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Renisa Aru Ariadno
Korelasi depresi dengan keparahan dermatitis seboroik di Kepala pada pasien Poliklinik Kulit dan Kelamin RS DR. Cipto Mangunkusumo tahun 2017 = Correlation between depression and seborrheic dermatitis severity on scalp in Dermatology and Venereology Clinic DR Cipto Mangunkusumo Hospital in 2017
"Dermatitis seboroik merupakan masalah kulit kronis yang ditandai gejala berupa eritema, skuama, dan papul pada kulit yang memiliki banyak kelenjar sebasea. Dermatitis seboroik ringan sering disebut ketombe. Sampai saat ini, belum ada penelitian yang menjelaskan faktor pencetus keparahan dermatitis seboroik, salah satunya depresi. Depresi adalah gangguan mood kronis yang ditandai dengan menurunnya pola hidup dan ritme biologis seseorang yang muncul akibat stress psikologis kronis. Keduanya diperkirakan memiliki korelasi meski sampai saat ini belum ada penelitian yang menunjukkan hasil bermakna. Tujuan dari penelitian ini adalah mencari korelasi antara depresi dengan keparahan dermatitis seboroik. Penelitian ini dilakukan secara cross sectional di Departemen Ilmu Kulit dan Kelamin Rumah Sakit dr. Cipto Mangunkusumo, Jakarta pada 2017. Keparahan dermatitis seboroik diukur dengan Seborrheic Dermatitis Area and Severity Index SDASI , sementara depresi diukur dengan kuesioner Beck Depression Inventory II BDI-II. Subjek penelitian sebanyak 82 pasien dermatitis seboroik. Uji normalitas data ditemukan tidak normal. Nilai median depresi sebesar 5 0-38 dan nilai median keparahan dermatitis seboroik sebesar 2,25 0,25-21. Hasil uji korelasi dengan Spearman menunjukkan hasil tidak signifikan dan tidak ada korelasi antara depresi dengan keparahan dermatitis seboroik P=0,249 dan r=-0,129. Kesimpulan dari penelitian ini adalah tidak ditemukan adanya korelasi antara depresi dengan keparahan dermatitis seboroik.
Seborrheic dermatitis is a chronic skin disease with specific manifestation such as erythematous, squamous, and papules on sebaceous glands rich skin. Mild seborrheic dermatitis usually recognized as dandruff. There were no previous studies that explained causal factors that affect seborrheic dermatitis severity, including depression. Depression is one of psychiatry disorders that affects mood chronically, changed lifestyle, and disturbed biological rythme which caused by chronic psychology stress. There were no studies that explained their correlation, despise the fact that there is relationship between emotional stress and dermatology disorders especially in neuroendocrine system that affects skin tissue homeostatic. This was a cross sectional research that applied in dermatology and venereology clinic dr. Cipto Mangunkusumo Hospital Jakarta in 2017 to find correlation between depression and seborrheic dermatitis severity. Seborrheic dermatitis severity measured by Seborrheic Dermatitis Area and Severity Index SDASI , and depression measured by Beck Depression Inventory II BDI II. The subjects were 82 seborrheic dermatitis patients. Median number for depression was 5 0 38 and median number for seborrheic dermatitis was 2.25 0.25 21. Correlation trials with spearman showed no statistically significant between depression and seborrheic dermatitis severity P 0.249 and r 0.129. Conclusion, this research showed there was no correlation between depression and seborrheic dermatitis severity."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
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UI - Skripsi Membership  Universitas Indonesia Library
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Rahma Evasari
Uji diagnostik sifilis menggunakan rapid test standard Q syphilis AB dari spesimen darah kapiler dan serum dibandingkan dengan treponema pallidum hemagglutination assay: Studi pada populasi risiko tinggi = Syphilis diagnostic test using rapid test standard Q syphilis AB of fingerprick whole blood and serum specimens compared to treponema pallidum hemagglutination assay: Study on high risk populations.
"Sifilis merupakan penyakit infeksi yang disebabkan oleh Treponema pallidum subspesies pallidum (T. pallidum), merupakan penyakit kronis dan bersifat sistemik. Sifilis merupakan penyakit yang progresif dengan gambaran klinis aktif (stadium primer, sekunder, dan tersier) serta periode tidak bergejala (sifilis laten). Sifilis masih merupakan masalah kesehatan di seluruh dunia dengan 80-90% kasus baru terjadi di negara berkembang dengan sedikit atau tidak ada akses diagnostik. Sejumlah besar sifilis tidak bergejala. Akibatnya, sebagian sifilis tidak terdiagnosis dan tidak mendapatkan tatalaksana yang baik, sehingga berpotensi menimbulkan gejala sisa serius, manifestasi sifilis tersier, kardiovaskular, neurologik, oftalmologik, otologik, dan berlanjutnya rantai penularan. Penelitian ini bertujuan untuk menilai kemampuan rapid Test STANDARD Q Syphilis Ab dengan menggunakan spesimen serum dan darah kapiler dibandingkan dengan TPHA dalam mendeteksi sifilis pada populasi risiko tinggi yang terdiri atas waria, lelaki yang berhubungan seksual dengan lelaki, dan wanita penjaja seks di Puskesmas Kecamatan Pasar Rebo, Jakarta Timur. Penelitian ini adalah uji diagnostik dengan dengan rancangan studi potong lintang. Hasil penelitian menggunakan spesimen serum memberikan hasil sensitivitas 91,30%, spesifisitas 97,53%, nilai duga positif 95,45%, nilai duga negatif 95,18%, dan akurasi 95,28% dibandingkan dengan TPHA sebagai baku emas. Hasil pengujian dengan spesimen darah kapiler memberikan hasil sensitivitas 84,78%, spesifisitas 98,77%, nilai duga positif 97,50%, nilai duga negatif 91,95%, dan akurasi 93,70% dibandingkan dengan TPHA sebagai baku emas. Kesesuaian hasil rapid test STANDARD Q Syphilis Ab antara spesimen serum dan darah kapiler sangat baik (κ = 0,8223). Rapid test STANDARD Q Syphilis Ab dapat dijadikan alternatif uji treponemal dalam menunjang diagnosis sifilis, baik sebagai penapisan rutin maupun konfirmasi hasil uji nontreponemal serta penggunaan spesimen darah kapiler dapat dijadikan alternatif uji treponemal yang lebih cepat dan mudah dilakukan.
Syphilis is a chronic and systemic disease caused by Treponema pallidum subspecies pallidum (T. pallidum). Syphilis is a progressive disease with active clinical features (primary, secondary, and tertiary syphilis) and asymptomatic periods (latent syphilis). Syphilis is still a worldwide health problem with 80-90% of new cases occurring in developing countries with little or no diagnostic access. A large number of syphilis are asymptomatic. As a result, some syphilis is undiagnosed and does not get good management, potentially causing serious sequelae, the manifestation of tertiary syphilis, cardiovascular, neurologic, ophthalmologic, otologic, and continuous chain of transmission. This study aimed to assess STANDARD Q Syphilis Ab's rapid test capability using serum and fingerprick whole blood specimens compared with TPHA in detecting syphilis in high-risk populations comprised of transgenders, men who have sex with men, and female sexual workers in Puskesmas Pasar Rebo. This study is a diagnostic test with a cross sectional study design. The results of this study using serum specimens were sensitivity of 91.30%, specificity of 97.53%, positive predictive value 95.45%, negative predictive value of 95.18%, and accuration 95.28%, compared to TPHA as the gold standard. Test results with fingerprick whole blood specimens gave sensitivity of 84.78%, specificity of 98.77%, positive predictive value of 97.50%, negative predictive value of 91.95%, and accuration 93.70%, compared to TPHA as the gold standard. Compatibility of rapid test STANDARD Q Syphilis Ab results between serum and fingerprick whole blood specimens was very good (κ = 0.8223). Rapid test STANDARD Q Syphilis Ab can be used as an alternative treponemal test in supporting syphilis diagnosis, either as routine screening or confirmation of nontreponemal test result and the use of fingerprick whole blood specimen can be used as treponemal test alternative which is faster and easier to do.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Tugas Akhir  Universitas Indonesia Library
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Karin Rachmani
Perbandingan ketahanan sun protection factor 30 tabir surya inorganik dan organik pada atlet renang = Comparison of Sun Protection Factor (SPF) 30 persistence between inorganik and organic sunscreen in swimmers
"Later belakang: Atlet renang berlatih di ruang terbuka terpajan sinar matahari dan dapat mengalami sunburn yang dapat dicegah dengan penggunaan tabir surya. Namun, aktivitas fisik dapat mengganggu efektivitas tabir surya, menurunkan kadar sun protection factor (SPF). Tabir surya diklasifikasikan menjadi inorganik dan organik. Tabir surya organik bertahan lebih lama, tetapi tabir surya inogranik memiliki spektrum luas, lebih fotostabil, dan jarang menimbulkan alergi.
Tujuan: Mengetahui ketahanan SPF 30 tabir surya inorganik dan organik setelah digunakan berenang 1,5 jam.
Metode: Penelitian merupakan uji klinis acak tersamar ganda dengan metode split body. Setiap subjek menerima dua perlakuan dengan randomisasi alokasi dan perlakuan. Perbedaan SPF kedua tabir surya dinyatakan tidak berbeda bila nilai p untuk uji berpasangan >0.05 dan batas atas interval kepercayaan tidak melebihi 4 SPF.
Hasil: Tidak ada perbedaan bermakna SPF kedua tabir surya sebelum berenang (p=0,220). Setelah berenang, terdapat penurunan SPF tabir surya inorganik, median 27 (23-47) menjadi 12,3 (8-19); dan organik, median 30 (24-47) menjadi 9,9 (6-19) yang bermakna secara statistik (p<0.0001). Setelah berenang, terdapat perbedaan penurunan SPF kedua kelompok yang bermakna secara statistik (p=0,017).
Kesimpulan: Terdapat penurunan SPF tabir surya inorganik dan organik setelah digunakan berenang 1,5 jam dengan ketahanan tabir surya inorganik lebih baik dibandingkan tabir surya organik.
Background: Outdoor swimmers are exposed to sun exposure, causing sunburn which is preventable by using sunscreen. However, physical activities interfere with sunscreen efficacy, decreasing its sun protection factor (SPF). Sunscreens are classified as inorganic and organic. Organic sunscreen last longer, however, inorganic sunscreen is broad-spectrum, more photostable, and less allergenic.
Objective: To determine SPF 30 persistence between inorganic and organic sunscreen after 1,5 hours swimming.
Methods: This is a randomized, split-body, double-blind, clinical trial. Each subject received two treatments. Subject allocation and treatment were randomized. The difference between sunscreens SPF is no different if p-value for paired test is >0.05 and the upper limit of confidence interval do not exceed 4 SPF.
Results: There was no significant difference between SPF before swimming (p=0.220). After swimming, there was a decrease in inorganic sunscreen SPF, median 27 (23-47) to 12.3 (8-19), and organic, median 30 (24-47) to 9.9 (6-19) which was statistically significant (p<0.0001). When compared, there was statistically significant difference in the decrease of SPF between the two groups (p=0.017).
Conclusion: There is a decrease in SPF of inorganic and organic sunscreen after 1.5 hours swimming with a better persistence of inorganic sunscreen compared to organic sunscreen."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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UI - Tugas Akhir  Universitas Indonesia Library
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Batubara, Irwan Saputra
Uji validitas, reliabilitas, dan perbandingan dua versi kuesioner Baumann Skin Type Indicator berbahasa Indonesia (BSTI-Ina) yang diadaptasi dari kuesioner berbahasa Inggris = Validity, reliability, and comparison of the Indonesian version of two Baumann Skin Type Indicator (BSTI) questionnaires adapted from English questionnaires
"Latar belakang: Baumann Skin Type Indicator (BSTI) merupakan instrumen yang dikembangkan pada tahun 2006 untuk menentukan tipe kulit berdasarkan empat parameter dikotom, yaitu: kering atau berminyak; sensitif atau resisten; berpigmen atau tidak berpigmen; dan kencang atau keriput. Kuesioner ini telah dimodifikasi pada tahun 2022 agar lebih praktis dan mudah digunakan. BSTI dapat membantu dokter untuk merekomendasikan produk perawatan kulit harian yang paling sesuai bagi pasien. Hingga saat ini, belum ada klasifikasi penentuan tipe kulit di Indonesia. Oleh karena itu, diperlukan alat yang valid dan reliabel untuk menentukan tipe kulit pada populasi di Indonesia. Penelitian ini bertujuan untuk mengembangkan Baumann Skin Type Indicators berbahasa Indonesia (BSTI-Ina).
Metode: Dilakukan penerjemahan dan adaptasi lintas budaya kuesioner BSTI tahun 2006 dan 2022 ke dalam bahasa Indonesia. Hasil terjemahan kuesioner dianalisis oleh komite yang beranggotakan dokter spesialis Dermatologi, Venereologi dan Estetika, ahli biostatistika, psikolog klinis, dan penerjemah. Hasil kuesioner yang telah disepakati oleh komite diisi oleh 150 subjek dewasa yang berusia antara 18 hingga 59 tahun. Validitas kuesioner BSTI-Ina tahun 2006 dan 2022 dinilai berdasarkan validitas konten dan validitas konstruksi. Reliabilitas dinilai berdasarkan konsistensi internal. Korelasi antara kuesioner BSTI-Ina tahun 2006 dan 2022 dinilai dengan intra-class correlation (ICC).
Hasil: Uji validitas menghasilkan nilai koefisien korelasi setiap pertanyaan pada BSTI-Ina tahun 2006 sebesar -0,037 hingga 0,751, untuk setiap pertanyaan pada BSTI-Ina tahun 2022 sebesar 0,231 hingga 0,685. Uji reliabilitas menunjukkan nilai α Cronbach untuk setiap pertanyaan pada BSTI-Ina tahun 2006 sebesar 0,613 hingga 0,718 dan untuk seluruh pertanyaan pada BSTI-Ina tahun 2022 sebesar 0,704. Intra-class correlation antara BSTI-Ina tahun 2006 dan 2022 sebesar 0,435.
Kesimpulan: Penelitian ini menunjukkan bahwa BSTI-Ina tahun 2006 dan 2022 valid, reliabel, dan dapat digunakan untuk menentukan tipe kulit populasi dewasa di Indonesia.
Backgorund: The Baumann Skin Type Indicator (BSTI) is an instrument developed in 2006 to determine skin types based on four dichotomous parameters, which are: dry or oily; sensitive or resistant; pigmented or non-pigmented; and tight or wrinkled. This questionnaire has been modified in 2022 to make it more practical and simple to use. The BSTI can assist dermatologists in recommending the most appropriate daily skin care products for patients. Until now, there is no classification for determining skin type in Indonesia. Therefore, valid and reliable tools are needed for determining skin type in the Indonesian population. This study aims to develop an Indonesian version of Baumann Skin Type Indicators (BSTI-Ina).
Methods: The English versions of 2006 and 2022 BSTI questionnaires were translated into Bahasa Indonesia and underwent cross-cultural adaptation. The translated questionnaires were analyzed by a committee consisting of dermato-venereologists and aestheticians, biostatistician, clinical psychologist, and translators. The questionnaires were completed online by 150 Indonesian adult subjects ranging between 18 and 59 years old. The validity of the translated questionnaires was measured by content and construct validity. The reliability was assessed by internal consistency. The correlation between the 2006 and 2022 BSTI-Ina was assessed by intra-class correlation (ICC).
Results: The validity test showed correlation coefficient scores for each question in 2006 BSTI-Ina was -0,037 to 0.751, and for each question in 2022 BSTI-Ina was 0,231 to 0,685. The reliability test showed a Cronbach’s α coefficient for each question in 2006 BSTI-Ina was 0,613 to 0,718 and for question in 2022 BSTI-Ina was 0,704. The ICC between 2006 and 2022 BSTI- Ina was 0.435.
Conclusion: This study demonstrates that both 2006 and 2022 BSTI-Ina are valid, reliable, and suitable for determining the skin type of the Indonesian adult population."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tugas Akhir  Universitas Indonesia Library
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Dini Daniaty
Pengaruh faktor risiko terhadap manifestasi kulit, rambut, dan kuku pasien kanker pada dua siklus kemoterapi berbasis antrasiklin = Risk factors impact on skin, hair, and nail manifestations during dual cycles of Anthracycline-Based chemotherapy in cancer patients
"Latar belakang: Hampir sebagian besar pasien kanker akan memiliki keluhan kulit, rambut, dan kuku (KRK) terkait efek samping kemoterapi yang diberikan. Antrasiklin merupakan kemoterapi yang banyak digunakan pada pasien kanker. Meskipun jarang mengancam nyawa, kelainan KRK dapat menyebabkan penurunan kualitas hidup. Berbagai faktor risiko berpengaruh terhadap kelainan tersebut. Waktu timbulnya manifestasi kelainan KRK pada pasien kanker yang menjalani kemoterapi berbasis antrasiklin juga beragam munculnya. Penelitian ini bertujuan untuk menganalisis hubungan antara usia, penyakit penyerta sistemik, status gizi, ECOG, dan anemia dengan manifestasi klinis KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.
Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan kohort prospektif yang diikuti dalam dua siklus pertama kemoterapi berbasis antrasiklin. Sebesar 65 pasien kanker berusia di atas 18 tahun yang mendapatkan kemoterapi siklus pertama berbasis antrasiklin di RSUPN dr. Cipto Mangunkusumo. Semua SP dilakukan anamnesis, pemeriksaan dermatovenereologikus, dan dokumentasi klinis sampai sebelum kemoterapi siklus ke-3. Pencatatan faktor risiko, jenis, dan waktu timbulnya kelainan dilakukan apabila ditemukan manifestasi KRK.
Hasil: Kelainan kulit terbanyak berupa xerosis dan hiperpigmentasi. Anagen effluvium ditemukan pada 89,2% pasien kemoterapi. Melanonikia dan xanthonikia ditemukan pada 87,7% pasien. Xerosis ditemukan dengan median (minimum-maximum) 7 (2-56) hari, anagen effluvium timbul dalam median (minimum-maximum) 13(1-27 hari), dan melanonikia dengan median (minimum-maximum) 23(1-65) hari. Tidak terdapat hubungan antara usia, penyakit penyerta sistemik, status gizi, status performa ECOG, dan anemia dengan manifestasi KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.
Kesimpulan: Semua pasien memiliki kelainan KRK. Kelainan yang paling cepat timbul adalah xerosis, diikuti anagen effluvium, dan melanonikia. Tidak ditemukan hubungan antara usia, penyakit penyerta sistemik, status gizi, status performa ECOG, dan anemia dengan manifestasi KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.
Background: Nearly most cancer patients experience skin, hair, and nail complaints due to chemotherapy side effects. Anthracycline-based chemotherapy is widely utilized in cancer care. While rarely life-threatening, cutaneous, hair, and nail alterations can significantly impact quality of life. Several risk factors influence these disorders. The onset timing of skin, hair, and nail manifestations varies among cancer patients undergoing anthracycline-based chemotherapy. This study analyses the association between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with clinical manifestations of skin, hair, and nails in cancer patients undergoing two cycles of anthracycline-based chemotherapy.
Methods: This is an analytical descriptive study involving a prospective cohort followed during the first two cycles of anthracycline-based chemotherapy. A total of 65 cancer patients aged above 18, receiving the first cycle of anthracycline-based chemotherapy at RSUPN dr. Ciptomangunkusumo, were enrolled. All subjects underwent anamnesis, dermatovenereological examination, and clinical documentation before the third chemotherapy cycle. Risk factors, type, and onset time of abnormalities were recorded upon detection of skin, hair, and nail manifestations.
