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Abstrak :

Minuman ringan berpemanis adalah minuman ringan yang diberi tambahan gula sederhana yang dapat menambah kandungan energi. Trigliserida merupakan salah satu bentuk simpanan lemak di dalam tubuh. Konsumsi minuman ringan berpemanis dapat meningkatkan kadar trigliserida melalui peningkatan lipogenesis de novo.  Lemak viseral adalah lemak yang terdapat pada rongga abdomen yang diketahui merupakan faktor risiko tinggi untuk penyakit metabolik di kemudian hari. Penelitian ini bertujuan untuk mengetahui korelasi antara frekuensi konsumsi minuman ringan berpemanis dengan kadar trigliserida dan visceral fat rating pada remaja putri. Penelitian ini menggunakan disain potong lintang dengan melibatkan 47 subjek yang direkrut melalui metode consecutive sampling. Frekuensi minuman ringan berpemanis diambil dengan metode FFQ. Sampel kadar trigliserida diambil dari darah tanpa puasa dan diukur menggunakan metode enzymatic colorimetric. Visceral fat rating diukur menggunakan BIA. Uji statistik menggunakan uji korelasi Pearson dan Spearman dengan SPSS. Subjek rata-rata mengonsumsi minuman ringan berpemanis sebanyak 8,91 + 4,71 kali/minggu. Nilai rata-rata kadar trigliserida subjek adalah 110,49 + 41,49 mg/dL. Nilai tengah visceral fat rating subjek adalah 3 (1 – 11) termasuk dalam kategori sehat. Pada penelitian ini didapatkan hasil korelasi positif bermakna dengan derajat sangat kuat (p = <0,001, r = 0,88) antara frekuensi konsumsi minuman ringan berpemanis dengan kadar trigliserida dan korelasi positif bermakna dengan derajat sedang (p = 0,003, r = 0,426) antara frekuensi konsumsi minuman ringan berpemanis dengan visceral fat rating.

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Sugar sweetened beverages are beverages that are given an addition of simple sugar so they can add energy content. Triglycerides are one form of fat deposits in the body. Consumption of sugar sweetened beverages can increase triglyceride levels through increasing de novo lipogenesis. Visceral fat, which is located in the abdominal cavity, is known to be a high risk factor for metabolic diseases in the future. This study aims to determine the correlation between consumption frequency of sugar sweetened beverages with triglyceride levels and visceral fat rating in female adolescence.  This study used a cross-sectional design involving 47 subjects recruited through a consecutive sampling method. The frequency of sugar sweetened beverages is taken by FFQ method. Triglyceride levels were taken from blood without fasting and measured using enzymatic colorimetric method. Visceral fat rating measured using BIA. Statistical test using Pearson and Spearman correlation test with SPSS. The average of subject that consumed sweetened soft drinks as much as 8.91 + 4,71 times / week. The average subject triglyceride levels 110,49 + 41,49 mg / dL. The median of the subject's visceral fat rating are 3 (1 - 11) is included in the healthy range. In this study a significant positive correlation was strongly found (p = <0.001, r = 0.88) between the consumption frequency of sweetened soft drinks and triglyceride levels and a positive correlation with moderate degrees (p = 0.003, r = 0.426) between consumption frequency of sugar sweetened beverages and visceral fat rating.

Abstrak :
Vitamin D memiliki efek mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay. Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan, didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut. ......Vitamin D has effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Studies that discuss the correlation between these two factors are still inconsistent.  A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital. Measurement of visceral fat levels using bioelectrical impedance analysis bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay method.  In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis, visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels. There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients.

