Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 2 dokumen yang sesuai dengan query
cover
Yudo Irawan
"ABSTRAK
Latar belakang: Frambusia atau yaws merupakan penyakit akibat infeksi Treponema pallidum subspecies pertenue yang menahun dan terutama mengenai kulit serta tulang. Penegakkan diagnosis berdasarkan klinis dan serologis. Program temuan kasus frambusia didasarkan atas temuan klinis menurut World Health Organization WHO , kemungkinan terdapat frambusia tanpa lesi klinis yang tidak terdiagnosis masih belum dapat disingkirkan. Belum ada penelitian proporsi di suatu desa yang dinyatakan endemis. Tujuan: Mengetahui proporsi kasus frambusia berdasarkan kriteria klinis WHO dan pemeriksaan serologis di desa Sei Berombang pada anak usia 1-12 tahun periode 22-27 Agustus 2016. Metode: Studi potong lintang ini dilakukan pada tanggal 22-27 Agustus 2016 di desa Sei Berombang, Sumatera Utara. Pemilihan sampel dilakukan secara consecutive sampling. Subjek kemudian dilakukan anamnesis, pemeriksaan fisis, dan pemeriksaan rapid diagnostic test RDT . Hasil : Didapatkan total 129 subjek dengan median usia 9 tahun termuda 1 tahun dan tertua 12 tahun . Sebanyak 14 anak dengan lesi klinis suspek frambusia, sedangkan 4 anak dengan RDT yang positif. Hanya 3 anak dari RDT yang positif memiliki temuan klinis. Lesi klinis suspek frambusia yang paling banyak ditemukan adalah makula hipopigmentasi dan skar atrofik, sedangkan lokasi tersering adalah tungkai bawah. Simpulan: Ditemukan proporsi suspek frambusia berdasarkan klinis adalah 10,85 , sedangkan proporsi frambusia konfirmasi berdasarkan klinis dan serologis adalah 2,33 . Dua subjek didiagnosis frambusia laten, sedangkan satu subjek didiagnosis sebagai frambusia primer. Kata kunci: frambusia, proporsi, anak

ABSTRACT
Background Yaws is a chronic infectious disease caused by Treponema pallidum subspecies pertenue, mainly affecting skin and bone. Diagnosis of yaws is based on clinical manifestation and serologic test. According to WHO, yaws detection program is focused on clinical manifestation. Thus, it is possible that latent yaws without any clinical manifestation is still under diagnosed. Until recently, there is no proportion study performed in remote endemic village.Objective To determine the proportion of yaws based on WHO clinical criteria and serologic test in children age 1 12 years old in Sei Berombang village.Methods This cross sectional study was conducted on 22nd 27th August 2016 in Sei Berombang village, North Sumatra. We recruited the subjects consecutively and performed anamnesis, clinical examination, and rapid diagnostic test RDT .Results A total of 129 subjects were examined with median age of 9 years old 1 12 years old . Yaws was suspected in 14 subjects, but only 4 subjects were reactive to RDT. Three subjects had clinical manifestation and RDT reactive. Hypopigmentation patch and atrophic scar were the most common clinical findings in this study. Most lesions were found in lower extremities. Conclusion Proportion of suspected yaws based on clinical manifestation is 10,85 in this study. Proportion of confirmed yaws based on clinical manifestation and serology is 2,33 . Two subjects diagnosed with latent yaws and one subject was diagnosed with primary yaws. "
2017
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Joses Saputra
"Indonesia saat ini merupakan penyumbang terbesar kasus frambusia di Asia Tenggara. Untuk mendukung eliminasi frambusia di Indonesia dibutuhkan uji diagnosik yang dapat mendiagnosis frambusia secara cepat, mudah, akurat sehingga uji tersebut dapat dipakai sebagai bagian dari survei komunitas. Uji diagnostik yang ada saat ini membutuhkan pemeriksaan serologi rapid plasma reagin (RPR)/veneral disease research laboratory (VDRL) sehingga akan menimbulkan kesulitan karena mayoritas kasus frambusia ditemukan di daerah terpencil yang tidak memiliki fasilitas laboratorium lengkap. Penelitian ini bertujuan untuk menentukan nilai diagnostik dari rapid diagnostic test (RDT) Chembio Dual Path Platform® (DPP) Syphilis Screen and Confirm dalam mendiagnosis frambusia pada anak usia 2 - 15 tahun di Kabupaten Alor, Nusa Tenggara Timur. Pemeriksaan RDT DPPÒ, RPR, dan treponema pallidum haemagglutination assay (TPHA) dilakukan pada setiap subjek penelitian. Sebanyak 197 subjek berpartisipasi dalam penelitian ini. Nilai sensitivitas, spesifisitas, nilai duga positif, dan nilai duga negatif garis non-treponemal RDT DPPÒ adalah tidak dapat dinilai, 73.6% (IK 95% 66.87- 79.61), 0%, dan 100%. Nilai sensitivitas, spesifisitas, nilai duga positif, dan nilai duga negatif garis treponemal RDT DPPÒ adalah 0%, 94.7% (IK 95% 90.63-97.47), 0%, dan 97.3% (IK 95% 97.24-97.41). Proporsi kasus frambusia, baik kasus konfirmasi maupun laten, berdasarkan pemeriksaan RPR dan TPHA adalah 0%. Berdasarkan hasil penelitian ini, kemampuan RDT DPPÒ untuk diagnosis kasus frambusia tidak dapat disimpulkan karena tidak ditemukan kasus aktif frambusia.

Indonesia is currently the largest contributor to yaws cases in Southeast Asia. To support yaws elimination in Indonesia, a diagnostic test that can diagnose yaws quick, easy, and accurate is needed so that the test can be used as part of a community survey. Current diagnostic tests require serologic rapid plasma reagin (RPR)/veneral disease research laboratory (VDRL) test, which will cause difficulties because the majority of yaws cases are found in remote areas that do not have complete laboratory facilities. This research aims to determine the diagnostic value of the rapid diagnostic test (RDT) Chembio Dual Path Platform® (DPP) Syphilis Screen and Confirm for diagnosing yaws in children aged 2 - 15 years in Alor, East Nusa Tenggara. RDT DPPÒ, RPR, and treponema pallidum haemagglutination assay (TPHA) test were performed on each subject. Total of 197 subjects participated in this study. The sensitivity, specificity, positive predictive value, and negative predictive value of the non-treponemal RDT DPPÒ line were unassessable, 73,6% (95% CI 66,87-79,61), 0%, and 100%. The sensitivity, specificity, positive predictive value, and negative predictive value of the treponemal RDT DPPÒ line were 0%, 94,7% (95% CI 90,63-97,47), 0%, and 97,3% (95% CI 97,24-97,41). The proportion of confirmed cases of yaws based on RPR and TPHA test was 0%. Based on the results of this study, the ability of RDT DPPÒ for the diagnosis of yaws cases cannot be concluded because there was no active yaws cases were found."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library