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Tesis ini bertujuan untuk menganalisis hasil studi-studi terdahulu mengenai keberhasilan tatalaksana implan gigi pada pasien dengan konsumsi bisfosfonat, baik berdasarkan cara pemberian bisfosfonat, maupun pengaruh waktu pemberian bisfosfonat terhadap keberhasilan tatalaksana implan gigi. Penelitian ini merupakan sebuah systematic review dengan desain deskriptif. Hasil penelitian ini menunjukkan bahwa keberhasilan implan pada pasien dengan konsumsi bisfosfonat cukup tinggi, baik berdasarkan cara pemberian maupun waktu pemasangan implan gigi terhadap waktu pemberian bisfosfonat; tidak semua pasien yang mengkonsumsi bisfosfonat akan mengalami osteonecrosis of the jaw.

 

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This study aims to analyze the results of previous studies on the successful management of dental implants in patients with bisphosphonate consumption, both based on the way bisphosphonates are administered, as well as the effect of the time of bisphosphonate administration on the successful management of dental implants. This study is a systematic review with a descriptive design. The results of this study indicate that the success of implants in patients with bisphosphonate consumption is quite high, both based on the way they are administered and when the dental implants are placed against the time of bisphosphonate administration; not all patients taking bisphosphonates will experience osteonecrosis of the jaw.

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"During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates."