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Abstrak :
Keberhasilan terapi ARV sangat ditentukan oleh kepatuhan minum obat ARV. YPImerupakan salah satu yayasan peduli HIV/AIDS tertua di Indonesia yang terletak diTebet, Jakarta Selatan. Beberapa pasien HIV/AIDS di YPI ditemukan pernahmengalami putus obat yang dapat berisiko kematian akibat kegagalan terapi ARV. Penelitian ini bertujuan untuk melihat gambaran kepatuhan minum obat ARV padapasien HIV/AIDS di YPI. Penelitian ini merupakan penelitian kualitatif denganmenggunakan wawancara mendalam. Pengambilan data dilakukan pada 10 orang darikelompok ODHA, keluarga, dan pihak YPI. Penelitian ini menunjukkan bahwa masih terdapat pasien yang tidak patuh minum obat ARV. 5 informan yang penelitiwawancarai, 2 informan menyatakan pernah mengalami putus obat, 2 informan lainpernah terlambat minum obat dan 1 informan patuh minum obat. Penelitian ini menunjukkan faktor penyebab ketidakpatuhan minum obat ARV yaitu kesibukan, kejenuhan minum obat, takut efek samping, dan merasa sudah sehat. ...... The success of antiretroviral therapy is largely determined by the adherence of taking an tiretroviral drugs. YPI is one of the foundation care HIV AIDS located in Tebet,South Jakarta. Several HIV AIDS patients in YPI have been found to have experienced drug withdrawal that could be at risk of death due to ARV therapy failure. This study aims to look at the picture of adherence to taking ARV drugs and factors that influence adherence in HIV AIDS patients at YPI. This research is a qualitative research using in depth interviews. Data were collected on 10 people from HIV patients, family, andYPI groups. This study shows that there are still patients who do not adhere to taking ARV drugs. 2 of 5 informants had a drug break, 2 informan not on time in taking medication. This study shows the factors that cause non adherence to take medication ARV that is busy, saturation of medicine, fear of side effects, and feel healthy.

Abstrak :
[ABSTRAK
Latar Belakang. Penderita HIV/AIDS di Indonesia semakin meningkat, sedangkan infeksi HIV/AIDS maupun terapi ARV dapat menyebabkan penurunan kadar testosteron yang sangat memengaruhi kualitas hidup penyandang HIV/AIDS. Gejala dan tanda penurunan kadar testosteron pada pria dengan HIV sangat tidak spesifik, sedangkan pemeriksaan laboratorium sangat mahal, sehingga perlu diketahui faktor-faktor pada pasien yang dapat memprediksi penurunan kadar testosteron. Tujuan. Mengetahui apakah jumlah CD4 awal, lamanya terapi ARV, jenis ARV, lipodistrofi dan besarnya lingkar pinggang memengaruhi kadar testosteron bebas pada pria dengan HIV yang mendapat ARV. Metode. Penelitian potong lintang dilakukan pada bulan Maret 2015 di Unit Pelayanan HIV Terpadu RSCM, Jakarta. Subjek adalah pria dengan HIV berusia 18-40 tahun, mendapat ARV teratur sekurangnya dalam 1 tahun terakhir. Pemeriksaan meliputi anamnesis, pengukuran lingkar pinggang dan lipodistrofi, pemeriksaan kadar testosteron total, SHBG dan testosteron bebas (Free Testosteron Index: FTi). Uji regresi linier digunakan untuk menilai faktor-faktor yang berhubungan dengan kadar testosteron bebas pada penelitian ini. Hasil. Dari 54 subjek, didapatkan median usia 35,11 tahun (21-40), median lamanya ARV 59 bulan (16-129), median CD4 awal 57/mm3 (3-443), rerata lingkar pinggang 82,4cm (SB 10,33). Subjek yang mengalami lipodistrofi sebanyak 17 orang (32%). Subjek yang menggunakan ARV lini pertama 48 orang. Median kadar testosteron bebas 30,87% (9,78-85,64) dan subjek yang memiliki kadar testosteron bebas rendah sebanyak 32 orang(59%). Terdapatnya lipodistrofi (p=0,003, OR= -12,25) dan lamanya menggunakan ARV (p=0,002, OR=-0,182) berhubungan dengan kadar testosteron bebas pada penelitian ini. Simpulan : Pada pria dengan HIV yang mendapat terapi ARV, adanya lipodistrofi dan lamanya terapi ARV berhubungan dengan kadar testosteron bebas. Kadar CD4 awal, jenis ARV dan lingkar pinggang tidak berhubungan dengan kadar testosteron bebas.

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ABSTRACT
Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels., Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level. Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV. Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study. Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level. Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.]

