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Penelitian ini bertujuan untuk menilai peranan Skintimammografi menggunakan Tc-99m sestamibi dalam mendeteksi lesi residif lokoregional pada karsinoma payudara. Terdapat 29 pasien dengan keeurigaaan residif kanker payudara pasca terapi yang mengikuti penelitian ini. Pemeriksaan skintimammografi dengan tehnik planar dilakukan dalam posisi pasien supine, lateral prone dan lateral pada meja pemeriksaan khusus dekat gamma camera. Dilakukan analisa secara kualitatif terhadap setiap lesi di payudara dan kelenjar getah bening lokoregional dan selanjutnya dikonfirmasi dengan pemeriksaan biopsi aspirasi jarum halus (FNAB). ......The aim of this study was to evaluate the possible role of Scintimammography (SMM) with technetium 99m sestamibi in locoregional recurrency of breast cancer. Twenty-nine patients with suspected have a recurrent breast cancer after therapy were included in this study. Planar scintigraphic image were done with supine anterior, prone lateral and lateral views, with patient in the table near the gamma camera. A qualitative analysis evaluating breast and lymph nodes was performed. All suspected breast lesions were confirmed by fine needle aspiration biopsy examination. In 15 of the 29 patients, Scintimammography was true positive with fine needle aspiration biopsy (FNAB) confirmed breast carcinoma, 11 pts were negative with scintimammography and FNAB, 2 pts were positive with scintimmography but negative in FNAB, and 1 pt was negative with scintimammography but positive in FNAB.