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Setiagung Ambari Bowo
EVALUASI PERBEDAAN NILAI ALBUMIN SERUM SEBELUM DAN SETELAH TINDAKAN EKSISI TANGENSIAL PADA PASIEN LUKA BAKAR = EVALUATION OF ALBUMIN SERUM LEVEL DIFFERENCE PRE AND POST TANGENTIAL EXCISION PROCEDURE IN BURN PATIENTS
"Unknown."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Budhi Arifin Noor
Pengaruh eksisi tangensial dini terhadap kadar prokalsitonin pasien luka bakar berat = The influence of early tangential excision to the level of procalcitonin serum in patients with severe burns
"[ABSTRAK
Luka bakar menyebabkan terbentuknya eskar. Endotoksin bakteri pada eskar dan mediator inflamasi yang terbentuk saat lisis eskar menyebabkan sepsis. Eksisi tangensial dini merupakan upaya menurunkan risiko sepsis melalui pembuangan eskar. Prokalsitonin (PCT) adalah penanda inflamasi yang baik pada sepsis yang akan menurun kadarnya dengan tatalaksana yang adekuat.
Sampai saat ini belum ada penelitian yang menghubungkan eksisi dini dengan PCT. Penelitian ini bertujuan untuk mengetahui pengaruh tindakan eksisi tangensial dini terhadap kadar PCT serum pasien luka bakar berat. Desain penelitian ini adalah analitik observasional pre and post intervention study. Besar sampel yang digunakan adalah empat puluh. Data PCT diambil dari data sekunder yaitu dari rekam medis kemudian dianalisis menggunakan uji Wilcoxon. Didapati perbedaan bermakna antara PCT sebelum operasi dengan PCT sesudah operasi (2,78 (0,09-50,62) vs 1,31 (0,02-83,14), p < 0,005).
ABSTRACT Burn trauma caused cell death with the formation of eschar. Bacteria endotoxins and inflammation mediators that are formed when eskar was lysis cause sepsis. Early tangential excision is the efforts to decrease the risk of sepsis by disposing the eschar. Procalcitonin (PCT) is a good biomarker of sepsis that will decreased with the proper treatment. Until now, there hasn?t been any research linked early excision with PCT. The aim of this research is to know the influence of early tangential excision to the level of PCT serum on severe burn patients. The study design was observational analytic pre and post interventional study. The sample size was forty. PCT data were taken from medical records then analyzed using the Wilcoxon test. There were significant differences between preoperative PCT to postoperative PCT (2.78 (0.09 to 50.62) vs 1.31 (0.02 to 83.14), respectively, p<0.005).;Burn trauma caused cell death with the formation of eschar. Bacteria endotoxins and inflammation mediators that are formed when eskar was lysis cause sepsis. Early tangential excision is the efforts to decrease the risk of sepsis by disposing the eschar. Procalcitonin (PCT) is a good biomarker of sepsis that will decreased with the proper treatment. Until now, there hasn?t been any research linked early excision with PCT. The aim of this research is to know the influence of early tangential excision to the level of PCT serum on severe burn patients. The study design was observational analytic pre and post interventional study. The sample size was forty. PCT data were taken from medical records then analyzed using the Wilcoxon test. There were significant differences between preoperative PCT to postoperative PCT (2.78 (0.09 to 50.62) vs 1.31 (0.02 to 83.14), respectively, p<0.005)., Burn trauma caused cell death with the formation of eschar. Bacteria endotoxins and inflammation mediators that are formed when eskar was lysis cause sepsis. Early tangential excision is the efforts to decrease the risk of sepsis by disposing the eschar. Procalcitonin (PCT) is a good biomarker of sepsis that will decreased with the proper treatment. Until now, there hasn’t been any research linked early excision with PCT. The aim of this research is to know the influence of early tangential excision to the level of PCT serum on severe burn patients. The study design was observational analytic pre and post interventional study. The sample size was forty. PCT data were taken from medical records then analyzed using the Wilcoxon test. There were significant differences between preoperative PCT to postoperative PCT (2.78 (0.09 to 50.62) vs 1.31 (0.02 to 83.14), respectively, p<0.005).]"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Anwar Lewa
Perbandingan luaran (mortalitas, lama rawat inap, insidensi sepsis) antara eksisi tangensial dini dan tertunda di Unit Luka Bakar Rumah Sakit Cipto Mangunkusumo = Comparison of outcome (mortality effect, length of hospitalization, incidence of sepsis) between early and delayed tangential excision at Burn Unit Cipto Mangunkusumo Hospital
"Latar belakang: Pada tahun 2018, diperkirakan tercatat 265.00 kematian yang disebabkan oleh luka bakar. Sekitar 96% kasus kematian terjadi di negara berkembang, dimana dua per tiga-nya terjadi di Afrika dan Asia Tenggara, termasuk Indonesia.
Metode:Subjek dibagi ke dalam dua grup yang diidentifikasi secara retrospektif dari rekam medis, dan dibandingkan secara prospektif. Studi ini membandingkan mortalitas, insiden sepsis, dan lama rawat inap pada pasien yang menjalani eksisi tangensial dini (n=23) yang dibandingkan dengan pasien yang menjalani eksisi tangensial tertunda (n=23). Data dianalisa dengan Fisher Exact Test dan Mann-Whitney.
Hasil: Dari Januari 2016 sampai Agustus 2018, terkumpul 46 pasien yang memenuhi kriteria inklusi penelitian. Kejadian sepsis pada pasien yang menjalani eksisi tangensial dini berbeda secara bermakna (p<0.001) dengan kejadian sepsis pada pasien yang menjalani eksisi tangensial tertunda dengan risiko relatif 0.233 (CI 95% 0.122-0.446). Tidak ada perbedaan yang bermakna pada mortalitas dan lama rawat inap pada kedua grup tersebut (p>0.05).
Kesimpulan: Eksisi tangensial dini bermanfaat untuk mencegah kejadian sepsis pada pasien luka bakar deep dermal dan luka bakar full thickness. Namun begitu, penilaian kedalaman luka bakar bersifat subjektif terhadap pengalaman klinis seorang dokter bedah. Eksisi tangensial dini harus dilakukan tidak lebih dari 96 jam setelah kejadian luka bakar.
Background: In the year 2018, it is estimated that 265.000 deaths are associated with burn injury annually. Approximately 96% of these cases occur in developing countries, out of which two-thirds are in the Africa and Southeast Asia regions, including Indonesia
Methods: There were two groups which are retrospectively identified from the medical records, and then prospectively compared. We compare mortality, sepsis incidence and hospital length of stay in patients underwent early tangential excision (n=23) to those who underwent delayed tangential excision (n=23) using Fisher Exact Test and Mann-Whitney.
Result: From January 2016 to August 2018, 46 patients met the inclusion criteria of this study. The incidence of sepsis was statistically significant with all sepsis incidence occurs only delayed tangential excision group (p<0.001) with relative risk 0.233 (CI 95% 0.122-0.446). There were no differences on the mortality as well as hospital length of stay between early and delayed tangential excision groups (p>0.05).
Conclusion: Early tangential excision is beneficial to prevent sepsis in patients with deep dermal and full thickness burn. Although burn depth assessment can be subjective to surgeon's clinical experience. Early tangential excision should be done no longer than 96 hours after burn injury."
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
T55514
UI - Tesis Membership  Universitas Indonesia Library