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Abstrak :
Atherosclerosis is a degenerative disease of large and medium arteries which loss their elasticity and the arterial walls are thickened which may cause coronary heart disease. Atherosclerosis is related to hyperlipidemia and concentration of serum lipoprotein cholesterol which are influenced by the intake of certain dietary lipids.

The polyunsaturated fatty acid (PUFA), particularly linoleic acid is believed to have a lowering effect, saturated fatty acid (SAFA) increase, and mono-unsaturated fatty acid (MUFA) is neutral or has no effect on serum triglyceride that PUFA especially when given ia a large amount besides HDL-c. MUFA seems to have a similar effect as PUFA but without lowering effect on HDL-c. Low LDL-c and high HDL-c levels have positive effect on preventing and curing atherosclerosis and contrary of high LDL-c and low HDL-c.

In this study, 60 albino, 2 month old male rats were put in separate cages and divides randomly into 6 groups. Each group received proportionally the first phase diet rich in margarine (40% of total energy) and cholesterol (10% w/w) for 3 months with additional oralforced feeding of proplythiouracil treated with the second phase diet with additional different types of fat source. The control group receieved normal diet. Determination of serum TG, total cholesterol, LDL-c, HDL-c and microscopic pathological examination of the aorta were carried out after treatment with the first and second phase diets.

Analysis of variance showed that there were significant differences in serum TG, total cholesterol and LDL-c levels, the amount of diet consumed and the body weight changes between the treatment serum TG, total cholesterol and LDL-c as peanut oil. Serum HDL-c appeared not to be influenced by the different types of dietary fat. Pathological examination did not reveal any identifiable atherosclerosis signs in the aorta of the rats.

Abstrak :
ABSTRACT
This study was carried out to ascertain the effect of essential amino acids supplementation in renal failure patients on dialysis. 22 renal failure patients on dialysis without any signs and symptoms of G.I. disorders, liver disease, uncontrolled diabetic mellitus were recruited to . the study. 11 patients served as subjects and received essential amino acids supplementation, 11 others served as control group who received placebo. The subjects had undergone basic physical examination, biochemical assessment (Hb, transferrin, ureum and creatinine) and dietary assessment at the beginning and at the end of the study. The study cone 1 uded that the essential amino acids supplementation given to renal failure patients on dialysis has significantly increased the transferrin value, this may suggest an improvement of the protein status of the patients. The study a 1 so pointed out that the increased in transferrin as an effect of the essential amino acids supplementation didt:l.'t cause an extra burden to the kidneys. Further investigations are needed to reconfirm this finding