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"ABSTRACTIt had been done a study on the assay and potency of three samples of Tetracycline Hydrochloride visually having different colours. The study on the assay of the three samples of Tetracycline Hydrocloride was done by using pectrophotometric method in alkaline media, while the study on their potency was done by using turbidimetric method with latin square pattern. The result obtained are as follows: - The change in colour that is significant in samples of Tetra cycline Hydrochloride examined, does not affect their contents or potency. - The spectrophotometric method has precision difference in-. significantly compared with turbidimetric one. With respect to the above results it is still necessary to look for the correlation between the amount of the content of anhydrotetracycline and its effect on spectrophotometric and turbidimetric method."

"Telah dilakukan penelitian penetapan kadar deksametason dalam sediaan tablet campuran dengan CTM secara spektrofotometri dengan pereaksi INH dan secara spektrofotodensitometri.Pada penetapan kadar deksametason secara spektrofotometridengan pereaksi INH, terjadi reaksi antara deksametason denganINH menghasilkan senyawa hidrazon yang berwarna kuning senyawainilah yang diukur secara spektrof otometri., Sedangkan padaspek.trofotodensitometri deksametason pada lempeng KLT pada daerahpanjang gelombang ultra violet memberikan fluoresensi, hasilfluoresensi inilah yang diukur secara spektrofotodensitometri.Hasil penelitian menunjukkan bahwa kedua metode penetapan kadar deksametason tersebutmemberikan hasil yang cukup baik dan reprodusibel dan tidak- memberikan perbedaan yang bermakna secara statistik.

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A study on quantitative assay of dexamethasone in tablet

mixed with CTM spectrbfotometrically with INK as reagent and

with spectrofotodensitometry had been done.

On quantitative assay of dexamethasone spectrofotometrically with INH as reagent, there occurs a reaction between dexamethasone with INH producing hydrazone, yellow in color,

this compound is measured spectrofotometrically. While on

spectrofotodensitometry dexamethasone on. TLC sheet at ultra

violet region gives fluorescence, this fluorescence is mea

sured spectrofotodensitometry..

The result of the study, showed that the two method of

quantitative assay of dexamethasone, gave quite good result

and reproducible and did not give difference significantlystatistically."