Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Pendahuluan: Alpha-actinin-3 (ACTN3) merupakan protein pengikat aktin yang mempengaruhi kinerja otot serta proporsi jenis serat otot. Secara spesifik, ACTN3 bertindak sebagai isoform spesifik dari protein fast twitch yang hanya diekspresikan pada serat otot tipe II dan merupakan bagian dari alat kontraktil serat glikolitik pada otot rangka manusia, termasuk otot mastikasi. Penelitian terdahulu telah menghubungkan antara jenis serat otot ke dalam perkembangan kraniofasial yang dapat menyebabkan terjadinya maloklusi. Tujuan: Mengetahui korelasi antara polimorfisme gen ACTN3 R557X dan Q523R terhadap pola skeletal pada sub-populasi Indonesia. Metode: Subyek merupakan pasien dengan maloklusi skeletal kelas I, II dan III yang menjalani perawatan ortodontik di RS Fakultas Kedokteran Gigi Universitas Indonesia. Amplifikasi sekuens DNA dilakukan pada folikel rambut pasien dengan menggunakan Polymerase Chain Reaction (PCR), sedangkan analisis polimorfisme genetik gen ACTN3 dilakukan dengan Restriction Fragment Length Polymorphism (RFLP). Pola skeletal ditentukan berdasarkan analisis radiografi sefalometri awal menggunakan sudut ANB (Anteroposterior), Facial axis dan Sudut Gonion (Vertikal). Kesimpulan: Tidak terdapat korelasi antara polimorfisme gen ACTN3 R557X dan Q523R dengan maloklusi skeletal kelas I, II, dan III, pertumbuhan vertikal wajah serta arah pertumbuhan 1/3 muka bawah. Namun ditemukan bahwa ACTN3 R557X dan Q523R pada sub-populasi Indonesia mengalami linkage disequilibrium. ......Background: The protein alpha-actinin-3 (ACTN3) is an actin-binding protein that influences muscle performance and the proportion of muscle fiber types. Moreover, it also acts as a specific isoform of fast twitch protein that is only expressed in type II muscle fibers and forms part of the contractile apparatus of fast glycolytic fibers in human skeletal muscle, including masticatory muscle. Previous study has incorporated muscle fiber type to craniofacial development that may lead to malocclusion. Aim: To determine the correlation between polymorphisms of ACTN3 R557X and Q523R gene on skeletal patterns in Indonesian Sub-Populations. Methods:  Subjects were patients with class I, II and III skeletal malocclusion undergoing orthodontic treatment at the Faculty of Dentistry Hospital, University of Indonesia. DNA sequence amplification was carried out on the patient's hair follicles using Polymerase Chain Reaction (PCR), while genetic polymorphism analysis of the ACTN3 gene was carried out using Restriction Fragment length Polymorphism (RFLP). The skeletal pattern was determined by initial cephalometric radiographic analysis using the ANB angle (Anteroposterior), Facial axis and Gonion angle (Vertical). Conclusion: There is no correlation between the ACTN3 R557X and Q523R gene polymorphisms with skeletal malocclusion class I, II, and III, vertical facial growth and growth direction of the lower third of the face. However, it is found that ACTN3 R557X and Q523R in the Indonesian sub-population experience linkage disequilibrium.

Abstrak :
Latar belakang: Maloklusi skeletal menjadi salah satu etiologi asimetri mandibula karena dapat mengakibatkan distribusi tekanan yang abnormal pada permukaan kondilus mandibula. Asimetri mandibula sendiri adalah ketidakseimbangan atau disproporsionalitas antara sisi kanan dan kiri pada sepertiga bagian bawah wajah atau mandibula. Tujuan: Mengetahui perbedaan proporsi terjadinya asimetri mandibula antara pasien dengan pola skeletal yang berbeda. Metode: Studi analitik komparatif dengan desain cross-sectional pada 105 pasien di RSKGM FKG UI. Perhitungan menggunakan metode Kjellberg pada analisis radiograf panoramik secara digital melalui software EzOrtho. Hasil: Terdapat 55,2% subjek mengalami kejadian asimetri mandibula. Uji bivariat Pearson Chi Square menunjukkan terdapat perbedaan bermakna proporsi terjadinya asimetri mandibula antara pasien dengan pola skeletal kelas I, II dan III. Uji bivariat Continuity correction menunjukan terdapat perbedaan bermakna proporsi terjadinya asimetri mandibula pada kelompok pola skeletal kelas I dibandingkan dengan kelompok pola skeletal kelas III, dan terdapat perbedaan bermakna proporsi terjadinya asimetri mandibula pada kelompok pola skeletal kelas II dibandingkan dengan kelompok pola skeletal kelas III. Namun, tidak terdapat perbedaan bermakna proporsi terjadinya asimetri mandibula pada kelompok pola skeletal kelas I dibandingkan dengan kelompok pola skeletal kelas II. Kesimpulan: Terdapat perbedaan proporsi terjadinya asimetri mandibula pada pasien dengan pola skeletal yang berbeda. ......Background: Skeletal malocclusion is one of the etiology of mandibular asymmetry because it caused abnormal pressure distribution on the mandibular condyle’s surface. Mandibular asymmetry is an imbalance or disproportionality between the right and left sides of the lower third of the face or mandible. Aim: The aim of this study was to assess the difference in the proportion of mandibular asymmetry between patients with different skeletal patterns. Methods: A comparative analytical study with a cross-sectional design on 105 patients at RSKGM FKG UI were conducted. Calculations were performed using the Kjellberg method on digital panoramic radiographic analysis using EzOrtho software. Results: The results of this study showed that 55.2% of subjects experienced mandibular asymmetry. The Pearson Chi-Square bivariate test showed that there was a significant difference in the proportion of mandibular asymmetry between patients with class I, II, and III skeletal patterns. The bivariate continuity correction test showed that there was a significant difference in the proportion of mandibular asymmetry in the class I skeletal pattern group compared to the class III skeletal pattern group, and there was a significant difference in the proportion of mandibular asymmetry in class II skeletal pattern group compared to the class III skeletal pattern group. However, there was no significant difference in the proportion of mandibular asymmetry in the class I skeletal pattern group compared to the class II skeletal pattern group. Conclusion: There was a difference in the proportion of mandibular asymmetry in patients with different skeletal patterns.

Abstrak :
It has been shown that more than 40 percent of the apical radiolucencies are radicular cyst, numerous endodontist claims that from 85 to 90 percent of apical lesions disappear or become reduced in size following conservative endodontic treatment and do not required surgical intervention. Maxillary anterior teeth are more frequently susceptible to trauma and there are numerous morphologic anomalies associated with maxillary incisors especially lateral incisors its call palato-radiocular groove (PRG), its caused non vital have been implicated in formation of periapical lesions. Periapical lesions can be cured by conventional endodontic treatment used Ca(OH)2 as an intracanal medication. One case with radicular cyst on the maxillary lateral incisors because of trauma 2 years ago will be presented. Fifteenth months during treatment showed that the cyst reduced in size and symptomless.

Abstrak :
Successful treatment of the adult patient with an open bite dental or skeletal pattern often presents a difficult challenge. The causes of open bite may be multifactorial in nature, there are spesific diagnostic criteria that may allow for an orthodontic treatment modality incorporating extraction therapy with retraction of incisors. The intent of this article is to describe and demonstrate the extraction treatment of a open bite caused by a hyperdivergent facial pattern.