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Abstrak :
ABSTRAK
Banyak studiBanyak studi epidemiologi, klinis dan in vitro terakhir menunjukkan hubungan antara vitamin D dengan tuberkulosis (TB) paru. Kadar 25-hidroksivitamin D (25(OH)D) yang rendah berhubungan dengan penyakit TB paru aktif dan laten. Namun, sampai saat ini belum ada data mengenai hubungan kadar 25(OH)D dan status vitamin D dengan derajat lesi TB paru. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dan kadar 25(OH)D dengan derajat lesi TB paru ringan, sedang dan berat. Desain penelitian potong lintang, terdiri dari 137 pasien TB paru terbagi menjadi kelompok derajat lesi TB paru ringan, sedang dan berat masing-masing 46, 47 dan 44 pasien. Diagnosis TB paru berdasarkan Pedoman Nasional Pengendalian Tuberkulosis, Kementerian Kesehatan Republik Indonesia. Derajat lesi TB paru dinilai secara radiologis berdasarkan klasifikasi dari National Tuberculosis and Respiratory Disease Association, New York. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkan sebanyak 122(89,1%) defisiensi dan 15(10,9%) insufiensi vitamin D. Proporsi defisiensi dan insufisiensi vitamin D kelompok TB paru ringan, sedang dan berat tidak didapatkan perbedaan bermakna, masing-masing dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan 9,1%. Kadar 25(OH)D kelompok TB paru ringan, sedang dan berat tidak berbeda bermakna, masing-masing dengan rerata 12,96 (SB±5,83)ng/mL, 12,42 (SB±5,13)ng/mL, dan 11,29 (SB±5,61)ng/mL. Kami menyimpulkan status vitamin D dan kadar 25(OH)D tidak berhubungan dengan derajat lesi TB paru. Proporsi defisiensi dan insufisiensi vitamin D kelompok TB paru ringan, sedang dan berat tidak didapatkan perbedaan bermakna, masingmasing dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan 9,1%.

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ABSTRACT
Most recent epidemiological, clinical and in vitro studies indicate that there is a the relationship between vitamin D and pulmonary tuberculosis (TB). Low concentration of 25- hydroxyvitamin D (25(OH)D) is associated with active and latent pulmonary TB disease. Nevertheless, there is no data about the relationship between vitamin D status and concentrations of 25(OH)D with severity of pulmonary TB. The aim of this study was to obtain the relationship between proportions of vitamin D and concentrations 25(OH)D with mild, moderate and severe degrees of pulmonary TB lesions. This was a cross-sectional study, 137 patients with pulmonary TB and 46, 47 and 44 patients each of mild, moderate and severe degree of pulmonary TB lesions, respectively. Diagnosis of pulmonary TB was based on National Tuberculosis Control Guideline, Ministry of Health of the Republic of Indonesia. The degree of pulmonary TB lesion was radiologically assessed based on classifications of the National Tuberculosis and Respiratory Disease Association, New York. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups. Vitamin D status of the subjects were 122 (89.1%) deficiency and 15 (10.9%) insufficiency of vitamin D. The proportions of vitamin D deficiency and insufficiency at mild, moderate and severe degree of pulmonary TB lesions were also not significantly different, i.e. 84.8% and 15.2%, 91.5% and 8.5%, 90.9% and 9.1%, respectively. Concentrations of 25 (OH) D in each group of mild, moderate and severe pulmonary TB lesions were not significantly different, with a mean (SD) 12.96 (5.83)ng/mL, 12.42 (5.13)ng/mL, and 11.29 (5.61)ng/mL respectively. It is concluded that vitamin D status and serum 25 (OH) D were not related to the degree of pulmonary TB lesion. The proportion of vitamin D deficiency and insufficiency at mild, moderate and severe degree of pulmonary TB lesions were also not significantly different, i.e. 84.8% and 15.2%, 91.5% and 8.5%, 90.9% and 9.1%, respectively.

Abstrak :
Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia subur yang bekerja di dalam ruangan mempunyai vitamin D yang rendah meskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevalua- si peranan paparan sinar matahari pada wanita usia subur terhadap status vitamin D dan tekanan darah. Desain penelitian yang digunakan adalah eksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian ini membandingkan status vitamin D dan tekanan darah sebelum dan setelah mendapat paparan sinar matahari pada wajah dan lengan tiga kali seming- gu selama 12 minggu. Analisis data menggunakan uji t-berpasangan. Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)D meningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar mata- hari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (ni- lai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali seminggu selama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah.

Ultraviolet B sunlight exposure is a primary source of vitamin D, but women of childbearing age who worked in room every day had low serum vitamin D despite Indonesia is a tropical country. The objective of this study was to evaluate the role of sun exposure in women of childbearing age on vitamin D status, and blood pressure. An intervention before-after study without group control was conducted on 21 healthy women. This study compared vitamin D status, and blood pressure before and after receiving ultraviolet B (UVB) from sun exposure on the face and both arms three times a week for 12 weeks. Anthropometric parameter and blood pressure were mea- sured, were determined at baseline and after 12 weeks of sun exposure. The effect of sun exposure can improve vitamin D. Serum 25 (OH)D in- crease 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly re- duced systolic blood pressure (p value = 0.004), and diastolic blood pres- Peranan Ultraviolet B Sinar Matahari terhadap Status Vitamin D dan Tekanan Darah pada Wanita Usia Subur The Role of Ultraviolet B from Sun Exposure on Vitamin D Status and Blood Pressure in Women of Childbearing Age Betty Yosephin* Ali Khomsan** Dodik Briawan** Rimbawa sure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3 times a week for 12 weeks improves the vitamin D status, and blood pres- sure.

Abstrak :
ABSTRAK
Berbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat. Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

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ABSTRACT
Recent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient. This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups. According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05). It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively.