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"This study was carried out to investigate the effect of 4NQO oral induction in oesophagus of male rat. Sixteen male Sprague Dawley rats were divided into three experimental groups and one untreated group as control. The experimental groups were applied with 0.5% 4-nitroquinoline 1-oxide on the dorsal mucosa of tongue thrice weekly for 8, 16 or 24 weeks, one brush stroke per application. At the end of the 36th week, all rats were sacrificed and the tongue and oesophagus were excised and fixed in 10% buffed formalin for 24 hours. The H&E sections were prepared for histological examination. The microscopial assessment showed that all rat tongues whether applied with 4NQO for 8, 16 or 24 weeks were identified having Squamous Cell Carcinoma (SCC). Microscopial examination of oesophagus indicated that 75% or the rats applied with 4NQO for 16 weeks showed hyperkeratosis, and 80% and 20% of the rats applied with 4NQO for 24 weeks showed malignancy changes and hyperkeratosis, respectively. No histological changes were detected either in the tongue or the oesophagus of the control rats. It was concluded that the effect of carcinogenic induction in oral mucosa caused malignant changes in oesophagus."

"Analisis Praktik Residensi Keperawatan Medikal Bedah dan Studi Kasus Pemberian Asuhan Keperawatan Pada Pasien Akalasia Esofagus Dengan Pendekatan Model Adaptasi Roy Di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo Jakarta Abstrak Pendahuluan: Pelaksanaan praktek klinik selama masa residensi keperawatan peminatan digestif bertujuan untuk mampu menampilkan peran perawat spesialis sebagai pemberi asuhan keperawatan lanjut, pendidik, advokat, konselor, kolaborator, pembaharu dan peneliti. Peran pemberi asuhan keperawatan lanjut dilakukan dengan menggunakan Model Adaptasi Roy pada pasien Akalasia Esofagus dan 30 pasien lainnya. Perilaku maladaptif paling banyak adalah mode adaptasi fisiologis dengan diagnosa keperawatan ketidakseimbangan nutrisi kurang dari kebutuhan tubuh. Intervensi keperawatan berupa manajemen nutrisi ditujukan untuk meningkatkan adaptasi pasien dalam mencapai status nutrisi. Evidence Based Nursing dilakukan dengan menerapkan pemberian minuman maltodekstrin pada pasien pra operasi elektif pada dua pasien untuk mengatasi mual, muntah dan nyeri pasca operasi, diperoleh hasil keluhan mual dan muntah tidak ada sama sekali pada 0-24 jam pasca operasi, sedangkan keluhan nyeri ringan masih dirasakan pada satu pasien. Program inovasi kelompok berupa penerapan protokol ERAS yaitu pemberian maltodekstrin pra operasi, mengunyah permen karet pasca operasi dan mobilisasi dini 2 jam pasca operasi terbukti efektif mengatasi keluhan mual dan muntah pasca operasi, meningkatkan motilitas usus dan mencegah nyeri bahu pasca operasi.

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Analysis of Medical Surgical Nursing Residency Practice and Case Study of Nursing Care Delivery on Achalasia Oesophagoes Using Roy Adaptation Model ApproachAbstractImplementation of clinical practice during the residency of digestive nursing aims to be able to showcase the role of specialist nurse as advanced nursing care provider, educator, advocator, counselor, collaborator, innovator and researcher. Role of specialist as advance nursing care provider was done by using Roy Adaptation Model on Achalasia Oesophagus and 30 other patients. Maladaptive behavior at most is a physiological adaptation mode with imbalanced nutrition: less than body requirement nursing diagnosis. Nursing outcome of nutrition management is aimed at improving patient adaptation in gaining nutrition status. Evidence Based Nursing was performed by applying preoperative oral carbohydrate loading to two patients undergoing laparoscopy cholesystectomy for relieving post operative nausea and vomiting. The innovation program was implementing ERAS protocol e.g preoperative oral carbohydrate loading, chewing gum and early mobilization proved effective as nursing intervention in pre and post operative management. "