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Abstrak :
ABSTRAK
Binders syndrome or maxillonasal dysostosis is a rare congenital condition that primarily affects the mid face and sometimes the vertebrae. It was named after von Binder who described three cases of hypoplastic maxilla nasal complex in 1962. It can either occur as a sporadic mutation or may be inherited in an autosomal recessive pattern with incomplete penetrance. Decrease in the naso labial angle, flat forehead, dish shaped face, absence of protrusion of nasal tip, absence of nasal flare with triangular or semilunar nostrils, palpable depression in the nasal floor and a class III tendency are characteristic of the syndrome. Vertebral anomalies are seen in some patients owing to the parallel development of the nasal complex and vertebrae in the third month of intrauterine life. Prenatal diagnosis may be done using ultrasonography at 21 weeks of pregnancy. A multi disciplinary approach towards planning of treatment for individuals with Binders syndrome includes orthodontic treatment along with osteotomies and grafting to correct the nasal and mid face defects.

Abstrak :
ABSTRAK
An increase in lipid peroxidation and a decrease in antioxidant activity have been reported in patients with cancer in comparison with normal subjects. Objective: To estimate the status of serum and saliva by assessing the serum and salivary vitamin E levels in patients with oral potentially malignant disorders and oral cancer. Methods: A total of 90 participants were enrolled in this study. 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls). Serum and saliva samples were collected and vitamin E levels were assessed. The data were analyzed using ANOVA for between group comparison. Post hoc Tukey analysis was used for comparing the two study groups with the control group. Pearson correlation coeffcient was used to determine concordance between the groups. Results: Mean vitamin E levels in serum and saliva were signifcantly decreased in oral potentially malignant disorders and oral cancer compared with controls. Conclusion: As signifcant reduction in vitamin E levels was observed in saliva, it was evident that salivary vitamin E levels potentially be used as a reliable, non invasive biomarker for diagnosing and managing oral potentially malignant disorders and oral cancer.