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"Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia suburyang bekerja di dalam ruangan mempunyai vitamin D yang rendahmeskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevalua-si peranan paparan sinar matahari pada wanita usia subur terhadap statusvitamin D dan tekanan darah. Desain penelitian yang digunakan adalaheksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian inimembandingkan status vitamin D dan tekanan darah sebelum dan setelahmendapat paparan sinar matahari pada wajah dan lengan tiga kali seming-gu selama 12 minggu. Analisis data menggunakan uji t-berpasangan.Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)Dmeningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar mata-hari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (ni-lai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali semingguselama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah.Ultraviolet B sunlight exposure is a primary source of vitamin D, but womenof childbearing age who worked in room every day had low serum vitaminD despite Indonesia is a tropical country. The objective of this study was toevaluate the role of sun exposure in women of childbearing age on vitaminD status, and blood pressure. An intervention before-after study withoutgroup control was conducted on 21 healthy women. This study comparedvitamin D status, and blood pressure before and after receiving ultravioletB (UVB) from sun exposure on the face and both arms three times a weekfor 12 weeks. Anthropometric parameter and blood pressure were mea-sured, were determined at baseline and after 12 weeks of sun exposure.The effect of sun exposure can improve vitamin D. Serum 25 (OH)D in-crease 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly re-duced systolic blood pressure (p value = 0.004), and diastolic blood pres-Peranan Ultraviolet B Sinar Matahari terhadap StatusVitamin D dan Tekanan Darah pada Wanita Usia SuburThe Role of Ultraviolet B from Sun Exposure on Vitamin D Status andBlood Pressure in Women of Childbearing AgeBetty Yosephin* Ali Khomsan** Dodik Briawan** Rimbawasure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3times a week for 12 weeks improves the vitamin D status, and blood pres-sure."

"ABSTRAKBerbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat.Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D.Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat.Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

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ABSTRACTRecent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient.This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups.According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05).It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively."