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"Salah satu komoditi pangan yang telah diteliti memiliki khasiat sebagai nutrasetika dalam pencegahan risiko diabetes adalah daun murbei Morus alba Linn. Penelitian ini bertujuan untuk membuat formula tablet effervescent dari ekstrak daun murbei. Tablet effervescent dibuat dalam 3 tiga formula yang dibedakan berdasarkan konsentrasi effervescent mix nya yaitu formula I 50 formula II 60 dan formula III 70. Ketiga formula dievaluasi berdasarkan persyaratan tablet effervescent yang baik dan diuji waktu larutnya. Formula yang terpilih diuji kesukaan terhadap parameter penampilan aroma dan rasa pada 30 panelis. Hasil evaluasi tablet menunjukkan ketiga formula memenuhi persyaratan tablet berdasarkan parameter organoleptis keragaman bobot keseragaman ukuran kekerasan dan keregasan. Hasil pengujian terhadap waktu larut yang diperoleh yaitu formula I 4 03 0 15 menit formula II 3 85 0 10 menit dan formula III 3 71 0 10 menit. Selanjutnya pengujian terhadap pH larutan diperoleh nilai pH berkisar antara 5 26 0 03 hingga 5 76 0 02. Hasil uji kesukaan berdasarkan parameter penampilan aroma dan rasa secara berurutan menunjukkan nilai uji kesukaan 4 70 3 83 dan 3 73. Berdasarkan nilai uji kesukaan dapat disimpulkan bahwa sediaan tablet effervescent dapat diterima oleh panelis Oleh karena itu ekstrak daun murbei dapat digunakan sebagai bahan aktif dari tablet effervescent sebagai sediaan nutrasetika antidiabetik.

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One of potential plant which can be used as nutraceutical dosage form's ingredient is mulberry leaves. Mulberry leaves have been suggested for preventing diabetes. The aim of this study was to optimize formula of effervescent tablet which contain mulberry leaves extract Effervescent tablets were made in three formulas. Formulas which were differentiated by its effervescent mix content are 50 effervescent mix content as formula I 60 effervescent mix content as formula II and 70 effervescent mix content as formula III. Thus each formula was evaluated by its effervescent tablet's characteristic and its disintegration time. Selected formula would have been tested by hedonic test to 30 panels.

The result of effervescent tablet's evaluation showed that tablets have a good characteristic in term of appearance weight uniformity diameter size and thickness hardness and friability. Moreover pH of effervescent solution were in acceptable range between 5 26 0 03 and 5 76 0 02. The result of disintegration time of each formula was 4 03 0 15 minutes in formula I 3 85 0 10 minutes in formula II and 3 71 0 10 minutes in formula III. The scores of hedonic test for appearance smell and taste were 4 70 3 83 and 3 73 respectively.

Based on the hedonic scores the effervescent tablet were acceptable for panels. Therefore mulberry leaves extract could be used as an active ingredient of effervescent tablets as anti diabetic nutraceutical dosage form."

"Kegiatan PKP (Praktek Kerja Profesi) yang dilaksanakan di sektor pemerintahan yaitu Bina Obat Publik dan Perbekalan Kesehatan, Direktorat Bina Kefarmasian dan Alat Kesehatan memiliki tujuan agar mahasiswa mengerti peranan, tugas, dan tanggung jawab apoteker di sektor pemerinthan , memiliki wawasan, pengetahuan, ketrampilan, dan pengalaman praktis untuk melakukan pekerjaan di sektor pemerinthan, dan memiliki gambaran nyata tentang permasalahan di sektor pemerinthan . Tugas khusus yang diberikan saat Praktek Kerja Profesi di sektor pemerinthan adalah Aplikasi Pemetaan Instalasi Farmasi. Tugas khusus ini memiliki tujuan untuk menambah pengetahuan tentang produk-produk pemerintah di bidang farmasi.

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PKP activities at Directorate of public medicine and medical supplies, General Directorate of Pharmacy and Medical Devices Development have the aims that students understand the role, duties and responsibilities of pharmacists in Directorate of public medicine and medical supplies , have the insight, knowledge, skills, and practical experience to do the work as pharmacist in Directorate of public medicine and medical supplies , and have a real picture about the problems of pharmacy jobs in Directorate of public medicine and medical supplies. Special assignment given during the Job Training Professionals in the Safa Pharmacy is making of APIF Analysis."