Results: All patients presented with skin, hair, or nail abnormalities. The most rapidly occurring abnormalities were xerosis, followed by anagen effluvium and melanonychia. No correlation was found between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with skin, hair, and nail manifestations in cancer patients undergoing two cycles of anthracycline-based chemotherapy. Conclusions: The most frequent skin abnormalities observed were xerosis and hyperpigmentation. Anagen effluvium was detected in 89.2% of chemotherapy patients. Melanonychia and xanthonychia were found in 87.7% of patients. Xerosis had a median (min-max) onset of 7 (2-56) days, anagen effluvium manifested within a median (min- max) of 13 (1-27) days, and melanonychia with a median (min-max) onset of 23 (1-65) days. There was no association found between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with skin, hair, and nail manifestations in cancer patients undergoing two cycles of anthracycline-based chemotherapy."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tugas Akhir  Universitas Indonesia Library
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Herni
Sensitivitas dan spesifisitas alur pemeriksaan duh tubuh vagina dengan menggunakan spekulum oleh dokter puskesmas di Kota Pontianak konfirmasi dengan pemeriksaan laboratorium = Sensitivity and specificity vaginal discharge examination algorithm using speculum by doctors in primary health care in Pontianak confirmed by laboratory examination
"[ABSTRAK
Duh tubuh vagina adalah cairan yang keluar dari alat genital perempuan yang tidak berupa darah. World Health Organization (2007) merekomendasikan dalam menegakkan diagnosis duh tubuh vagina dengan menggunakan alur pemeriksaan dengan spekulum. Kementerian Kesehatan Republik Indonesia telah merekomendasikan alur tersebut untuk seluruh puskesmas di Indonesia. Penelitian ini bertujuan untuk mengetahui nilai sensitivitas dan spesifisitas alur pemeriksaan duh tubuh vagina dengan spekulum oleh dokter puskesmas di Kota Pontianak yang dikonfirmasi dengan pemeriksaan laboratorium. Uji diagnostik sensitivitas dan spesifisitas dilakukan terhadap 52 subyek penelitian. Hasil penelitian menunjukkan nilai sensitivitas dan spesifisitas diagnosis vaginitis menggunakan spekulum sebesar 57,1% dan 52%, sedangkan sensitivitas dan spesifisitas untuk diagnosis servisitis sebesar 75% dan 57,7%. Hal tersebut menunjukkan nilai sensitivitas dan spesifisitas yang rendah (≤85%), menunjukkan bahwa pemeriksaan menggunakan spekulum tidak cukup baik untuk digunakan sebagai dasar dalam menegakkan diagnosis duh tubuh vagina.
ABSTRACT
Vaginal discharge is the discharge from womens genitals which does not consist of blood. World Health Organization in 2007 provide recommendations for diagnosis vaginal discharge in health care one of them by using a speculum. The Ministry of Health of Indonesia has recommended speculum examination of vaginal discharge to all health centers in Indonesia. This research aim was to study the sensitivity and specificity of vaginal discharge examination using a speculum by doctors in primary health care in Pontianak confirmed by laboratory examination. Sensitivity and specificity of diagnostic testing were conducted on 52 research subjects. The result of the study showed the sensitivity and specificity for the diagnosis of vaginitis using a speculum were 57.1% and 52%, whereas the sensitivity and specificity for the diagnosis of cervicitis were 75% and 57.7%. Low sensitivity and specificity values (≤85%), indicating that the use of a speculum examination is not good enough to be used as a basis in the diagnosis of vaginal discharge., Vaginal discharge is the discharge from womens genitals which does not consist of blood. World Health Organization in 2007 provide recommendations for diagnosis vaginal discharge in health care one of them by using a speculum. The Ministry of Health of Indonesia has recommended speculum examination of vaginal discharge to all health centers in Indonesia. This research aim was to study the sensitivity and specificity of vaginal discharge examination using a speculum by doctors in primary health care in Pontianak confirmed by laboratory examination. Sensitivity and specificity of diagnostic testing were conducted on 52 research subjects. The result of the study showed the sensitivity and specificity for the diagnosis of vaginitis using a speculum were 57.1% and 52%, whereas the sensitivity and specificity for the diagnosis of cervicitis were 75% and 57.7%. Low sensitivity and specificity values (≤85%), indicating that the use of a speculum examination is not good enough to be used as a basis in the diagnosis of vaginal discharge.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Zunarsih
Perbandingan proporsi kejadian reaksi eritema nodosum leprosum pada pasien kusta dengan dan tanpa koinfeksi oral karies, gingivitis, dan periodontitis = Proportion of erythema nodosum leprosum reaction between leprosy patient with and without oral coinfection caries, gingivitis, and periodontitis
"[ABSTRAK
Latar belakang. Koinfeksi oral karies, gingivitis dan periodontitis merupakan salah satu pencetus reaksi eritema nodosum leprosum (ENL).
Tujuan. Untuk mengetahui perbedaan proporsi kejadian ENL pada pasien kusta dengan koinfeksi oral dibandingkan dengan pasien kusta tanpa koinfeksi oral Metoda. Studi potong lintang komparatif. Pasien kusta (n=30) dengan dan tanpa koinfeksi oral dipilih sebagai SP. Dilakukan pemeriksaan secara klinis untuk mengetahui angka kejadian reaksi ENL pada masing-masing kelompok.
