACE adalah prediktor dalam menilai risiko keparahan COVID-19. Asesmen prediksi instrumen translasional menunjukkan bahwa 31% dari kelompok hipertensi berisiko tinggi terhadap kejadian COVID-19 dan 46% memiliki berisiko sangat tinggi untuk mengalami keparahan yang lebih tinggi. Asesmen prediksi instrumen translasional hipertensi menunjukkan bahwa 22% subjek memiliki risiko sangat tinggi dan 23% diantaranya memerlukan penyesuaian pola terapi. Variasi gen ACE rs4331, rs1799752, dan rs4343, bersama dengan faktor risiko non-genetik, dapat digunakan sebagai prediktor untuk kejadian hipertensi, COVID-19, dan keparahan COVID-19. Variasi gen dan faktor non-genetik ini dapat dikembangkan menjadi model pengobatan presisi untuk mengevaluasi tingkat risiko dan penanganan individu terhadap hipertensi, COVID-19, dan keparahan COVID-19 di kalangan populasi Palu-Sulawesi Tengah secara translasional. ......Hypertension is the most common comorbidity in COVID-19 sufferers. Risk factors such as genetics, sociodemographics, and initial clinical conditions are thought to influence an individual's susceptibility to hypertension and COVID-19. One of the genes associated with hypertension is the ACE gene. This study examines the ACE gene's genetic variation in summary with the risk of developing hypertension and COVID-19 using the Palu-Central Sulawesi population model. This research is an observational study with a cross-sectional design. Data on non-genetic factors were obtained from medical records and questionnaires. Identification of genetic variations was carried out at 4 locations in the ACE gene, namely rs1799752 (I/D) using the PCR method, rs4331 (A/G), rs4341 (G/C), and rs4343 (G/A) using rhAmp SNP genotyping. Data on genetic and non-genetic factors are then compiled into a translational instrument model. The study involved 136 subjects, and analysis of genetic variations showed that the dominant genotype for rs1799752 was II (50%), rs4331 was GG (51%), rs4341 was GG (100%), and rs4343 was AA (65%). The variant D allele rs1799753, A allele rs4331, and G allele rs4343 showed an association with susceptibility to hypertension, COVID-19, and severity of COVID-19. Regression analysis showed that gender, age, history of hypertension, LDL, uric acid, blood glucose, and genetic variations of the ACE gene were predictors in assessing the level of hypertension risk. Meanwhile, gender, triglycerides, HDL, comorbid hypertension, and genetic variations of the ACE gene are predictors in determining the risk of COVID-19. In contrast, comorbid hypertension, BMI, uric acid, and genetic variations of the ACE gene are predictors in assessing the risk of COVID-19 severity. -19. The translational instrument prediction assessment showed that 31% of the hypertension group were at high risk of experiencing COVID-19, and 46% were at very high risk of experiencing higher severity. The translational instrument prediction assessment for hypertension showed that 22% of subjects had a very high risk, and 23% of them required adjustment of therapy patterns. ACE gene variations rs4331, rs1799752, and rs4343, together with non-genetic risk factors, can be used as predictors for the incidence of hypertension, COVID-19, and severity of COVID-19. These gene variations and non-genetic factors can be developed into a precision medicine model to evaluate the risk level and individual treatment of hypertension, COVID-19, and the severity of COVID-19 among the Palu-Central Sulawesi population in a translational.