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"ABSTRAKPenelitian ini bertujuan untuk mengetahui akurasi parameter pola gambaran ultrasonografi dan kadar CA 125 untuk membedakan endometrioma dengan kistadenoma musinosum yang merupakan penelitian uji diagnostik dengan desain penelitian cross-sectional yang dilakukan di Rumah Sakit Cipto Mangunkusumo dengan mengambil data retrospektif dari Januari 2015 hingga Desember 2017. Pasien poliklinik rawat jalan ginekologi dengan kecurigaan memiliki neoplasma ovarium kistik direkrut. Sebagai Gold standar adalah temuan histologi dari massa adneksa yang dioperasi. Pola gambaran ultrasonografi dan kadar CA 125 akan disusun menjadi model untuk mendiagnosis endometrioma, kistadenoma musinosum, tumor jinak lain, dan tumor ganas/ borderline. Analisis statistik dari prediksi model untuk mebedakan endometrioma dengan kistadenoma musinosum dihitung berdasarkan cross tabulation sehingga didapatkan nilai akurasi, sensitivitas, spesifisitas, nilai prediksi positif dan nilai prediksi negatif. Penelitian ini melibatkan 200 pasien, sebanyak 83 kasus (41,5%) adalah endometrioma, 50 kasus (25%) adalah kistadenoma musinosum, 35 kasus (17,5%) adalah tumor jinak lain, 32 kasus (16%) adalah tumor ganas/ borderline. Karakteristik endometrioma adalah median CA 125 158,25 IU/mL, dinding tipis (72,29%), unilokuler (78,31%), bilateral ( 56,60%), ekogenisitas ground glass (66,27%), adanya perlengketan (68,7%), tanpa komponen padat (80,7%), sementara itu karakteristik kistadenona musinosum adalah median CA 125 52,85 IU/mL, dinding tipis (58 %), multilokuler (76%), unilateral (98%), ekogenisitas campuran (52%), tanpa perlengketan (84%), dan tanpa komponen padat (66%). Akurasi dari model regresi multinomial untuk membedakan endometrioma dengan kistadenoma musinosum yaitu 86%, dengan nilai sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif masing-masing 87%, 84%, 92%, dan 77%. Model ini akurat  secara statistik (p <0,05). Sebagai kesimpulan didapatkan parameter pola gambaran ultrasonografi dikombinasikan dengan kadar CA 125 memiliki kemampuan yang baik untuk membedakan endometrioma dengan kistadenoma musinosum.

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ABSTRACTThis study was aimed to assess the accuracy a set of parameter which are based on ultrasonography features and CA 125 level to discriminate endometrioma and mucinous cystadenoma. This was [i-[1] a diagnostic test research with cross-sectional study design conducted at Cipto Mangunkusumo Hospital with retrospective data from January 2015 through December 2017. Gynecological outpatients clinics with suspicion of having ovarian cyst neoplasms based on patient history, clinical examination and ultrasonography were recruited. The gold standard is the histological findings of discarded adnexal masses. We conducted models based on multinomial regression analysis using gray-scale ultrasound characteristics and CA 125 level variables to diagnose endometrioma, mucinous cystadenoma, other benign tumor, malignant/ borderline tumor. Statistical analysis were calculated using cross-tabulation, to get accuracy, sensitivity, specificity, positive predictive value, and negative predictive value to differentiate endometrioma and mucinous cystadenoma. This study involved 200 patients, as many as 83 cases (41.5%) were endometriomas, 50 cases (25%) were mucinous cystadenoma, 35 cases (17,5%) were other benign tumor, and 32 cases were (16%) malignant/ borderline tumor. The characteristic endometrioma patients were median CA 125 level 158,25 IU/mL, thin wall (72,29%), unilocular cysts (78,31%), bilateral ( 56,60%), ground glass echogenicity (66,27%), adhesion (68,7%), without solid component (80,7%), while the ovarian mucinous cystadenomas were median CA 125 52,85 IU/mL, thin wall (58 %), multilocular (76%), unilateral (98%), variable echogenicity (52%), without adhesion (84%), and without solid component (66%). The multinomial logistic models can discriminate endometrioma and mucinous cystadenoma with accuracy 86%, and sensitivity, specificity, positive predictive value, negative predictive value of 87%, 84%,  92%, and 77%, respectively. The models were significantly accurate (p<0,05). Inconclusion, a multinomial logistic model derived from ultrasonography features and CA 125 level can accurately to discriminate endometriomas and mucinous cystadenoma [i-[1]"

"Penelitian ini membahas perbandingan performa diagnostik sistem skoring International Ovarian Tumor Analysis (IOTA) dengan Risk of Malignancy Index-4 (RMI-4) dan indeks morfologi Sassone dalam memprediksi keganasan ovarium prabedah. Dilakukan uji diagnostik potong-lintang secara retrospektif dengan pasien neoplasma ovarium di RSUPN Dr. Cipto Mangunkusumo dari Januari hingga Desember 2013. Nilai diagnostik dari keempat metode skoring dihitung dengan luaran: sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, akurasi dan nilai AUC. Penelitian ini menyimpulkan IOTA simple-rules memiliki performa diagnostik lebih baik dibandingkan IOTA subgroup, RMI-4 dan indeks morfologi Sassone.