Abstrak :
Human Immunodeficiency Virus (HIV) adalah virus yang menginfeksi sel darah putih yang disebut sel CD4 dan menargetkan daya tahan tubuh. kasus HIV di DKI Jakarta pada tahun 2022 memiliki kasus HIV secara kumulatif sebanyak 79.043 sehingga menempati urutan provinsi tertinggi. Kasus terbanyak yang dilaporkan pada Tahun 2020 oleh Profil Kesehatan DKI Jakarta berada pada wilayah Jakarta Selatan. Salah satu upaya untuk meningkatkan angka harapan hidup ODHIV adalah penggunaan obat antiretroviral (ARV). Secara umum pemberian terapi ARV diberikan dalam bentuk kombinasi yang harus dikonsumsi seusia hidup. Angka kepatuhan di Puskesmas Kecamatan Setiabudi yaitu 45.6%. Angka ini lebih rendah dari target kemenkes yaitu 95% pasien mengalami supresi virus. Kepatuhan terapi antiretroviral di Puskesmas Kecamatan Setiabudi ini dipengaruhi oleh berbagai faktor. Penelitian ini bertujuan untuk mengetahui gambaran dan faktor yang berhubungan dengan kepatuhan terapi antiretroviral di Puskesmas Kecamatan Setiabudi. Penelitian ini menggunakan desain cross sectional dengan wawancara responden berdasarkan kuisioner yang sudah dibuat. Populasi adalah pasien ODHIV >18 tahun dengan minimal terapi selama 6 bulan. Sampel sebanyak 90 orang didapatkan melalui rumus uji beda proporsi. Berdasarkan analisis univariat diperoleh rerata kepatuhan terapi antiretroviral di Puskesmas Kecamatan Setiabudi 84.3 dari skala 100. Hasil uji regresi logistik berganda menunjukkan bahwa keyakinan diri memiliki hubungan dengan kepatuhan terapi antiretroviral. Keyakinan diri merupakan variabel dominan yang berhubungan dengan kepatuhan terapi antiretroviral di Puskesmas Kecamatan Setiabudi (p=0.023, OR 2.87). Monitoring kepatuhan dapat menjadi intervensi yang baik bagi Puskesmas Kecamatan Setiabudi. ......The Human Immunodeficiency Virus (HIV) is a virus that infects white blood cells called CD4 cells and targets the body's immune system. The cases of HIV in DKI Jakarta in 2022 have cumulatively reached 79,043, making it the province with the highest number of cases. The highest number of cases reported in 2020 by the DKI Jakarta Health Profile were in the South Jakarta area. One of the efforts to increase the life expectancy of people living with HIV (PLWH) is the use of antiretroviral (ARV) drugs. Generally, ARV therapy is given in combination and must be consumed for life. The adherence rate at the Puskesmas in Kecamatan Setiabudi is 45.6%. This figure is lower than the Ministry of Health's target of 95% of patients achieving virus suppression. Adherence to antiretroviral therapy at the Puskesmas in Kecamatan Setiabudi is influenced by various factors. This study aims to understand the picture and factors associated with adherence to antiretroviral therapy at the Puskesmas in Kecamatan Setiabudi. This study uses a cross-sectional design with respondent interviews based on a pre-made questionnaire. The population is HIV patients >18 years old with a minimum of 6 months of therapy. A sample of 90 people was calculated using a difference of proportion test formula. Based on a univariate analysis, the average adherence to antiretroviral therapy at the Puskesmas in Kecamatan Setiabudi is 84.3 out of 100. The results of the multiple logistic regression tests show that self-efficacy is associated with adherence to antiretroviral therapy. Self efficacy is the dominant variable associated with adherence to antiretroviral therapy at the Puskesmas in Kecamatan Setiabudi (p=0.023, OR 2.87). Monitoring adherence can be a good intervention for the Puskesmas in Kecamatan Setiabudi.

Abstrak :
ABSTRAK
Skripsi ini membahas evaluasi hasil terapi ARV terhadap perubahan jumlah CD4 dan berat badan, serta terapi OAT terhadap perubahan berat badan pada pasien koinfeksi TB/HIV di RSCM tahun 2009. Penelitian ini dilakukan untuk mengetahui keefektifan terapi ARV dan OAT, serta melihat pengaruh karakteristik demografi terhadap perubahan berat dan jumlah CD4 pada pasien koinfeksi TB/HIV di RSCM. Desain studi yang dipakai adalah Cross sectional. Hasil penelitian membuktikan bahwa pasien yang mendapat terapi ARV mengalami peningkatan jumlah CD4 rata - rata sebesar 200,44 sel/mm3 dengan p value 0,0005 (bermakna secara statistik). Pada pengukuran berat badan, ternyata terapi ARV meningkatkan berat badan pasien rata - rata sebesar 5,12 kg dengan p value 0,0005 (bermakna secara statistik), dan pada pasien yang mendapatkan terapi OAT secara lengkap berat badan meningkat rata ? rata sebesar 4,79 kg dengan p value sebesar 0,0005 (bermakna secara statistik). Berdasarkan karakteristik demografi, bahwa pada pasien dengan kelompok umur lebih dari 30 tahun, pendidikan lebih dari SMA, sudah menikah, bekerja dan jenis kelamin laki-laki mempunyai peningkatan berat badan yang lebih tinggi, namun uji statistik tidak signifikan. Jika dilihat dari peningkatan jumlah CD4, pasien dengan kelompok umur lebih dari 30 tahun, pendidikan lebih dari SMA, sudah menikah, bekerja dan jenis kelamin perempuan mempunyai peningkatan jumlah CD4 yang lebih tinggi, namun uji statistik tidak signifikan. Maka, kesimpulannya adalah karakteristik demografi tidak mempengaruhi peningkatan berat badan maupun jumlah CD4.

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ABSTRACT
This research discusses the evaluation results of antiretroviral therapy on CD4 cell count changes and weight, and OAT therapy on weight changes in patients coinfected with TB/HIV in RSCM in 2009. The study was conducted to determine the effectiveness of ARV therapy and OAT and see the impact of demographic characteristics to changes in weight and CD4 count in patients coinfected with TB/HIV in RSCM. Study designed used was cross sectional. Research shows that patients who received antiretroviral therapy experienced an increase in mean CD4 counts average of 200,44 cell/mm3 with a p value 0.0005 (statistically significant). In the measurement of body weight, ARV therapy can increase a patients weight average of 5,12 kg with a p value 0.0005 (statistically significant), and in patient receiving OAT full weight increase average of 4,79 kg with a p value of 0.0005 (statistically significant). Based on demographic characteristics, that in patients with age group over 30 years, more than high that in patients with age group over 30 years, more than high school education, married, working and male gender had a weight gain is higher, but the test was not statistically significant. If viewed from an increase in CD4 cell counts, patients with the age group over 30 years, more than high school education, married, working and women gender have increased CD4 counts are higher, but the test was not statistically significant. Thus, the conclusion is the demographic characteristics did not affect weight gain and CD4 cell count

Abstrak :
Anak dengan HIV/AIDS membutuhkan terapi Antiretroviral (ARV) dan merupakan suatu tantangan bagi keluarga untuk tetap mempertahankan kepatuhan terhadap terapi. Penelitian kualitatif ini menggunakan pendekatan fenomenologis deskriptif yang bertujuan mengeksplorasi pengalaman keluarga merawat anak dengan HIV/AIDS yang menjalani terapi ARV. Partisipan yang terlibat dalam penelitian ini adalah lima orang. Hasil penelitian ini mengidentifikasi 5 tema yaitu 1) dimensi pemberian terapi ARV, 2) keyakinan terhadap pengobatan, 3) dukungan dari tenaga kesehatan terhadap terapi ARV, 4) merasa takut, 5) mengalami proses berduka. Hasil penelitian ini diharapkan dapat meningkatkan pengetahuan, pengalaman dan masukan bagi perawat dalam memberikan pelayanan keperawatan pada anak dengan HIV/AIDS

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Abstract
Children living with HIV who undergo Antiretroviral (ARV) therapy give challenge to their family in order to adhere to the therapy. This qualitative study used descriptive phenomenology approach, the purpose of this study is to explore family?s experience in caring children living with HIV who undergo Antiretroviral (ARV) therapy. Five participants were involved in this study. Five themes were identified, namely: 1) Antiretroviral (ARV) therapy dimension, 2) faith on the therapy, 3) health professional support in Antiretroviral (ARV) therapy, 4) feeling afraid, and 5) experienced grieving process. From this study, it is suggested that nurses need to improve their knowledge and skill in caring children living with HIV.

Abstrak :
Peningkatan pravelensi Orang dengan HIV/AIDS ODHA dari tahun ke tahun merupakan salah satu masalah kesehatan global yang serius. Antiretroviral ARV merupakan satu-satunya pilihan terapi yang tersedia bagi ODHA yang harus dikonsumsi seumur hidup dengan kepatuhan tinggi 95 guna mencapai efektfitas obat. Akan tetapi, masalah kepatuhan masih menjadi masalah utama bagi ODHA. Pengetahuan tentang penyakit dan pengobatannya merupakan faktor yang dapat mendukung tingkat kepatuhan dalam menjalani pengobatan. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan tentang HIV/AIDS, terapi ARV dan infeksi oportunistik dengan tingkat kepatuhan ODHA dalam menjalani terapi antiretroviral. Digunakan metode cross sectional consecutive total sampling dengan jumlah sampel sebanyak 50 responden. Hasil penelitian ini menunjukkan tidak terdapat hubungan yang bermakna antara tingkat pengetahuan dengan tingkat kepatuhan dalam menjalani terapi ARV p value = 0.107 > 0.05. ......Increasing the number of People Living with HIV AIDS PLWHA from year to year is one of the serious global health problems. Antiretroviral ARV is the only available therapeutic option for PLWHA to be consumed for a lifetime with high adherence 95 in order to achieve drug effectiveness. However, compliance issues are still a major problem for PLWHA. Knowledge about the disease and theraphy are factors that can support medication adherence. This study aims to determine the correlation between the level of knowledge about HIV AIDS, ARV therapy and opportunistic infections and the level of adherence of PLWHA in antiretroviral therapy. The method of cross sectional consecutive total sampling was used with 50 respondents in total. The results of this study indicate there is no significant correlation between the level of knowledge and the level of adherence in undergoing antiretroviral therapy p value 0.107 0.05.