Hasil. Reaksi ENL lebih banyak terjadi pada kelompok koinfeksi oral sebesar (66,7%) dibandingkan dengan kelompok tanpa koinfeksi oral sebesar (33,3%) meskipun secara statistik tidak bermakna didapatkan p=0.068 (95% IK 0,9-4,45). Pada analisis lebih lanjut didapatkan perbedaan proporsi kejadian reaksi ENL pada SP dengan karies dibandingkan dengan SP tanpa karies dengan p=0,028 (95% IK 1,028-5,080).
Kesimpulan. Dalam tatalaksana reaksi ENL semua faktor pencetus diantaranya koinfeksi oral terutama karies harus dihilangkan.
ABSTRACT
Background. Oral coinfection such as caries, gingivitis and periodontitis is one of Erythema Nodosum Leprosum (ENL) reaction trigger factors.
Aim. To find the difference in proportion of ENL reaction between leprosy patient with and without oral coinfections.
Method. Cross sectional comparative study. Leprosy patients (n=30) with and without oral coinfection were selected. Proportion of ENL reactions among the two groups was compared.
Result. ENL reaction is more frequent in group with oral coinfection (66.7%) than in group without oral coinfection (33.3%) even though it was statistically insignificant p=0.068 (95% CI 0.9-4.45). Furher analysis discovered statistically significant difference in proportion of ENL reaction in leprosy patient with caries compared to non caries with p=0.028 (95% CI 1.028-5.080).
Conclusion. It is important to eliminate all trigger factors of ENL reaction such as oral coinfection especially caries.;Background. Oral coinfection such as caries, gingivitis and periodontitis is one of Erythema Nodosum Leprosum (ENL) reaction trigger factors.
Aim. To find the difference in proportion of ENL reaction between leprosy patient with and without oral coinfections.
Method. Cross sectional comparative study. Leprosy patients (n=30) with and without oral coinfection were selected. Proportion of ENL reactions among the two groups was compared.
Result. ENL reaction is more frequent in group with oral coinfection (66.7%) than in group without oral coinfection (33.3%) even though it was statistically insignificant p=0.068 (95% CI 0.9-4.45). Furher analysis discovered statistically significant difference in proportion of ENL reaction in leprosy patient with caries compared to non caries with p=0.028 (95% CI 1.028-5.080).
Conclusion. It is important to eliminate all trigger factors of ENL reaction such as oral coinfection especially caries., Background. Oral coinfection such as caries, gingivitis and periodontitis is one of Erythema Nodosum Leprosum (ENL) reaction trigger factors.
Aim. To find the difference in proportion of ENL reaction between leprosy patient with and without oral coinfections.
Method. Cross sectional comparative study. Leprosy patients (n=30) with and without oral coinfection were selected. Proportion of ENL reactions among the two groups was compared.
Result. ENL reaction is more frequent in group with oral coinfection (66.7%) than in group without oral coinfection (33.3%) even though it was statistically insignificant p=0.068 (95% CI 0.9-4.45). Furher analysis discovered statistically significant difference in proportion of ENL reaction in leprosy patient with caries compared to non caries with p=0.028 (95% CI 1.028-5.080).
Conclusion. It is important to eliminate all trigger factors of ENL reaction such as oral coinfection especially caries.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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Anesia Tania
Sebaran obat penyebab dan polimorfisme gen hla-b pada erupsi obat alergik tipe sindrom stevens-johnson dan nekrolisis epidermal toksik : studi pada lima rumah sakit di Jakarta = Causative drugs and hla-b polymorphism in drug induced stevens johnson syndrome and toxic epidermal necrolysis cutaneous : a study in five hospital in Jakarta
"ABSTRAK
Latar belakang: Erupsi obat alergik EOA tipe sindrom Stevens-Johnson dan nekrolisis epidermal toksik SSJ/NET adalah EOA berat yang jarang terjadi namun dapat mengancam nyawa. Tata laksana utama EOA tipe SSJ/NET saat ini adalah menghentikan pajanan obat penyebab. Di beberapa negara Asia, polimorfisme gen HLA-B telah digunakan sebagai metode skrining pada pemberian obat berisiko tinggi. Tujuan: Mengetahui sebaran obat penyebab dan polimorfisme gen HLA-B pada pasien EOA tipe SSJ/NET di Jakarta. Metode: Studi potong lintang ini dilakukan pada bulan April ndash; Juni 2017 di RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, dan RSUD Tarakan. Pemilihan sampel dilakukan secara total sampling pada pasien EOA tipe SSJ/NET di 5 RS tersebut selama 2 tahun. Dilakukan anamnesis dan penentuan obat dengan algoritma ALDEN dan pemeriksaan typing gen HLA-B dengan metode PCR ndash;SSOP. Hasil: Didapatkan 22 subjek dengan median usia 45,5 tahun dan sebagian besar perempuan. Obat penyebab tersering yang ditemukan adalah karbamazepin. Pada subjek, alel HLA-B yang tersering adalah HLA-B 15:02 dan HLA-B 18:01. Alel HLA-B 15:02 ditemukan pada lima 72 dari tujuh SP dengan obat penyebab karbamazepin. Simpulan: Obat penyebab EOA tipe SSJ/NET yang paling sering ditemukan pada SP adalah karbamazepin, dengan 5 dari 7 SP memiliki gen HLA-B 15:02.
ABSTRACT
Background Stevens Johnson syndrome and toxic epidermal necrolysis is a very rare but life threatening type of cutaneous drug eruption. The principle management of SJS TEN is withdrawal of causative drug and preventing reexposure to said drug. In other countries in Asia, spesific HLA B allele has already been utilized as a screening method to prevent SJS TEN. Objective to acquire data regarding causative drugs and HLA B allele polymorphism in SJS TEN patient in Jakarta. Method This cross sectional study was performed in RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, and RSUD Tarakan from April to June 2017. The sampling method is total sampling of all patient in all five hospital from March 2015 to March 2017. Subject fulfilling the inclusion and exclusion criteria was interviewed and their blood sample was taken for DNA extraction. The DNA was examined with PCR SSOP and Luminex technology for high resolution HLA B typing. Results We studied 22 subjects. The median age was 45,4 years old 14 74 and female gender predominate. The most common causative drug in this study is carbamazepine. HLA B 15 02 and HLA B 18 01 were the most common allele in all subjects. HLA B 15 02 was found in five 72 out of seven subjects whose condition was caused by carbamazepine. Conclusion The most common causative drug of SJS TEN in five hospitals in Jakarta is carbamazepine, with five 72 out seven subjects had HLA B 15 02 allele. "
2017
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Izzah Aulia
Hubungan Kadar Kalsidiol Serum Pasien Keratosis Seboroik di Daerah Pesisir dengan Sun Index dan Asupan Vitamin D = Association of Serum Calcidiol of Seborrheic Keratoses Patient in The Coastal Area with Sun Index and Vitamin D Intake
"Keratosis Seboroik (KS) merupakan salah satu tumor jinak epidermis dengan faktor risiko utama pajanan matahari yang berlebihan. Selain pajanan matahari, defisiensi vitamin D diduga berperan pada patogenesis KS. Defisiensi vitamin D dapat disebabkan pajanan matahari yang kurang maupun kurangnya asupan vitamin D. Daerah pesisir memiliki karakteristik pajanan matahari yang tinggi. Oleh karena itu, diperlukan penelitian yang menilai hubungan kadar vitamin D (kalsidiol serum) pasien KS di daerah pesisir dengan pajanan matahari (sun index) dan asupan vitamin D. Penelitian ini bersifat deskriptif-analitik dengan desain potong lintang. Dilakukan wawancara dengan menggunakan kuesioner sun index, food frequency questionnaire semikuantitatif vitamin D, pemeriksaan fisis dan dermoskopi untuk menilai ukuran terbesar lesi KS, serta pengukuran kadar kalsidiol serum pada 39 individu usia 19-59 tahun di Kecamatan Cilincing, Jakarta Utara. Median ukuran lesi KS adalah 2 mm; median nilai sun index adalah 3,95; median kadar kalsidiol serum sebesar 14,3 ng/ml, dan median asupan vitamin D adalah 4,3 mcg/hari. Tidak ditemukan korelasi yang bermakna antara sun index dan kadar kalsidiol dengan ukuran lesi KS, serta sun index dan asupan vitamin D dengan kadar kalsidiol pada masyarakat pesisir tersebut.
Seborrheic keratosis (SK) is a benign epidermal tumor with high sun exposure as a major risk factor. In addition, vitamin D deficiency is thought to play a role in the pathogenesis of SK. Vitamin D deficiency can be caused by insufficient sun exposure or a lack of vitamin D intake. Coastal areas are characterized by high sun exposure. Therefore, research assessing the relationship of vitamin D levels of SK patients living in a coastal area with sun exposure and vitamin D intake needs to be done. This is an analytic-descriptive cross-sectional study. We performed interview using sun index questionnaire; semi quantitative food frequency questionnaire for vitamin D; physical examination and dermoscopy to determine the largest diameter of SK lesions; and measurement of serum calcidiol levels in 39 individuals with 19-59 years age living in Cilincing District, North Jakarta. The Spearman correlation test was used to assess the relationship between variables. Median of the largest SK lesions size, sun index, serum calcidiol, and vitamin D intake were 2 mm, 3.95, 14.3 ng/ml, and 4.3 mcg/day, respectively. There were no significant correlations between sun index and calcidiol level with SK lesion size, as well as sun index and vitamin D intake with calcidiol level in this coastal population."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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Rika Anggraini
Efektivitas dan Keamanan Krim 5-Fluorourasil 1 % dan Krim 5-Fluorourasil 5% dibandingkan dengan Larutan Asam Trikloroasetat 90 % untuk Terapi Kutil Anogenital: Uji Klinis Acak Terkontrol = The Effectivity and Safety of 5-Fluorouracil 1 % Cream and 5-Fluorouracil 5 % Cream compared to Trichloroacetic Acid 90% Solution for Anogenital Wart Treatment: Randomized Control Trial
"Latar belakang : Insidens kutil anogenital KA terus mengalami peningkatan. Hingga saat ini belum ada terapi yang efektif untuk semua jenis KA. Terdapat berbagai macam pilihan terapi KA, antara lain terapi yang dapat diaplikasikan sendiri, contohnya krim 5-fluorourasil 5-FU 1 dan 5-FU 5 dan terapi yang diaplikasikan oleh dokter, contohnya larutan asam trikloroasetat TCA 90 . Larutan TCA 90 merupakan terapi standar KA, memerlukan kurang lebih 4-6 kali kunjungan tiap minggu untuk mencapai kesembuhan. Hingga saat ini terapi KA yang dapat diaplikasikan sendiri oleh pasien sendiri, belum tersedia di Indonesia. Tujuan : Mengetahui efektivitas dan keamanan krim 5-FU 1 dan krim 5-FU 5 dibandingkan dengan larutan TCA 90 untuk terapi KA pada genitalia eksterna dan atau perianus. Metode : Uji klinis acak terkontrol dilakukan terhadap pasien KA pada bulan Januari hingga Mei 2018. Pasien yang memenuhi kriteria penerimaan dan bersedia mengikuti penelitian akan mendapat terapi 5-FU 1 , 5-FU 5 , atau larutan TCA 90 sesuai dengan randomisasi blok. Pasien dicatat identitas, jumlah, dan ukuran lesi KA kemudian diamati respons terapi dan efek samping subyektif dan obyektif setiap minggu, hingga minggu ketujuh. Dilakukan analisis intention to treat. Hasil : Didapatkan total 72 subjek. Terdapat 5 SP drop out, dua dari kelompok 5-FU 1 dan tiga dari kelompok TCA 90 . Tidak terdapat perbedaan efektivitas antara kelompok 5-FU 1 dengan TCA 90 p=0,763 . Respons sempurna pada 5-FU 1 adalah 671 , sedangkan TCA 90 adalah 63 . Begitupula dengan perbandingan efektivitas antara kelompok 5-FU 5 dengan TCA 90 . Pada awalnya saat minggu kedua TCA 90 tampak lebih cepat memberikan kesembuhan daripada 5-FU 5 p=0,036 , namun setelah enam minggu terapi ternyata tidak ada perbedaan efektivitas antara keduanya p=0,274 . Didapatkan bahwa respons sempurna pada 5-FU 5 adalah 46 dan 63 pada TCA 90 . Terdapat perbedaan efek samping subyektif yang lebih ringan secara bermakna pada kelompok 5-FU 1 dibandingkan dengan kelompok TCA 90 p=0,004 . Terdapat pula perbedaan efek samping subyektif yang lebih ringan secara bermakna pada kelompok 5-FU 5 dibandingkan dengan kelompok TCA 90 p=0,001 . Efek samping gatal ketika evaluasi minggu keempat pada kelompok 5-FU 1 adalah 21 dan 33 pada kelompok 5-FU 5 . Efek samping tersering pada kelompok TCA 90 adalah nyeri 96 ketika aplikasi TCA 90 pertama kali. Terdapat perbedaan efek samping obyektif yang lebih ringan secara bermakna ketika evaluasi minggu kedua, keenam, dan ketujuh pada kelompok 5-FU 1 dibandingkan dengan TCA 90 p
Background: Anogenital wart incidence is increasing lately. Up till now there is no effective therapy for every type of anogenital wart. There are various kind of anogenital wart therapy, such as self applied therapy e.g. 5-fluorouracil 1 cream and 5-fluorouracil 5 cream and physician-applied therapy e.g. trichloroacetic acid 90 solution . Trichloroacetic acid is the standard therapy for anogenital wart, need around 4-6 times until totally improved. Currently, there is no self applied anogenital wart therapy available in Indonesia. Objective: To know the effectivity and safety of 5-fluorouracil 1 cream and 5-fluorouracil 5 cream compared to trichloroacetic acid 90 solution in the treatment of anogenital wart. Methods: A randomized control study of adult patients with anogenital wart during the period of January-Mei 2018. Patients who fulfiled inclusion criteria and willing to follow this research, allocated to receive 5-fluorouracil 1 cream, 5-fluorouracil 5 cream, or trichloroacetic acid 90 solution in accordance with block randomization. The identity, number and size of the anogenital wart were recorded, then the response of therapy and side effect subjective and objective were observed each weeks, up to seventh week. The data was analyzed with intention to treat analysis. Result: A total of 72 subjects were enrolled, two subjects from 5-FU 1 and three subjects from TCA 90 dropped out. There was no diference in the effectivity between 5-FU 1 group compared to TCA 90 p=0,763 . Total response in 5-FU 1 was 67 and 63 in TCA 90 . Likewise the comparison of effectivity between 5-FU 1 group and TCA 90 group. On the second week TCA 90 gave faster improvement than 5-FU 5 p=0,036 , but after 6 weeks treatment there was no difference between both groups p=0,274 . Total response in 5-FU 5 was 46 and 63 in TCA 90 . There was significant milder subjective side effect on 5-FU 1 compared to TCA 90 group p=0,004 , as well as significant milder subjective side effect on 5-FU 5 compared to TCA 90 p=0,001 . On the fourth week there was 21 in the 5-FU 1 group felt itchy and 33 in TCA 90 group. The most common side effect in TCA 90 group was painful, 96 of the subjects experienced it while their first TCA application. We also found significant milder objective side effect in 5-FU 1 group on the second week, sixth week, and seventh week evaluation compared to TCA 90 group p"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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