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This study compared diagnostic performance of scoring system of International Ovarian Tumor Analysis (IOTA) with Risk of Malignancy Index-4 (RMI-4) and Sassone morphology index to predict ovarian malignancy preoperatively. A retrospective study was done involving subject with ovarian neoplasm at National General Hospital Dr. Cipto Mangunkusumo on January to December 2013. Sensitivity, specificity, positive predictive value, negative predictive value, accuracy and AUC value were calculated. This study concluded that diagnostic performance of IOTA simple-rules were significantly better than IOTA subgroup, RMI-4 and Sassone morphology index."

"[ABSTRAKTujuan. Penelitian ini membahas perbandingan performa diagnostik antara pemeriksaan ultrasonografi dengan pemeriksaan klinis dalam mengukur ukuran lesi primer kanker serviks.Metode. Dilakukan uji diagnostik potong-lintang secara retrospektif terhadap pasien kanker serviks stadium IB di RSUPN Dr. Ciptomangunkusumo dari tahun 2009 hingga tahun 2014. Nilai diagnostik dari kedua pemeriksaan dihitung dengan luaran: sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi. Uji kesesuaian dari kedua pemeriksaan juga dihitung dengan ukuran makroskopik sebagai standar baku emas.Hasil. Dari periode tahun 2009 hingga tahun 2014, didapatkan 92 subjek yang memenuhi kriteria inklusi dengan komposisi yaitu 65 kasus (70%) kanker serviks stadium IB1 dan 27 kasus (30%) kanker serviks stadium IB2. Ultrasonografi didapatkan memiliki nilai diagnostik yaitu sensitivitas 92%, spesifisitas 96%, nilai prediksi positif 92%, nilai prediksi negatif 96%, dan akurasi 95%. Sementara itu, pemeriksaan klinis didapatkan memiliki nilai diagnostik yaitu sensitivitas 51%, spesifisitas 92%, nilai prediksi positif 73%, nilai prediksi negatif 82%, dan akurasi 80%. Dari perhitungan kesesuaian antara ukuran pemeriksaan ultrasonografi dan ukuran makroskopik, didapatkan perbedaan rata-rata 0,56 cm. Sementara itu, dari perhitungan kesesuaian antara ukuran pemeriksaan klinis dan ukuran makroskopik, didapatkan perbedaan rata-rata 0,97 cm.Kesimpulan. Penelitian ini menyimpulkan bahwa pemeriksaan ultrasonografi memiliki performa diagnostik yang lebih baik dibandingkan pemeriksaan klinis dalam mengukur ukuran lesi primer kanker serviks.

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ABSTRACTObjective. The purpose of this study is to compare the diagnostic value of ultrasound and clinical examination in measuring the size of primary tumor of cervical cancer.Methods. It is a retrospective cross sectional study for patients with cervical cancer stage IB in Cipto Mangunkusumo hospital from 2009 to 2014. Diagnostic value of both examinations were calculated with outcome: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Resemblance test of both examinations were also calculated with macroscopic size as the gold standart.Result. From period 2009 until 2014, there were 92 subject which fulfilled the inclusion criteria, consisted of 65 cases (70%) cervical cancer stage IB1 and 27 cases (30%) cervical cancer stage IB2. Ultrasonografi was found to have diagnostic values as follow: sensitivity 92%, specificity 96%, positive predictive value 92%, negative predictive value 96%, and accuracy 95%. Meanwhile, clinical examination was found to have diagnostic values as follow: sensitivity 51%, specificity 92%, positive predictive value 73%, negative predictive value 82%, and accuracy 80%. From the calculation of resemblance between ultrasound and macroscopic size, there was an average difference approximately 0.56 cm. Meanwhile, from the calculation of resemblance between clinical examination and macroscopic size, there was an average difference approximately 0.97 cm.Conclusion. It can be concluded that the ultrasound has better diagnostic value compare to clinical examaination in examining the size of primary tumor of cervical cancer., Objective. The purpose of this study is to compare the diagnostic value of ultrasound and clinical examination in measuring the size of primary tumor of cervical cancer. Methods. It is a retrospective cross sectional study for patients with cervical cancerstage IB in Cipto Mangunkusumo hospital from 2009 to 2014. Diagnostic value of bothexaminations were calculated with outcome: sensitivity, specificity, positive predictive value,negative predictive value, and accuracy. Resemblance test of both examinations were alsocalculated with macroscopic size as the gold standart. Result. From period 2009 until 2014, there were 92 subject which fulfilled the inclusioncriteria, consisted of 65 cases (70%) cervical cancer stage IB1 and 27 cases (30%) cervicalcancer stage IB2. Ultrasonografi was found to have diagnostic values as follow: sensitivity92%, specificity 96%, positive predictive value 92%, negative predictive value 96%, andaccuracy 95%. Meanwhile, clinical examination was found to have diagnostic values as follow:sensitivity 51%, specificity 92%, positive predictive value 73%, negative predictive value 82%,and accuracy 80%. From the calculation of resemblance between ultrasound and macroscopicsize, there was an average difference approximately 0.56 cm. Meanwhile, from the calculationof resemblance between clinical examination and macroscopic size, there was an averagedifference approximately 0.97 cm. Conclusion. It can be concluded that the ultrasound has better diagnostic value compare to clinical examaination in examining the size of primary tumor of cervical cancer.]"