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Abstrak :
Piper retrofractum, Imperata cylindrica, dan Moringa oleifera telah diuji secara in vitro dapat mengurangi agregasi platelet yang berperan penting dalam patogenesis trombosis. Penelitian ini bertujuan untuk mengevaluasi efek ekstrak Piper retrofractum, Imperata cylindrica, dan Moringa oleifera sebagai antitrombotik secara in vivo. Mencit jantan dibagi menjadi kontrol normal CMC , negatif CMC , positif aspirin , dan dosis 1, 2, 3 pada masing-masing ekstrak. Perlakuan awal yaitu pemberian masing-masing suspensi berdasarkan pengelompokan, yang dilakukan selama 7 hari. Kemudian, pengamatan dilakukan menggunakan parameter waktu perdarahan ekor mencit yang diamputasi dan data diolah secara statistik p le; 0.05 , serta parameter perhitungan angka harapan hidup setelah induksi trombosis oleh penyuntikan intravena kolagen-epinefrin. Hasilnya yaitu dosis 3 ekstrak Piper retrofractum 11,76 mg/20 g , ekstrak Imperata cylindrica 11,2 mg/20 g , dan ekstrak Moringa oleifera 11,2 mg/20 g memperpanjang rata-rata waktu perdarahan menjadi 17.70 2.10; 19.54 0.65; 17.11 3.07 dan meningkatkan persentase angka harapan hidup 80 ; 60 ; 60. Dapat disimpulkan bahwa ekstrak Piper retrofractum, Imperata cylindrica, dan Moringa oleifera memiliki potensi sebagai antitrombotik. ...... Piper retrofractum, Imperata cylindrica and Moringa oleifera had been studied in vitro for their activity to reduce platelet aggregation which have important role in the pathogenesis of thrombosis. This study aimed to evaluate the effect of Piper retrofractum, Imperata cylindrica and Moringa oleifera extracts as antitrombotic in vivo. Male mice were divided into normal CMC , negative CMC , positive Aspirin , 1st, 2nd and 3rd for each extract. Pretreatments were given orally for 7 days and the experiment used two parameters, including bleeding time was observed on amputated mice tail and then analyzed statistically p le 0.05 , and survival rate was observed on calculation of dead paralyzed mice after trombosis induction by injecting collagen ndash epinephrine intravenously. The results are the 3rd dose extracts of Piper retrofractum 11,76 mg 20 g , Imperata cylindrica 11.2 mg 20 g , and Moringa oleifera 11.2 mg 20 g can prolonged the bleeding time to 17.70 2.10 19.54 0.65 17.11 3.07, then increased the survival rate to 80 60 60 . The extracts of Piper retrofractum, Imperata cylindrical and Moringa oleifera has a potential activity as antithrombotic.

Abstrak :
Praktik Residensi Keperawatan Medikal Bedah merupakan suatu rangkaian kegiatan Pendidikan Ners Spesialis Keperawatan yang berfokus pada penerapan ilmu, riset dan teknologi keperawatan dalam memenuhi kebutuhan dasar pada pasien dewasa secara komprehensif. Kegiatan praktik residensi ini terdiri dari pemberian asuhan keperawatan pada pasien dengan gangguan sistem perkemihan menggunakan pendekatan model adaptasi Roy, dilaksanakan di RS Fatmawati Jakarta. Asuhan keperawatan utama dilakukan pada pasien Sindrom Nefrotik dengan Efusi Pleura dan Asites Moderat. Penerapan Evidence Based Nursing (EBN) berupa intervensi teknik needle bevel down dalam mengurangi waktu perdarahan post removal kanulasi fistula pada pasien hemodialisis. PD SMART MODUL merupakan proyek inovasi yang dilakukan residen berupa Peritoneal Dialysis Nurse Educator Guidance dalam upaya meningkatkan mutu pelayanan training pasien baru dan menurunkan risiko komplikasi CAPD. ......Surgical Nursing Residency Practice is a series of Nursing Specialist Ners Education activities that focus on the application of nursing science, research and technology in meeting basic needs in adult patients comprehensively. This residency practice activity consists of providing nursing care to patients with urinary system disorders using the Roy adaptation model approach, carried out at Fatmawati Hospital. The main nursing care is carried out in patients with Nephrotic Syndrome with pleural effusion and moderate ascites. Application of Evidence Based Nursing (EBN) in the form of needle bevel down insertion interventions for hemodialysis patients in reducing post-removal fistula cannulation bleeding time. PD SMART MODUL is an innovation project carried out by residents in the form of Peritoneal Dialysis Nurse Educator Guidance in an effort to improve the quality of new patient training services and reduce the risk of CAPD complications.