"Marasi (Curculigo latifolia) merupakan salah satu tanaman dari famili Hypoxidaceae yang terdapat di Indonesia, Semenanjung Malaya hingga Indo-China. Tanaman ini secara tradisional digunakan untuk mengobati kanker, diabetes melitus, demam, infeksi mata, infeksi bakteri. Curculigo latifolia mengandung senyawa curculigine, norlignane, terpenoid, flavonoid, tannin, glikosida fenol dan turunannya yang bersifat antioksidan dan antimikroba. Penelitian ini bertujuan untuk standardisasi dan mengkaji aktivitas antimikroba dari ekstrak terpilih tanaman Curculigo latifolia terhadap bakteri Propionibacterium acne, Staphylococcus aureus dan Staphylococcus epidermidis. Pada penelitian ini dilakukan ekstraksi, uji zona hambat, uji KHM dan KBM, serta standardisasi ekstrak terpilih. Bagian tanaman yang digunakan antara lain daun, batang dan akar. Masing-masing bagian tanaman diekstraksi secara maserasi bertingkat menggunakan pelarut n-heksana, etil asetat, dan etanol 70%. Ekstraksi menggunakan pelarut etanol 70% v/v memberikan rendemen tertinggi di semua bagian tanaman, dengan nilai berkisar antara 9,3% hingga 12,64%. Uji zona hambat dari semua ekstrak yang dihasilkan, dilakukan dengan metode difusi cakram. Uji KHM dan KBM dilakukan dengan metode dilusi. Berdasarkan hasil uji antibakteri, ekstrak etil asetat dari bagian batang menunjukkan aktivitas antibakteri paling signifikan terhadap S. aureus dan S. epidermidis, sedangkan ekstrak n-heksana dari bagian akar memberikan hasil terbaik terhadap S. epidermidis. Ekstrak terpilih ditunjukkan oleh ekstrak etil asetat dari daun karena memiliki aktivitas antibakteri pada ketiga bakteri serta menjadi ekstrak dengan aktivitas tertinggi terhadap P. acne. Zona hambat ekstrak terpilih terhadap P. acne sebesar 11±1.4mm, nilai KHM sebesar 2.5%, dan KBM sebesar 5%. Analisis kualitatif menggunakan LC-HRMS menunjukkan terdapat 462 senyawa terdeteksi di dalam ekstrak terpilih Curculigo latifolia, termasuk senyawa kimia ursolic acid. Hasil standardisasi mutu menunjukkan bahwa ekstrak terpilih memenuhi standar keamanan dan kualitas, dengan kadar air kurang dari 10%, kadar abu total yang rendah, dan tidak terdeteksi adanya cemaran logam berat maupun mikroba.

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Marasi (Curculigo latifolia) is one of the plants from the family Hypoxidaceae, found in Indonesia, the Malay Peninsula, and Indo-China. Traditionally, this plant is used to treat cancer, diabetes mellitus, fever, eye infections, and bacterial infections. Curculigo latifolia contains compounds such as curculigine, norlignane, terpenoids, flavonoids, tannins, phenolic glycosides, and their derivatives, which have antioxidant and antimicrobial properties. This study aims to standardize and evaluate the antimicrobial activity of the most active extract of Curculigo latifolia against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The research involved extraction, inhibition zone testing, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and standardization of the most active extract. The plant parts used include leaves, stems, and roots. Each part of the plant was subjected to multilevel maceration extraction using solvents n-heksanae, ethyl acetate, and 70% ethanol. Extraction with 70% ethanol (v/v) provided the highest yield across all plant parts, with values ranging from 9.3% to 12.64%. The inhibition zone test for all extracts was performed using the disk diffusion method. MIC and MBC tests were conducted using the dilution method. Based on the antibacterial tests, the ethyl acetate extract of the stem showed the most significant antibacterial activity against S. aureus and S. epidermidis, while the n-heksanae extract of the root showed the best results against S. epidermidis. The most active extract was identified as the ethyl acetate extract of the leaves, as it exhibited antibacterial activity against all three bacteria and showed the highest activity against P. acnes. The inhibition zone of the most active extract against P. acnes was 11±1.4mm, with an MIC value of 2.5%, and an MBC value of 5%. Qualitative analysis using LC-HRMS detected 462 compounds in the most active extract of Curculigo latifolia, including the chemical compound ursolic acid. The quality standardization results indicated that the most active extract met safety and quality standards, with a moisture content of less than 10%, low total ash content, and no detectable contamination from heavy metals or microbes."