Abstrak :
Latar Belakang: Prevalensi obesitas, hipertensi dan penyakit ginjal kronis (PGK) pada pekerja kantor di Jakarta cukup tinggi. Meningkatnya volume lemak viseral pada obesitas, khususnya obesitas sentral,  memiliki kemaknaan klinis yang lebih besar dalam memprediksi kejadian hipertensi dan PGK. Studi ini bertujuan untuk meneliti korelasi nilai lemak viseral tubuh dengan tekanan darah (TD) dan fungsi ginjal pada populasi pekerja kantor dengan obesitas di Jakarta. Metode: Studi potong lintang dilakukan pada 101 pekerja kantor dengan obesitas di RSUPN Cipto Mangunkusumo Jakarta. Pengukuran volume lemak viseral menggunakan alat bioelectrical impedance analysis multifrekuensi SECA mBCA 525. TD diukur dengan tensimeter digital, fungsi ginjal dari hasil perhitungan estimasi laju filtrasi glomerulus (eLFG) berdasarkan nilai kreatinin serum. Hasil: Subjek terbagi menjadi dua kelompok berdasarkan kategori lemak viseral. Sebanyak 91% subjek berada di dalam kelompok lemak viseral tidak normal, dimana didominasi perempuan serta rerata usia dan indeks massa tubuh lebih tinggi dibandingkan kelompok normal. Pada kelompok tersebut, 33,7% diantaranya memiliki TD sistolik ≥140 dan/ atau diastolik ≥90 mmHg, dan 18,5% memiliki eLFG <90 ml/menit/1,73 m2. Adanya korelasi positif antara nilai lemak viseral dengan tekanan darah sistolik (r =0,436, p =0,000) dan diastolik (r =0,306, p =0,002), serta korelasi negatif dengan eLFG (r =-0,284, p =0,004). Kesimpulan: Terdapat korelasi yang bermakna antara lemak viseral dengan tekanan darah dan fungsi ginjal pada pekerja kantor dengan obesitas. ......Background: The prevalence of obesity, hypertension and chronic kidney disease (CKD) among office workers in Jakarta is relatively high. Increased visceral fat in obesity, especially central obesity, has greater clinical significance in predicting the incidence of hypertension and CKD. This study aims to examine the correlation of visceral fat values with blood pressure (BP) and kidney function in office workers in an obese population in Jakarta. Methods: A cross-sectional study was conducted on 101 office workers with obesity at Cipto Mangunkusumo General Hospital, Jakarta. Visceral fat volume was measured using a multi-frequency bioelectrical impedance analysis SECA mBCA 525. BP was measured with a digital tensimeter, and kidney function was taken from the estimated glomerular filtration rate (eGFR) calculation based on serum creatinine. Results: Subjects were divided into two groups based on the category of visceral fat. About 91% of the subjects were in the abnormal visceral fat group, dominated by women, and the mean age and body mass index were higher than the normal group. In this group, 33.7% had systolic BP ≥140 and/or diastolic ≥90 mmHg, and 18.5% had an eGFR <90 ml/min/1.73 m2. There was a positive correlation between visceral fat values with systolic (r =0.436, p =0.000) and diastolic BP (r =0.306, p = 0.002) and a negative correlation with eGFR (r =-0.284, p =0.004). Conclusion: There is a significant correlation between visceral fat and blood pressure and kidney function in office workers with obesity.

Abstrak :
ABSTRAK
Prevalensi obesitas di Indonesia makin meningkat . Obesitas yang terjadi akibat energi yang masuk lebih besar daripada yang dikeluarkan akan menyebabkan peningkatan massa lemak total tubuh, termasuk massa lemak viseral. Massa lemak dapat melatarbelakangi penyakit degeneratif. Tujuan dari penelitian ini untuk mengetahui korelasi rasio asupan energi (AE) terhadap kebutuhan energi total (KET) individu dengan massa lemak viseral dan kadar HbA1c plasma pada subjek obesitas di Indonesia. Penelitian ini merupakan studi potong lintang, yang dilakukan di kantor Balaikota DKI Jakarta pada bulan September sampai dengan Oktober 2014. Subjek penelitian didapatkan melalui Simple Random Sampling, sebanyak 52 orang yang sesuai kriteria penelitian ditetapkan sebagai subjek penelitian. Didapatkan hasil sebagian besar subjek termasuk usia 46–55 tahun (55,8%), sebagian besar subjek penelitian adalah perempuan (65,4%), dengan IMT sama besar antara obes 1 dan 2. Lebih dari separuh subjek penelitian mempunyai rasio AE terhadap KET yang kurang karena under report pada pelaporan asupan per hari. Hampir seluruh subjek laki-laki mempunyai massa lemak viseral berlebih (94,4%), sementara pada subjek perempuan sebagian besar mempunyai massa lemak viseral normal. Seluruh subjek mempunyai massa lemak total berlebih. Kadar HbA1c plasma pada 75% subjek termasuk kategori berisiko DM. Tidak terdapat korelasi yang bermakna antara rasio AE terhadap KET dengan massa lemak viseral (r = 0,1; p=0,7). Korelasi antara rasio AE terhadap KET dengan kadar HbA1c didapatkan hasil bermakna dengan kekuatan sedang untuk usia 46–55 tahun (r=0,42;p=0,02). Tidak terdapat korelasi yang bermakna antara massa lemak viseral dengan kadar HbA1c plasma.

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ABSTRAK
The prevalence of obesity in Indonesia is increasing. Obesity, as the consequence of greater energy ingested than energy expended, cause an increase in total body fat mass including visceral fat mass that underlie degenerative diseases. The aim of this study was to find correlation between ratio of energy intake (EI) to individual total energy requirement (TER) with visceral fat mass and HbA1c levels in obese subject. The method used in this study was cross sectional, held in the institution of Balaikota DKI Jakarta during September to October 2014. The subject was obtained by simple random sampling and 52 subjects who meet study criteria were enrolled in this study. The results showed most of subjects age between 46–55 years (55,8%), majority of subjects were female (65,4%), with the same number of subjects categorized as obese 1 and obese 2. More than half of this subjects have ratio of EI to TER less than normal. Majority of the male subject have visceral fat mass greater than normal criteria (94,4%), while most of female subjects have normal criteria of visceral fat mass. All of the subjects have greater level of total body fat mass. Level of HbA1c in most of the subject are normal categories (75%). Ratio EI to TER did not correlate significantly with visceral fat mass (r=0,1; p=0,7). There were significant positive correlation between ratio EI to TER with HbA1c level in age of 46–55 year (r=0,42;p=0,02). Visceral fat mass did not correlate significantly with HbA1c plasma levels.

Abstrak :
Latar Belakang: Obesitas menjadi masalah Kesehatan global dengan tren peningkatan populasi yang berlanjut. Keseimbangan energi positif, dimana asupan energi lebih besar dari pengeluaran energi akan menyebabkan penumpukan lemak. Obesitas akibat akumulasi lemak, khusunya lemak viseral merupakan penyebab fator risiko terjadinya penyakit tidak menular, Pegawai kantor berpeluang mengalami obesitas dengan memiliki gaya hidup diet tinggi kalori dan gaya hidup sedenteri. Penelitian ini bertujuan untuk melihat korelasi antara asupan energi dan aktivitas fisik dengan lemak viseral pada pegawai kantor yang mengalami obesitas. Metode: Studi potong lintang ini dilakukan pada subjek pegawai kantor yang mengalami obesitas di RSCM. Asupan energi dinilai dengan 3 x 24-h food recall. Aktivitas fisik dinilai dengan kuesioner GPAQ dan lemak viseral dinilai dengan BIA multifrekuensi. Hasil: Sebanyak 85 subjek penelitian dengan rerata usia 41 tahun, dengan sebagian besar perempuan dan temasuk dalam kategori obesitas derajat I. Hampir seluruh subjek memiliki volume lemak viseral tidak normal dengan median 2,95 L (1,3 – 8,5 L). Sebagian besar memiliki asupan energi lebih dengan rerata asupan 2196 ± 467 kkal. Sebagian besar memiliki aktivitas fisik sedang dengan nilai median 1850 MET (120 – 4680 MET). Terdapat korelasi sedang antara asupan energi dengan lemak viseral (r=0,554, p<0,001) dan korelasi lemah antara aktivitas fisik dengan lemak viseral (r=-324, P=0,008). Kesimpulan: Terdapat korelasi sedang antara asupan energi dengan lemak viseral dan korelasi lemah antara aktivitas fisik dengan lemak viseral ......Background: Obesity is a global health problem with a continuing trend of increasing population. A positive energy balance, where energy intake is more remarkable than energy expenditure, will cause fat accumulation. Obesity due to the accumulation of fat, especially visceral fat, is a risk factor for non-communicable diseases. Office employees can become obese by having a high-calorie diet and a sedentary lifestyle. This study aims to see the correlation of energy intake and ohysical activity with visceral fat in obese office workers. Method: This cross-sectional study was conducted on obese office staff at RSCM. Energy intake was assessed with 3 x 24-h food recalls. Physical activity was assessed with the GPAQ questionnaire, and visceral fat was assessed with multifrequency BIA. Results: A total of 66 study subjects with an average age of 41 years were women and included in the category of obesity degree I. Almost all subjects had abnormal visceral fat volume with a median of 2.95 L (1.3 – 8.5 L). Most have more energy intake, with an average intake of 2196 ± 467 kcal. Most had a moderate physical activity with a median value of 1850 MET (120 – 4680 MET). There was a moderate correlation between energy intake and visceral fat (r=0.554, p<0.001) and a weak correlation between physical activity and visceral fat (r=-324, P=0.008). Conclusion: There was a moderate correlation between energy intake and visceral fat and a weak correlation between physical activity and visceral fat.

Abstrak :
ABSTRAK
Lingkar pinggang merupakan sebuah alat ukur obesitas sentral yang berpengaruh pada kejadian sindrom metabolik. Penelitian ini dilakukan untuk memperoleh faktor dominan yang mempengaruhi nilai lingkar pinggang pada petugas satpam laki-laki Universitas Indonesia. Penelitian ini menggunakan desain studi crosssectional dengan pendekatan kuantitatif. Variabel independen yang dinilai berhubungan signifikan dengan nilai lingkar pinggang berdasarkan penelitian ini antara lain adalah umur, indikator lemak tubuh (indeks massa tubuh, persen lemak tubuh, dan level lemak viseral), aktivitas fisik, serta kebiasaan merokok. Hasil penelitian ini menunjukkan level lemak viseral sebagai faktor dominan terhadap nilai lingkar pinggang dengan rata-rata nilai lingkar pinggang responden sebesar 79,3 cm.

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ABSTRACT
Waist cicumference is an indicator of central obesity which leads to metabolic syndrome. This study was conducted to find the dominant factor of waist circumference of male security guard of University of Indonesia in 2014. This study uses cross-sectional design with quantitive method. The independent variables that corelate significantly with the waist circumference are age, indicator of body fat (body mass index, body fat percentage, visceral fat level), physical activity, and smoking habit. The result of this study showed that visceral fat level was the dominant factor of waist circumference with the average waist circumference of the subject are 79,3 cm.

Abstrak :
Obesitas merupakan masalah kesehatan yang ditandai dengan nilai Indeks Massa Tubuh ≥ 30. Obesitas dapat memicu penyakit lain seperti Diaebetes Mellitus dan penyakit Kardiovaskular. Pada penelitian sebelumnya, ekstrak Caesalpinia sappan L. atau dikenal di Indonesia sebagai kayu Secang, terbukti dapat mengurangi akumulasi lemak secara in vitro. Sementara, kombucha dipercaya dapat meningkatkan sistem imun. Pada penelitian ini, dilakukan eksperimen secara in vivo pada kombucha C.sappan. Penelitian ini menggunakan tikus putih betina Sprague-Dawley yang dibagi menjadi 8 kelompok, yaitu kontrol sham dan kontrol negatif (CMC-Na 0,5% 2 mL/200 grBB), kontrol positif (Tamoksifen 0,4 mg/200gr BB), ekstrak Secang (20 mg/200grBB), kombucha (1 mL/200grBB), serta 3 kelompok variasi dosis kombucha Secang dengan D1 (1 mL/200 gr BB), D2 (3 mL/200 grBB/), dan D3 (3 mL/200 grBB/3 kali sehari), dengan pemberian secara oral. Semua tikus dilakukan ovariektomi, kecuali kelompok sham dilakukan pembedahan tanpa pengambilan ovarium. Tikus dipelihara 4 minggu pasca operasi, lalu diberi perlakuan selama 28 hari. Parameter yang diukur adalah berat badan, food intake, akumulasi lemak viseral, dan ukuran sel adiposit. Berdasarkan penelitian, kombucha Secang dosis 3 (3 mL/200grBB/3 kali sehari) menurunkan berat badan, nafsu makan, mengurangi akumulasi lemak viseral dan ukuran sel adiposit. ......Obesity is a health problem characterized by a Body Mass Index value ≥ 30. Obesity can trigger other diseases such as diabetes mellitus and cardiovascular disease. In previous studies, Caesalpinia sappan L. extract was shown to reduce fat accumulation in vitro. Meanwhile, kombucha is believed to boost the immune system. In this study, in vivo experiments were conducted on kombucha from C. sappan extract. This study used female Sprague-Dawley white rats which were divided into 8 groups, namely sham and negative control (CMC-Na 0.5% 2 mL/200grBW), positive control (Tamoxifen 0.4 mg/200grBW), C.sappan extract (20 mg/200grBW), kombucha (1 mL/200grBW), as well as 3 groups of dose variations of C.sappan kombucha with D1 (1 mL/200 gr BB), D2 (3 mL/200grBW), and D3 (3 mL/200grBW/3 times a day), with oral administration. All rats were ovariectomized, except for the sham group. After 4 weeks ovariectomy, rats were treated for 28 days. Parameters measured were body weight, food intake, visceral fat accumulation, and adipocyte cell size. Based on the study, C. sappan kombucha dose 3 (3 mL/2grBW/3 times a day) decreased body weight, food intake, reduced visceral fat accumulation and adipocyte cell size.

Abstrak :
Tujuan penelitian membahas hubungan Indeks Massa Tubuh (IMT) dan faktor-faktor lain dengan status lemak tubuh pada pramusaji di Pelayanan Gizi Unit Rawat Inap Terpadu Gedung A RSCM Jakarta. Penelitian bersifat kuantitatif dengan desain cross sectional, pengambilan sampel secara purposive sampling. Data antropometri didapatkan dengan pengukuran langsung saat penelitian. Analisis data meliputi crosstabs dan chi-square, menggunakan SPSS versi 13.0. Hasil penelitian, 88.9% dan 38.9% orang berstatus gizi lebih masing-masing memiliki persen lemak tubuh mendekati tinggi/tinggi dan lemak viseral tinggi(p<0.05). Disarankan kepada pramusaji untuk membiasakan sarapan pagi, mengkonsumsi makanan tinggi serat dan sering beraktivitas fisik. ......The aim of this study is how Body Mass Index and Other Factors Related to Body Fat Status on Waitress at Nutrition Service of Integrated Admission Unit Building A RSUPN Dr.Cipto Mangunkusumo Jakarta. This is a quantitative study with cross sectional approach, samples are collected by purposive sampling. Anthtopometry data are collected directly by measurement. Analysis included crosstabs dan chisquare, by using SPSS version 13.0. The result, 88.9% dan 38.9% are overweight with each of them have slightly high/high body fat percentage and high visceral level(p<0.05). The researcher sugested that waitress should have breakfast gradually, consume foods containing high dietary fiber, frequent physical activity.

Abstrak :
Latar Belakang: Dermatitis seboroik (DS) merupakan kelainan inflamasi kronik pada area kulit yang kaya kelenjar sebasea. Hingga saat ini patogenesis DS terus berkembang, termasuk dikaitkan dengan kejadian sindrom metabolik. Oleh karena sindrom metabolik terjadi akibat resistensi insulin yang diperankan oleh jaringan lemak viseral, maka diduga kedua hal tersebut juga memiliki peran terhadap kejadian DS. Tujuan: mengetahui rerata HOMA-IR dan skala jaringan lemak viseral pada pasien DS, serta menilai perbedaannya dibandingkan dengan kontrol. Metode: Penelitian kasus-kontrol berpasangan ini dilakukan di Poliklinik Dermato-venereologi RSCM selama Juli-Agustus 2022. Kelompok kasus ialah pasien berusia ≥18 tahun, tidak hamil, IMT ≥18,5 kg/m2 yang terdiagnosis DS secara klinis, serta tidak memiliki penyakit imunokompromais, infeksi kronis, kanker, autoimun, atau degeneratif lainnya. Kelompok kontrol ialah pasien non-DS yang match berdasarkan usia, jenis kelamin, dan kategori IMT. Seluruh subjek menjalani pemeriksaan klinis, laboratorium, dan pengukuran skala lemak viseral menggunakan alat BIA TANITA® SC330. Hasil: Masing-masing kelompok DS dan kontrol berjumlah 36 subjek pada studi ini. Median(min-maks) usia kelompok DS ialah 26,5(20-45) tahun, jenis kelamin laki-laki 52,8%, dan median(min-maks) IMT sebesar 24,2(18,5-38,8) kg/m2. Median HOMA-IR ditemukan lebih tinggi pada kelompok DS dibandingkan kontrol (1,54[0,72-4,09] VS. 1,22[0,53-2,73]; p=0,031). Namun, tidak terdapat perbedaan yang bermakna secara statistik untuk skala lemak viseral antara kelompok DS dengan kontrol (6,5[1-14] VS. 6,0[1-12]; p=0,149). Kesimpulan: Nilai median HOMA-IR dan skala jaringan lemak viseral pada pasien DS adalah masing-masing 1,54 (IK95% 0,72-4,09) dan 6,5 (IK95% 1-14). Nilai HOMA-IR pada pasien DS lebih tinggi dibandingkan dengan kontrol dan bermakna secara statistik, tetapi tidak terdapat perbedaan bermakna secara statistik untuk skala lemak viseral. ......Background: Seborrheic dermatitis (SD) is a chronic inflammatory disorder in sebaceous gland-rich skin. Until today the pathogenesis of SD continues to develop, including investigation about the link association between SD and metabolic syndrome. Metabolic syndrome is a disease caused by insulin resistance in which visceral fat tissue may play important role, therefore insulin resistance and visceral fat tissue are hypothesized to influence the development of SD. Objective: To measure the HOMA-IR and visceral fat rating scale in SD patients, and to investigate the differences compared to the control group. Methods: A matched case-control study was conducted in Dermatovenereology Clinic Cipto Mangunkusumo General Hospital in July-August 2022. Case group was non-pregnant patients aged ≥18 years old and BMI ≥18,5 kg/m2 which were clinically diagnosed with SD, and did not have any of immunocompromise, chronic infection, cancer, autoimmune, or degenerative disease. Control group was non-SD patients that were matched according to the age, gender, and BMI categories. All the subjects assigned for clinical and laboratory examination, and visceral fat measurement using BIA TANITA® SC330. This study involved 36 subjects in each SD and control group. Median(min-max) of age in SD group was 26.5(20-45) yo, male 52.8%, and median(min-max) of BMI was 24.2(18.5-38.8) kg/m2. Median HOMA-IR was significantly higher in SD group compared to the control group (1.54[0.72-4.09] VS. 1.22[0.53-2.73]; p=0.031). However, there was no significant difference for visceral fat rating scale between SD and control group (6.5[1-14] VS. 6.0[1-12]; p=0.149). Conclusion: The median HOMA-IR and visceral fat rating scale in SD were 1.54 (95%CI 0.72-4.09) and 6.5 (95%CI 1-14). HOMA-IR in SD group is higher to the control group and statistically significant, but there is no significant difference for visceral fat rating scale.

Abstrak :
Latar Belakang: Vitamin D memiliki efek non-skeletal dalam mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar lemak viseral dan kadar vitamin D serum pada pasien stroke akut. Metode: Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia selama bulan November -Desember 2023. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis (BIA) bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay (CMIA). Analisis bivariat dan multivariat digunakan untuk menilai korelasi dan hubungan antara variable bebas dan terikat, serta mengidentifikasi faktor perancu lain yang berhubungan dengan kadar vitamin D serum. Hasil: Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan dengan regresi linear untuk faktor perancu lain, hanya didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) yang menjadi faktor paling signifikan dalam menilai kadar vitamin D serum. Kesimpulan: Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut. ......Background: Vitamin D has non-skeletal effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Until now, studies that discuss the correlation between these two factors are still inconsistent. This study aims to determine the correlation between visceral fat levels and serum vitamin D levels in acute stroke patients. Methods: A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital during November - December 2023. Measurement of visceral fat levels using bioelectrical impedance analysis (BIA) bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay (CMIA) method. Bivariate and multivariate analyses were used to assess the correlation and relationship between independent and dependent variables, as well as identify other confounding factors associated with serum vitamin D levels. Results: In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis with linear regression for other confounding factors, only visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels. Conclusion: There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients.