Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Pembuatan obat dalam industri farmasi sangat memerlukan perhatian penting, dalam penerapan CPOB setiap industri farmasi memerlukan sertifikat CPOB yang menandakan proses pembuatan obat dalam industri tersebut telah terkualfiikasi dengan hasil dan mutu yang baik. Beberapa produk di industri farmasi yaitu sediaan tablet yang perlu perhatian penting terkait spesifikasi kritisnya yaitu disolusi dan kadar obat. Nilai disolusi secara langsung mempengaruhi kadar obat dan ketersediaan obat dalam tubuh (Bioavaibility). Beberapa zat aktif memiliki sifat disolusi yang buruk sehingga perlu treatment tambahan untuk meningkatkan disolusi seperti co-grinding. Tujuan dari penelitian ini yaitu untuk mengetahui penyebab variasi nilai disolusi dan alternatif peningkatan nilai disolusi. Metode pengambilan data yang dipakai dalam penelitian ini adalah metode retrospektif dan secara analisis diolah menggunakan Microsoft Exel dan Minitab melalui uji T dan Cpk. Data menunjukkan penyebab variasi antara lain dari karakteristik raw material, proses pengayakan dan kekerasan yang berbeda, alternatif penanganannya dengan kontrol kekerasan dan waktu hancur, pemilihan raw material dengan ukuran partikel kecil dan pembuatan prosedur slugging/grinding untuk meningkatkan disolusi. ......Drug manufacturing in the pharmaceutical industry requires important attention, in implementing CPOB each pharmaceutical industry requires a CPOB certificate indicating that the drug manufacturing process in the industry has been qualified with good results and quality. Some of the products in the pharmaceutical industry i.e. tablet dosage need important attention related to their critical specifications, namely dissolution and drug levels. Dissolution value directly affects drug levels and drug availability in the body (Bioavaibility). Some active substances have poor dissolution properties so additional treatment is needed to increase dissolution such as co-grinding. The purpose of this research is to find out the causes of variations in dissolution values and alternatives to increase dissolution values. The data collection method used in this study is the method retrospective and analyzed using Microsoft Exel and Minitab through the T-test and Cpk test. The data shows the causes of variation including the characteristics of the raw material, the different sieving processes, and hardness, alternative handling by controlling hardness and disintegration time, choosing raw materials with small particle sizes, and making slugging/grinding procedures to increase dissolution.

Abstrak :
Salah satu sumber gas alam Indonesia yang terletak di area Natuna Barat memiliki potensi besar untuk memenuhi peningkatan kebutuhan energi. Flow assurance diperlukan untuk menjamin gas alam dapat terus mengalir pada sistem transportasi perpipaan gas alam dalam berbagai kondisi. Hal yang mampu menghambat mengalirnya pasokan gas alam adalah terbentuknya slugging karena penurunan laju alir gas alam serta beberapa faktor lainnya. Studi ini bertujuan untuk memperoleh profil aliran multifasa yang terbentuk di sepanjang pipa transportasi gas alam jika laju alir gas alam mengalami penurunan, mendapatkan pengaruh profil aliran multifasa terhadap terjadinya slugging di dalam sistem perpipaan gas alam, dan memperoleh metode penanganan cairan yang dilakukan di fasilitas penerima. Studi dianalisis menggunakan simulator aliran multifasa minyak dan gas. Simulasi dilakukan pada 3 skenario kondisi sumur, yaitu initial life, mid life, dan late life yang berturut-turut memiliki laju alir gas sebesar 57, 31, dan 5 MMSCFD. Berdasarkan hasil simulasi diperoleh bahwa semakin rendah laju alir gas alam, maka kemungkinan terjadi slugging akan meningkat. Pada studi ini, slugging terjadi pada kondisi late life. Penanganan cairan yang diajukan oleh penulis untuk memitigasi slugging adalah dengan penambahan control valve yang diletakkan pada aliran masukan separator dan memiliki bukaan 60%......Indonesia's natural gas sources located in the West Natuna area has great potential to meet increasing energy needs. Flow assurance is needed to ensure that natural gas can continue to flow in the natural gas pipeline transportation system under various conditions. One of the things that can hinder the supply of natural gas is the formation of slugging due to a decrease in the flow rate of natural gas and several other factors. This study aims to simulate the multiphase flow that forms along the natural gas transportation pipeline if the flow rate of natural gas decreases, to obtain the effect of the multiphase flow profile on the occurrence of slugging in the natural gas piping system, and to obtain the method of handling liquids carried out at the receiving facility. The study was analyzed using a multiphase oil and gas flow simulator. Simulations were carried out on 3 scenarios of well conditions, namely initial life, mid life, and late life which had gas flow rates of 57, 31, and 5 MMSCFD, respectively. Based on the simulation results, it is found that the lower the natural gas flow rate, the higher the probability of slugging. In this study, slugging occurs in late life conditions. The liquid handling and process improvement proposed by the author to mitigate slugging is by adding a control valve which is placed at the inlet flow of the separator and has an opening of 60%.

Abstrak :
Salah satu sumber gas alam Indonesia yang terletak di area Natuna Barat memiliki potensi besar untuk memenuhi peningkatan kebutuhan energi. Flow assurance diperlukan untuk menjamin gas alam dapat terus mengalir pada sistem transportasi perpipaan gas alam dalam berbagai kondisi. Hal yang mampu menghambat mengalirnya pasokan gas alam adalah terbentuknya slugging karena penurunan laju alir gas alam serta beberapa faktor lainnya. Studi ini bertujuan untuk memperoleh profil aliran multifasa yang terbentuk di sepanjang pipa transportasi gas alam jika laju alir gas alam mengalami penurunan, mendapatkan pengaruh profil aliran multifasa terhadap terjadinya slugging di dalam sistem perpipaan gas alam, dan memperoleh metode penanganan cairan yang dilakukan di fasilitas penerima. Studi dianalisis menggunakan simulator aliran multifasa minyak dan gas. Simulasi dilakukan pada 3 skenario kondisi sumur, yaitu initial life, mid life, dan late life yang berturut-turut memiliki laju alir gas sebesar 57, 31, dan 5 MMSCFD. Berdasarkan hasil simulasi diperoleh bahwa semakin rendah laju alir gas alam, maka kemungkinan terjadi slugging akan meningkat. Pada studi ini, slugging terjadi pada kondisi late life. Penanganan cairan yang diajukan oleh penulis untuk memitigasi slugging adalah dengan penambahan control valve yang diletakkan pada aliran masukan separator dan memiliki bukaan 60%. ...... Indonesia's natural gas sources located in the West Natuna area has great potential to meet increasing energy needs. Flow assurance is needed to ensure that natural gas can continue to flow in the natural gas pipeline transportation system under various conditions. One of the things that can hinder the supply of natural gas is the formation of slugging due to a decrease in the flow rate of natural gas and several other factors. This study aims to simulate the multiphase flow that forms along the natural gas transportation pipeline if the flow rate of natural gas decreases, to obtain the effect of the multiphase flow profile on the occurrence of slugging in the natural gas piping system, and to obtain the method of handling liquids carried out at the receiving facility. The study was analyzed using a multiphase oil and gas flow simulator. Simulations were carried out on 3 scenarios of well conditions, namely initial life, mid life, and late life which had gas flow rates of 57, 31, and 5 MMSCFD, respectively. Based on the simulation results, it is found that the lower the natural gas flow rate, the higher the probability of slugging. In this study, slugging occurs in late life conditions. The liquid handling and process improvement proposed by the author to mitigate slugging is by adding a control valve which is placed at the inlet flow of the separator and has an opening of 60%.

Abstrak :
Slugging as a water hammer initiator is a fascinating topic because it has a strategic impact on equipment safety in industrial systems, i.e. pressurized water reactors (PWR), heat exchangers, etc. The present research’s objective was to investigate slugging as initiating the water hammer phenomenon through indirect contact steam condensing in a horizontal pipe heat exchanger. The experiment apparatus used in the present experimental study consisted of an inner annulus pipe made of copper (din = 17.2 mm, do = 19 mm) with a length of 1.8 m and an outer annulus pipe of galvanized iron (din = 108.3 mm, do = 114. 3 mm) with a length of 1.6 m. The tested liquid was water. The experiments were conducted at a static pressure of Ps = 108.825 kPa and the temperature of T = 119.7°C. The obtained experimental data of temperature and differential pressure fluctuations were analyzed using statistical analysis. The results were as follows: 1) the flow pattern area of non-slugging (stratified and wavy flow), transition (wavy-slug flow), and slugging (slug and large-slug) were determined, with the transition flow pattern of slug and large-slug defined as initiating water hammer; 2) transition area ranges for the wavy-slug flow pattern are from ?co=1´10-1 kg/s to ?co=6´10-1 kg/s for ?st=6´10-3 kg/s to ?st=7.5´10-3 kg/s, and ?co< 3´10-1 kg/s for ?st=8´10-3 kg/s to ?st=9´10-3 kg/s. These obtained data are very important in order to develop a database for the input of an early warning system design in a safe, two-phase flow installation piping system during steam condensation.