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"Penelitian ini bertujuan mengetahui perbedaan perubahan kadar trigliserida (TG) serum postprandial setelah 2 jam dan 4 jam pemberian konsumsi satu butir telur omega-3 dibandingkan dengan telur ayam biasa. Penelitian ini merupakan studi eksperimental dengan desain cross over, alokasi acak, tersamar tunggal yang dilakukan terhadap individu sehat berusia 19-24 tahun di FKUI Jakarta, bulan September 2013. Berdasarkan kriteria penelitian, didapat 24 orang subyek yang dibagi menjadi dua kelompok, masing-masing kelompok terdiri dari 12 orang. Data yang diperoleh meliputi sebaran dan karakteristik subyek, asupan lemak, karbohidrat, kolesterol dan polyunsaturated fatty acid (PUFA), serta kadar TG serum awal, 2 jam dan 4 jam postprandial. Analisis data menggunakan uji t berpasangan dan Wilcoxon. Median usia subyek penelitian adalah 21 tahun dan sebagian besar subyek penelitian ini adalah laki-laki yaitu 15 orang dari total 24 orang. Rerata IMT subyek termasuk ke dalam kategori normal untuk Asia Pasifik. Asupan karbohidrat antar kedua kelompok pada periode run in tidak berbeda bermakna (p = 0,30) begitupun pada periode wash out (p = 0,44). Asupan lemak subyek kedua kelompok pada periode run in tidak berbeda bermakna (p = 0,74) dan pada periode wash out juga tidak berbeda bermakna (p = 0,85). Asupan kolesterol pada subyek melebihi jumlah anjuran dan jumlah asupan PUFA di bawah nilai anjuran. Perubahan kadar TG serum 2 jam postprandial pada kelompok perlakuan telur omega-3 yaitu -2,79±13,86 mg/dL sedangkan pada kelompok kontrol telur ayam biasa 4,38±10,07 mg/dL. Terdapat perbedaan yang bermakna antar kedua kelompok (p = 0,03). Perubahan kadar TG serum 4 jam postprandial antar kedua kelompok juga terdapat perbedaan bermakna (p = 0,04) yaitu pada kelompok perlakuan 0,00(-38-57) mg/dL dan pada kelompok kontrol 6,00±13,25 mg/dL. Dari penelitian ini disimpulkan pengaruh konsumsi satu butir telur omega-3 lebih baik dibandingkan satu butir telur ayam biasa terhadap kadar TG serum postprandial.

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The objective of this study was to evaluate the change of 2 and 4 hours postprandial triglycerides serum after given an omega-3 egg compared with an ordinary egg in healthy young adult. This is an experimental, randomized, single blind, cross over study on healthy young adult 19-24 years of age in FKUI Jakarta, September. By study criteria, 24 subjects were randomly allocated to one of two groups, 12 subjects for each group. Data collected in this study consist of subject distribution and characteristic, intake of carbohydrate, fat, cholesterol, polyunsaturated fatty acids (PUFA) and triglycerides serum, that were assessed before treatment, 2 hours and 4 hours after. The statistical analyses used dependent t-test and Wilcoxon. Median of age in subject is 21 years and 15 subjects of the study are male . BMI of study subjecst is in normal category for Asia Pacific. The carbohydrate intakes between both groups in 'run in period' are not significantly different (p = 0.30) and also in 'wash out period' (p = 0,44). Intakes of fat between both groups are also not significantly different in 'run in period' (p = 0,74) and 'wash out period' (p = 0,85). Cholesterol intake in both groups was higher than recommendation, and PUFA lower than recommendation. Changes of 2 hours postprandial triglycerides serum in omega-3 group (treatment) is -2,79±13,86 mg/dL and in ordinary egg group (control) is 4,38±10,07 mg/dL. There is significantly different in both groups (p = 0,03). Changes of 4 hours postprandial triglycerides serum in both groups is also significantly different (p = 0,04) which is in treatment group is 0,00(-38-57) mg/dL and in control group is 6,00±13,25 mg/dL. The conclusion from this study is the effect of an omega-3 egg consumption is better than an ordinary egg consumption on postprandial TG serum."

"Latar Belakang: Keberhasilan terapi demam neutropenia berkaitan erat dengan pemberian antibiotik empiris awal. Pola kuman patogen berbeda-beda pada tempat satu dan yang lain. Penelitian mengenai kesesuaian antibiotik dengan kuman patogen dan pengaruhnya terhadap keberhasilan terapi penting diteliti untuk mendapat gambaran mengenai pilihan antibiotik empiris di RSCM.Tujuan: Mengetahui kesesuaian antibiotik empiris dengan kuman patogen dan pengaruhnya terhadap keberhasilan terapi.Metode. Desain kohort retrospektif dengan menggunakan data rekam medis RSCM periode Januari 2015-Maret 2018. Analisis kesesuaian menggunakan Uji Mc Nemar dan analisis kesesuaian terhadap keberhasilan terapi menggunakan Uji Chi Square dan menghitung nilai relative risk (RR).Hasil: Didapatkan 114 subyek yang memenuhi kriteria penelitian. Kejadian demam neutropenia lebih banyak dijumpai pada perempuan (52,6%), usia <60 tahun (80,7%), tumor hematologi (57%), tidak ada komorbid (54,4%), pasca kemoterapi siklus pertama (43,9%), regimen intensitas tinggi (57,9%), dan skor Multinational Association of Supportive Care in Cancer < 21 (72,8%); dengan nilai Absolute Neutrophil Count awal ≥100/uL (75,4%) dan durasi ≤ 7 hari (78,1%). Pada 38,6% kasus tidak ditemukan fokus infeksi. Penggunaan antibiotik anti-pseudomonas 86,8% dengan jenis tersering meropenem (20,3%). Patogen non-pseudomonas mendominasi (83,3%) dengan kuman terbanyak Klebsiella pneumoniae (22,7%). Angka keberhasilan terapi cukup tinggi (63,2%) dengan mortalitas 21,1%. Tidak terdapat kesesuaian antibiotik dengan patogen (nilai Kappa 0,012). Analisis bivariat menunjukkan tidak ada faktor perancu pada penelitian ini. Kesesuaian antibiotik tidak mempengaruhi keberhasilan terapi, dengan nilai RR 1,07 (IK 95% 0,79-1,45). Kesimpulan: Tidak terdapat kesesuaian antara antibiotik empiris dengan kuman patogen namun hal ini tidak mempengaruhi keberhasilan terapi pada pasien demam neutropenia pasca kemoterapi di RSCM.

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Background: Success rate of febrile neutropenia therapy closely related with initial empirical antibiotic. Spectrum of pathogen may differ from place to place. The appropriateness of empirical antibiotic therapy with pathogen and its effect toward successful therapy were vital in choosing the appropriate empirical antibiotic in Cipto Mangunkusumo Hospital.Objectives: To identify appropriateness of empirical antibiotic therapy with pathogen and its effect toward success of therapy.Methods: A cohort retrospective study was conducted by using secondary data in Cipto Mangunkusumo Hospital from January 2015-March 2018. Mc Nemar test was used to analyze the appropriateness and Chi Square analysis was used to obtain relataive risk of success rate related with appropriateness.Results: One hundred and fourteen subjects were included in this study. Febrile neutropenia more common in female (52,6%), <60 years of age (80,7%), hematological malignancies (57%), no comorbid (54,4%), after the first cycle of chemotherapy (43,9%), high intensity regimen (57,9%), and Multinational Association of Supportive Care in Cancer score < 21 (72,8%); with baseline Absolute Neutrophil Count ≥100/uL (75,4%) and ≤ 7 days of duration (78,1%). No documented infection in 38,6% cases. The use of anti-pseudomonas antibiotic were 86,8% with meropenem as the mostly used (20,3%). Non-pseudomonas pathogen were found in 83,3% cases with Klebsiella pneumoniae as the most common pathogen (22,7%). Success rate was good (63,2%) with 21,1% mortality. There were no appropriateness between antibiotics and pathogen (Kappa value 0,012). There were no confounding factors in this study. The relation between appropriateness and success rate were not statistically significant (RR 1,07; 95%CI 0,79-1,45). Conclusion: There were no appropriateness between antibiotics and pathogen and there were no relation between appropriateness and success rate in chemo-related febrile neutropenic patients at Cipto Mangunkusumo Hospital."